JOURNAL OF MEMBRANE SCIENCE
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2018
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IF 6.578
Yuqian Sui,Huayuan Hu,Mitsuru Ueda,Lianjun Wang,Xuan Zhang
In this study, a novel poly[vinyl-(4-benzyl- N , N , N -trimethylammonium bromide) ketone] (QA-PVBK) homopolymer was synthesized by conventional free-radical polymerization, followed by benzyl bromination, and in-situ quaternization reaction, successively. Blend membranes were further constructed between QA-PVBK and commercially available polybenzimidazole (PBI), as novel anion exchange membrane materials. Owing to the short repeating unit of QA-PVBK, the ion-clusters for the ion transport were highly aggregated on the microscale, which significantly contributed to the excellent hydroxide conductivity of the blend membranes. The PBI was introduced as a physical reinforcement, strengthening the membranes’ robustness and suppressing excessive swelling. Membrane PBI/QA-PVBK-OH(70%), with the QA-PVBK-OH (hydroxide form) content of 70% over the entire membrane matrix, exhibited a high hydroxide conductivity of 50.8 mS cm −1 at 60 °C, and, consequently, a good peak power density of 170.6 mW cm −2 at 60 °C/100% relative humidity condition in a H 2 /O 2 single cell test. The blend membranes also demonstrated acceptable chemical stability towards the alkaline condition (1 M NaOH at 60 °C) with the residual conductivity over 59.4% after 168 h. In light of these promising results, the present study demonstrates a facile blending process for simultaneously addressing the ion conductivity and mechanical properties of anion exchange membranes.
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JOURNAL OF MOLECULAR LIQUIDS
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2016
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IF 2.74
Junzhi Li,Junqiang Wang,Wei Zhao,Xiaoliang Li
Isobaric vapor-liquid equilibrium (VLE) data for the four systems n -heptane + 2-methylthiophene, 2,2,4-trimethylpentane + 2-methylthiophene, n -nonane + 2-methylthiophene, n -decane + 2-methylthiophene were measured at 90.00 kPa with a modified Rose-Williams still. Gas chromatography equipped with a flame ionization detector was used to analyze composition of the samples from the vapor-liquid equilibrium systems. All the VLE measurements passed the thermodynamic consistent test using the Herington method and the Van Ness test. The azeotropic behavior was found in the 2,2,4-trimethylpentane + 2-methylthiophene system. The experimental data were correlated by the Wilson and NRTL activity coefficient models and also compared with the original UNIFAC predictive model. The corresponding parameters for the three models were obtained. The results exhibited that the measured data got agree well with the calculated values using the Wilson, NRTL and original UNIFAC models.
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INDUSTRIAL CROPS AND PRODUCTS
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2025
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IF 6.2
Qi Zhang,Minghui Li,Zhuofan Zuo,Tianhang Zhan,Xiaoyan Li,Wei Zhang
Cotton, as one of the world’s most crucial economic crops, suffers from a markedly shortened service life of its fabrics due to microbial degradation. In this study, N-isopropylacrylamide (NIPAM) containing amide bonds was grafted onto cotton fibers via atom transfer radical polymerization (ATRP) to develop a heat-resistant and wash-durable N-halamine functionalized cotton fabric (PN@CF-Cl). The resulting material exhibited rapid and potent antibacterial activity, killing over 85 % of bacteria within 1 min of contact and achieving > 99.9 % inactivation of Staphylococcus aureus and Escherichia coli within 10 min. After 50 washing cycles at 75 °C, the antibacterial activity retention remained above 97 %. Following storage for 30 days, rechlorination restored the active chlorine content to its initial level. Even after 10 consecutive chlorination–reduction cycles, the active chlorine recovery reached 98.9 %. In addition, the fabric demonstrated high hydrophobicity, air permeability, and moisture vapor transmission. Molecular dynamics (MD) simulations further validated the dynamic interconversion between N–Cl and N–H in the material, elucidating the underlying mechanism for its regenerative performance. Functionalized cotton fabrics based on the N–Cl/N–H dynamic cycling mechanism can extend product lifespan and hold significant promise for applications in medical protective equipment and smart home textiles.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2018
·Vol. 29
·期 8
·1-14
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IF 2.448
Liu Chundong,Wang Jianhua,Huang Sheng,Yu Lin,Wang Yan,Chen Hang,Wang Dong
Peptide nucleic acid (PNA) holds enormous potentials as antisense/antigenic drug due to its specific binding ability and biostability with DNA or RNA. However, the poor cellular delivery is the key obstacle in development of PNA therapy. To overcome this difficulty, we developed self-assembled nanoparticles (NPs) for delivery of PNA to living cells using amphiphilic CS derivatives. A series of N,N,N-trimethyl-O-alkyl chitosans (TMACs) with different lengths of alkyl chains were synthesized. The structures of these synthesized chemicals were characterized with FT-IR and 1 H NMR. We found that the TMACs were all able to self-assemble in aqueous condition to form nano-size NPs. These nano-size NPs are spherical shape with a size range of around 100 nm and a zeta potential above +30 mV. PNA was easily encapsulated into chitosan derivative NPs by an ultrasonic method with entrapment efficiency up to 75%. The PNA-loaded TMAC NPs released the drug in a sustained manner in PBS (pH 7.4) at 37 °C. N,N,N-trimethyl-O-cetyl chitosan (TMCC) showed the best in vitro hemocompatibility and cell viability. These TMCC based NPs were able to dramatically increase the cellular uptake of PNA, specifically, 66-fold higher compared to without using these nanoparticles. The results suggest that the designed TMCC NPs might be a promising solution for improving cellular delivery of PNA.
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TOXICOLOGY LETTERS
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2026
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IF 2.9
Liya Fang,Chanlin Fang,Shanshan Di,Xinquan Wang,Yuanxiang Jin
This study examined the hepatic effects of parous exposure to the rubber-derived contaminant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), in C57BL/6 mice during gestation and lactation. Both compounds exhibited dose-dependent bioaccumulation in the liver of the F0 generation and lactated F1 offspring, with 6PPDQ accumulating more due to its greater stability. Lactational transmission of both compounds was observed, and the accumulation declined with age, disappearing by 8 weeks. Notably, 6PPDQ exposure resulted in reduced body weight in mature F1 female mice, which was associated with altered cholesterol metabolism and disrupted expression of the estrogen receptor gene. In these mice, molecular analysis revealed dysregulation of key cholesterol-related genes, such as HMGCR and PCSK9. In contrast, male offspring showed less pronounced effects. These results indicate that the toxicity of 6PPD and 6PPDQ can be transmitted through placental and lactational pathways, with 6PPDQ presenting a greater risk, particularly to female mice, through its impact on cholesterol metabolism and endocrine signalling. These findings offer valuable insights for assessing the environmental and health risks associated with these compounds.
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International Journal of Ophthalmology
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2026
·Vol. 19
·期 4
·655
·
IF 2
Xiao-Qing Cai,Ping Zhang,Zhou-Fan Zhang,Jing Gu,Ting-Ting Chen,Ai-Na Chen
AIM To investigate the therapeutic efficacy and underlying mechanisms of epigallocatechin gallate (EGCG), a major green tea catechin with potent antioxidant properties, in an N-methyl-N-nitrosourea (MNU)-induced mouse model of retinitis pigmentosa (RP). METHODS C57BL/6 mice were randomly divided into control (PBS), MNU-induced RP, and MNU+EGCG pretreatment groups. EGCG (50 mg/kg, intraperitoneal) was administered daily for 3 consecutive days prior to a single MNU injection (50 mg/kg). Retinal function was evaluated by scotopic electroretinography (ERG). Retinal structure was assessed using optical coherence tomography (OCT) and hematoxylin-eosin staining, with outer nuclear layer (ONL) thickness measurement. Mechanisms were explored via RNA sequencing, reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) validation of oxidative stress- and inflammation-related genes, and immunohistochemistry for microglial activation, astrocytic gliosis, and apoptosis markers. RESULTS Compared with the MNU group, EGCG pretreatment significantly preserved scotopic ERG a-wave and b-wave amplitudes ( P <0.001). OCT and histological analysis showed that EGCG markedly attenuated MNU-induced thinning of total retina and ONL ( P <0.005, P <0.001, respectively). RNA sequencing identified 1147 differentially expressed genes modulated by EGCG, with significant upregulation of antioxidant genes ( Nrf2 , Sod1 , Gpx4 , Cat1 , Ho-1 ) and downregulation of pro-inflammatory genes. Immunohistochemistry confirmed that EGCG significantly reduced microglial activation, glial fibrillary acidic protein (GFAP) expression, and cleaved caspase-3-positive cells ( P <0.01 to P <0.001). CONCLUSION EGCG exerts robust neuroprotective effects in MNU-induced RP through enhancement of antioxidant defenses, suppression of neuroinflammation, and preservation of retinal structure and function. These findings suggest EGCG as a promising candidate for adjuvant antioxidant therapy in RP.
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COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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2025
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IF 4.3
Hua Zhang,Chenglong Liu,Yulu sun,Shuqiong Tang,Yan Lei,Weixin Zhang,Bo Cheng,Yan Zhao,Qiang Luo
N, N-Diethyl-meta-toluamide (DEET) is a widely used insect repellent that can be detected in water and soil worldwide. Although adverse reactions have been reported following the use of DEET - containing products, there are few toxicity studies. In this study, zebrafish were exposed to 0, 0.2 mg/mL, 0.25 mg/mL, and 0.3 mg/mL of DEET. With increasing exposure concentrations, zebrafish mortality increased and body length development was reduced. At 72 hours post fertilization (hpf), zebrafish exhibited pericardial edema, decreased heart rate, and yolk sac edema. Significant abnormalities in the looping morphology of the heart were observed, with the atrium and ventricle positioned along the midline, resulting in cardiac linearization. The expression levels of genes related to cardiac development ( myh6 , nppa , nkx2.5 , gata4 , tbx5a , vmhc ) increased. On the other hand, the quantity of neutrophils and macrophages exhibited a decrease, and the expression level of genes related to mediating inflammatory response ( myd88 , ifn-γ , tlr4 ) and inflammatory factor genes ( il-6 , il-8 , il-10 ) increased. In addition, DEET exposure caused a reduction in newly generated neurons at 24 hpf. At 72 hpf, the activity of acetylcholinesterase (AChE) was inhibited, and motor behavior show that the total distance and average speed were significantly reduced. Further research found that oxidative stress was activated, and reactive oxygen species (ROS) content increased significantly. In summary, DEET cause multiple toxicities to the heart, immune system, and nervous system during early developmental stages of zebrafish embryos, and these toxicities may be induced by oxidative stress.
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Materials
·
2023
·Vol. 16
·期 3
·1053
·
IF 3.4
Yanpei Dang,Tianhao Li,Yangzhong Zhao,Liantai Duan,Jianning Zhang,Ke Chen,Liu He,Qing Huang,Chuanzhuang Zhao,Yujie Song
Polyborosilazanes with controllable B/N ratio were synthesized using high-boron-contentm-carborane, dichloromethylsilane, and hexamethydisilazane. After high-temperature pyrolysis, Si–B–C–N quaternary ceramics with SiC and B4C as the main phases were obtained. The B/N ratio in the precursors corresponded to the change in the feeding ratio of carborane and dichloromethylsilane. The effects of boron content and B/N ratio on the ceramic precursors and microphase structure in Si–B–C–N quaternary ceramics were explored in detail through a series of analytical characterization methods. A high boron content results in a significant increase in the ceramic yield (up to 71 wt%) of polyborosilazanes, and at the same time, the B/N molar ratio was regulated from 28.4:1 to 1.62:1. The appearance of the B4C structure in the Si–B–C–N quaternary ceramics through the regulation of the B/N ratio, has rarely been reported.Keywords:polyborosilazane;SiBCN;carborane;polymer derived ceramics;B/N ratio;microphase evolution
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Nanomaterials
·
2022
·Vol. 12
·期 17
·2967
·
IF 5.719
Xiaohan Wang,Fan Zhang,Feiyue Hu,Yaya Li,Yongqiang Chen,Hailong Wang,Zhiyu Min,Rui Zhang
To solve the pollution problem of electromagnetic waves, new electromagnetic shielding materials should meet the requirements of being lightweight with high electrical conductivity. In this work, the combination of silver (Ag) nanoparticles and nitrogen doping (N-doping) was expected to tune the electromagnetic and physical properties of Ti3C2TxMXene, and the Ag@N-Ti3C2Txcomposites were fabricated through the hydrothermal reactions. The nitrogen doped (N-doped) Ag@Ti3C2Txcomposites showed a hollow structure with a pore size of 5 μm. The influence of N-doped degrees on the electromagnetic interference (EMI) shielding performance was investigated over 8–18 GHz. Therefore, the controlled N-doping composites exhibited reflection-based EMI shielding performance due to the electrical conductivity and the special three-dimensional (3D) honeycomb-like structure. The achieved average EMI shielding values were 52.38 dB at the X-band and 72.72 dB at the Ku-band. Overall, the Ag@N-Ti3C2Txfoam, due to its special 3D honeycomb-like structure, not only meets the characteristics of light weight, but also exhibits ultra-high-efficiency EMI shielding performance, revealing great prospects in the application of electromagnetic wave shielding field.Keywords:nitrogen doping;Ag@N-Ti3C2Txcomposites;honeycomb-like structure;electromagnetic interference;multi-reflections
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Biotechnology for Biofuels
·
2019
·Vol. 12
·期 1
·1-17
·
IF 5.452
Chen Yumeng,Wu Chuan,Shen Yaling,Ma Yushu,Wei Dongzhi,Wang Wei
Background The filamentous fungus Trichoderma reesei produces cellulase enzymes that are widely studied for lignocellulose bioconversion to biofuel. N,N-dimethylformamide (DMF) is a versatile organic solvent used in large quantities in industries.Results In this study, we serendipitously found that biologically relevant concentrations of extracellular DMF-induced cellulase production in the T. reesei hyper-cellulolytic mutant Rut-C30 and wild-type strain QM6a. Next, by transcriptome analysis, we determined that plc-e encoding phospholipase C was activated by DMF and revealed that cytosolic Ca2+ plays a vital role in the response of T. reesei to DMF. Using EGTA (a putative extracellular Ca2+ chelator) and LaCl3 (a plasma membrane Ca2+ channel blocker), we demonstrated that DMF induced a cytosolic Ca2+ burst via extracellular Ca2+ and Ca2+ channels in T. reesei, and that the cytosolic Ca2+ burst induced by DMF-mediated overexpression of cellulase through calcium signaling. Deletion of crz1 confirmed that calcium signaling plays a dominant role in DMF-induced cellulase production. Additionally, 0.5–2% DMF increases the permeability of T. reesei mycelia for cellulase release. Simultaneous supplementation with 1% DMF and 10 mM Mn2+ to T. reesei Rut-C30 increased cellulase activity approximately fourfold compared to that without treatment and was also more than that observed in response to either treatment alone.Conclusion sOur results reveal that DMF-induced cellulase production via calcium signaling and permeabilization. Our results also provide insight into the role of calcium signaling in enzyme production for enhanced cellulase production and the development of novel inducers of cellulase.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Huifang Wang,Yisheng Zhang,Wenman Xue,Xinyu Zhang,Xiaoli Jia,Tianren Xue,Ruijie Guo,Baolong Niu,Hong Yan
In this contribution, a novel soluble and antibacterial polymer, O-xanthonyl-chitosan (CTMC-Xan), was synthesized successfully by grafting 1,3-dihydroxy-xanthone (Xan) to the side chains of O -carboxymethyl- N , N , N -trimethyl chitosan (CTMC). The chemical structure and physical properties of the polymer were analyzed by 1 H NMR, FT-IR spectra, UV spectra and XRD. The results showed that Xan could covalently bond with the carboxyl groups of CTMC by esterification at a grafting ratio of 9.1%. XRD patterns indicated that CTMC-Xan does not exhibit crystallization. The solubility tests showed that CTMC-Xan was completely dissolved and stable in neutral solution but unstable in acid or basic conditions. Moreover, it was found that the antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) of CTMC-Xan was much stronger than that of Xan and CTMC, and the minimal bactericidal concentration (MBC) was 125 μg·mL −1 . Due to the enhanced solubility and antibacterial activity, CTMC-Xan could potentially serve as a desirable biomaterial for food and pharmaceutical applications .
研究领域:
生物材料学
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化学
·
药学
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APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Wen-Li Xin,Lian-Hua Xu,Kun-Kun Lu,Dan Shan
Fe-N catalysts are one of the promising candidates with efficient oxygen reduction reaction (ORR) activities comparable to Pt-based catalysts. Therefore, in this work, a novel Fe-N based electrocatalyst with high activity, porous structure, and durability were prepared. Highly active N,N′-carbonyldiimidazole (CDI) was used to form zinc-based zeolitic imidazole frameworks involved with zinc carbonate (Zn-ZIFs@ZnCO 3 ). Fe-doping can be feasibly achieved by partial substitution Zn by Fe using Fe (NO) 3 . Owing to the presence of ZnCO 3 and Fe 3+ , carbonization of Fe/Zn-ZIFs@ZnCO 3 at 925 °C under N 2 atmosphere endows the pyrolysis products with many highly active heterostructures of 3D graphene structure. The obtained Fe-N@ZnO possesses superior ORR performance to commercial 20% Pt/C catalysts, such as positive half-wave potential (0.851 V), good durability and methanol tolerance in 0.1 M KOH.
研究领域:
材料科学
·
电化学
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危险品化学品经营许可证（带存储）