IEEE SENSORS JOURNAL
·
2024
·Vol. 24
·期 6
·7530-7536
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IF 4.3
Zhihao Zhou,Wei Tan,Jun Cai,Yujiang Wu,Ping-An Yang,Xin Huang,Wenjing Fan,Litao Bai,Rui Li
Wearable electrical textiles are of great value for future personalized healthcare applications. Herein, we report a 3-D meshed textile pressure sensor, using a facile dip coating strategy, that combing the sensitive 2-D Ti3C2Tx MXene nanolayer with woven textile fibers. Based on the sensitive 3-D cross-connected conductive network, the textile sensor achieves simultaneously a high sensitivity of up to 81.9 kPa−1 and a fast response time of 30 ms in a wide pressure detection range (0–19 kPa) as well as prominent durability of more than 5000 cycles. Benefiting from superior performances, the textile sensor can be applied for real-time human physiological signals monitoring from pulse waves to human joint motion. This work represents a solid step toward personalized healthcare and clinical diagnosis.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Wuhan Sang,Miaomiao Liu,Li Xu,Shilong Yang,Yanqin Wang,Caihua Zhang,Wen Lu
A binuclear Cu(II) complex, [Cu2L2(OAc)4]·H2O (Coupy-Cu), with 3-(pyridin-3-yl) coumarin as the ligand, was synthesized by the slow solvent evaporation method. Complex Coupy-Cu was characterized by elemental analysis and infrared spectroscopy, and its crystal structure was determined by X-ray single-crystal diffraction, revealing a distorted octahedral geometry around each copper center. The antiferromagnetically coupled dimeric structure was further confirmed by EPR and VSM, which indicated a diamagnetic singlet ground state (S = 0) with weak paramagnetic susceptibility. Complex Coupy-Cu exhibited favorable cytotoxic activity against a panel of human cancer cell lines (HeLa, A549, MCF-7, and HepG2), with anti-proliferative efficacy against HepG2 cells superior to that of oxaliplatin and induced 43.3% apoptosis at 20 µM in a concentration-dependent manner. It is worth emphasizing that the complex showed significantly lower toxicity toward normal cells compared to cisplatin and oxaliplatin, displaying a safety index 5.2 times that of oxaliplatin and 30.4 times that of cisplatin. Investigations via electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurements, and molecular docking indicated that the complex binds to calf thymus DNA (CT-DNA) primarily through an intercalative mode. This binding was further validated via molecular dynamics simulations, which demonstrated stable complex formation and a calculated binding free energy of −13.74 kcal mol−1, driven predominantly by van der Waals interactions.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
·
IF 4
Qingchen Luo,Xinyan Xu,Qian Fan,Fei Pan,Lei Zhao,Liang Zhao
BACKGROUND 2-Amino-3-methylimidazo[4,5- f ]quinoline (IQ), a typical heterocyclic amine, is a common dietary carcinogen raising gastric and colorectal cancer risks. As an abundant anthocyanin monomer with established antioxidant and anti-inflammatory activities, cyanidin-3- O -glucoside (C3G) might attenuate IQ toxicity. Nevertheless, whether and how C3G alleviates IQ-triggered gastrointestinal damage remains unclarified. This study investigated the protective mechanisms of C3G against IQ-induced gastrointestinal injury in mice using biochemical assays, histopathology, western blotting, 16S rRNA sequencing, and molecular simulation. RESULTS The results demonstrated that C3G significantly ameliorated IQ-induced gastric and colonic tissue damage. It effectively reduced key inflammatory markers (nitric oxide, interleukin-6, and tumor necrosis factor-α) and the oxidative stress marker MDA in repaired mouse tissues and serum, while elevating antioxidant enzyme levels. Western blot analysis revealed tissue-specific protective mechanisms. In gastric tissue, C3G activated the Keap1-Nrf2 pathway to enhance antioxidant capacity and suppressed the NF-κB pathway to attenuate inflammation. In the colon, C3G inhibited inflammation via MyD88/TLR4/NF-κB signaling and upregulated the expression of tight junction proteins to restore intestinal barrier function. Gut microbiota analysis revealed that C3G reversed IQ-induced dysbiosis and increased the relative abundance of beneficial bacteria such as Roseburia and Enterorhabdus . Molecular dynamics simulations demonstrated that C3G could enhance IKKβ stability and interfere with its phosphorylation by forming hydrogen bonds with residues ASP151 and ASP109. CONCLUSION This study elucidates that C3G alleviates IQ-induced gastrointestinal injury through a multidimensional mechanism involving microbiota modulation, antioxidation, anti-inflammation, and intestinal barrier repair, providing a theoretical basis for anthocyanin-based dietary interventions against heterocyclic amine toxicity. © 2026 Society of Chemical Industry.
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高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2019
·
IF 2.29
Xuzhao Yang,Jun Wang,Yun Fang
A novel asymmetrical gemini ionic liquid, 1-(3-(trimethylammonio)prop-1-yl)-3-methylimidazolium bis(dicyanamide) ([N 111 C 3 MIM][N(CN) 2 ] 2 ), was synthesized and characterized by 1 H NMR, 13 C NMR. Thermal stability of [N 111 C 3 MIM][N(CN) 2 ] 2 was investigated through thermogravimetric analysis under pure nitrogen atmosphere. Heat capacity of pure [N 111 C 3 MIM][N(CN) 2 ] 2 was measured using differential scanning calorimetry in the temperature range 298.15–423.15 K and enthalpy H T -H 298.15K , and entropy S T -S 298.15K were obtained. Densities and viscosities were measured for the binary system of [N 111 C 3 MIM][N(CN) 2 ] 2 and isopropanol (IPA) over the entire range of mole fractions at various temperatures from 283.15 to 333.15 K under the pressure of 0.101 MPa. Moreover, the excess molar volumes ( V m E ) and the viscosity deviations (Δ η ) for the binary mixtures were determined and well fitted to the Redlich−Kister polynomials. The negative values of V m E and Δ η result from strong self-association and weak hydrogen bonding interaction between the molecules of [N 111 C 3 MIM][N(CN) 2 ] 2 and IPA. Excess Gibbs energy of activation (Δ G *E ) of viscous flow for the present binary mixtures were also calculated. Results have been discussed in terms of molecular interactions and structures.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2016
·Vol. 181
·期 4
·1347-1359
·
IF 1.606
Dai Yong,Huan Bin,Zhang Hai-Sheng,He Yu-Cai
To increase the biocatalytic activity of Escherichia coli CCZU-T15 whole cells, choline chloride/glycerol ([ChCl][Gly]) was firstly used as biocompatible solvent for the effective biotransformation of ethyl 4-chloro-3-oxobutanoate (COBE) into ethyl ( S )-4-chloro-3-hydroxybutanoate [( S )-CHBE]. Furthermore, L-glutamine (150 mM) was added into [ChCl][Gly]–water ([ChCl][Gly] 12.5 vol%, pH 6.5) media instead of NAD + for increasing the biocatalytic efficiency. To further improve the biosynthesis of ( S )-CHBE (>99 % e.e. ) by E. coli CCZU-T15 whole cells, Tween-80 (7.5 mM) was also added into this reaction media, and ( S )-CHBE (>9 % e.e. ) could be effectively synthesized from 2000 and 3000 mM COBE in the yields of 100 and 93.0 % by whole cells of recombinant E. coli CCZU-T15, respectively. TEM image indicated that the cell membrane was permeabilized and lost its integrity and when the cell was exposed to [ChCl][Gly]–water media with Tween-80. Clearly, this bioprocess has high potential for the effective biosynthesis of ( S )-CHBE (>99 % e.e. ).
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2024
·
IF 3.1
Baoyan Ding,Wei Meng,Xiaoling Zang,Zhihua Lv
A small molecule, (S)-ethyl 1-(3-(4-chlorophenoxy)-2-hydroxypropyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate (SEC), has been reported to be capable of suppressing metastasis of prostate cancer (PCa) cells. In this study, SEC was used to study the metabolic responses of PCa cell lines (LNCaP, PC3, and DU145) with different metastatic potential and the alterations of mTOR, p-mTOR, AMPK, and p-AMPK levels, when the PCa cells were inhibited. The ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS)-based analysis showed that SEC induced the decreases of intracellular metabolites including glutamic acid, glutamine, and histidine (LNCaP); creatinine, citric acid/isocitric acid, and aspartic acid (PC3); and spermidine, S-hydroxymethylglutathione, LPE (20:3), and palmitic amide (DU145), and the increases of intracellular LPC (18:0) (LNCaP); tyrosine, pyroglutamic acid/pyrroline hydroxycarboxylic acid (PC3); and tyrosine, phenylalanine, phenylacetylglycine, spermine, histidine, and choline (DU145). SEC also caused the decrease of extracellular N1-acetylspermidine (LNCaP), erythronic acid/threonic acid (PC3 and DU145), and nicotinic acid/picolinic acid (DU145), and the increase of extracellular 5’-methylthioadenosine (DU145). High metastatic PC3 and DU145 cells exhibited changes in aromatic amino acid metabolism including tyrosine metabolism, phenylalanine, tyrosine, and tryptophan metabolism, and phenylalanine metabolism (PC3 and DU145), TCA cycle (PC3), arginine and proline metabolism, and glycerophospholipid metabolism (DU145), different from the low metastatic LNCaP cells, which had changes in alanine, aspartate, and glutamate metabolism, and arginine biosynthesis. In addition, the levels of p-mTOR and p-AMPK were shown to be obviously downregulated and upregulated, respectively, in high metastatic PC3 and DU145 cells upon SEC inhibition, while this behavior was not detected in LNCaP cells.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 24
·52348
·
IF 3.057
Yang Ma,Yanjun Hou,Yuhang Zhang,Lijing Chang,Rui Li,Haijun Niu
Based on the performance of improving the stabilities and coloring efficiencies of triphenylamine polymers, this paper separately synthesized different diamines and 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylic acid, and the electrochromic functions of the polymer films were studied on indium-tin oxide glass (ITO) glass. The polymers had a thiophene group, which was rich in π-electrons and conducive to molecular stability, and showed good stabilities. Ultraviolet spectrum showed that all the six polymers had a wide absorption band in the neutral range of 200–700 nm. Electrochromic analysis showed that the six kinds of polymer films all showed reasonable optical contrast, short response time and low band gap in the infrared spectrum range of 200–1000 nm. Among them, the film formed by PAD2 on ITO glass had better electrochromic properties, longer bleaching response time ( t c = 1.3 s, t b = 4.1 s), PAD3 had better coloration efficiency (214 cm 2 C −1 ).
研究领域:
材料科学
·
电化学
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高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2024
·
IF 6.9
Zhenbo Yang,Yilin Xie,Mengyang Li,Wenxian Chen,Changsheng Zhong,Jin Ju,Qin Deng,Huifang Wang,Ting Cheng,Lei Zhang,Weijie Du,Haihai Liang
Reperfusion stands as a pivotal intervention for ischemic heart disease. However, the restoration of blood flow to ischemic tissue always lead to further damage, which is known as myocardial ischemia/reperfusion injury (MIRI). Ramelteon is an orally administered drug used to improve sleep quality, which is famous for its high bioadaptability and absence of notable addictive characteristics. However, the specific mechanism by which it improves MIRI is still unclear. Sirtuin-3 (Sirt3), primarily located in mitochondria, is crucial in mitigating many cardiac diseases, including MIRI. Based on the structure of Sirt3, we simulated molecular docking and identified several potential amino acid binding sites between it and ramelteon. Therefore, we propose a hypothesis that ramelteon may exert cardioprotective effects by activating the Sirt3 signaling pathway. Our results showed that the activation levels and expression level of Sirt3 were significantly decreased in MIRI tissue and H 2 O 2 stimulated H9C2 cells, while ramelteon treatment upregulated Sirt3 activity and expression. After treat with 3-TYP, a classic Sirt3 activity inhibitor, we constructed myocardial ischemia/reperfusion surgery in vivo and induced H9C2 cells with H 2 O 2 in vitro. The results showed that the myocardial protection and anti-apoptotic effects of ramelteon were antagonized by 3-TYP, indicating that the activation of Sirt3 is a key mechanism for ramelteon to exert myocardial protection. In summary, our results confirm a novel mechanism by which ramelteon improves MIRI by activating Sirt3 signaling pathway, providing strong evidence for the treatment of MIRI with ramelteon.
研究领域:
心脏病学
·
药理学
·
分子生物学
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高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2024
·
IF 3.1
Fangqi Cao,Shuchen Yu,Xiujuan Chen,Lu Xiao,Tingting Qiu,Xiru Wang,Daiwen Zhang,Xiaoliang Yuan,Ping Shi
Synthetic cannabinoids (SCs) are an evolving class of new psychoactive substances (NPS) with structurally various compounds that are increasing over the past few years. Therefore, they are initially hard to identify because of the lack of analytical information. Moreover, there is little to no information regarding the pharmacology of these compounds despite human abuse. In the present study, gas chromatography-mass spectrometry (GC-MS), ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF MS), and nuclear magnetic resonance (NMR) spectroscopy were used to identify the structure of three compounds obtained from seized materials. The pharmacological properties of these compounds were evaluated by subsequent behavioral testing, including von Frey and cold allodynia tests. The results indicated that these compounds were determined to be 2-(1 H -indazole-3-carboxamido)-3,3-dimethylbutanoate (MDMB-INACA), N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1 H -indazole-3-carboxamide (ADB-INACA), and N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1 H -indazole-3-carboxamide (ADB-HINACA) via GC-MS, UPLC-Q-TOF MS and NMR analysis, and they can attenuate mechanical and cold allodynia induced by paclitaxel in rats with peripheral neuropathy. Compared with MDMB-INACA and ADB-HINACA, ADB-INACA showed better analgesic effects on paclitaxel-induced peripheral neuropathy (PIPN) in rats, and its effect was similar to that of the positive drug N′-(1-hexyl-2-oxoindolin-3-ylidene) benzohydrazide (MDA-19).
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高影响因子
Bioresources and Bioprocessing
·
2018
·Vol. 5
·期 1
·1-11
·
IF 0
Liu Xin,Wang Weiwei,Hu Haiyang,Lu Xinyu,Zhang Lige,Xu Ping,Tang Hongzhi
Background Benzofuran and its derivatives contain central pharmacophores and are important structures in medicinal chemistry. Chemical synthesis of benzofuran rings often requires expensive catalysts and stringent operational conditions. Biosynthesis is recognized as a promising way to save energy and produce valuable compounds. Dioxin biodegradation pathways can form several benzofuran derivatives, and these pathways may be a better choice for further synthesis of important biological compounds. 2-Hydroxy-4-(3′-oxo-3′ H -benzofuran-2′-yliden)but-2-enoic acid (HOBB), a benzofuran derivative, can be biosynthesized from dibenzofuran (DBF) through co-metabolic degradation in a lateral dioxygenation pathway. Results Efficient biosynthesis of HOBB was observed using whole cells of Pseudomonas putida strain B6-2. After cultivation in LB medium containing biphenyl, the cells were suspended to an OD 600 of 5 to conduct biosynthesis in the presence of 0.5-mM DBF at pH 7 for 8 h. The bacterial cells were used twice to degrade approximately 0.70-mM DBF, and in batch process, accumulated about 0.29-mM HOBB. HOBB could be easily purified from the reaction with ethyl acetate using the neutral-acid extraction method, and 13.58 ± 0.31 mg of HOBB was obtained from 22.49 ± 0.74-mg DBF with an overall production yield of 60.4% (w/w). The product HOBB, which is a yellow powder, could be detected and identified by LC–MS, GC–MS, and NMR. Conclusions In this study, a new biological route was developed to produce HOBB from DBF using whole cells of P. putida B6-2 (DSM 28064). The biosynthesis of HOBB may contribute to studies of the DBF lateral pathway and provide a new green route for synthesizing benzofuran derivatives with pharmacological activities.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Xiaoyu Jiang,Ziqi Zeng,Lifen Xiao,Xinping Ai,Hanxi Yang,Yuliang Cao
Development of intrinsically safe and long lifespan sodium-ion batteries (SIBs) is urgently needed for large-scale energy storage applications. However, most of the currently developed SIBs suffer from insufficient cycle life and potential unsafety. Herein, we construct an all-phosphate sodium-ion battery (AP-SIB) using a Na3V2(PO4)3 cathode, NaTi2(PO4)3 anode, and nonflammable trimethyl phosphate (TMP) electrolyte. The AP-SIB exhibits not only high safety, high rate performance, and ultralong cycle life but also zero-strain characteristics due to the inverse volume change of the phosphate cathode and anode during charge and discharge cycles, offering a safer and cycle-stable Na-ion technology for electric storage applications.
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高影响因子
Ceramics-Switzerland
·
2024
·Vol. 7
·期 1
·426-435
·
IF 2.7
Yuan-Bin Chen,Yu Fan,Shiuan-Ho Chang,Shaobing Shen
In this study, we used solid-state synthesis to prepare Ba[(ZnxCo1−x)1/3(Nb0.5Ta0.5)2/3]O3microwave ceramics for mobile communications. Compared with Ba[Zn1/3(Nb0.5Ta0.5)2/3]O3, in the prepared materials, Co2+substitution with Zn2+improved the Q × f value and enabled densification and sintering at a lower temperature. We used X-ray diffraction (XRD) and scanning electron microscopy (SEM) to analyze the obtained microstructure. Ba[(ZnxCo1−x)1/3(Nb0.5Ta0.5)2/3]O3was found to have a 1:2 ordered hexagonal structure, and its Q × f value increased with the increase in sintering temperature. In this work, excellent microwave dielectric properties—τf= −0.7 ppm/°C, εr= 34.5, and Q × f = 110,000 GHz—were obtained by sintering Ba[(Zn0.3Co0.7)1/3(Nb0.5Ta0.5)2/3]O3at 1400 °C for 5 h.
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