REACTIVE & FUNCTIONAL POLYMERS
·
2017
·
IF 3.151
Xuhai Xiong,Xinghua Ma,Ping Chen,Lu Zhou,Rong Ren,Siyang Liu
New aryl-ether-imide/phthalide-containing bismaleimide oligomers (MPEIBMI) with different molecular weight were designed and synthesized by adjusting the addition amount of diamine compound derived from o -cresolphthaleine, and dianhydride 4,4′-(4,4′-isopropylidene diphenoxy)-bis(phthalicanhydride) (mole ratio: 1.25/1.5/2.0). The chemical structures of the oligomers and their intermediate compounds were confirmed by Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance ( 1 H and 13 C NMR) spectroscopy and elementary analysis. X-ray diffraction (XRD) results showed a blunt diffraction peak, suggesting an amorphous structure. The oligomers exhibited good solubility in a variety of common organic solvents . The heat flow curves of the oligomers measured by differential scanning calorimeter (DSC) displayed a broad curing exothermic peak. The thermal stability and thermal mechanical properties of the cured resins were investigated by thermogravimetric analysis (TGA) and dynamic mechanical analysis (DMA). The results indicated that the introduction of phthalide cardo structure and imide rings into the polybismaleimide network could effectively improve the thermal properties. The glass transition temperature and initial thermal decomposition temperature were above 260 °C and 423 °C, respectively, and the residual weight percentages at 700 °C were all > 58%. The mechanical tests revealed that the cured MPEIBMI films had excellent tensile strength and good retention at the temperatures above 200 °C.
✓ 已验证
DOI
高影响因子
Environmental Science-Nano
·
2021
·Vol. 8
·期 9
·2618-2628
·
IF 8.131
Ting Chen,Zhiliang Zhu,Yujie Bao,Hua Zhang,Yanling Qiu,Daqiang Yin
The effective construction of electron transport channels has essential significance for electron-transfer rate enhancement in REDOX processes during peroxymonosulfate (PMS) activation. This study focuses on the establishment of Cu-involved covalent bonds due to the unique electron configuration of Cu ions. The strategy was achieved by anchoring Cu atoms to an O-doped g-C3N4 (Cu–O–CN) matrix. The C–O–Cu linkage was successfully constructed, derived from the precise incorporation of oxygen. From XAFS, H2-TPR, and solid-ESR characteristic observations, the desired REDOX performance was verified. The constructed C–O–Cu linkages were treated as electron transport channels for electron transfer while reacting with PMS, effectively accelerating the REDOX circulation of the Cu(II)/Cu(I) redox couple and promoting the consecutive generation of active species. Consequently, nearly 100% bisphenol A (BPA) was degraded in the Cu–O–CN/PMS reaction system within 30 min. This demonstrates the effectiveness of Cu–O–CN for PMS activation. The prepared Cu–O–CN exhibited definite stability and potential reusability. This research not only highlights the tailored design of heterogeneous catalysts for PMS activation but also broadens its application in water purification.
✓ 已验证
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2017
·
IF 2.329
Honest N.E. Kessy,Kai Wang,Lei Zhao,Molin Zhou,Zhuoyan Hu
Enzyme-assisted extraction and biotransformation of phenolic compounds from litchi pericarps were investigated. Pectinase, β-glucosidase and tannase were used individually and sequentially. The effects of various enzymes and hydrolysis conditions on recovery and biotransformation of phenolic compounds were evaluated. The results indicated that the optimum conditions for enzymatic extraction were 3% (w/w) of pectinase, 1% (w/w) of tannase and 1% (w/w) of β-glucosidase, incubation time and temperature were 180 min and 35 °C, respectively. Under these conditions, pectinase treatment was more efficient in liberating phenolic compounds compared to tannase and β-glucosidase. Sequential enzyme treatment produced more phenolic compounds than the untreated litchi pericarps. As revealed by HPLC, apart from the phenolic compounds observed in pectin and pectin–tannase treated litchi pericarps, quercetin was observed in the pectinase-β-glucosidase and pectinase-β-glucosidase-tannase treated samples, indicating that flavonols probably underwent transformation from glycosylated (rutin) to deglycosylated (quercetin) during sequential enzymatic treatments. Ferric reducing antioxidant power, DPPH radical scavenging capacity, and angiotensin I-converting enzyme inhibition capacity of the enzyme produced extracts were significantly improved compared to the untreated sample. These results suggest that enzyme-assisted produced extracts could be a promising ingredient in developing natural functional foods, and in pharmaceutical products against hypertension in humans.
✓ 已验证
DOI
高影响因子
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
·
2023
·
IF 2.9
Hua-Ping Zhou,Ding-Ran Wang,Chen-Lu Xu,Ye-Wang Zhang
Heparinase I (EC 4.2.2.7), is an enzyme that cleaves heparin, showing great potential for eco-friendly production of low molecular weight heparin (LMWH). However, owing to its poor catalytic activity and thermal stability, the industrial application of heparinase I has been severely hindered. To improve the catalytic activity, we proposed to engineer both the substrate and Ca2+ binding domains of heparinase I. Several heparinases I from different organisms were selected for multiple sequence alignment and molecular docking to screen the key residues in the binding domain. Nine single-point mutations were selected to enhance the catalytic activity of heparinase I. Among them, T250D was the most highly active one, whereas mutations around Ca2+ binding domain yielded two active mutants. Mutant D152S/R244K/T250D with significantly increased catalytic activity was obtained by combined mutation. The catalytic efficiency of the mutant was 118,875.8 min−1·µM−1, which was improved 5.26 times. Molecular modeling revealed that the improved activity and stability of the mutants were probably attributed to the formation of new hydrogen bonds. The highly active mutant had great potential applications in industry and the strategy could be used to improve the performance of other enzymes.
✓ 已验证
DOI
PubMed
高影响因子
mSphere
·
2025
·Vol. 10
·期 6
·
IF 3.1
Jieying Li,Yuxiao Liu,Jingsi Jiang,Fang Chen,Nan Zhang,Xun Kang,Lin Liu,Yingjuan Wang,Qianfeng Xia,Chuanlong Zhu,Dai Kuang
Klebsiella pneumoniae is a globally recognized microbial pathogen with significant clinical impact. The bacterium harbors the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems, which provide adaptive immunity against invading foreign nucleic acids. Recent studies suggest that certain CRISPR-Cas systems can regulate endogenous genes, influencing bacterial virulence. However, their role in regulating pathogenicity in K. pneumoniae remains poorly understood. This study investigates the regulatory role of the type I-E* CRISPR-Cas system in a hypervirulent K. pneumoniae strain, focusing on its impact on histidine metabolism and pathogenicity. Transcriptome analyses identified differentially expressed genes (DEGs) between the casABECD-deletion and wild-type strains, including significant upregulation of the histidine utilization (Hut) operon and downregulation of biofilm-related genes. These molecular changes resulted in enhanced histidine metabolic activity, reduced biofilm formation, attenuated virulence in A549 lung epithelial cells, and improved survival of Galleria mellonella, as validated through phenotypic and virulence assays. Our bioinformatic analysis indicated that the CRISPR-Cas system in K. pneumoniae targets the hutT sequence, which is part of the Hut operon. Furthermore, the overexpression of hutT mitigated CRISPR-Cas-mediated repression of the Hut operon, as observed in virulence assays, while simultaneous deletion of hutH and casABECD restored the reduced virulence in the ΔcasABECD strain. Additionally, deletion of casABECD significantly enhances the growth of the strain in medium with histidine as the sole carbon source, highlighting the intricate regulatory role of the CRISPR-Cas system in metabolic adaptation. Collectively, these findings uncover a novel role for the CRISPR-Cas system in regulating metabolic pathways and virulence in hypervirulent K. pneumoniae.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Zhongkun Wang,Rui Zhu,Chenrui Li,Weiwei Xu,Liangyou Zhao,Guangjin Gao,Weihao An,Xiang Dong,Qingqing Miao,Qing Li
Bacterial infections pose a significant global health challenge, further exacerbated by the emergence of antibiotic-resistant strains, thereby necessitating the development of alternative therapeutic strategies. Type I photosensitizers, as an emerging phototheranostic modality, hold great promise for antibacterial treatment but are limited by poor specificity. Herein, we report a hydrogen sulfide (H 2 S)-activatable theranostic probe (CyIN) that integrates near-infrared (NIR) fluorescence imaging and type I photodynamic therapy (PDT) functionalities into a single platform for the precise treatment of drug-resistant bacterial infections. CyIN is rationally constructed by masking the hydroxyl group of iodine-substituted hemicyanine with a H 2 S-cleavable 2,4-dinitrophenyl group, which efficiently quenches NIR fluorescence and suppresses reactive oxygen species generation. Such molecular configuration allows CyIN to turn on its NIR fluorescence signal and type I photodynamic action upon interaction with bacterial-derived H 2 S, achieving distinguishable detection of drug-resistant bacterial infection, potent bacterial clearance (>99 %), and accelerated healing of bacteria-infected wounds. Furthermore, histological analyses confirm that the CyIN treatment can reduce inflammation, enhance collagen deposition, and promote tissue regeneration without systemic toxicity. Thus, this work presents a promising H 2 S-responsive phototheranostic platform for precise bacterial detection and efficient photodynamic eradication of drug-resistant bacterial infections.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR DIVERSITY
·
2025
·
IF 3.8
Luo Zhi,Zhang Shuangkun,Bai Enqi,Cai Kasha
A bis(NHC) manganese-catalyzed protocol for facile benzylic alkylation of a diverse range of arenes has been successfully developed. This innovative method enables the efficient synthesis of various alkylated arenes, including formal sp 2 C3-mono-alkylated indenes, sp 3 C1, sp 2 C3-di-alkylated indenes and other sp 3 C–H alkylated arenes, all derived from commonly accessible primary and secondary alcohols. Central to this alkylation reaction is the bis(NHC) manganese catalyst, which plays a pivotal role in facilitating the transformation of simple alcohols into complex and valuable organic compounds. Graphical abstract
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Rui Jiang,Jie Zhao,Yifei Qiao,Bo Tan,Jialin Yin,Zhenyu Dai,Shiliang Mei,Wanlu Zhang,Ruiqian Guo
Near-infrared (NIR) emission has garnered significant attention owing to its broad application potential in next-generation optoelectronics. Among various candidates, indium phosphide (InP) quantum dots (QDs) have emerged as particularly promising candidate due to their environmentally benign composition and relatively facile synthesis. However, the synthesis of NIR-emitting InP-based QDs exhibiting high luminescence efficiency remains a critical challenge. The inherent difficulties primarily stem from insufficient core nucleation and the complex shell growth processes essential for achieving high-performance QDs. Herein, we report an expeditious synthetic strategy for achieving NIR-I emissive core-only InP QDs with tunable emission ranging from 683 to 742 nm, mediated by the synergistic effect of ZnCl 2 and NH 4 PF 6 . Under the competitive adsorption between ZnCl 2 and NH 4 PF 6 , high-covalent InP QDs with sizes of approximately 6 to 10 nm can be obtained within 5 min. During the later stages in this dual-salt system, PF 6 − effectively eliminates surface oxides while zinc ion enrichment establishes a negatively charged surface. This Zn-related configuration promotes subsequent adsorption and defect passivation by NH 4 + . The final core-only QDs exhibit bright NIR-I emission with a photoluminescence quantum yield of up to 74 % in solution. Furthermore, the application potential of these core-only QDs is demonstrated through simple patterning. This work establishes a straightforward, post-treatment-free synthesis of high-performance NIR-I core-only InP QDs, highlighting their substantial promise for next-generation optoelectronic devices.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 33
·16183-16191
·
IF 3.925
Ping Ouyang,Rui Zhang,Jian Zhou,Haiyan Liu,Zhichang Liu,Chunming Xu,Shaojuan Zeng,Qian Su,Xiangping Zhang,Xianghai Meng
The effective electrochemical recovery of metal for bimetallic composite ionic liquid (IL) is related to the ion species and even the reaction mechanism under different Cu(I) contents. Thus, bimetallic composite ILs (Et3NHCl–1.54AlCl3–xCuCl, x = 0–0.23) were synthesized to investigate the Cu(I) speciation, voltammetric behavior and electrodeposition mechanism under different Cu(I) contents. For the cyclic voltammogram, three cathodic peaks of Et3NHCl–1.54AlCl3–0.010CuCl were related to the reduction of Cu(II) to Cu(I), Cu(I) to Cu(0), and Al(III) to Al(0), respectively. Meanwhile, for Et3NHCl–1.54AlCl3–0.23CuCl, the cathodic and anodic peaks were related to the redox reaction of copper. The whole offline detection of bimetallic composite ILs showed that the anodic reaction under low content of Cu(I) (≤ 0.60 wt%) was dominated by the generation of chlorine gas, while the cathodic reaction was related to the potential. However, when the Cu(I) content was higher than 2.23 wt%, only the disproportionation reaction of Cu(I) occurred and CuCl2 was obtained on the anode. Long-term electrodeposition showed that the effective recovery of copper from industrial bimetallic composite IL was realized. This study lays a good foundation for the clear understanding and comprehensive implementation of the resource utilization.
✓ 已验证
DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Zhen Tong,Jia-Peng Zou,Su-Yun Wang,Wei-Wei Luo,Yan-Yi Wang
Interferons (IFNs) activate JAK-STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in parallel with STAT1. IRF3-deficiency impairs transcription of a subset of downstream effector genes induced by IFN-β and IFN-γ. Mechanistically, IFN-induced activation of IRF3 is dependent on the cGAS-STING-TBK1 axis. Both IFN-β and IFN-γ cause mitochondrial DNA release into the cytosol. In addition, IFNs induce JAK1-mediated tyrosine phosphorylation of cGAS at Y214/Y215, which is essential for its DNA binding activity and signaling. Furthermore, deficiency of cGAS, STING, or IRF3 impairs IFN-β- or IFN-γ-mediated antiviral and antitumor activities. The findings reveal a novel IRF3 activation pathway parallel with the canonical STAT1/2 activation pathways triggered by IFNs and provide an explanation for the pleiotropic roles of the cGAS-STING-IRF3 axis in host defense.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Junhu Cai,Xiang Zhang,Yu Chen,Wenzong Lai,Wenyan Zhang,Zexi Lin,Yun Ye,Sheng Xu,Tailiang Guo,Jiajun Luo,Enguo Chen
Inorganic metal halide perovskite quantum dots (PQDs) have recently emerged as promising candidates for color conversion materials in Micro-LED displays, due to their outstanding color purity, high absorption coefficient, tunable emission wavelength . However the inferior stability and undesirable photoluminescence quantum yield (PLQY) restrict their particle applications. Herein, CsPbX 3 /PMMA (X = Br, I) composites with improved stability and optical performance were successfully prepared by a general and mild in-situ polymerization strategy. The ester carbonyl (C O) group in MMA formed complexes with Pb 2+ , leading to the in-situ thermal polymerization of polymethyl methacrylate (PMMA) under the action of the initiator. The multifunctional PMMA can efficiently passivate halogen vacancies while acting as a barrier against the degradation caused by heat, water, and oxygen. As a result, the PLQYs and stability of PMMA-coated CsPbX 3 PQDs have been significantly improved. When implementing CsPbX 3 /PMMA/PDMS composites as color conversion layers in Micro-LEDs, they achieve an impressive color gamut of 127.23% with excellent stability. We believe our work will stimulate the exploration of perovskite/polymer composites for industrial Micro-LED applications.
✓ 已验证
DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Wei-yun Zhang,Jin-song Liao,Jun-ru Qi
Differences in the prebiotics of pectin cannot be fully explained by the sources and single structure. Microbiota exhibit distinct preferences for different structure of pectin, influencing the microbial composition by lowering pH and producing short-chain fatty acids (SCFAs) in the fermentation. However, the effect on the pectin fine structure on its fermentation properties and microbiota still controversial. Here, three pectin polysaccharides with different degree of esterification (DE) and rhamngalacturonan-I (RGI) ratio while ensuring that either the degree of RGI or the DE remained constant were prepared. By using in vitro fermentation model and microbiomics, the mechanisms by which the pectin fine structure in modulating the composition of gut microbiota and the metabolism of SCFAs were proposed. Pectins enriched with RGI structures promoted the growth of Phascolarctobacterium and Parabacteroides, and increased concentration of the SCFAs (such as acetic acid and propionic acid) associated with fat loss. Bacteria groups such as Tyzzerella , Collinsella , Prevotella-9 , Dialister and Sutterella were sensitive to DE and thereby promote SCFA production (such as hexanoic acid, butyric acid, etc). As pectin promotes the growth of probiotics and an increase in SCFAs, contributing to a decrease in pH, the growth of Lachnospiraceae_UCG-004 , Escherichia-Shigella and Lachnoclostridium is significantly inhibited. We identified thatkey roles of the DE and RGI within pectin in promoting the growth of probiotic microbiota and production of SCFAs. These results provide new a reference for the prediction of the pectin physiological activity and the development of functional pectin polysaccharide prebiotics.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）