ACS Applied Nano Materials
·
2023
·
IF 5.9
Hongjing Wang,Xu Mu,Qiqi Mao,Kai Deng,Hongjie Yu,You Xu,Ziqiang Wang,Liang Wang
It is of great significance to develop electrocatalysts with high activity, selectivity, and stability for the electrosynthesis of H2O2. Here, we successfully prepare low-crystalline two-dimensional Pd metallene sulfide with isolated Pd sites and rich sulfur vacancies (L-PdS-Vs metallene) via a solvothermal method. The ultrathin two-dimensional structure, amorphous/crystalline heterophase structure, and plentiful sulfur vacancy of L-PdS-Vs metallene can provide sufficient active sites and a strong electronic effect. Moreover, sulfidation induces the isolation of Pd sites that can inhibit the dissociation of O–O bonds. As such, L-PdS-Vs metallene exhibits excellent electrocatalytic performance with high H2O2 selectivity (>90%) under a wide application potential. The average H2O2 productivity at 0.3 V is as high as 1.12 mol gcat–1 h–1, and the corresponding FE is over 90%. The sulfidation strategy has multiple advantages and provides an effective strategy for the design of high-performance 2e– ORR electrocatalysts.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Jia-Rui Du,Deng-Ke Teng,Yang Wang,Qimeihui Wang,Yuan-Qiang Lin,Qiang Luo,Jia-Nan Xue,Ling-Yu Zhu,Peng Dong,Gen-Mao Zhang,Yan Liu,Zhi-Xia Sun,Hui Wang,Guo-Qing Sui
Purpose Sonodynamic therapy (SDT), with its high tissue penetration and noninvasive advantages, represents an emerging approach to eradicating solid tumors. However, the outcomes of SDT are typically hampered by the low oxygen content and immunosuppression in the tumor microenvironment (TME). Accordingly, we constructed a cascade nanoplatform to regulate the TME and improve the anti-tumor efficiency of SDT.Methods In this study, we rationally design cascade nanoplatform by incorporating immunostimulant hyaluronic acid (HA) and sonosensitizer chlorin e6 (Ce6) on the polydopamine nanocarrier that is pre-doped with platinum nanozymes (designated Ce6/Pt@PDA-HA, PPCH).Results The cascade reactions of PPCH are evidenced by the results that HA exhibits reversing immunosuppressive that converts M2 macrophages into M1 macrophages in situ, while producing H2O2, and then platinum nanozymes further catalyze the H2O2 to produce O2, and O2 produces abundant singlet oxygen (1O2) under the action of Ce6 and low-intensity focused ultrasound (LIFU), resulting in a domino effect and further amplifying the efficacy of SDT. Due to its pH responsiveness and mitochondrial targeting, PPCH effectively accumulates in tumor cells. Under LIFU irradiation, PPCH effectively reverses immunosuppression, alleviates hypoxia in the TME, enhances reactive oxygen species (ROS) generation, and enhances SDT efficacy for eliminating tumor cells in vivo and in vitro. Meanwhile, an in vivo dual-modal imaging including fluorescence and photoacoustic imaging achieves precise tumor diagnosis.Conclusion This cascade nanoplatform will provide a promising strategy for enhancing SDT eradication against tumors by modulating immunosuppression and relieving hypoxia.
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Jimin Huang,Yi Zheng,Huicong Niu,Jinzhou Huang,XinXin Zhang,Jiajie Chen,Bing Ma,Chengtie Wu,Yi Cao,Yufang Zhu
Diabetic wound is one of the chronic wounds that is difficult to heal, and effective treatment of it still confronts a great challenge. Monitoring the variation of diabetic wound microenvironment (such as hydrogen peroxide (H 2 O 2 )) can understand the wound state and guide the wound management. Herein, we developed a multifunctional hydrogel with the abilities of monitoring the H 2 O 2 concentration, alleviating oxidative stress and promoting wound healing, which was prepared by encapsulating manganese-containing bioactive glass (MnBG) and CePO 4 :Tb in biocompatible Gelatin methacryloyl (GelMA) hydrogel (CPT-MnBG-Gel). On the one hand, the H 2 O 2 -dependent fluorescence quenching effect of the CePO 4 :Tb contributed to visible monitoring of the H 2 O 2 concentration of wounds via smartphone imaging, and the CPT-MnBG-Gel hydrogel could effectively monitor the H 2 O 2 level of 10.35-200 μmol L −1 . On the other hand, MnBG could alleviate oxidative stress and promote the proliferation, migration and differentiation of fibroblasts and endothelial cells in vitro owing to the bioactive Mn and Si ions, and in vivo evaluation also demonstrated that the CPT-MnBG-Gel hydrogels could effectively accelerate wound healing. Hence, such multifunctional hydrogel is promising for diabetic wound management and accelerating wound healing. This article is protected by copyright. All rights reserved
研究领域:
材料科学
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生物医学工程
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伤口愈合
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生物材料
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荧光成像
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Yicai Zhu,Junjun Wang,Yingyong Ni,Qingpeng Rao,Xiaojiao Zhu,Jianhua Yu,Sen Wang,Hongping Zhou
In this work, the phenothiazine fragment with powerful electron-donating ability was specifically selected to construct a multifunctional detector (noted as T1 ) in double-organelle with near-infrared region I (NIR-I) absorption. The changes of SO 2 /H 2 O 2 content in mitochondria and lipid droplets were observed through red/green channels respectively, which was due to the reaction between benzopyrylium fragment of T1 and SO 2 /H 2 O 2 to achieve red/green fluorescence conversion. Additionally, T1 was endowed with photoacoustic properties deriving from NIR-I absorption to reversibly monitor SO 2 /H 2 O 2 in vivo . This work was significant for more accurately deciphering the physiological and pathological processes in living organisms.
研究领域:
分析化学
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生物化学
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生物医学工程
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分子生物学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Xinmeng Zhang,Xin Wen,Jiahan Yang,Ji Li,Yuanting Wu
The Globe Thistles-Like (GTL) NiCo 2 S 4 nanostructures were supported on reduced graphene oxide modified filter paper (FP). The prepared GTL NiCo 2 S 4 /rGO/FP is investigated as a disposable and flexible electrode for the electrochemical detection of H 2 O 2 in alkaline media. Owing to the rich redox active sites, the synergistic effect between Co 3+ and Ni 2+ , and the rapid electron transportation of substituting sulfur (S) for oxygen (O) in NiCo 2 O 4 , the GTL NiCo 2 S 4 /rGO/FP exhibits considerable enzyme-free H 2 O 2 sensing performance with wide linear H 2 O 2 ranging from 38.8 to 37306.8 μM, high sensitivity of 2.4326 mA mM −1 cm −2 , and low detection limit of 0.08 μM. The GTL NiCo 2 S 4 /rGO/FP electrode has stable sensing performance and is highly selective toward analyte for physiological interfering species. The excellent electrochemical performance of GTL NiCo 2 S 4 /rGO/FP composite is attributed to the GTL structure of NiCo 2 S 4 . By studying the hydrothermal reaction time, electrochemical active surface area, and hydrophilic-hydrophobic surfaces of GTL NiCo 2 S 4 /rGO/FP composite, the relationship between the microstructure and sensing performance of the composite was elucidated. Surely this study opens up new possibilities for the application of low-cost, biodegradable flexible electrode materials in wearable sensors in the near future.
研究领域:
材料科学
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生物医学工程
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分析化学
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产品关联
DOI
高影响因子
ACS ES&T Engineering
·
2023
·
IF 7.1
Zhipeng Li,Xu Zhang,Yuan Meng,Hong Yao,Zhanjun Cheng,Guanyi Chen,Peizhe Sun
The recent significant increase in the amount of municipal solid waste (MSW) is a remarkable environmental issue. Pyrolysis is a promising thermal treatment process, as it can reduce MSW and produce some valuable products as well. This study evaluated the potential of the carbon residue (CR) as an efficient H2O2 activator. The CR was produced from the copyrolysis of a mixture of abandoned cartons and plastic wraps, which are becoming increasingly dominant in MSW. The results show an interesting interaction between cartons and PVC, that the introduction of PVC into the carton greatly enhanced the activation rates of H2O2 by CR below the ratio of 0.2:1 (PVC/carton, w/w), whereas higher PVC content lowered its activation ability. EPR signals under different conditions revealed that CR directly activated H2O2 to mainly produce •O2–, which was responsible for pollutant degradation. A mechanistic study suggested that the rates of H2O2 activation were mainly governed by two factors: the amount of oxidative sites on CR and the conductivity of CR, which both were also quantitatively correlated with the activation rates of H2O2. Surface defects and surface-bound radicals were attributed to the two factors, respectively. The introduction of a limited amount of PVC to the carton greatly increased both factors mainly contributed from the generation of HCl during pyrolysis of PVC. In summary, this study may provide some new insights on the catalytic features of CRs, which are generated from the pyrolysis of a mixture of abandoned plastic wraps and cartons.
研究领域:
环境科学
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化学工程
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产品关联
DOI
高影响因子
Molecular Catalysis
·
2023
·
IF 4.6
Jianhong Zheng,Xi Chen,Xiaoxiao Yin,Kai Chen,Aili Liu,Xiaochun Yu,Shun Wang,Zhongwei Chen
A highly efficient and organic solvent-free synthetic strategy for the selective oxidation of anilines to azoxybenzenes was developed by employing porous Zr-MOFs as catalysts in aqueous hydrogen peroxide solution. The impact of cluster nodes, pore size, and linker functionalities on the catalytic performance of Zr-MOFs was fully evaluated and discussed. Featuring abundant bridging Zr-OH-Zr catalytic sites and confined microenvironments, the pristine UiO-66(Zr) could create abundant reactive oxygen species (ROS) with high H 2 O 2 efficiency, affording quantitative yield of azoxybenzene under mild conditions. Furthermore, the UiO-66(Zr)/H 2 O 2 heterogeneous catalytic system exhibited broad and size-selective substrate scope and excellent stability in consecutive catalytic cycles. Mechanism studies demonstrated that the azoxybenzenes were produced through radical pathway on bridging Zr-OH-Zr sites. This study provided alternative strategies exploiting green catalytic systems with porous MOFs, which might further expand the potential application of the MOFs family.
研究领域:
化学
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材料科学
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Xin Tian,Yun Qin,Yuning Jiang,Xiaoyu Guo,Ying Wen,Haifeng Yang
Hydrogen peroxide (H 2 O 2 ) residue in foodstuffs will bring great harm to human health. We immobilize the composite of the reduced polyaniline (PANI R ) modified gold nanoparticles on the surface of ITO (ITO/AuNPs/PANI R ) to develop surface-enhanced Raman scattering (SERS) sensor for H 2 O 2. detection. The principle is that PANI R is oxidized by H 2 O 2 to generate a new SERS peak at 1460 cm −1 for realizing quantitative analysis of H 2 O 2 . Fe 2+ -Fenton reaction is introduced to catalytically react with H 2 O 2 to hydroxyl radical, which speeds up the oxidation of PANI R . Before SERS detection, acidic treatment could guarantee the reduced state of PANI R in composite. Limit of detection of ITO/AuNPs/PANI R -based SERS assay for H 2 O 2 is down to 1.78 × 10 −12 mol/L and a good linear relationship from 1 × 10 −10 to 3.16 × 10 −7 mol/L is achieved. Furthermore, the SERS sensor could be regenerated by acidic treatment. As a scenario, the renewable SERS sensor is utilized to monitor H 2 O 2 residues in food and environmental samples.
研究领域:
分析化学
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食品安全
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环境科学
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2017
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IF 0.795
Liang-Liang WU,Zhi-Juan QIAN,Zheng-Jun XIE,Ying-Ying ZHANG,Chi-Fang PENG
A sensitive colorimetric method for detection of copper ions (Cu 2+ ) was developed based on surface modification of Ag/Pt nanoclusters (Ag/Pt NCs) and regulation of the peroxidase-like activity. It was found that 3-mercaptopropionic acid (MPA) could inhibit the catalytic ability of Ag/Pt NCs, however it would lose the inhibition toward catalytic ability of Ag/Pt NCs after oxidization by oxygen through the catalysis of Cu 2+ . On the basis of this, a colorimetric method was developed for the detection of Cu 2+ by measuring the colorimetric signal variation of the TMB-H 2 O 2 reaction. This method exhibited high sensitivity and selectivity toward Cu 2+ over a panel of other metal ions, in the linear range of 10–100 nM with a detection limit of 5.0 nM. The method was simple and low cost, and suitable for Cu 2+ detection in real water samples.
研究领域:
分析化学
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纳米技术
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环境科学
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DOI
高影响因子
Journal of Analysis and Testing
·
2019
·Vol. 3
·期 3
·277-285
·
IF 0
Li Xinxue,Huang Qingwei,Li Wei,Zhang Jinli,Fu Yan
Abstract N -Acety-L-cysteine (NAC), enriched with multiple electron-rich groups involving –SH, –C=O, and –COOH, exhibits strong affinities to transition metal ions. Herein, NAC was adopted as the stabilizing agent to synthesize a series of peroxidase-like Pt nanoclusters (NCs) with different physicochemical properties. Both the cluster size and the charge state of NAC–Pt NCs are highly dependent upon the molar ratio of [K 2 PtCl 4 ]/[NAC], contributing to different peroxidase mimicking activities. The most active Pt nanozyme (~ 1.7 nm), composed of 60% metallic Pt 0 and 40% positively charged Pt 2+ respectively, exhibits the K m of 0.132 mM for 3,3′,5,5′-tetramethylbenzidine and 35 mM for H 2 O 2 . Based on the heparin-activated enzymatic activity of NAC–Pt at pH 6.0, an ultrasensitive test was established for quantitative determination of heparin, giving the linear response of 0.5–20 μg/mL as well as the limit of detection of 2 × 10 −3 μg/mL. This proposed method is also applicable in biological fluid for practical applications. Such a colorimetric method possesses several advantages involving high sensitivity, short response, eco-friendly synthesis, low consumption of material and energy, free of expensive instrument, as well as simple operation. Graphic abstract
研究领域:
纳米技术
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分析化学
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生物化学
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DOI
Nanoscale
·
2017
·Vol. 9
·期 47
·18699-18710
·
IF 7.367
Bing Tan,Huimin Zhao,Weihao Wu,Xuan Liu,Yaobin Zhang,Xie Quan
Two-dimensional (2D) metal–organic framework (MOF) nanosheets emerging as a new member of the 2D family have received significant research interest in recent years. Herein, we have successfully synthesized 2D copper-based MOF nanosheets with bimetallic anchorage using a facile two-step process at room temperature and ambient pressure, denoted as Cu(HBTC)-1/Fe3O4-AuNPs nanosheets. The as-synthesized 2D bimetallic MOF nanosheets displayed enhanced peroxidase-like activity with relatively high catalytic velocity and affinity for substrates compared with previously reported peroxidase mimics. Furthermore, their intrinsic peroxidase-like catalytic activity could be flexibly regulated by single-stranded DNA (ssDNA), exhibiting the enhancement of 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation or inhibition of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt (ABTS) oxidation due to the adsorption of ssDNA via π–π stacking. Accordingly, on the basis of their peroxidase-like activity, our prepared 2D bimetallic immobilized MOF nanosheets achieved ultra-sensitive detection of H2O2 with a linear range of 2.86 to 71.43 nM, and comparable detection performance for glucose with a linear range of 12.86 to 257.14 μM. By means of their controllable peroxidase-like activity, a versatile colorimetric sensing platform was developed which realized the detection of sulfadimethoxine (SDM) with a linear range of 3.57 to 357.14 μg L−1 and the limit of detection (LOD) of 1.70 μg L−1. With the multiplexed performance for detecting various targets, our as-synthesized bimetallic MOF nanosheets hold great promise for applications in environmental monitoring, as well as bioassays by virtue of their good biocompatibility.
研究领域:
纳米材料科学
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生物医学工程
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分析化学
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DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Zewei Huang,Yingjie Wang,Meiying Ye,Heyong Cheng
Two TiO2 inverse opal films (F-TiO2-IOF and CO-TiO2-IOF) were synthesized on glass substrates by a limited planar rapid evaporation method, which was time- and reagent-saving, and it was easy to control their shape. The CO-TiO2-IOF displayed a smoother mophology and better photocatalytic efficiency and stability than F-TiO2-IOF. Over 95% of 5 mg L–1 rhodamine B (RhB) was degraded within 120 s in the IOF-modified microreactors. A higher photocatalytic efficiency could be achieved with the synergistic catalysis of H2O2 and CO-TiO2-IOF, based on which the online monitoring of RhB was realized within 2 min in the IOF-modified photocatalytic microreactor integrated with the flow cell of a UV–vis spectrophotometer. Other nitrogen-containing dyes like tartrazine and indigo carmine were also degraded in CO-TiO2-IOF-modified microreactors with degradation rates of 83–95%.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
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