Journal of Food Measurement and Characterization
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2026
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IF 3.6
Wang Xin,Peng Huainan,Chang Menghan,Liu Qianqian,Wang Ziyu,Zhang Xinshuai,Fan Meijing,Yue Chonghui
The synergistic effects of long-chain inulin and ferulic acid in regulating the rheological properties of wheat dough and gluten network formation was comprehensively investigated. In this study, dynamic rheological analysis, texture profile analysis, low field nuclear magnetic resonance (LF-NMR), differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy, zeta potential and particle size analysis, fluorescence spectroscopy, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and scanning electron microscopy (SEM), laser confocal microscopy (CLSM) observation, etc. The results showed that the 2.5FXL-1FA treatment reduced the hardness of the dough from 385.71 N to 354.35 N compared to the 1FA treatment, while increasing the disulfide bond (SS) content from 18.10 µmol/L to 25.56 µmol/L. This combination treatment also elevated both storage modulus (G′) and loss modulus (G″), indicating enhanced dough elasticity and viscosity. Furthermore, the combination treatment increased the peak temperature (Tp) and enthalpy change (ΔH) values of dough, suggesting improved dough stability during heating. At lower concentrations, the FXL-FA combination reduced the zeta potential and fluorescence intensity of gluten, which was associated with improved gluten stability and a more compact network structure. However, higher doses of FXL-FA were found to negatively affect dough quality and gluten protein network stability, indicating that optimal doses are critical for maximizing the benefits of FXL-FA in dough formulation. This highlights the critical importance of optimizing the FXL-FA dosage to maximize the benefits of this combination in dough formulation.
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Scientific Reports
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2026
·
IF 4.9
Yin Lingxuan,Pang Shutong,Li Xianping,Deng Guoxian,Shao Wei,Xia Xiaowen,Zhu He,Yan Junan,Yao Jiwei
Voluntary urination—the conscious control over urine release based on internal and external cues—is essential for social functioning and physiological homeostasis, yet the neural mechanisms underlying this behavior remain poorly understood. Effective mechanistic dissection requires genetically tractable models with robust naturalistic behaviors. However, C57BL/6J mice, despite their rich genetic toolkit, exhibit weak scent-marking unless subjected to prolonged social isolation, whereas BALB/c mice display robust marking but lack genetic accessibility. To bridge this gap, we employed F1 hybrid males (C57BL/6J × BALB/c) to combine these complementary strengths and established a 10-minute odor-driven paradigm in which both group-housed and socially isolated F1 males exhibited robust scent-marking toward estrous female urine. To facilitate efficient and accurate analysis of urine deposition from this behavioral paradigm, we trained a YOLOv8-based deep learning model for automated quantification, achieving high accuracy. Furthermore, whole-brain c-Fos mapping revealed significant activation in the prefrontal cortex, brainstem, and other key regions implicated in regulating this voluntary voiding behavior. Thus, our study establishes a novel behavioral paradigm for odor-induced voluntary urination, providing a genetically accessible model system to dissect the neural circuits governing physiological voiding and neurogenic lower urinary tract dysfunction.
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BioNanoScience
·
2026
·Vol. 16
·期 5
·320
·
IF 4
Ma Yingying,Xue Linying,Wang Yancai
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the leading clinical cause of dementia. Magnolol has promising therapeutic potential for AD. However, its poor aqueous solubility and the challenge of achieving brain-targeted delivery have severely hindered its clinical usage. This study designed a thermosensitive in situ hydrogel nasal spray for co-delivery of magnolol nanosuspensions and berberine, targeting AD treatment via nose-to-brain delivery. The magnolol nanosuspensions were prepared via a wet-milling approach to improve the drug’s solubility. A thermosensitive hydrogel based on poly(N-isopropylacrylamide) (PNIPAM) was synthesized and formulated as an in situ nasal spray to enable brain-targeted co-delivery of the two drugs. In vitro PC12 cells AD models and in vivo mice was used to evaluation the thermosensitive multifunctional in-situ hybrid gel effectiveness and distribution. Morphological characterization confirmed successful preparation of magnolol nanosuspensions with a mean particle size of 220 ± 10 nm, which exhibited a high dissolution rate of 82.36 ± 1.62% within 300 min. The nanosuspensions were embedded in the hydrogel, which has a lower critical solution temperature (LCST) of approximately 32 °C - allowing rapid phase transition in the nasal cavity (local temperature ~ 35 °C). On PC12 cells and mice AD models, the thermosensitive hydrogel co-delivery system increased cell survival by 27.13% and significantly enhanced drug accumulation in the brain. This multifunctional drug delivery system provides an efficient strategy for the brain-targeted delivery of magnolol nanosuspensions and berberine, offering a promising approach for AD treatment.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 12
·942
·
IF 3.2
Guo Chaofan,Du Yiping,Guan Haoyang,Zhu Jinglong,Ma Lin,Yan Zhengguang,Xiao Jiawen
Narrowband photodetectors exhibit considerable potential for high-resolution imaging and encrypted communication systems owing to their high spectral resolution capabilities. In this study, a composite perovskite single-crystal heterojunction (SCH) consisting of MAPbBr 3 and MAPbI 3 was fabricated by epitaxially growing MAPbI 3 on a MAPbBr 3 single crystal substrate. A carbon paste light-window electrode was applied to the MAPbI 3 surface following a spatially modulated electrode strategy. The resulting device demonstrates outstanding narrowband detection performance, featuring a full width at half maximum ( FWHM ) of 21 nm, a spectral rejection ratio ( SRR ) of 137, a specific detectivity of 1.24 × 10 11 Jones (cm Hz 1/2 W −1 ), a responsivity of 0.56 A W −1 , and a fast response time (34.86/42.81 μs). The exceptional narrowband detection capabilities of this single-crystal heterojunction device would broaden the application prospects of perovskite-based photodetectors in the field of optoelectronics.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Shen Xiang,Lan Zixun,Zhu Yaqiong,Zhong Tingting,Li Bozhang,Chen Jiaheng,Zhu Yanglong,Ye Jing,Wang Xiaolei
The core pathological mechanism of osteoporosis (OP) resides in the imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Furthermore, the accumulation of reactive oxygen species (ROS) and pro-inflammatory factors in bone tissue induces disorders in the immune microenvironment, which substantially elevates the risk of fracture. Inspired by the biological behaviors of sea cucumbers, we designed and constructed a bone-targeting platform (BA@PDA-PA) based on black phosphorus (BP) and amorphous calcium carbonate (ACC). This platform enables precise targeted therapy for diseased bone tissue while improving drug bioavailability. Upon reaching the target site, BA@PDA-PA can respond to the acidic microenvironment of OP lesions, and then release BP and calcium ions (Ca 2+ ) on demand. Specifically, BP efficiently scavenges local excessive ROS and improves the immune microenvironment. Meanwhile, the Ca 2+ released from ACC degradation, along with the low phosphorus oxides derived from BP breakdown, work together to promote osteoblast proliferation and differentiation while inhibiting osteoclast activity. This establishes a synergistic therapeutic mechanism involving “targeted delivery, microenvironment regulation, and bone metabolism remodeling.” In vivo experimental results demonstrate that this platform significantly improves the pathological bone microstructure of OP mice, thereby providing a promising therapeutic strategy for OP treatment. Graphical abstract The alternative text for this image may have been generated using AI.
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AAPS PHARMSCITECH
·
2026
·Vol. 27
·期 4
·198
·
IF 5.1
Zhou Ziling,Chen Xian,Liu Yuxin,Zheng Rongjiao,Huang Junxiang,Pan Xin,Wu Chuanbin,Jiang Junhuang
Besides improving drug solubility and stability, co-amorphous systems (COAMS) have recently been reported to enhance the pulmonary delivery efficiency of dry powder inhalation (DPI), offering a novel approach to the development of DPI. Conventional drug formulation development utilizes trial-and-error experiments, which require a laborious workload and resources. Moreover, the correlation of forming COAMS to enhanced pulmonary deposition remains underrepresented. Therefore, we proposed applying multiple machine learning (ML) models to the development of co-amorphous DPIs. In this study, we first constructed the database of COAMS through literature mining and then preprocessed the dataset with a molecular representation method. Subsequently, we successfully developed and evaluated the predictive performance of multiple ML models (i.e., logistic regression, random forests, XGBoost, LightGBM, and support vector machines) for forming a co-amorphous system. The five ML models' performance varied, yet all achieved satisfactory predictive accuracy (ACC) of around 0.80 in the testing subset. Specifically, LightGBM exhibited the highest ACC of 0.790 in cross-validation and 0.845 in the testing subset. In addition, SHapley Additive ex Planations (SHAP) analysis revealed that several molecular features (i.e., API_EState_VSA10, Co-former_BCUT2D_MRHI) are critical for models' prediction. More importantly, we conducted experimental validation by using salbutamol sulfate and indomethacin as model drugs to prepare co-amorphous DPIs based on the fine-tuned LightGBM model. The co-amorphous DPIs showed satisfactory aerodynamic performance with fine particle fractions of 41.87%—69.30%. In conclusion, we successfully demonstrated the feasibility of ML for guiding the formation of co-amorphous DPIs, further facilitating the development process in the future. Graphical
The alternative text for this image may have been generated using AI.
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Nature Communications
·
2026
·
IF 18.1
Li Xuezhong,Lai Genming,Deng Wei,Wei Zhifang,Li Jianwei,Fang Chi,Zuo Taisen,Cheng He,Pakawanit Phakkhananan,Cui Suihan,Qiu Bao,Zhou Xufeng,Zheng Jiaxin,Tang Yongbing
Unraveling the origins of Li dendrite growth remains a critical challenge for lithium metal batteries. Existing studies often treat diffusion-reaction mismatches or electrode surface excess charge in isolation, overlooking the coupled interfacial processes at the nanoscale solid-liquid interface that govern Li dendrite growth. Herein, we introduce the interfacial excess charge distribution factor, a quantitative descriptor that captures the dynamic equilibrium by integrating the contributions of electrode surface excess charge, charge depletion rate and solvation chemistry. We further propose an electrochemical method to monitor Li dendrite growth rates, confirming that electrolytes with rapid excess charge redistribution ability favor planar Li plating. Our findings reveal that the depletion rate of interfacial excess charge governed by Li⁺-dipole-anion interactions, and the degree of electrode excess charge modulated by solvation structures and cation screening, competitively determine the interfacial excess charge dynamics. Guided by these insights, we designed an electrolyte with optimized excess charge redistribution capability, which suppresses dendrite formation and enables stable cycling in ~6.4 Ah lithium metal batteries. This work provides mechanistic insight into how competitive interfacial processes dictate Li dendrite growth.
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npj Science of Food
·
2026
·
IF 9.7
Liu Miao,Li Lin,Wang Jianhui,Deng Na,Li Hui,Chen Zhe,Ni Panxianzhi,Hou Xiaoyi,Van der Meeren Paul
This study evaluated the efficacy of black pepper essential oil (BPEO) as a natural preservative for bighead carp heads during superchilling storage, with a focus on controlling biogenic amine (BA)-producing bacteria. Six dominant BA-producing strains were isolated and identified. BPEO exhibited measurable in vitro growth-inhibitory effects and reduced detectable amino acid decarboxylase protein levels in certain strains. Compared with controls, BPEO treatment delayed sensory deterioration, reduced total viable counts in fish meat by approximately 1.0 log CFU/g, lowered TVB-N values by about 24% at day 8, and extended shelf life by approximately 2 days. Untargeted metabolomic analysis indicated that BPEO treatment was associated with alterations in BA-related metabolic pathways. Notably, putrescine (PUT) levels at day 10 were significantly lower in the BPEO-treated groups compared with controls ( p < 0.001). Reduced PUT accumulation was accompanied by changes in ornithine- and proline-related metabolites in fish meat. This study provides integrated microbiological and metabolomic evidence supporting BPEO as a plant-derived preservation strategy to enhance the safety and quality of aquatic products. The alternative text for this image may have been generated using AI.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Sun Xianlong,Peng Wangui,Guo Shuai,Hu Kaiyu,Ji Yi,Zhao Muyun,Wang Lujun,Peng Jin,Huang Weihong,Xu Wanzhen,Yang Wenming
An “inside-outside” synergistic modification strategy is proposed to construct a photoelectrochemical (PEC) sensing platform based on a boron-doped carbon nitride/nitrogen-doped carbon quantum dot (BCN/NCQDs) heterojunction. The inside modification refers to boron doping within graphitic carbon nitride to modulate its electronic structure, narrowing the bandgap and extending visible light absorption. The outside modification involves the formation of a 0D/2D heterointerface with NCQDs, which establishes a built-in electric field to facilitate directional charge separation. Material characterization shows that the heterojunction exhibits a photocurrent response of approximately 1100 nA and enhanced charge separation efficiency. An aptamer-functionalized PEC sensor was fabricated for the detection of sulfadiazine, yielding a linear range from 0.01 to 1000 ng/mL and a detection limit of 2.7 pM. The sensor shows selectivity, reproducibility (RSD = 3.253%), and stability in operation. In real water and milk samples, recoveries range from 98.53 to 104.73%, consistent with chromatographic methods. This work presents a strategy for designing photoelectrochemical materials and biosensors.
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Nature Communications
·
2026
·Vol. 17
·期 1
·2821
·
IF 18.1
Xiao Hai-Tao,Song Peng,Jin Jing,Wang Yong-Dan,Xu Yin-Yue,Wu He,Shao Xue-Xue,Gan Qi-Feng,He Jian,Wen Yan-Rong,Zhu Jing,Chen Bao-Yi,Zhou Ping,Lai Li-Na,Yang Hua,Li Ping,Zheng Zu-Guo
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern that affects nearly one-quarter of the world’s population. General control non-repressed protein 5 (GCN5), a histone acetyltransferase (HAT), has been implicated in the progression of several diseases, but its role in MASLD remains unclear. Here, we provide the experimental evidence that progressive human and male murine MASLD is driven by GCN5, but not by p300/CREB binding protein associated factor (PCAF) activation. Hepatocyte-specific GCN5 overexpression accelerates MASLD progression, whereas its ablation alleviates disease severity. Moreover, pharmacological inhibition of GCN5 with CPTH2 protects against MASLD. Metabolomics and RNA-seq analyses demonstrate that GCN5 promotes de novo lipogenesis (DNL) by upregulating SREBP1c-mediated transcription of lipogenic genes. Mechanistically, GCN5 acetylates histone H3 at the SREBP1c promoter, enhancing transcription through its intrinsic acetyltransferase activity. Our findings further identify GCN5 as a key regulator of LXRα-induced SREBP1c expression, suggesting that targeting GCN5 may selectively inhibit SREBP1c-driven DNL without impairing LXRα-mediated reverse cholesterol transport (RCT). Notably, combined treatment with the Liver X Receptor (LXR) agonist T0901317 and CPTH2 synergistically reduced lipid accumulation in vitro and in vivo, highlighting a promising therapeutic strategy for MASLD.
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Journal of Animal Science and Biotechnology
·
2026
·Vol. 17
·期 1
·77
·
IF 7.9
Li Yanqing,Fu Min,Yu Lijuan,Zhang Zhen,Xue Zhiyong,Huang Lanhui,Olsen Rolf Erik,Yao Yuanyuan,Yang Yalin,Ran Chao,Wang Chen,Ding Qianwen,Zhou Zhigang
Background The application of traditional vitamin C (VC) and sodium acetate (SA) in aquafeeds is hampered by significant limitations. VC suffers from poor stability during feed processing and storage, as well as low bioavailability. SA is highly hygroscopic, thermally unstable, and rapidly absorbed, leading to short duration of action. This study aimed to design, synthesize, and evaluate tetraacetyl vitamin C ester (TVCE), a novel VC-acetic acid conjugate, as a superior alternative. Results TVCE was successfully synthesized via a one-step acetylation reaction with high yield (90%) and purity (> 95%). By optimizing the distillation recovery process, the by-product acetic acid from the reaction was efficiently recovered and recycled. TVCE demonstrated excellent lipophilicity, remarkable thermal stability (withstanding 160 °C), and was efficiently hydrolyzed by pancreatic lipase in simulated intestinal fluid, indicating its function as a prodrug. In zebrafish, TVCE enhanced systemic antioxidant capacity (increasing superoxide dismutase activity and total antioxidant capacity, while decreasing malondialdehyde content) comparably or superiorly to sodium VC-2-phosphate, even at a lower VC-equivalent dosage. In tilapia, dietary inclusion of TVCE, particularly at 0.1%, significantly improved the weight gain rate and survival rate ( P < 0.05). Notably, despite providing only 48% of the acetate equivalent found in the physical mixture (sodium VC-2-phosphate + SA) group, TVCE still demonstrated superior performance. Furthermore, TVCE supplementation ameliorated liver and intestinal health, as evidenced by reduced serum alanine aminotransferase, diamine oxidase levels, and liver total triglyceride levels, improved tissue morphology, and an optimized gut microbiota structure characterized by an increased abundance of Bacteroidota. Conclusions TVCE is successfully synthesized through a simple, green, and environmentally friendly process, which has successfully achieved the co-production of TVCE and acetic acid. TVCE effectively overcomes the stability and bioavailability issues of conventional VC and SA. In vivo studies demonstrated that TVCE significantly enhances growth performance, antioxidant status, and liver-intestine health in fish. These benefits are attributed to the synergistic effects of VC and acetic acid released upon hydrolysis, which results in a higher biological titer and achieving a "1 + 1 > 2" outcome. These findings establish TVCE as a promising multi-functional nutritional precursor with significant application potential in aquatic feeds.
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Scientific Reports
·
2026
·
IF 4.9
Tang Cuiping,Bai Jie,Liu Xinqi,He Yong,Chen Yong,Zang Xiaoya,Guan Jinan,Varfolomeev Mikhail A.,Liang Deqing
The anti-hydrate surface is considered as a promising solution to prevent gas hydrate blockages. Previously, superhydrophobic surfaces have been investigated. But their surface micro structures are easily damaged and lack durability, thereby leading to promote hydrate nucleation and increase the adhesion of hydrates to the wall. In this work a hydrophilic dual network gel coating Zr 4+ /D-Gel was proposed and tested for the inhibition tetrahydrofuran (THF) hydrates formation as an example and for the reduction of the adhesion force of hydrates on the wall surface. In comparison to the uncoated surface, the Zr 4+ /D-Gel hydrophilic coating significantly prolongs the induction time for THF hydrate formation and diminishes the adhesion strength of THF hydrates. Moreover, THF hydrates in contact with the Zr 4+ /D-Gel coating exhibit a cycle of formation and decomposition over time, and a distinct unfrozen water layer was observed at the solution edges during hydrate formation. This work may provide novel insights and direction for the safe and efficient exploitation and transportation of natural gas hydrates.
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