Environmental Science-Nano
·
2022
·Vol. 9
·期 8
·2653-2664
·
IF 9.473
Guofang Zhang,Guoli Cao,Rong-Hua Luo,Qingle Song,Yanqiao Zeng,Ke Liu,Jing Qu,Xian Lin,Feng-Liang Liu,Guocheng Wang,Hongchang Li,Liang Li,Yong-Tang Zheng,Diana Boraschi,Lidong Wu,Yan-Zhong Chang,Yang Li
Microplastics (MP) pollution is a global issue that raises concerns about potential toxicity for environmental and human health. The notion that SARS-CoV-2 is more stable when adsorbed on plastic surfaces urged us to examine whether the virus can attach to MP, which may facilitate infection upon inhalation or ingestion. Here, we describe that MP can bind SARS-CoV-2 pseudovirus on their surface and enhance infection of human cells in vitro. This enhanced in vitro infectivity was confirmed with authentic SARS-CoV-2, in parallel with increased expression of inflammation-related caspase-3, IL-8 and TNF-α genes. These results suggest that the presence of MP in the environment or in our respiratory or gastrointestinal tracts has the potential to interact with SARS-CoV-2, and potentially increase viral infectivity and spreading.
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ACS Applied Bio Materials
·
2019
·
IF 0
Xiang Li,Hua-Mo Yin,En Luo,Songsong Zhu,Peng Wang,Zhen Zhang,Gui-Qing Liao,Jia-Zhuang Xu,Zhong-Ming Li,Ji-Hua Li
Although artificial polymeric scaffolds act as vital characters in bone repair, their application is limited due to their inferior bioactivity. Herein, osteoinductive poly(ε-caprolactone) (PCL) composite scaffolds were prepared by synchronously enlisting bioactive nanohydroxyapatite (nHA), bioglass (BG), and bone morphogenetic protein-2 (BMP-2), which was bound up with polydopamine (pDA). It was found that pDA deposition not only significantly enhanced hydrophilicity and cell affinity of composite scaffolds but also endowed steady immobilization of BMP-2 with long-term yet sustained release. Compared to pure PCL and PCL/nHA/BG (PHB) scaffolds, the designed PHB-pDA-BMP-2 scaffolds significantly induced the differentiation of bone marrow stromal cells toward an osteogenic lineage. Meanwhile, in vivo examinations revealed the prominent osteogenic capability of PHB-pDA-BMP-2 scaffolds, which enabled complete bone healing of calvarial bone defects in rabbits by 12 weeks. This finding indicates that the developed porous composite scaffolds hold great potential for bone regeneration.
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ENERGY & FUELS
·
2020
·
IF 3.421
Xuefei Li,Dong Feng,Muyuan Chai,Shengchao Xu,Ammar Mohammedomar,Wenbo Zhao
Removal of sulfur dioxide (SO2) from flue gas by developing a highly efficient phase-change absorption solution is an effective way to tackle increasingly serious air pollution problems. In this study, the phase-change absorption behaviors of SO2 by using low cost 2-(diethylamino)ethanol (DEEA)/hexadecane as absorbent/solvent was systematically studied. The homogeneous solution could be facilely and quickly changed into two immiscible liquid phases upon introducing low partial pressure SO2. The liquid–liquid phase-change phenomenon was attributed to the formation of zwitterionic product by the reaction of DEEA with SO2, which was insoluble in low polarity hexadecane. Specifically, the absorption capacity of DEEA toward SO2 under 20 °C could reach 0.51 and 1.56 g of SO2/g of DEEA at 0.02 and 1 atm, respectively, which exhibited front-rank absorption capacity to most reported works. In addition, it was suggested that the present absorbent exhibited a highly selective absorption property and high removal efficiency of SO2. The well-matched absorbent/solvent phase-change system holds a promising application in the treatment of industrial flue gases.
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CLAYS AND CLAY MINERALS
·
2024
·Vol. 66
·期 5
·415-425
·
IF 2
Honghai Wu,Zhenhao Song,Meixiang Lv,Dan Zhao,Guangping He
Many types of oxidative pollutants are dangerous chemicals and may pose a health risk, but an inexpensive and effective method for mitigating those risks would offer significant advantages. The objective of this study was, therefore, to investigate the potential for Fe-pillared montmorillonite to fill that gap. Surface mediated reduction reactions by ferrous species often play an important role in governing the transport, transformation, and fate of hazardous oxidative contaminants. Compared to the untreated montmorillonite (Mnt), the synthetic polyhydroxyl-Fe pillared montmorillonite (Fe-Mnt) was found to be somewhat similar to goethite in promoting the ability of specifically adsorbed Fe(II) to reductively transform 2-nitrophenol (2-NP). The 2-NP was efficiently removed within 30 min from solutions at the optimum neutral pH in a mixed reduction system of Fe(II)/Fe-Mnt under an anoxic atmosphere. This demonstrated that the specifically adsorbed Fe(II) of Fe-Mnt can enhance 2-NP reduction. The highly enhanced 2-NP reduction by Fe(II) through Fe-Mnt surface catalysis can, therefore, be ascribed to clearly increased amounts of an adsorbed Fe(II) species surface complex, which gave rise to enhanced Fe(II) reductive activity that enabled the rapid reduction of 2-NP. The reduction processes produced a faster transformation of 2-NP in a Fe-Mnt suspension than in a Mnt suspension. The transformation kinetics were described using pseudo-first-order rate equations. Moreover, in addition to the effects of mineral surface properties, the interactions were affected by the aqueous chemistry, and the removal rates of 2-NP were increased at pHs of 6.0–7.3. In the present study, the structure and surface reactivity of Fe-Mnt was characterized in depth. The polyhydroxyl-Fe added to Mnt and the pH were determined to be the two key controlling factors to mediate the reductive transformation of 2-NP in the presence of Fe-Mnt in comparison to goethite and Mnt. Finally, the catalysis mechanism responsible for the enhanced 2-NP reduction by Fe(II) was elucidated using cyclic voltammetry.
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Phytochemistry Letters
·
2014
·
IF 1.542
Guoyong Luo,Min Zhou,Yan Liu,Qi Ye,Jian Gu,Tianfang Huang,Guolin Zhang,Yinggang Luo
Two new 3-formyl-2-arylbenzofurans, iteafuranals A and B, were isolated from the 95% EtOH extract of the aerial parts of Itea ilicifolia . Their structures were elucidated as ( E )-2-(3,4-dihydroxyphenyl)-3-formyl-4-hydroxy-5-(prop-1-en-1-yl)benzofuran ( 1 , iteafuranal A) and ( E )-2-(3-hydroxy-4-methoxyphenyl)-3-formyl-4-hydroxy-5-(prop-1-en-1-yl)benzofuran ( 2 , iteafuranal B) by comprehensive analyses of spectroscopic data including 1- and 2-D NMR, UV, IR, and HRMS data. The structure of 1 was confirmed by X-ray crystallography analysis. Compound 1 showed DPPH free radical scavenging capacity with an IC 50 value of 0.34 mg/mL. Compounds 1 and 2 showed ABTS cation radical scavenging capacity with IC 50 values of 0.23 and 0.30 mg/mL, respectively.
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CHINESE JOURNAL OF CHEMICAL PHYSICS
·
2022
·Vol. 35
·期 2
·242-248
·
IF 1.09
Min Yan-jun,Yuan Wen-peng,Yang Dong-yuan,Dai Dong-xu,Yu Sheng-rui,Wu Guo-rong,Yang Xue-ming
The S 1 state decay dynamics of 2-hydroxypyridine following UV excitation at a wavelength range of 276.9−250.0 nm is investigated using femtosecond time-resolved photoelectron imaging technique. Based on pump wavelength dependence of the decay dynamics, a refined decay picture is proposed. At pump wavelength of 276.9 nm, the S 1 state is depopulated through intersystem crossing to lower triplet state(s). At 264.0 nm, both intersystem crossing to lower triplet state(s) and internal conversion to the ground state are in operation. At 250.0 nm, internal conversion to the ground state becomes dominated.
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CRYSTAL GROWTH & DESIGN
·
2021
·
IF 4.076
Yunping Zhoujin,Xing Yang,Mingtao Zhang,Ju Guo,Sean Parkin,Tonglei Li,Faquan Yu,Sihui Long
A lactam–lactam dimer (LLD) and lactam NH···O═C (amide) catemer (LAC) are two competing motifs in N-phenyl-2-hydroxynicotinanilides (PHNAs). Steric effects play an important role in determining the outcome of this competition, and in general, PHNAs with no or negligible steric hindrance take on a near-planar conformation and form LLDs, rather than the widely observed amide NH···O═C hydrogen-bond chains. Conversely, those with significant steric hindrance are forced to take on a twisted conformation and form a lactam NH···O═C (amide) hydrogen bond. Nevertheless, steric factors are not the only criteria, as an LLD and an LAC have been observed in the two polymorphs (1-I and 1-II) of 2-hydroxy-N-m-tolyl-nicotinamide (namely 2-oxo-1,2-dihydropyridine-3-carboxylic acid m-tolylamide, compound 1), although the molecules in both forms have a nearly identical conformation, in contrast to five other newly synthesized PHNAs (2–6), whose crystal structures are sustained on the LLD. Thus, synthon polymorphism is possible in conformationally planar PHNAs. Theoretical studies were performed to provide an explanation for this observation. The lattice energies of the two forms of 1 showed only an insignificant difference. A Hirshfeld analysis revealed that the loss of stability due to less hydrogen bonding in 1-II is compensated by the participation of π–π stacking. Other than the commonly observed LLD in the crystals, π–π stacking provides a significant stabilization for each crystal, with its particular effects being dependent on the substitution pattern of the compound. A noncovalent interaction (NCI) analysis further provided a visual demonstration of the important intermolecular interactions. Potentially the other planar compounds could behave in a similar manner.
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ACS Applied Nano Materials
·
2021
·
IF 5.097
Jianguang Yuan,Haixiang Huang,Zan Jiang,Yujie Lv,Bogu Liu,Bao Zhang,Youhua Yan,Ying Wu
Borohydride magnesium is widely studied as a promising hydrogen storage material due to its high gravimetric and volumetric density (14.9 wt % and 112 g/L, respectively). Different types of catalysts play a good catalytic role in enhancing the hydrogen desorption rates in borohydride systems. In the present paper, multiwalled carbon nanotubes supported Ni (Ni/MWCNTs) were synthesized by a chemical reduction method, and the catalyst was introduced into Mg(BH4)2 to enhance the dehydrogenation kinetics. The effect of Ni/MWCNTs on the microstructural evolution and hydrogen storage properties of Mg(BH4)2 is studied. The Mg(BH4)2-5wt% Ni/MWCNTs (95M@5NiMWCNTs) sample exhibits the best hydrogen storage performance; it starts to release hydrogen at 93 °C, which is 113 °C lower than that of the primary Mg(BH4)2 sample. Moreover, it takes only 3600 s to desorb hydrogen completely at 300 °C, showing a significant improvement on hydrogen desorption kinetics. In comparison with the primary Mg(BH4)2 sample, the dehydriding apparent activation energy of the 95M@5Ni3MWCNTs2 sample is significantly lowered to 119.5 kJ mol–1. Transmission electron microscopy analysis exhibits that the striking improvement of dehydriding properties of Mg(BH4)2 is mainly due to the synergistic catalysis of Ni and MWCNTs. This work provides a new method for designing and synthesizing high-performance catalysts in borohydride hydrogen storage materials, which is potentially utilized as a hydrogen supplier for hydrogen fuel cells.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2020
·
IF 2.985
Ruixue Wang,Lianyun Lin,Yiqiang Zheng,Peng Cao,Zhiguang Yuchi,Hui-Yuan Wu
Cytosolic carboxypeptidases (CCPs) comprise a unique subfamily of M14 carboxypeptidases and are erasers of the reversible protein posttranslational modification– polyglutamylation . Potent inhibitors for CCPs may serve as leading compounds targeting imbalanced polyglutamylation. However, no efficient CCP inhibitor has yet been reported. Here, we showed that 2-phosphonomethylpentanedioic acid (2-PMPA), a potent inhibitor of the distant M28 family member glutamate carboxypeptidase II (GCPII), rather than the typical M14 inhibitor 2-benzylsuccinic acid, could efficiently inhibit CCP activities. 2-PMPA inhibited the recombinant Nna1 (a.k.a. CCP1) for hydrolyzing a synthetic peptide in a mixed manner, with Ki and Ki’ being 0.11 μM and 0.24 μM respectively. It inhibited Nna1 for deglutamylating tubulin, the best-known polyglutamylated protein, with an IC 50 of 0.21 mM. Homology modeling predicted that the R-form of 2-PMPA is more favorable to bind Nna1, unlike that GCPII prefers to S-form. This work for the first time identified a potent inhibitor for CCP family.
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULES
·
2024
·
IF 5.1
Priyanka Chohan,Csilla György,Oleksandr O. Mykhaylyk,Giles M. Prentice,Sorin V. Filip,Marc J. Payne,Gouranga Manna,Steven P. Armes
We report the reversible addition–fragmentation chain transfer (RAFT) dispersion polymerization of 2-hydroxyethyl methacrylate (HEMA) in n-dodecane using a poly(lauryl methacrylate) (PLMA) precursor at 90 °C. This formulation is an example of polymerization-induced self-assembly (PISA), which leads to the formation of a colloidal dispersion of spherical PLMA–PHEMA nanoparticles at 10–20% w/w solids. PISA syntheses involving polar monomers in non-polar media have been previously reported but this particular system offers some unexpected and interesting challenges in terms of both synthesis and characterization. First, GPC analysis requires chemical derivatization of the pendent hydroxyl groups in the PHEMA block using excess acetyl chloride to ensure that both blocks are fully soluble in chloroform. Second, DLS, TEM and 1H NMR spectroscopy studies of the periodically sampled polymerizing mixture indicate the transient formation of anomalously large, colloidally unstable aggregates at around 50% conversion, which approximately corresponds to the maximum rate of polymerization. Remarkably, such aggregates immediately break up to form well-defined nanoparticles, which remain colloidally stable at the end of the HEMA polymerization. Moreover, depending on the target degree of polymerization (DP) for the PHEMA block, TEM studies typically indicate bimodal particle size distributions for PLMA–PHEMA nanoparticles prepared using a one-shot batch protocol. This is attributed to a side-reaction between HEMA monomer and the dithiobenzoate-based RAFT agent. Fortunately, this problem can be prevented by conducting such PISA syntheses under monomer-starved conditions by continuous addition of the HEMA monomer using a syringe pump. Alternatively, unimodal spheres can also be produced via adding HEMA in multiple batches. This PISA formulation has been optimized to produce monomodal particle size distributions while targeting a PHEMA DP of up to 1000 at the maximum possible copolymer concentration. Finally, time-resolved small-angle X-ray scattering (SAXS) studies indicate the rapid formation of well-defined near-monodisperse spheres when targeting PLMA14–PHEMA50 nanoparticles.
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PubMed
高影响因子
NanoImpact
·
2025
·
IF 5.5
Yuan-Yuan Liu,Jie Liu,Yuan Guo,Qiangqiang Zhang,Aoneng Cao,Haifang Wang
Nanoplastics enter the human body mainly by ingestion through the gastrointestinal tract and thus the uptake and release of nanoplastics in intestinal cells have been studied. However, the fate of nanoplastics in intestinal cells remains poorly understood, particularly how they are exocytosed. Herein, we investigated the uptake, distribution, and exocytosis of nanoplastics in Caco-2 cells using 70 nm red fluorescent polystyrene (R70PS) as a nanoplastic model. The results show that R70PS readily enters Caco-2 cells and the content per cell peaks at around 24 h, but the total intracellular content in all cells increases continuously over 72 h. In addition, the uptake mechanisms change over incubation time, i.e. R70PS entered Caco-2 cells via both the energy-independent pathway and the energy-dependent caveolae-mediated endocytosis and macropinocytosis at 4 h incubation, but almost all R70PS entered cells in an energy-dependent manner via caveolae-mediated endocytosis, macropinocytosis, and clathrin-mediated endocytosis at 12 h incubation. Most of the intracellular R70PS accumulated in lysosomes, but R70PS also entered the mitochondria and its level increased over time. Approximately 45 % of the intracellular R70PS could be cleared from the cells within 12 h, mainly via the lysosomal pathway. Exocytosis was also associated with autophagy and was facilitated by the increase in the number of mitochondria and lysosomes, but inhibited by serum in the medium. Our findings deepen the understanding of the interaction between nanoplastics and intestinal cells, which is helpful for the risk assessment of nanoplastics.
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Jinbin Liu,Yajun Bai,Tai-ping Fan,Xiaohui Zheng,Yujie Cai
Proteus mirabilis could convert l-phenylalanine into 2-phenylethanol (2-PE) via the Ehrlich pathway, the amino acid deaminase pathway, and the aromatic amino acid decarboxylase pathway. The aromatic amino acid decarboxylase pathway was proved for the first time in P. mirabilis. In this pathway, l-aromatic amino acid transferase demonstrated a unique catalytic property, transforming 2-penylethylamine into phenylacetaldehyde. Eleven enzymes were supposed to involve in 2-phenylethanol synthesis. The mRNA expression levels of 11 genes were assessed over time by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in vivo. As a result, the expression of 11 genes was significantly increased, suggesting that P. mirabilis could transform l-phenylalanine into 2-phenylethanol via three pathways under aerobic conditions; nine genes were significantly overexpressed, suggesting that P. mirabilis could synthesize 2-phenylethanol via the Ehrlich pathway under anaerobic conditions. This study reveals the multipath synthetic metabolism for 2-phenylethanol in P. mirabilis and will enrich the new ideas for natural (2-PE) synthesis.
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高影响因子
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