ANALYTICAL LETTERS
·
2022
·
IF 2.267
Hui Cao,Zixin Chen,Yanan Kong,Ziqi Wei,Tai Ye,Min Yuan,Jinsong Yu,Xiuxiu Wu,Liling Hao,Fengqin Yin,Fei Xu
Rapid dispersive liquid-liquid microextraction (DLLME) based on the solidification of a switchable hydrophilicity solvent (SHS) was established for the preconcentration of pyrethroid pesticides from grain prior to determination using high‐performance liquid chromatography (HPLC) with photodiode array (PDA). Lauric acid was selected to be the switchable hydrophilicity solvent due to its conversion between hydrophobic and hydrophilic forms and solidification at low temperature, thereby avoiding a time-consuming centrifugation step. The results show that the optimal conditions for pyrethroid pesticides included 30 mmol/L lauric acid, hydrochloric acid as the hydrogen donor, a 1:1.8 stoichiometric ratio of sodium laurate and hydrochloric acid, an extraction temperature of 50 °C, an extraction time of 8 min, and a solidification time of 3 min. Under the optimal conditions, this approach provided a high enrichment factor (308.4 to 330.2), a short pretreatment period of less than 15 min, and sensitive detection limits from 5 to 20 ng/g suitable for the analysis of food. The method was employed for the determination of pyrethroid pesticides in grain. The recoveries were 84.3% to 115.7%, and the relative standard deviation was less than 9.9%.
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高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-10
·
IF 5.3
Liu Hao,Sun Xuyuan,Dai Zhengyuan,Wang Ying,Li Li,Fan Jie,Ding Yaping
Nifedipine (NIF), as one of the dihydropyridine calcium channel blockers, is widely used in the treatment of hypertension. However, misuse or ingestion of NIF can result in serious health issues such as myocardial infarction, arrhythmia, stroke, and even death. It is essential to design a reliable and sensitive detection method to monitor NIF. In this work, an innovative molecularly imprinted polymer dual-emission fluorescent sensor (CDs@PDA-MIPs) strategy was successfully designed for sensitive detection of NIF. The fluorescent intensity of the probe decreased with increasing NIF concentration, showing a satisfactory linear relationship within the range 1.0 × 10 −6 M ~ 5.0 × 10 −3 M. The LOD of NIF was 9.38 × 10 −7 M (S/N = 3) in fluorescence detection. The application of the CDs@PDA-MIPs in actual samples such as urine and Qiangli Dingxuan tablets has been verified, with recovery ranging from 97.8 to 102.8% for NIF. Therefore, the fluorescent probe demonstrates great potential as a sensing system for detecting NIF. Graphical abstract
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PubMed
高影响因子
ANALYTICAL LETTERS
·
2024
·
IF 1.6
Jingjing Gu,Chunyang Chen,Tingting Liu,Yanyan Li,Xuedong Wang
Here is reported effervescent reaction-enhanced switchable hydrophilic-hydrophobic solvent-based salting-out microextraction (ERSSM) with high-performance liquid chromatography with photodiode array detection (HPLC-PDA) for the preconcentration, extraction, and trace-level determination of polybrominated diphenyl ethers (PBDEs) in milk and water. The important variables were rigorously optimized to be 150 µL of hexanoic acid as the extraction solvent, 400 µL of Na2CO3 as the alkaline source, 350 µL of H2SO4 solution as the acid source, and NaCl as the salting-out agent. The optimized conditions provided a linear range from 0.2 to 50 µg L−1 with limits of detection and quantitation from 0.026 to 0.085 µg L−1 and 0.087 to 0.28 µg L−1 for six PBDEs. The intra-day and inter-day precision values were from 2.48% to 6.75%, and the fortified recoveries for PBDEs were between 78.06% and 103.07% in water and milk samples. The developed procedure avoids the use of a traditional organic disperser and mechanical mixing allowing the determination of PBDEs outdoors by synchronous extraction method and high efficiency for the analytes. These advantages suggest a high potential for the routine monitoring of PBDEs in liquid food and environmental samples.
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Scientific Reports
·
2020
·Vol. 10
·期 1
·1-10
·
IF 3.998
Bi Changfen,Yuan Ye,Tu Yuran,Wu Jiahui,Liang Yulu,Li Yiliang,He Xiwen,Chen Langxing,Zhang Yukui
The development of methods to effectively capture N-glycopeptides from the complex biological samples is crucial to N-glycoproteome profiling. Herein, the hydrophilic chitosan–functionalized magnetic graphene nanocomposites (denoted as Fe 3 O 4 -GO@PDA-Chitosan) were designed and synthesized via a simple two-step modification (dopamine self-polymerization and Michael addition). The Fe 3 O 4 -GO@PDA-Chitosan nanocomposites exhibited good performances with low detection limit (0.4 fmol·μL −1 ), good selectivity (mixture of bovine serum albumin and horseradish peroxidase tryptic digests at a molar ration of 10:1), good repeatability (4 times), high binding capacity (75 mg·g −1 ). Moreover, Fe 3 O 4 -GO@PDA-Chitosan nanocomposites were further utilized to selectively enrich glycopeptides from human renal mesangial cell (HRMC, 200 μg) tryptic digest, and 393 N-linked glycopeptides, representing 195 different glycoproteins and 458 glycosylation sites were identified. This study provides a feasible strategy for the surface functionalized novel materials for isolation and enrichment of N-glycopeptides.
研究领域:
材料科学
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分析化学
·
生物化学
·
纳米技术
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高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xunzhou Yu,Danfeng He,Ximu Zhang,Hongmei Zhang,Jinlin Song,Dezhi Shi,Yahan Fan,Gaoxing Luo,Jun Deng
Since generating toxic reactive oxygen species is largely dependent on oxygen, bacteria-infected wounds’ hypoxia significantly inhibits photodynamic therapy’s antibacterial efficiency. Therefore, a novel therapeutic method for eradicating multidrug-resistant bacteria is developed based on the light-activated alkyl free-radical generation (that is oxygen independent). According to the polydopamine-coated carboxyl graphene (PDA@CG), an initiator-loaded and pH-sensitive heat-producible hybrid of bactericides was synthesized. According to fluorescence/thermal imaging, under the low pH of the bacterial infection sites, this platform turned positively charged, which allows their accumulation in local infection site. The plasmonic heating effects of PDA@CG can make the initiator decomposed to generate alkyl radical (R•) under the followed near-infrared light irradiation. As a result, oxidative stress can be elevated, DNA damages in bacteria can be caused, and finally even multidrug-resistance death can be caused under different oxygen tensions. Moreover, our bactericidal could promote wound healing in vivo and negligible toxicity in vivo and in vitro and eliminate abscess. Accordingly, this study proves that combination of oxygen-independent free-radical-based therapy along with a stimulus-responsiveness moiety not only can be used as an effective treatment of multidrug-resistant bacteria infection, but also creates a use of a variety of free radicals for treatment of multidrug-resistant bacteria infection wounds.
研究领域:
材料科学
·
纳米医学
·
抗菌治疗
·
生物医学工程
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Mengxue Wang,Lingsha Li,Haipeng Yan,Yong You,Xiaohong He,Zhongxiang Bai,Ying Li,Kui Li,Xulin Yang,Pan Wang
Separating oil-water emulsions in harsh conditions poses a substantial challenge for filtration membrane systems. In response, this study presented a continuous electrospinning technique to fabricate a robust bifacial composite membrane. Two types of high-performance polyarylene ether nitrile (PEN) polymers, PEN-BPA and PEN-B/P, with different wettability, are employed to construct the AB bifacial structure. Further, the A-side is modified with hydrophilic polydopamine (PDA) and antibacterial silver nanoparticles (Ag NPs) to prepare Ag@PDA/PEN-BPA, while the B-side is altered with photocatalytic titanium dioxide nanoparticles (TiO 2 ) to prepare TiO 2 /PEN-B/P. The resulting Ag@PDA/PEN-TiO 2 /PEN-B/P bifacial membrane demonstrates remarkable photocatalytic degradation efficiency, particularly for MB, reaching 99.8% degradation efficiency. Moreover, the permeation flux and oil-water emulsion separation rejection rate of the membrane reach 5180.34 L m − 2 ·h −1 and 99%. The PEN substrates are not only used to construct the AB bifacial structure but also to enhance the membrane's toughness and durability, ensuring stability in high-temperature and corrosive environments, with a rejection rate reaching 99% after 10 reuse cycles. Furthermore, integrating Ag NPs imparts excellent antibacterial properties to the membrane, sustaining a 99.99% antibacterial rate after oil-water emulsion separation, photocatalytic dye degradation, and exposure to high-temperature NaCl immersion. This study offers novel insights into multifunctional water treatment materials in harsh environments.
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