FOOD CHEMISTRY
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2026
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IF 10.4
Jian Wang,Aiqian Ye,Jian He,Huadong Sheng,Hua Huang,Kan Jiang,Qiaozhi Zhang,Linglin Fu
Synergistic pH-shifting and glycation modify β-Lg's structure and functionality. • Acidic pH shifting enhances β-Lg flexibility, improving glycation efficiency. • XOS shows superior glycation efficiency with β-Lg compared to branched GOS. • Acidic-XOS treatment improves emulsifying and foaming properties of β-Lg. • Basic-GOS conjugation achieves the greatest reduction in IgE-binding capacity. As a major milk allergen with limited functionality, β-lactoglobulin (β-Lg) requires effective modification strategies to enhance its applicability. This study investigated the synergistic effects of pH-shifting pretreatment and glycation on the structure, functional properties, and allergenic potential of β-Lg. The protein was first treated under strongly acidic or basic conditions to induce conformational rearrangements, followed by glycation with galacto-oligosaccharides (GOS) or xylo-oligosaccharides (XOS). Pretreatment under acidic conditions enhanced the protein structural flexibility, exposing more glycation sites, especially for the linearly structured XOS. Acidic pH-shifting with XOS glycation significantly improved the emulsifying and foaming properties of β-Lg, while reducing its IgE-binding capacity. In comparison, basic pH-shifting plus glycation resulted in the greatest reduction in protein allergenicity through a synergistic masking effect, albeit with compromised functionality due to aggregation. Overall, the combined modulation of structure and conjugation provides an effective strategy to tailor the functionality and allergenicity of milk proteins. Download: Download high-res image (120KB) Download: Download full-size image
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JOURNAL OF APPLIED POLYMER SCIENCE
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2026
·
IF 3.1
Shuolei Ma,Peiyuan Li,Jiangfeng Luo,Jianxiong Wang,Zhiyu Wang,Honglin Zheng,Lexuan Su,Shuwen Sun,Weihong Guo,Jikui Wang
Conductive hydrogels hold great promise for applications in flexible sensors. However, for such soft hydrogel systems, achieving a synergistic integration of high mechanical robustness, excellent conductivity, and outstanding self-healing capability remains a significant challenge. To address this issue, this study introduces β -cyclodextrin-functionalized multi-walled carbon nanotubes ( β -CD@MWCNTs) combined with a dynamic redox initiation system undergoing rapid polymerization to prepare hydroxyethyl cellulose/polyacrylic acid/ β -CD@MWCNTs (HEC/PAA/ β -CD@MWCNTs) semi-interpenetrating network hydrogels. The incorporated β -CD@MWCNTs serve as additional physical crosslinking points within the system, which not only markedly enhance the mechanical properties of the hydrogel—including fracture strain (1407.28%), toughness (734.71 kJ m −3 )—while retaining the low modulus (13.08 kPa) characteristic of typical hydrogels, but also confer a remarkable self-healing capability (with up to 88.65% healing efficiency for elongation at break). Furthermore, β -CD@MWCNTs can form a stable ion-electron synergistic conductive pathway with Fe 3+ , endowing the hydrogel with excellent electrical conductivity (37.21 mS cm −1 ) and high strain sensitivity (gauge factor [GF] = 3.77). This study introduces functionalized carbon nanotubes, providing a novel strategy for developing high-performance conductive hydrogels that combine low modulus with high stretchability, excellent conductivity, and self-healing capability, underscoring their broad application potential in flexible sensing including human motion monitoring, information encryption, and handwriting anti-counterfeiting.
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Chinese Physics B
·
2022
·Vol. 31
·期 7
·076101
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IF 1.652
Hengli Xie,Jiaxiang Wang,Lingrui Wang,Yong Yan,Juan Guo,Qilong Gao,Mingju Chao,Erjun Liang,Xiao Ren
Germanium diselenide (GeSe2) is a promising candidate for electronic devices because of its unique crystal structure and optoelectronic properties. However, the evolution of lattice and electronic structure of β-GeSe2 at high pressure is still uncertain. Here we prepared high-quality β-GeSe2 single crystals by chemical vapor transfer (CVT) technique and performed systematic experimental studies on the evolution of lattice structure and bandgap of β-GeSe2 under pressure. High-precision high-pressure ultra low frequency (ULF) Raman scattering and synchrotron angle-dispersive x-ray diffraction (ADXRD) measurements support that no structural phase transition exists under high pressure up to 13.80 GPa, but the structure of β-GeSe2 turns into a disordered state near 6.91 GPa and gradually becomes amorphous forming an irreversibly amorphous crystal at 13.80 GPa. Two Raman modes keep softening abnormally upon pressure. The bandgap of β-GeSe2 reduced linearly from 2.59 eV to 1.65 eV under pressure with a detectable narrowing of 36.5%, and the sample under pressure performs the piezochromism phenomenon. The bandgap after decompression is smaller than that in the atmospheric pressure environment, which is caused by incomplete recrystallization. These results enrich the insight into the structural and optical properties of β-GeSe2 and demonstrate the potential of pressure in modulating the material properties of two-dimensional (2D) Ge-based binary material.
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INORGANIC CHEMISTRY
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2026
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IF 4.6
Peng Lin,Junpu Yang,Weinan Sun,Zhonghui Liao,Xian Zeng,Guobin Yu,Zhiguo Li,Fangbo Zhao,Yongxin Li,Jian Lin
Metal–organic frameworks (MOFs) have recently emerged as promising scintillation platforms owing to their highly tunable architectures, versatile photophysical properties, and ability to incorporate high-Z elements and luminescent centers into a single lattice. In this study, we present a Bi-based MOF, Bi-ndc, along with its Eu-doped derivative, Eu@Bi-ndc, and provide a comparison of their scintillation characteristics. Bi-ndc, constructed from high-Z Bi3+ metal nodes and π-conjugated naphthalenedicarboxylate organic linkers, exhibits ligand-centered radioluminescence but suffers from inefficient utilization of triplet excitons. The doping of Eu3+ into the framework activates an antenna-type sensitization pathway in which linker triplet states transfer energy to Eu3+, thereby enabling effective harvesting of both singlet and triplet excitons. Consequently, Eu@Bi-ndc displays enhanced X-ray–excited luminescence, achieving a detection limit of 6.36 μGy s–1, which is 111-fold lower than that of Bi-ndc. Beyond X-ray detection, Eu@Bi-ndc represents the second MOF material to exhibit a measurable β-ray scintillation spectrum and the second example of a lanthanide-based MOF β-ray scintillator. Under β-ray irradiation from a 90Sr–90Y source, Eu@Bi-ndc exhibits distinct Eu3+ emission signatures, outperforming Bi-ndc in terms of scintillation efficiency. This work underscores the critical role of lanthanide doping in enhancing the scintillation performance of MOF-based materials.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 7
·3226
·
IF 5.6
Yan-Bo Xue,Shi-Meng Gong,Yuan-Yuan Peng,Defu Yu,Ruhong Zhou,Liquan Huang
Bitter taste receptors (TAS2Rs) are G protein-coupled receptors best known for detecting bitter compounds in the oral cavity. However, their expression patterns and physiological roles in the liver remain largely unexplored. Here, we employed molecular and immunohistochemical approaches to demonstrate that multiple TAS2Rs are expressed in human Hep3B cells and mouse primary hepatocytes (MPHs) and co-localized with β-adrenergic receptors (βARs) at the bile canaliculi. Bioluminescence resonance energy transfer (BRET), cAMP assays, and Western blot analyses revealed that certain TAS2Rs exhibit ligand-dependent coupling preferences for the G protein subunits Gαi1, Gαi2, and Gαi3. This coupling leads to inhibition of cAMP production and a reduction in protein kinase A (PKA) substrate phosphorylation. Biochemical assays further showed that TAS2R activation significantly attenuates βAR-mediated lipolysis, as well as the production of glycerol and free fatty acid in both Hep3B cells and MPHs. These effects were partially reversed by small interfering RNA (siRNA)-mediated knockdown of TAS2Rs. Moreover, studies using a steatotic mouse model demonstrated that bitter compounds inhibit lipid droplet degradation, resulting in hepatic triacylglycerol accumulation. Collectively, these findings reveal a role for TAS2Rs in modulating hepatic lipid metabolism and highlight their potential as therapeutic targets for the prevention and treatment of liver diseases.
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JOURNAL OF SEPARATION SCIENCE
·
2026
·Vol. 49
·期 3
·e70400
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IF 3.6
Xin Chen,Lingyun Shao,Wenping Qian,Huaijie Yao,Hongyan Mao,Wenfen Zhang,Shusheng Zhang
The synthesis of covalent organic polymers (COPs) with abundant active sites remains challenging. To address this, we developed β-cyclodextrin (β-CD) functionalized COPs through a modular synthesis strategy, which was comprehensively characterized and subsequently employed as a stationary phase for capillary electrochromatographic separations. Compared with the unmodified column, the β-CD-functionalized COP monolithic column exhibited better separation performance for analytes spanning a wide range of physicochemical properties, including monosubstituted benzenes, alkylbenzenes, phenols, isomers, and chiral compounds, achieving baseline resolution > 1.5 for all tested compounds and a maximum column efficiency of 35 013 plates m −1 for chlorobenzene. Experiments and non-covalent interaction analysis indicated that the synergistic effect between the β-CD cavity and aromatic groups enables the β-CD-functionalized COP stationary phase to exhibit multiple interaction modes (e.g., hydrophobic, π …π stacking, and hydrogen bonding), providing a theoretical foundation for the experimental data. Moreover, the column demonstrated good repeatability and stability, with relative standard deviations for intra-day, inter-day, and column-to-column repeatability all below 2.1%. The column was successfully applied to the determination of monosubstituted benzenes in wastewater samples, showing satisfactory linearity ( R 2 ≥ 0.998), which confirms its potential for complex sample analysis.
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FITOTERAPIA
·
2026
·
IF 2.9
Yupei Sun,Yanhui Yi,Bingkang Wang,Jinrong Li,Feng Zhao,Jianzeng Xin,Sheng Liu
In this study, a series of N-9 substituted β-carboline derivatives were designed, synthesized, and further evaluated for their anti-tumor activity through an integrated approach combining network pharmacology, chemical synthesis, in vitro pharmacological assays, and molecular docking. Furthermore, the underlying mechanism of action was elucidated. Firstly, 33 kinds of β-carboline alkaloids in Picrasma quassioides were screened by TCMSP, HERB and other databases. 493 potential anti-tumor targets were obtained by target prediction and intersection analysis. Combined with GO and KEGG enrichment analysis, MAPK and NF-κB signaling pathways were determined as the core research directions. Ten β-carboline N-9 substituted derivatives were successfully synthesized from L-tryptophan by Pictet-Spengler reaction, oxidative cyclization and amide condensation reaction. The yields were 55.29% ∼ 77.39%. The results showed that compound 4 had significant anticancer activity in vitro, and its mechanism was related to the targeted regulation of MAPK and NF-κB signaling pathways. It can block the activation of NF-κB and ERK 1/2 signaling pathways by down-regulating the expression of p-p65 and p-ERK 1/2 proteins. Molecular docking results showed that compound 4 could form a stable binding conformation with p65, ERK 1 and ERK 2 target proteins through intermolecular forces such as van der Waals force and hydrogen bond, among which the binding affinity with ERK 1 was the strongest. This finding provides experimental basis and theoretical support for the development of targeted anticancer drugs derived from natural products.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Longyang Liang,Wanying Su,Zhiyuan Luo,Zhangcheng Wang,Yinghan Sun,Jianshe Chen,Ruojun Mu
All-polysaccharide GT/KGM emulsion gels serve as multifunctional dysphagia carriers. • Increasing GT strengthened the network, immobilized water, and improved lubrication. • IDDSI classification shifted from Level 4 to Level 6 with increasing GT concentration. • GT/KGM gels significantly protected β-carotene against time, heat, light, and pH stress. Texture-modified foods for dysphagia should provide bolus safety, oral comfort, structural stability, and nutritional value, but many current systems rely mainly on thickening or pureeing and have limited capacity to protect lipophilic nutrients. In this study, gum tragacanth/konjac glucomannan (GT/KGM) emulsion gels were developed for dysphagia. The gels were prepared with a fixed KGM concentration of 0.2% (w/v) and GT concentrations of 0.1%, 0.3%, 0.5%, 0.7%, and 0.9% (w/v), corresponding to KG1-KG5. Then, the resulting gels were evaluated for stability, structure, water distribution, rheological and tribological behavior, IDDSI classification, and β-carotene retention. Experimental results showed that increasing GT concentration improved droplet dispersion and shifted part of the relatively mobile water toward network-immobilized water. All samples exhibited solid-like viscoelastic behavior and shear-thinning flow, indicating deformable but structured gel networks. Tribological analysis showed Stribeck-like lubrication, with GT-rich formulations exhibiting lower friction at intermediate and high sliding speeds. TPA combined with IDDSI testing revealed a GT-driven transition from Level 4 (KG1) to Level 5 (KG2-KG3) and Level 6 (KG4-KG5). Both KG4 and KG5 met IDDSI Level 6. KG4 had lower hardness, gumminess, chewiness, and springiness than KG5. β-Carotene-loaded gels maintained high retention under heating, light exposure, and different pH conditions. These results show that all-polysaccharide emulsion gels can control texture for swallowing and protect lipophilic nutrients. They may be used to develop foods for people with dysphagia in the future. Download: Download high-res image (137KB) Download: Download full-size image GT/KGM emulsion gels for dysphagia-oriented texture control, oral lubrication, and β-carotene protection. GT and KGM were used to construct all-polysaccharide emulsion gels with corn oil as the lipid phase. Increasing GT concentration reinforced the gel network, improved water retention and reduced friction during simulated oral processing, supporting IDDSI-based swallowing suitability. The structured lipid phase further served as a protective carrier for β-carotene under environmental stresses. These results suggest that GT/KGM emulsion gels can integrate swallowing safety, oral comfort and lipophilic nutrient protection for dysphagia-oriented food design.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Yuanchao Zhu,Yaqi Tang,Rumeng Wang,Dezhuang Gong,Fengzhao Wang,Danshi Zhu,Zhenzhen Zhang,Fangchao Cui,Jianrong Li
A robust organic Cur@β-CD composite photocatalyst was successfully synthesized. • A novel visible-light-driven antibacterial composite films were well fabricated. • Cur@β-CD markedly improved physicochemical properties of the as-prepared films. • The developed films significantly prolonged the storage shelf life of fresh bananas. Declining and unstable antibacterial activity restricts the application of packaging films. In this study, a curcumin/β-cyclodextrin inclusion complex (Cur@β-CD, CβCD) with excellent photodynamic activity was synthesized and incorporated as a functional filler into chitosan/polyvinyl alcohol (CS/PVA)-based composite films. The structural characteristics of CβCD were analyzed using FTIR and XRD, and the film morphology was observed using SEM. The physicochemical properties and photoresponsive antibacterial activities of the CβCD-CS/PVA films were investigated. Incorporating 15% CβCD improved the overall performance of the composite films. The tensile strength reached 13.87 MPa, and the water vapor permeability decreased to 1.34 × 10 −11 g m −1 ·s −1 ·Pa −1 . Under visible-light irradiation, the optimized photoresponsive film resulted in extremely low survival rates for Escherichia coli and Staphylococcus aureus . Furthermore, compared with the control, bananas packaged with the as-prepared active film exhibited a markedly longer shelf life. This study provides a feasible strategy for developing high-efficiency photoresponsive antibacterial packaging films. Download: Download high-res image (349KB) Download: Download full-size image
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ONCOGENE
·
2026
·
IF 9.1
Tian Shuai,Gu Shuchen,Sun Shuangwu,Wang Zhaoyang,Zhao Yingming,Yuan Bo,Liu Xia,Zhao Bin,Xu Pinglong,Cao Jin,Xiao Mu,Yu Yi,Feng Xin-Hua
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates cell proliferation, differentiation, migration, and apoptosis. It is generally accepted that TGF-β induces cellular responses through Smad-dependent gene transcription. However, the underlying mechanisms that modulate the transcriptional activities of Smads are not yet fully understood. Here, we identify BRD2, a member of the bromodomain and extraterminal (BET) family, as a key transcriptional coactivator for Smad3. BRD2 physically interacts with Smad3 through a newly identified Smad3-binding region (SBR). This BRD2-Smad interaction enhances Smad’s association with chromatin and amplifies its transcriptional activity, playing a vital role in TGF-β transcriptional and tumor-suppressive responses. Our findings establish BRD2 as an important modulator of TGF-β signaling and suggest that it may serve as a potential target for TGF-β-related diseases.
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Materials
·
2026
·Vol. 19
·期 7
·1370
·
IF 3.7
Yi Luo,Nan Li,Lingjing Yang,Jinlong Wei,Yuantao Yang,Wentao Wang,Yang Zhao,Ruidong Xu,Xuanbing Wang
The high energy consumption of lead anodes in zinc production is caused by the slow oxygen evolution reaction (OER). We made a La-Mn co-doped β-PbO2anode using electrodeposition to solve this issue. The XRD and XPS results show that adding La shrinks the lattice and changes the electron structure. This helps Mn4+change into active Mn3+and creates more active oxygen on the surface, making the reaction easier. EIS tests show that the charge transfer resistance (Rct) decreased by 4.2 times, decreasing from 147.6 Ω to 34.72 Ω at 1.0 V. The Bode phase peak also moved to a lower frequency (from 122 Hz to 0.215 Hz), proving that the electrochemically active surface area (ECSA) increased significantly. At the industrial current of 50 mA cm−2, the anode shows a low overpotential of 840 mV and a Tafel slope of 265 mV dec−1. This improved performance saves 187.10 kWh of energy per ton of zinc. Therefore, the LaMn-β-PbO2anode is a promising and energy-saving option for industrial zinc production.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Huimin Li,Zhangyan Ouyang,Bing Li,Di Gong,Jiaming Bai,Jiying Li,Sixian Zhang,Zujin Liang,Danfeng Long
This study investigated the protective effects of yeast β-glucan (YBG) against alcohol-related brain injury (ARBI), with a focus on potential mechanisms mediated by the gut-brain axis. Our findings revealed that YBG supplementation significantly alleviated alcohol-induced anxiety-like behaviors and cognitive deficits in mice. In the brain, YBG mitigated oxidative stress, reduced neuroinflammation, and ameliorated neurotransmitter dysregulation. In the gut, YBG protected the alcohol-damaged intestinal barrier, upregulating the expression of tight junction proteins (Claudin-1, Occludin, and ZO-1) by 1.5- to 4.5-fold. Furthermore, YBG modulated the gut microbial community, markedly increasing the relative abundance of genera such as Akkermansia (from 0.13% to 4.3%) and Lactobacillus (from 0% to 0.89%), while suppressing alcohol-associated taxa including Alistipes (from 0.20% to 0.05%) and Colidextribacter (from 0.61% to 0.01%). These gut-level ecological changes were accompanied by significant shifts in the microbial metabolome, including elevated short-chain fatty acid levels and altered profiles of neuroactive amino acids, particularly L-tryptophan and L-tyrosine (which exhibited 2.9- and 2.7-fold increases, respectively). KEGG pathway analysis revealed that differential metabolites were primarily enriched in amino acid biosynthesis pathways. Correlation analysis showed strong positive associations among YBG-enriched bacteria, favorable metabolites, and markers of brain health. Together, these findings suggest that YBG's protective effects against ARBI are closely associated with the restoration of gut barrier integrity, restructuring the gut microbiota, and modulating microbial metabolism, which collectively correlate with the attenuation of neuroinflammation and oxidative stress.
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