EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2025
·
IF 2
Yue-Ling Sun,An-Hua Gong
A new barium zincophosphite BaZn 2 (HPO 3 ) 3 is obtained via a simple hydrothermal reaction. BaZn 2 (HPO 3 ) 3 crystallizes in the P space group and exhibits a novel 3D crystal structure. It possesses a short ultraviolet cutoff edge of 205 nm, corresponding to a large experimental bandgap of 5.55 eV. BaZn 2 (HPO 3 ) 3 also has good thermal stability. This present work provides a comprehensive characterization of its crystal structure and optical properties. Additionally, first-principles calculations are employed to analyze the structure–activity relationship of BaZn 2 (HPO 3 ) 3 . Graphical BaZn 2 (HPO 3 ) 3 possesses a novel 3D anion framework, short ultraviolet cutoff edge, large bandgap, and good thermal stability.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2015
·
IF 2.912
Chang Li,Hanbing Jia,Mingyue Shen,Yuting Wang,Shaoping Nie,Yi Chen,Yongqiang Zhou,Yuanxing Wang,Mingyong Xie
The capacities of six antioxidants to inhibit the formation of 3-monochloropropane-1,2 diol (3-MCPD) esters were examined in this study. Inhibitory capacities of the antioxidants were investigated both in chemical models containing the precursors (tripalmitoyl glycerol, 1,2-dipalmitoyl-sn-glycerol, monopalmitoyl glycerol, and sodium chloride) of 3-MCPD esters and in oil models (rapeseed oil and sodium chloride). Six antioxidants, butylated hydroxytoluene (BHT), butylated hydroxy anisole (BHA), tert-butyl hydroquinone (TBHQ), propyl gallate (PG), l-ascorbyl palmitate (AP), and α-tocopherol (VE), were found to exhibit inhibiting capacities on 3-MCPD ester formation both in chemical models and in oil models. TBHQ provided the highest inhibitory capacity both in chemical models and in oil models; 44% of 3-MCPD ester formation was inhibited in the presence of TBHQ (66 mg/kg of oil) after heating of rapeseed oil at 230 °C for 30 min, followed by PG and AP. BHT, BHA, and VE appeared to have weaker inhibitory abilities in both models. VE exhibited the lowest inhibition rate; 22% of 3-MCPD esters were inhibited in the presence of VE (172 mg/kg of oil) after heating of rapeseed oil at 230 °C for 30 min. In addition, the inhibition rates of PG and VE decreased dramatically with an increase in temperature or heating time. The results suggested that some antioxidants, such as TBHQ, PG, and AP, could be the potential inhibitors of 3-MCPD esters in practice.
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ACS Omega
·
2025
·
IF 4.3
Zhenghu Min,Xingdan Wang,Xiaoqiu Yang,Qiwei Zhang,Qi Zheng
Glycosylation profiling is an effective methodology for achieving a comprehensive understanding of glycoproteins and their alterations in a multitude of pathological conditions. However, in comparison to N-glycosylation, O-glycosylation presents significant challenges in terms of both qualitative and quantitative mass spectrometric analyses. A recently developed oxidative release protocol enables the selective formation of O-glycans containing a carboxyl group derived from the amino acid residue. In this study, 3-nitrophenylhydrazine was used to derivatize the common carboxyl group in a mild hydrophilic solution. Derivatization resulted in the generation of a series of report ions for serine, threonine, sialic acid, and O-acetylated sialic acid residues, thereby facilitating the identification of O-glycans and their attached amino acid residues, as well as the determination of the number of O-acetyl groups. A total of 65 O-glycans can be identified from bovine mucin. Furthermore, the analytical strategy revealed that O-acetylated N-acetylneuraminic acid (Neu5Ac)-containing O-glycans from horse serum exhibited distinctive fragmentation patterns in comparison to those from bovine mucin. Additionally, the presence of deaminoneuraminic acid (KDN)-containing O-glycans was successfully confirmed in fish intestinal tissue. These findings suggest that this method provides an economical and potentially valuable tool for large-scale O-glycosylation studies in complex biological samples.
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Microorganisms
·
2025
·Vol. 14
·期 1
·11
·
IF 4.2
Qianxin Lu,Huisha Du,Xin Jiang,Bingwen Zeng,Tianhui Li,Ying-Chun Dai
The GI.3 norovirus is the most detected and recombinant-rich genotype within genogroup I, yet the mechanistic basis for its epidemiological success remains poorly understood. This study integrates Bayesian evolutionary analysis with in vitro enzymology to investigate the link between RdRp function and the evolutionary dynamics of GI.3 NoV. We analyzed 831 GI.3 sequences, finding that prevalent strains (GI.3[P3] and GI.3[P13]) exhibited significantly higher evolutionary rates in both the RdRp and VP1 genes than non-prevalent strains (GI.3[P10] and GI.3[P14]). While the RdRp gene displayed a strong molecular clock signal, the VP1 gene’s evolution was more complex, showing cluster-specific trends. Functionally, the RdRps from prevalent strains demonstrated superior enzymatic activity and substrate affinity (Km: GI.3[P13] = 0.092 mM; GI.3[P3] = 0.176 mM) compared to non-prevalent strains (Km: GI.3[P14] = 0.273 mM). Notably, GI.3 RdRp required higher manganese ion concentrations for optimal activity than previously reported for GII strains, suggesting a potential biochemical constraint. Our findings demonstrate a clear correlation between RdRp enzymatic efficiency, evolutionary rate, and strain prevalence. We propose that a highly active RdRp may potentially accelerate VP1 evolution and confer a replicative advantage, underpinning the dominance of specific GI.3 lineages. This work provides crucial experimental evidence linking viral polymerase function to evolutionary and epidemiological outcomes.
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Toxics
·
2025
·Vol. 13
·期 12
·
IF 4.1
Huai-Fan Zhai,Ya-Nan Tian,Yu-Xin Sheng,Ya-Jia Pu,Yan-Rong Gao,Jia-Yi Chen,Jia-Di Liu,Jia Ma,Hai-Ming Xu,Peng-Bin Yang
Benzophenone-3 (BP-3), a widely used ultraviolet absorber in various scenarios, exhibits estrogenic toxicity at environmental concentrations—as demonstrated in our prior work. Given the importance of hepatic metabolism and the limitations of previous hepatotoxicity research (high-dose models, lack of mammalian data, etc.), we evaluated BP-3’s hepatic effects on postpartum mice at environmentally relevant levels. Postpartum mice were exposed to BP-3 via drinking water from postpartum day 1 (PPD1) to PPD35. Groups solvent control (0.001% DMSO), 10–1000 nM BP-3, and diethylstilbestrol (DES) were established. Basic growth performance, histopathological changes, and a range of molecular indicators were assessed. The results showed that BP-3 exposure induced dose-dependent increases in liver weight, histopathological alterations (sinusoidal dilation, hepatocyte edema, and necrosis), and significant upregulation of oxidative stress markers (Ros,Mda), chemokines (Ccl27a/b), and inflammatory factors (Tnf-α,Il-6,Nf-κb) at the mRNA level (allp< 0.05). Conversely, levels of antioxidant enzymes (Cat,Sod1/2) and anti-inflammatory factorHo-1were markedly decreased (p< 0.05). A clear dose-effect relationship was confirmed using the Integrated Biomarker Response (IBR) framework. This pioneering study establishes the hepatotoxicity of environmentally relevant BP-3 levels in mammals and offers methodological insights for endocrine disruptor assessment.
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Molecular Medicine Reports
·
2016
·Vol. 13
·期 5
·4506-4512
·
IF 1.559
Guoqiang Liang,Fei Wang,Xiudao Song,Lurong Zhang,Zhen Qian,Guorong Jiang
3-Deoxyglucosone (3DG), a highly reactive dicarbonyl intermediate generated during glycation, has been confirmed to be markedly elevated in the plasma of patients with diabetes. Our previous study found that there is an association between increasing accumulation of plasma 3DG and impaired glucose regulation in non-diabetic seniors (females, >50 years old; males, >55 years old). It was also found that 3DG led to impaired plasma glucose homeostasis in healthy mice, however, the mechanisms underlying the deleterious effect of 3DG in diabetes remain to be fully elucidated. The present study aimed to investigate the ability of 3DG to cause hepatic insulin resistance in a cell model by assessing glucose uptake and glycogen content. In addition, the molecular signaling events, including the phosphoinositide 3‑kinase (PI3K)/AKT/glucose transporter 2 (GLUT2) and PI3K/AKT/glycogen synthase kinase‑3 (GSK‑3) pathways, which affect hepatic insulin resistance, were further investigated using Western blot analysis. The results showed that 3DG (10‑300 ng/ml) had no significant effect on HepG2 cell viability, however, the viability of the HepG2 cells decreased with exposure to concentrations of 500 and 1,000 ng/ml. Treatment with non‑cytotoxic 3DG concentrations resulted in decreased uptake of glucose and glycogen content with insulin stimulation, but not under basal conditions. The insulin‑induced expression of GLUT2 and p‑GSK‑3 were eliminated by 3DG (80 and 300 ng/ml), in addition to inhibiting the phosphorylation of downstream effectors of the insulin signaling pathway, including insulin receptor substrate 1, PI3K and AKT. In conclusion, the findings of the present study indicated that the addition of exogenous 3DG directly contributed to the induction of insulin resistance by impairing insulin signaling in the HepG2 cells, which suggested that 3DG may be involved in worsening of the diabetic condition.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Sitong Wu,Xingbo Yu,Haoyu Wang,Xing Guo,Chuangang Zhou,Dong Zhao,Shengbo Sang
Matrix metalloproteinase 3(MMP-3) has attracted increasing attention as a biomarker for osteoarthritis (OA) due to its crucial role in the early prevention and diagnosis of the disease. In this study, we achieved magnetic electric coupling and magnetic sensitization by doping magnetic nanoparticles into the conversion layer of the surface stress sensor to introduce magnetic force. Under a magnetic field, the magnetic effect of polydimethylsiloxane composite film doped with Fe 3 O 4 nanoparticles eliminates the gravity interference of sensitive film and magnifies its surface stress-induced concave convex deformation. The detection of OA-related MMP-3 is used as a proof-of-concept of the magnetic sensitization of the biosensor, which achieved a limit of detection (LOD) of 3.16 ng/mL, a significantly lower value than without a magnetic field. Moreover, the magneto-stress-electric coupled biosensor exhibited high specificity, selectivity, and stability. Overall,the results demonstrate that magnetic sensitization improves the performance of surface stress biosensors in detecting MMP-3. The biosensor also provides a platform for sensitive qualitative and quantitative clinical detection of OA markers.
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DRUG DEVELOPMENT RESEARCH
·
2019
·Vol. 80
·期 6
·750-757
·
IF 1.742
Chang Zheng,Wen Hou,Jun Liu,Xiao-Fang Xu,Jing Lin,Ping-Hua Sun,Wei-Min Chen
The prevalence of multidrug resistance among clinically significant bacterial pathogens underlines a critical need for the development of new classes of antibacterial agents with novel structural scaffolds. Cajaninstilbene acid (CSA), which is isolated from pigeonpea leaves, has shown potent antibacterial activity. In this study, a series of 2-hydroxyl-4-methoxyl-3-(3-methylbut-2-en-1-yl)-6-(4-phenylbenzoylamino)benzoic acid derivatives derived from CSA were designed and synthesized, and their antibacterial activities were evaluated. Several synthesized compounds exhibit better antibacterial activity than CSA against Staphylococcus aureus , Staphylococcus epidermidis , and two strains of methicillin-resistant S. aureus . Meanwhile, the results of 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assays illustrate the good selectivity between bacteria and normal cells of the most active compounds 6u and 6v . Furthermore, well combinations with bacterial RNA polymerase of 6u arising from docking study imply the possible mechanism of antibacterial activity of these synthetic compounds.
研究领域:
药物化学
·
微生物学
·
合成化学
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JOURNAL OF ORGANIC CHEMISTRY
·
2019
·
IF 4.745
Yong-Long Zhao,Xing-Hai Fei,Yong-Qin Tang,Peng-Fei Xu,Fen-Fen Yang,Bin He,Xiao-Zhong Fu,Yuan-Yong Yang,Meng Zhou,Yuan-Hu Mao,Yong-Xi Dong,Chun Li
An organocatalytic asymmetric α-sulfenylation of 2-substituted indolin-3-ones with N-(alkylthio or arylthio)succinimides has been developed for the first time using Cinchona-derived squaramide as the catalyst. Various chiral 2,2-disubstituted indole-3-ones with S- and N-containing heteroquaternary carbon stereocenters were obtained with up to 98% yield and 99% ee.
研究领域:
有机化学
·
合成化学
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JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
You-Ping Zhang,Ling-Xiao Xiong,Ying Wang,Kuan Li,Bang-Jin Wang,Sheng-Ming Xie,Jun-Hui Zhang,Li-Ming Yuan
Polyimine macrocycles are a new class of organic macrocycles with cyclic structures, well-defined molecular cavities, and multiple cooperative binding sites, which have recently aroused considerable research interest in molecular recognition and separation. Herein, we report the bonding of a [3+3] chiral polyimine macrocycle (H 3 L, C 78 H 78 N 6 O 3 ) on thiol-functionalized silica gel using thiol-ene click chemistry to prepare a chiral stationary phase (CSP) for high performance liquid chromatography (HPLC). The fabricated column exhibited excellent chiral separation capability under both normal-phase and reversed-phase conditions. Fourteen and 10 racemates were well resolved on the column in normal-phase mode (using n -hexane/isopropanol as the mobile phase) and reversed-phase mode (using methanol/water as the mobile phase), respectively, including alcohols, esters, ethers, ketones, aldehydes, epoxides and organic acids. Moreover, the column also shows good selectivity toward positional isomers. Six positional isomers (dinitrobenzene, chloroaniline, bromoaniline, iodoaniline, nitrobrobenzene and nitrochlorobenzene) were well separated on the column. In addition, the effects of the injection mass and mobile phase composition on the separation were investigated. The column shows good reproducibility and stability after multiple injections with the relative standard deviation (RSD) ( n = 5) of the retention time and resolution being < 0.96 % and 0.65 %, respectively. This study indicates that this type of chiral polyimine macrocycles is a promising chiral selector for HPLC enantioseparation and will push forward the applications of more novel chiral macrocycles for chiral chromatographic separation.
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ChemPlusChem
·
2020
·Vol. 85
·期 1
·240-246
·
IF 2.753
Sheng Tang,Xinyu Xiao,Jing Hu,Bo Gao,Hunglin Chen,Zongyang Peng,Jianchun Wen,Masanao Era,Dechun Zou
Graphical Solvent-free is best : Mixed halide hybrid perovskites (MHPs) are prepared through a solvent-free mechanochemical synthesis (MCS) route with superior control over halide compositions. The MCS route eliminates the problem in the preparation of MAPb(I x Br 1− x ) 3 with continuously varying x , while maintaining the material properties and suppressing phase segregation in solvent synthesis (SS) routes. Thus, the optical band gaps can be tuned easily by compositional control. Hybrid perovskites have recently received much attention in optoelectronic applications. However, hybrid perovskites are unstable in a humid environment. Mixed halide perovskites (MHPs) show enhanced stability and band-gap tunability upon engineering of their halide composition. Here, MHPs are prepared through a solvent-free mechanochemical synthesis (MCS) route that allows superior control over halide compositions than the solvent synthesis routes (SS). The MCS route eliminates the problem in the preparation of MAPb(I x Br 1− x ) 3 with continuously varying x , while maintaining the material properties and suppressing phase segregation present in SS routes. UV-vis absorption and X-ray diffraction patterns confirm the production of the desired pure-phase MHPs. For MAPb(I x Br 1− x ) 3 (0≤ x ≤1), with increased ratio of halide ( x ), the cubic phase gradually transforms into the tetragonal phase and band-gap tunability is accomplished. The MCS route for the preparation of MHPs is a very promising and efficient technique for superior control in optoelectronic properties, leading to improved control in fabrication approaches.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2019
·
IF 3.17
Qi-meng Liu,Qing Xiao,Xiang Zhu,Kai-feng Chen,Xia-wen Liu,Ru-chao Jiang,Dan Wu,Jun-min Shi,Li-jun Dai,Jun-jun Huang
Benign prostatic hyperplasia (BPH) is a common disorder of the urinary system in aging men. 2-(1H-indol-3-yl)-N-[3-(4-(2-methoxyphenyl) piperazinyl) propyl] acetamide (HJZ-3), which is derived from naftopidil , exhibited 97.7- and 64.6-fold greater inhibitory effects for a 1D adrenoceptor than for a 1B - and a 1A -adrenoceptors in vitro, respectively. To investigate the therapeutic potential for treating BPH, we evaluated the pharmacological activity of HJZ-3. Specifically, we evaluated through estrogen/androgen-induced rat benign prostatic hyperplasia model in vivo. HJZ-3 effectively prevented the progression of rat prostatic hyperplasia by suppressing the increase in prostate index and reducing the quantitative analysis of the relative acinus volume, relative stroma, epithelial volume and epithelial thickness and expression of proliferating cell nuclear antigen and α -smooth muscle actin. HJZ-3 decreased α 1A - and α 1D -adrenoceptor protein expressions in prostate tissue. HJZ-3 is a good alternative for α 1A - and α 1D -adrenoceptor blocker. It may relax smooth muscle tone and relieve symptoms of BPH.
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