GREEN CHEMISTRY
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2012
·Vol. 14
·期 9
·2506-2512
·
IF 6.32
Jianjian Wang,Jiawen Ren,Xiaohui Liu,Jinxu Xi,Qineng Xia,Yanhong Zu,Guanzhong Lu,Yanqin Wang
5-Hydroxymethylfurfural (HMF) is a very important intermediate in the fine chemical industry. This study aims to investigate the direct conversion of glucose or glucose-based carbohydrates, such as sucrose, cellobiose, inulin, starch and cellulose, to HMF by using a Sn-Mont catalyst. With the use of this catalyst, a HMF yield of 53.5% was achieved from glucose in a mono-phase medium of tetrahydrofuran (THF)/dimethylsulfoxide (DMSO) at 160 °C for 3 h. The success of one-step conversion of glucose to HMF is attributed to the Sn-Mont catalyst containing two types of acid sites, Lewis acid and Brønsted acid sites. The former one plays a crucial role in the isomerization of glucose to fructose and the latter one is active in the dehydration of generated fructose to HMF. Furthermore, Sn-Mont catalyst also demonstrated excellent activity in the conversion of disaccharides and polysaccharides and as high as 39.1% HMF was directly obtained from cellulose in a THF/H2O–NaCl bi-phasic system.
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mSphere
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2024
·
IF 3.7
Danping Liu,Li-Sheng Xie,Shitao Lian,Kexin Li,Yun Yang,Wen-Zhao Wang,Songnian Hu,Shuang-Jiang Liu,Chang Liu,Zilong He
Anaerostipes hadrus (A. hadrus) is a dominant species in the human gut microbiota and considered a beneficial bacterium for producing probiotic butyrate. However, recent studies have suggested that A. hadrus may negatively affect the host through synthesizing fatty acid and metabolizing the anticancer drug 5-fluorouracil, indicating that the impact of A. hadrus is complex and unclear. Therefore, comprehensive genomic studies on A. hadrus need to be performed. We integrated 527 high-quality public A. hadrus genomes and five distinct metagenomic cohorts. We analyzed these data using the approaches of comparative genomics, metagenomics, and protein structure prediction. We also performed validations with culture-based in vitro assays. We constructed the first large-scale pan-genome of A. hadrus (n = 527) and identified 5-fluorouracil metabolism genes as ubiquitous in A. hadrus genomes as butyrate-producing genes. Metagenomic analysis revealed the wide and stable distribution of A. hadrus in healthy individuals, patients with inflammatory bowel disease, and patients with colorectal cancer, with healthy individuals carrying more A. hadrus. The predicted high-quality protein structure indicated that A. hadrus might metabolize 5-fluorouracil by producing bacterial dihydropyrimidine dehydrogenase (encoded by the preTA operon). Through in vitro assays, we validated the short-chain fatty acid production and 5-fluorouracil metabolism abilities of A. hadrus. We observed for the first time that A. hadrus can convert 5-fluorouracil to α-fluoro-β-ureidopropionic acid, which may result from the combined action of the preTA operon and adjacent hydA (encoding bacterial dihydropyrimidinase). Our results offer novel understandings of A. hadrus, exceptionally functional features, and potential applications.
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SOLID STATE SCIENCES
·
2017
·
IF 1.811
Yisong Wang,Tao Du,Yanli Song,Shuai Che,Xin Fang,Lifeng Zhou
ZSM-5 type zeolite with mesoporous structure was prepared and then amine-functionalized with tetraethylenepentamine (TEPA) by wet impregnation method to form a series of CO 2 adsorbents (ZTx). The structural properties of ZSM-5 and ZTx were characterized by XRD , FTIR , TGA/DTG, nitrogen adsorption/desorption, SEM and EDX techniques. The adsorption capacity of the adsorbents with different amine loading was measured at a temperature from 40 to 100 °C and the adsorption capacity of ZT7 was 1.80 mmol/g at 100 °C. The adsorption process and mechanism were studied by fitting the experimental data used the three adsorption kinetic models, and a complex physical and chemical mixing process was produced as the amine entered the surface and pore size of the zeolite. The high adsorption selectivity at 10% CO 2 concentration and the stability of the five adsorption desorption cycles indicated that ZT7 is a suitable and promising CO 2 adsorbent for the purification of industrial flue gas .
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Shaoan Cheng,Yangxi Li,Zhen Yu,Ruonan Gu,Wei Wu,Yuqing Su
Polyethylene terephthalate (PET) accounts for 40 % of discarded plastics, and its recycling products have outstanding environmental protection and energy-saving performance, so how to improve the current low recycling rate of waste PET has caught increasing attention. In this paper, waste PET plastic was depolymerized to prepare terephthalic acid (TPA) as an organic linker to synthesize MOF-5. MOF-5 was applied to the adsorption of tetracycline (TC). The batch experiments exhibited that kinetic and isotherm data best fitted the pseudo-first-order model and Langmuir isotherm model with a maximum adsorption capacity of 2325.55 mg g −1 . The regeneration rate of MOF-5 at the fifth cycle was 85.51 %. X-ray photoelectron spectroscopy (XPS) technique and Fourier Transform Infrared (FTIR) spectroscopy both indicated the main adsorption mechanism of MOF-5 toward TC could be attributed to hydrogen bonding and the ionic interactions between the unsaturated bonds (C = O and O–C = O) in MOF-5 and TC molecules. Alginate hydrogel with 30–150 mg MOF-5 loading provided better adsorption performance toward TC than MOF-5 powder, and 90 mg MOF-5 loaded hydrogel performed the highest removal rate of 66.28 %. This work proposed a novel method using waste plastics as raw materials to synthesize pollutant adsorbent, which had an enlightening effect on pollutant treatment.
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Journal of Energy Chemistry
·
2024
·
IF 14
Shilin Fan,Bin Zhu,Xiao Yu,Yang Gao,Weiping Xie,Yong Yang,Jian Zhang,Chunlin Chen
Biomass, derived from plant photosynthesis that captures carbon dioxide to form carbohydrates, offers vast renewable reserves. The electrooxidation of biomass, coupled with the hydrogen evolution reaction, enables the simultaneous production of biomass-based plastic monomers and green hydrogen, attracting significant scholarly interest. However, ambiguity remains regarding the adsorption mechanism at the catalyst surface (Langmuir-Hinshelwood or Eley-Rideal) and the adsorbed substrate groups. To address this, we prepared a Ni/Co electrode for the electrooxidation of 5-hydroxymethylfurfural (HMF) into 2,5-furandicarboxylic acid (FDCA) through a corrosion reaction and electro-reduction pathway. HMF conversion reached 100.00%, FDCA yield reached 96.82%, and Faradic efficiency (FE) reached 92.14%. Meaningfully, utilizing in-situ spectroscopy and electrochemical methods, this work provided valuable insights into active sites and catalyst surface adsorption.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
·
IF 3.8
Dezhu Zhang,Su Fan,Kenan Xu,Haotian Liu,Nana Chang,Yijie Wang,Yixing Wang,Kang Huang,Zhi Xu
Vanadium flow battery (VFB) shows great potential in balancing the volatility of renewable energy. In this work, we investigated, for the first time, the various properties of crystalline ZSM-5 membranes prepared through the organic template-free gel strategy in VFB. The subnano windows (∼0.55 nm) of ZSM-5 zeolite provided selective transport paths for protons (∼0.27 nm) and blocked the vanadium (>0.6 nm) migration through pore repulsion effect. The zeolite membranes exhibited a very low vanadium penetration rate (0.05 mmol L–1 h–1), achieving a Coulombic efficiency (CE) of 96.1%, a voltage efficiency of 78.3%, and an energy efficiency of 75.3% at the current density of 40 mA cm–2. Notably, ZSM-5 prepared using the template-free strategy eliminates the need for a high-temperature calcination step, and the membrane has a lower defect density and exhibits a higher CE. The self-discharge time of the ZSM-5 zeolite membrane increased up to 78 h. Furthermore, the charge–discharge performance kept stable more than 300 cycles at 60 mA cm–2.
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Environmental Chemistry
·
2024
·Vol. 20
·期 7
·292-301
·
IF 2
Xiao-Yan Cao,Min Liu,Ling Li,Gui-Peng Yang
Environmental context Organophosphorus (OP) is bioavailable to phytoplankton with photolysis can play an important role in the process. The photolysis behaviour of an OP (adenosine 5′-monophosphate, AMP) in seawater was investigated, and AMP can release inorganic phosphate under environmentally relevant light conditions, indicating OP photodegradation might be important in the phosphorus biogeochemical cycle. The results are helpful to further understand the bioavailability and cycle of OP in marine environment.Rationale Organic phosphorus (OP) is a potential source of bioavailable phosphorus for phytoplankton through photolysis and other degradation processes. Therefore, OP photodegradation plays an important role in phosphorus biogeochemical cycle.Methodology Taking adenosine 5′-monophosphate (AMP) as a model OP, we investigated the photolysis behaviour in seawater and discussed the mechanism. The photolysis dynamics were studied based on the inorganic phosphorus production at appropriate time intervals, which was analysed by spectrophotometric molybdenum blue method. The effects of medium, light and radicals were investigated.Results It was found that AMP can release inorganic phosphate under photosynthetically active radiation and ultraviolet (UV) with UVB being the most reactive band. The degradation of AMP in seawater was lower than that in deionised water under the same conditions, and the fresh seawater was more beneficial than aged seawater. The kinetics could be described by apseudo-first order equation. Fe3+ can promote the photolysis due to the generation of ·OH radicals, while within the range of this study, changes of Fe3+ content have no substantial effect on the promotion. The influence of ethanol and tetrahydrofuran as radical inhibitor showed evident inhabitation to the degradation, indicating that ·OH and 1O2 played an important role in the process, and ·OH seemed more important than 1O2.Discussion OP photodegradation is of importance in the phosphorus biogeochemical cycle. Varying properties of the medium and light can affect the OP transformation in seawater. The results are helpful to further understand the bioavailability and cycle of OP in the marine environment.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2025
·
IF 21.1
Chunxiao Gong,Zhaoyang Ju,Qixuan Lin,Xianqing Lv,Richard Lee Smith,Lujiang Xu,Yang Cao,Li Shuai,Zhen Fang
Cellulose acetate (CA) is a versatile biopolymer derivative widely used in consumer products such as cigarette filters, textiles, and plastics. The extensive use of CA-based products generates substantial plastic waste, which can persist in the environment for over a decade due to its low biodegradability, posing serious environmental challenges. Herein, we report a one-step conversion process that transforms CA plastic waste into 5-hydroxymethylfurfural (HMF) while simultaneously recovering acetic acid. By employing AlCl 3 as a catalyst in an acetone-water solvent system at 160°C for 50 min, CA exhibited a 53.7 % HMF yield, a threefold increase compared to untreated cellulose, while also achieving a 97.3 % theoretical yield of acetic acid. The HMF yield exceeded 50 % when cigarette filters or CA fabrics were used as substrates. Molecular dynamics simulations revealed that the acetyl groups in CA enhance its coordination with acetone molecules, reducing the probability of protonation at the C1 and C4 oxygen atoms of the CA monomer and thereby suppressing the formation of undesired byproducts. Furthermore, the in-situ regenerated acetic acid actively promotes the HMF production. This study establishes a viable pathway for upcycling CA waste while advancing sustainable management strategies for CA-based plastics, offering a promising solution to mitigate environmental impacts.
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Nanomaterials
·
2025
·Vol. 15
·期 9
·639
·
IF 4.3
Mingbo Guo,Yijun Wang,Lei Zhang,Junran Lu,Chang Gong,Wanning Zhang,Yuxi Fang,Xinyuan Zhu,Shunai Che
Zeolite is increasingly recognized for its enhancement of low-frequency acoustic performance in microspeakers. The aging characteristics of zeolite have been regarded as the critical factor for the commercial viability of mobile phones products, but the mechanism remains ambiguous. Here, the low-frequency acoustic performance of hierarchically structured ZSM-5 was investigated through aging with water and acetic acid (AA). It was discovered that water vapor augmented the resonance offset as it enhanced the structure of the zeolite, resulting in a lower water content. The resonance offset of ZSM-5 significantly decreased after the adsorption of AA vapor, as excessive AA was adsorbed through both physical and chemical adsorption, causing partial destruction of supermicropore and mesopores. The performance of ZMS-5 stored with vapor of AA and water mixture did not significantly deteriorate, indicating that water effectively protected the pores of zeolite to prevent excessive adsorption of AA. This was attributed to the fact that water was adsorbed by Brønsted acid sites of ZSM-5 more preferentially than AA, thereby avoiding excessive adsorption of AA.
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AMERICAN JOURNAL OF PATHOLOGY
·
2025
·Vol. 195
·期 12
·2320-2335
·
IF 3.6
Jing Li,Meixue Chen,Lingling Lu,Yinmiao Wang,Wei Wu,Yanhong Feng
Pediatric asthma is a respiratory disease in which M2 macrophages play a critical role. Here, the role and molecular mechanism of lysophosphatidic acid receptor 5 ( LPAR5 ) were investigated in pediatric asthma through in vivo and in vitro experiments. LPAR5 expression was increased in peripheral blood mononuclear cells from children with asthma. In an ovalbumin-induced neonatal asthmatic mouse model, LPAR5 antagonist alleviated airway inflammation by suppressing the release of inflammatory cytokines and inflammatory cell infiltration. Ovalbumin-induced M2 macrophage activation in neonatal mouse lung tissue was suppressed by LPAR5 antagonist, accompanied by decreased YM1 protein (encoded by chitinase 3 like 1) secretion. Differentiated THP-1 cells were stimulated with IL-4 to mimic M2 macrophages in vitro . M2 macrophage activation was reduced by both LPAR5 antagonist or LPAR5 knockdown. Furthermore, KLF transcription factor 5 ( KLF5 ) was significantly up-regulated and positively correlated with LPAR5 expression in peripheral blood mononuclear cells from children with asthma. KLF5 bound to the promoter of LPAR5 and transcriptionally promoted LPAR5 expression. LPAR5 overexpression increased M2 macrophage activation in KLF5-depleted THP-1 cells. The underlying mechanism of LPAR5 was investigated by phosphorylomics analysis, which identified mitogen-activated protein kinase kinase kinase 7 as a possible downstream effector. The results showed that LPAR5 antagonist attenuated airway inflammation in neonatal mice by decreasing M2 macrophage activation. KLF5 positively regulates the expression of LPAR5, which further increased the phosphorylation of mitogen-activated protein kinase kinase kinase 7 protein in macrophages. This article highlights that LPAR5 might serve as a potential target in pediatric asthma.
研究领域:
呼吸病学
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免疫学
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分子生物学
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儿科医学
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信号转导
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炎症性疾病
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转化医学
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xiaoping Liu,Yunbo Zhai,Zhixiang Xu,Yun Zhu,Yin Zhou,Zhexian Wang,Liming Liu,Fashen Liang,Wanying Ren,Yu Xie,Caiting Li,Min Xu
Natural deep eutectic solvents (NADES) coupled with hydrothermal treatment was innovatively proposed to process waste activated sludge for sustainable production of 5-methylfurfural (5-MF) and enhanced dewaterability. The yield of 5-MF up to 11.54 kg/t volatile solids (VS) with a NADES dosage of 2.0 mL, hydrothermal temperature of 180 °C and holding time of 30 min. The decreased capillary suction time (CST) and bound water content indicated that NADES with hydrothermal treatment substantially improved the dewaterability of sludge. The variations of sludge physicochemical properties and extracellular polymeric substances (EPS) compositions revealed that NADES disrupted the structure of sludge biopolymers. Density functional theory (DFT) calculations indicated that NADES weakened the hydrogen bond strength between EPS components, and thus promoted the solubilization of proteins and polysaccharides. Besides, transition state analysis showed that NADES also lowered the energy barrier of polypeptide hydrolysis and carbohydrates dehydration reactions for the production of 5-MF.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
·
IF 5.7
Yinglu Chen,Yitao Yan,Jie Chen,Ben Zheng,Youwei Jiang,Zhengzhong Kang,Jun Wu
Given the prevalence of the malignant weed Chinese Sprangletop (Leptochloa chinensis (L.) Nees) in rice fields, the development of novel herbicides against this weed has aroused wide interest. Here, we report a novel diphenyl ether-pyrimidine hybrid, DEP-5, serving as a systematic pre/postemergence herbicide candidate for broad-spectrum weed control in rice fields, specifically for L. chinensis. Notably, DEP-5 exhibits over 80% herbicidal activity against the resistant biotypes even at 37.5 g a.i./ha under greenhouse conditions and has complete control of L. chinensis at 150 g a.i./ha in the rice fields. We uncover that DEP-5 acts as a noncompetitive inhibitor of acetohydroxyacid synthase (AHAS) with an inhibition constant (Ki) of 39.4 μM. We propose that DEP-5 binds to AHAS in two hydrophobic-driven binding modes that differ from commercial AHAS inhibitors. Overall, these findings demonstrate that DEP-5 has great potential to be developed into a herbicide for L. chinensis control and inspire fresh concepts for novel AHAS-inhibiting herbicide design.
研究领域:
植物学
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农业科学
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分子生物学
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