APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Minghua Wang,Yaxin Zheng,Dongchen Yang,Yichun Ren,Wei Gao,Ningzhao Shang,Jinlin Zhang,Shutao Gao,Zexiu An,Chun Wang
Co 3 N nanozyme with peroxidase-like activity is synthesized via ammonia-assisted calcination of Co-based Prussian blue analogue, which displays superior catalytic activity for the oxidative degradation of organic pollutants. Co 3 N/peroxymonosulfate (PMS) system achieves complete degradation of imidacloprid (10 mg L −1 ) within 15 min under low catalyst loading (2 mg L −1 Co 3 N and 150 mg L −1 PMS), corresponding to a modified kinetic rate constant of 243.3 min −1 M −1 . Density functional theory (DFT) calculation reveals that the strong electronegativity of nitrogen reduces Co 3d electron occupancy, optimizing the Co d -band center and effectively overcoming the "oxygen wall" barrier, thereby enhancing PMS activation and promoting the formation of high-valent metal-oxo (HVMO) species, Co(IV)=O, which is the key species to achieve selective oxidation in advanced oxidation processes (AOPs). This work demonstrates that modulating the d -band center position of transition metals is a viable strategy for breaking "oxygen wall" limitation and facilitating HVMO species generation in AOPs.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 12
·2618
·
IF 4.6
Kaining Sun,Xinyi Yang,Fei Qi,Yingjie Liu,Lijing Wang,Bo Feng,Jiankang Yu,Guangbo Che
Peroxymonosulfate (PMS)-based advanced oxidation technology has emerged as an effective means for removing organic pollutants from water due to its strong oxidizing ability. However, enhancing the activation efficiency of PMS represents a key challenge at present. SrTiO3, a typical perovskite metal oxide, holds potential in the field of the photocatalytic degradation of pollutants, yet its application is limited by the wide bandgap and fast carrier recombination rates. This study optimized the photocatalytic performance of SrTiO3by regulating its electronic structure and optical properties through cobalt (Co) doping. Experimental results (TRPL, TPV, UV–Vis DRS, ESR, etc.) and DFT calculations (GGA-PBE) demonstrated that Co doping shifted the d-band center of SrTiO3upwards, optimized the adsorption energy of SO4−, enhanced the sunlight response range, and significantly improved carrier extraction efficiency. Under visible light irradiation, 2,4-dichlorophenol (2,4-DCP) could be effectively degraded within 60 min in a wide pH range. Through Fukui function calculation (B3LYP/6-31G*) and experimental characterization analysis (HPLC-MS and IC), the possible degradation pathways of 2,4-DCP and the mechanism for photocatalysis were investigated. The toxicity analysis (T.E.S.T) confirmed the reduced toxicity of the degradation products of 2,4-DCPs. This study provides a reference for the catalyst design and optimization strategy of PMS-based advanced oxidation technology.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 30
·1-13
·
IF 2.8
Huang Yi-Rui,Li Wei,Wang Ze-Hong,Jian Xiao-Jian,Zhou Zi-Zhe,Jia Xiang-Xiang,Liu Hong-Yu,Lu Yi-Fan,Wang Jun-Chuan,Wu Xiang-Feng,Wang Hui,Zhou Er-Peng
Chiral optoelectronic sensors detect chirality by selectively binding with chiral substrates, causing changes in electrical signals, which have attracted wide attention for their chiral recognition ability. In this study, the Ti 3 C 2 /ZIF-67/D-His electrochemical sensors were successfully synthesized. Firstly, ZIF-67/D-His was obtained using hexahydrated cobalt nitrate, dimethylimidazole, and D-histidine (D-His). Then, the ZIF-67/D-His film was grown on the surface of the Ti 3 C 2 film using a spin-coating method. By changing the spin-coating cycles, the influence of the ZIF-67/D-His film thickness on the detection performance was studied. The results showed that when the spin-coating cycle was three, the electrochemical sensor (Ti 3 C 2 /ZIF-67/D-His-3) exhibited good detection performance for D-Ala with a detection limit of 1.1 μM, and additionally demonstrated an excellent selective detection ability for D-Ala, with a significant difference in the differential pulse voltammetry (DPV) current intensity between D-Ala and L-Ala solutions. Besides, the detection curve for D-Ala showed a linear relationship with the concentration of the D-Ala solution. Furthermore, the Ti 3 C 2 /ZIF-67/D-His-3 electrochemical sensor demonstrated good stability and could be reused multiple times after simple cleaning. The Ti 3 C 2 /ZIF-67/D-His prepared in this work shows promising application potential in the area of electrochemical sensors.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Jiangkun Dai,Wenjia Dan,Nian Li,Ruixue Wang,Yao Zhang,Nannan Li,Ruizhi Wang,Junru Wang
Thirty-one canthin-6-one analogues, mainly including C 2 or C 5 or D ring modified canthin-6-ones, were designed and synthesized in order to study their antibacterial activity and structure-activity relationships. The analogue 28 with the highest bioactivity had a peak minimum inhibitory concentration of 4 μg/ml and showed low cytotoxicity against L02 cells and good “drug-like” properties. The antibacterial effect of 28 was characterized further by scanning electron microscopy, cytoplasmic β -galactosidase leakage assay, molecular docking evaluation, UV–visible analysis and isothermal titration calorimetry (ITC) measurement. The results showed that 28 may exert its bactericidal effect by damaging bacterial cell membranes and disrupting the function of DNA topoisomerases, both of which could lead to rapid cell death.
研究领域:
药理学
·
有机化学
·
微生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2016
·
IF 3.782
Hui Zhang,Jiangkang Xu,Liang Xing,Jianbo Ji,Aihua Yu,Guangxi Zhai
Doxorubicin (DOX) is one of the most common chemotherapeutic agents for the treatment of various cancers, but its clinical usage is limited by dose-dependent cardiotoxicity. We have recently synthesized a series of Chondroitin sulfate/poly ( d , l -lactideco-glycolide) block copolymers (Chs- b -PLGA) with different length of hydrophobic block by an end-to-end coupling strategy. The structure of the amphiphilic block copolymers with low critical micelle concentration (∼28 mg/L) were confirmed by 1 H NMR. The copolymers could self-assemble into stable micelles in aqueous environment with homogeneous size distribution and negative zeta potential . The hemolytic study indicated their excellent blood compatibility and potential application for intravenous administration. DOX can be efficiently encapsulated by the Chs- b -PLGA micelles. The DOX-loaded micelles showed a sustained and pH dependent drug release behavior. The cytotoxicity assay showed no associated toxicity with blank micelles while concentration-related cell inhibition with DOX-loaded micelles. Moreover, fast cellular uptake of DOX-loaded micelles was observed by fluorescent microscope. In vivo pharmacokinetics study showed that the Chs- b -PLGA micelles could significantly prolong the blood circulation time of DOX. The maximum tolerated dose (MTD) of DOX-loaded micelles in Kunming mice was about 2-fold higher of the MTD of free DOX, indicating a high tolerance of the DOX-loaded micelles. In conclusion, the Chs- b -PLGA micelles would be a potentially useful drug delivery system for cancer therapy.
研究领域:
药剂学
·
药物递送
·
纳米医学
·
高分子科学
·
癌症治疗
·
生物医学工程
✓ 已验证
DOI
高影响因子
Fermentation-Basel
·
2026
·Vol. 12
·期 1
·
IF 3.3
Fenghao An,Yanchun Feng,Da Li,Mei Hua,Xiuquan Wang,Xifei Xu,Yuguang He,Xinyu Miao,Mubai Sun,Honghong Niu
As one of the few carotenoid-producing microorganisms,Rhodotorula mucilaginosaremains underexplored for its antioxidant activity. This study investigated the effects ofR. mucilaginosaJAASSRY on D-galactose-induced aging mice. The high-dose JAASSRY (HR) significantly increased body weight by 9.89% compared to the model group (AM), while reducing organ indices of the spleen, liver, kidneys, and brain (p< 0.01). Compared with the AM group, the HR group exhibited increased serum activities of SOD (20.26%), GSH-Px (9.03%), and CAT (133.01%), with a 24.87% decrease in MDA level. In brain tissue, SOD, GSH-Px, and CAT activities increased by 79.49%, 8.45%, and 60.23%, respectively, while MDA decreased by 8.29%.R. mucilaginosaJAASSRY also dose-dependently alleviated structural damage in the hippocampus and spleen and improved motor strength and learning-memory capacity. Furthermore,R. mucilaginosaJAASSRY increased the abundance ofLactobacillusand reducedProteobacteria,Helicobacter, andOscillospira, while enhancing antioxidant capacity by modulating nucleotide, lipid, and carbohydrate metabolism.LactobacillusandPediococcuswere positively correlated with memory latency and CAT/SOD activities (p< 0.05), whereasActinormycesandDehalobacteriumshowed negative correlations. Notably, HR performed comparably or superiorly to β-carotene in improving cerebral oxidative stress and beneficial microbiota, suggesting its potential in neuroprotection and gut–brain axis regulation. In conclusion,R. mucilaginosaJAASSRY mitigates aging-related oxidative damage and behavioral deficits by modulating gut microbiota structure and function, demonstrating its promise as a β-carotene alternative in animal husbandry and functional foods.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Chaoyu Tong,Yang Song,Daniel Schlenk,Jing Liu
1,4-Dichlorobenzene (1,4-DCB), a widely used household insect repellent and fungicide, has been epidemiologically linked to ulcerative colitis, yet its potential mechanisms remain poorly understood. In this study, juvenile male mice developed colonic inflammation following exposure to 1,4-DCB at doses of 0.03–3 mg/kg/day, a range corresponding to the human estimated daily intake (EDI) and relevant internal exposure levels in adolescents. This was evidenced by increased fecal moisture (by 12.22%–18.21%) and colon weight (17.57%–38.33%), shortened colon length (13.51%–24.88%), crypt expansion, and connective tissue hyperplasia. 1,4-DCB exposure upregulated the colonic expression of regenerating family member 3 gamma (Reg3γ), a key antimicrobial peptide that targets Gram-positive bacteria. This upregulation was accompanied by gut microbiota dysbiosis, elevated colonic levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines, as well as decreased levels of tight junction proteins. Microbiota depletion alleviated these colitis symptoms induced by 1,4-DCB. In human colonic cells, we further validated LPS-induced inflammation and impaired permeability as well as identified vitamin D receptor (VDR) as a potential primary molecular target for 1,4-DCB. Overall, this study provides the first evidence that environmentally relevant levels of 1,4-DCB induce colonic inflammation through the VDR-Reg3γ-gut microbiota axis. These findings highlight the potential colonic health risk posed by this prevalent indoor pollutant.
✓ 已验证
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2017
·
IF 2.238
Guihua Cui,Dehai Zhao,Peng Lv,Zhengguo Gao,Shuiying Chen,Nannan Qiu,Toshifumi Satoh,Toyoji Kakuchi,Qian Duan
A series of novel fluorescent complexes was formed by chelation of the thermosensitive polymers with europium(III) ions. The polymers was synthesized via atom transfer radical polymerization (ATRP), which composed of poly( N -isopropyl acrylamide) (PNIPAM) and 2-amino-2-deoxy- d -glucopyranose( d -glucosamine, GA). The aqueous solutions of the polymers and its Eu(III) complexes exhibited a lower critical solution temperatures (LCSTs), and which were approximately equal to body temperature. The maximum emission intensity of the complexes at 613 nm was enhanced by a factor of approximately 10 relative to that of the corresponding Eu(III) chloride. Cell viability assays suggested that these thermosensitive polymers and Eu(III) complexes showed excellent biocompatibility in vitro.
研究领域:
材料化学
·
高分子科学
·
无机化学
·
发光材料
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Siwei Sun,Xinxin Zhang,Haitao Yu,Ying Xie
NiFe alloy is regarded as a promising electrocatalyst for water splitting owing to its superior conductivity, tunable electronic structure, and abundant active sites. Nevertheless, its practical application is hindered by slow water dissociation kinetics and unfavorable adsorption of hydrogen intermediates. Herein, we develop a composite catalyst, denoted as Co/Ni 3 Fe@NC-3 through a coordination-pyrolysis route, where ZIF-67-derived Co nanoparticles are anchored on Ni 3 Fe@NC porous nanosheets. In 1 M KOH, the catalyst exhibits remarkable bifunctional activity, requiring overpotentials of 67 mV for HER and 240 mV for OER at 10 mA cm −2 . Notably, a symmetric electrolyzer based on this catalyst (Co/Ni 3 Fe@NC-3) (+||−) achieves overall water splitting at a low voltage of 1.499 V (10 mA cm −2 ), superior to the commercial Pt/C||RuO 2 benchmark (1.592 V), and sustains stable operation for 100 h at 100 mA cm −2 . In-situ electrochemical impedance spectroscopy (EIS) indicates that Co incorporation optimizes the interfacial electronic structure, leading to faster charge transfer and reduced impedance. Density functional theory (DFT) calculations and experimental results further demonstrate that Co-induced interfacial electron redistribution upshifts the d-band centers ( E d ) of Ni/Fe sites, strengthens the adsorption of H* and H 2 O, and thus synergistically enhances both HER and OER performance. This study highlights the effectiveness of interface engineering and electronic structure modulation, providing a viable strategy for designing advanced NiFe-based water-splitting catalysts.
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2023
·
IF 0
Xiaoyu Xia,Han Li,Xianbing Xu,Chao Wu,Zhenyu Wang,Junjie Yi,Guanghua Zhao,Ming Du
Recombinant human H-ferritin nanocage (rHuHF) loaded with natural antioxidative lycopene molecules (LYC) was successfully constructed for the first time, aiming to enrich LYC in the brain and explore the regulation mechanism of this nanoparticles on neurodegeneration. Here, the mouse model was constructed via D-galactose-induced neurodegeneration based on behavioural analysis, histological observation, immunostaining analysis, Fourier transform infrared microscopy, and Western blotting analysis for the regulation of rHuHF-LYC. rHuHF-LYC improved the behaviour of mice in a dose-dependent manner. Besides, rHuHF-LYC can attenuate neuronal damage, maintain the number of Nissl body, increase the level of unsaturated fat, inhibit the activation of glial cells, and prevent excessive accumulation of neurotoxic proteins in the hippocampus of mice. More importantly, synaptic plasticity was activated in response to the regulation of rHuHF-LYC with excellent biocompatibility and biosafety. This study proved the validity of the direct use of natural antioxidant nano drugs for treating neurodegeneration, providing a promising therapeutic option against further imbalances in the degenerative brain microenvironment.
✓ 已验证
产品关联
DOI
PubMed
Polymers
·
2023
·Vol. 15
·期 10
·2274
·
IF 5
Zipeng He,Binhua Mei,Hongmei Chu,Yanjun Hou,Haijun Niu
In this study, six conjugated oligomers containing D–A structures were synthesized using the Stille coupling reaction and named PHZ1–PHZ6. All the oligomers utilized demonstrated excellent solubilities in common solvents and notable color variations in the domain of electrochromic characteristics. By designing and synthesizing two electron-donating groups modified with alkyl side chains and a common aromatic electron-donating group, as well as cross-binding them with two electron-withdrawing groups with lower molecular weights, the six oligomers presented good color-rendering efficiencies, among which PHZ4 presented the best color-rendering efficiency (283 cm2·C−1). The products also demonstrated excellent electrochemical switching-response times. PHZ5 presented the fastest coloring time (0.7 s), PHZ3 and PHZ6 presented the fastest bleaching times (2.1 s). Following 400 s of cycling activity, all the oligomers under study showed good working stabilities. Moreover, three kinds of photodetectors based on conducting oligomers were prepared, and the experimental results show that the three photodetectors have better specific detection performances and gains. These characteristics indicate that oligomers containing D–A structures are suitable for use as electrochromic and photodetector materials in the research.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Yang Li,Bingxuan Ji,Ziyang Chen,Zhenghua Zhang
Secondary effluent from municipal wastewater treatment plants can be used to produce reclaimed water through membrane distillation (MD), providing a potential solution to the current global water crisis. However, membrane fouling over extended periods of operation reduces the separation performance of MD systems and significantly shortens the operational life-span of the membrane. Herein, in order to overcome these limitations, a novel surface-modified PTFE membrane was fabricated by depositing polydopamine and grafting dextro ( d )-tyrosine (Tyr/PDA@PTFE). This synergistic coating was designed to reduce surface hydrophobicity of the PTFE membrane and provide anti-adhesive properties for bacteria, while enhancing flux and anti-fouling performance during MD. The Tyr/PDA@PTFE membranes demonstrated enhanced MD performance and the Tyr-300/PDA@PTFE membrane (with d -tyrosine coating solution concentration of 300 μM) exhibited the best MD performance during direct contact membrane distillation (DCMD) of the secondary effluent, with the highest flux (49.1 LMH) compared with the pristine PTFE membrane (34.7 LMH), achieving a flux increase of 41.5%. Long-term DCMD operation showed that the Tyr-300/PDA@PTFE membrane exhibited improved anti-fouling performance compared with the pristine PTFE membrane, with 43.8% flux decay observed after three cycles of use, while the pristine PTFE membrane was unable to complete three cycles of use with an 87.2% decrease in flux observed by middle of the third round. The quality of permeate formed by the Tyr/PDA@PTFE membranes during MD, indicated that they could be operated stably for three cycles of use over a 40 h period, intercepting organic matter in the feed solution. The Tyr-300/PDA@PTFE membrane was especially effective for the removal of low molecular weight and humus-like substances, achieving rejection rates of 89.5% and 86.7%, respectively. Additionally, the Tyr/PDA@PTFE membrane carried the more negative charge and exhibited a high level of resistance to bio-adhesion. This study demonstrates the feasibility of use of this novel Tyr/PDA@PTFE membrane in MD, for the effective treatment of secondary effluent from wastewater treatment plants and the production of reclaimed water.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）