FOOD SCIENCE AND BIOTECHNOLOGY
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2019
·Vol. 28
·期 4
·1235-1240
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IF 0.888
Kwon Yeji,Yu Seungmin,Choi Gwang Su,Kim Jang Hwan,Baik Mooyeol,Su Seung Tae,Kim Wooki
The roots of Rehmannia glutinosa (RG) have been widely used for medicinal purposes in Asia. The traditional processing of RG involves repetitive steaming and drying, and 9-time-steamed RG (NSRG) is the most commonly consumed form. For a development of a convenient processing method, RG was puffed at various pressures resulting in significantly increased solid extraction yield by up to 14%. The amount of the Maillard reaction product 5-hydroxymethylfurfural and the antioxidant capacities determined by the ABTS and DPPH radical scavenging assays were enhanced at increasing puffing pressure. Treatment of lipopolysaccharide-stimulated RAW 264.7 macrophages with RG extracts revealed that puffing of RG enhanced its suppression of the pro-inflammatory cytokine IL-6 by up to 37%. The 5-hydroxymethylfurfural contents, ABTS/DPPH radical scavenging capacities, and IL-6 regulatory effects of puffed RG samples were greater than those of the NSRG control, indicating that puffing is a desirable processing technique for development of nutraceuticals using RG.
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Journal of Materials Chemistry B
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2019
·Vol. 7
·期 9
·1404-1414
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IF 5.047
Yamin Chai,Jie Chen,Tingting Wang,Jian Chen,Yingda Ma,Guanghui Cheng,Chunran Li,Qian Zhang,Lailiang Ou,Wenzhong Li
A novel nano-CaCO3 (nCaCO3) particle composite-derived polystyrene (PS) resin was successfully synthesized by a suspension polymerization method. The nCaCO3 reinforced PS material (PS/nCaCO3) possessed a structure with abundant mesopores of high porosity, high specific surface area (828.3 m2 g−1) and large pore volume (1.83 cm3 g−1). It was revealed that the incorporation of nCaCO3 into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, MW = 24.0 kDa) from human plasma. The adsorption isotherm could be described by the Langmuir model and classified as S-3 type, showing an IL-6 uptake of up to 25.6 ng g−1 at an equilibrium concentration of about 500 ng L−1. The adsorption capacity for IL-6 of PS/nCaCO3 is not only significantly higher than that of PS (without nCaCO3), but also superior to those of currently available adsorbents that are under clinical studies (e.g., CytoSorb™ towards cytokines). In addition, the PS/nCaCO3 adsorbent also had good hemocompatibility and showed no leakage of nCaCO3 in the plasma in a flowing model system. Therefore, the synthesized PS/nCaCO3 nano-composite has a great potential to be used as an efficient adsorbent for the removal of interleukin-6 (IL-6) from blood of inflammatory and auto-immune disease patients through hemoperfusion.
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COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2019
·
IF 6.282
Tao Zhang,Yue Xu,Hongfu Li,Boming Zhang
In this study, the effect of carbon fiber (CF) surface chemistry and grafting of nano-SiO 2 on CF surface with respect to the interfacial adhesion of CF-reinforced nylon 6 composites was investigated. CFs were oxidized and reacted with poly(oxypropylene) diamines to modify the surface chemistry. The oxidized CFs were modified with 3-aminopropyltriethoxysilane and then grafted with SiO 2 nanoparticles. Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), scanning electron microcopy (SEM), and atomic force microscopy (AFM) were used to characterize the chemistry and topographies of the CF surface. The transverse fiber bundle strength of CF oxidized and grafted nano-SiO 2 increased to 31.92 MPa and 39.35 MPa, respectively, from 12.57 MPa for untreated CF. The results indicated that the reaction between the carboxyl group and nylon 6 led to chemical bonding at the interface and it meanwhile was strengthened and toughened by uniformly distributed SiO 2 nanoparticles on the CF surface.
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Polymers
·
2019
·Vol. 11
·期 7
·1152
·
IF 3.164
Huiqin Zhang,Pan Liu,Zheng Chi,Xuegang Chen
Hydrophilic copolymers containing 2,2′:6′,2″-terpyridine moieties and acrylic acid (AA) units poly (acrylic acid-co-4-(2,2′:6′,2″-terpyridin-4′-yl)styrene) (P(AA-co-TPY)) were synthesized and characterized. Coordinated with different transition metal ions, the dilute aqueous solution of the copolymers exhibited red-shifted UV-vis absorption peaks of π-π* transition from 317 to 340 nm. Further, interacting with iron ions, the copolymer showed new absorption peaks at a longer wavelength region (570 nm) and the absorption intensity enhanced with increase of the ion concentration. When enough ions were added to coordinate with the 2,2′:6′,2″-terpyridine moieties, novel metallo-supramolecular hydrogels were obtained due to the formation of metal coordination bonds between polymer back bones and transition metal ions (Ni2+, Zn2+, Cd2+, Fe2+and Cu2+), which acted as self-assembly crosslinking structures. The mechanical strength and morphology of the resulting metallo-supramolecular hydrogels have been investigated.Keywords:terpyridine;hydrophilic polymer;metallo-supramolecular;hydrogels
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Functional Materials Letters
·
2018
·
IF 1.084
Jujie Luo,Xing Yang,Shumin Wang,Yuhong Bi,Amit Nautiyal,Xinyu Zhang
The metal organic framework (MOF) [Ni 3 (HCOO) 6 ] was synthesized via the simple and fast microwave method, and the effect of irradiation power on crystallinity of synthesized Ni-based MOF was studied. The samples were characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The synthesized Ni-based MOF was electrochemically characterized by using galvanostatic charge–discharge (GCD), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) techniques. The synthesized MOF showed the highest specific capacitance of 1196.2 F/g at 1 A/g with excellent cyclability (86.04% capacitance retention after 2,000 cycles), thereby demonstrating its potential application in supercapacitors.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Wen-Shu Zhang,Ya-Ning Wang,Yue Wang,Zhang-Run Xu
6-thioguanine is an anticancer drug with narrow safe dose range and intense toxic reactions, so it is urgently necessary to evaluate its clinical usage. Reproducibility and analysis speed are important factors to take into account when analyzing drug concentration in body fluids. In this work, we fabricated a droplet-based microfluidic chip for detecting 6-thioguanine in human serum by using the surface-enhanced Raman scattering (SERS) technique. The easily-prepared Au nanoparticles were used as SERS substrates, and reagent mixing and signal acquiring happened in droplets one by one. This assay device is endowed with the superiority in improving determination repeatability with coefficient of variation of no more than 5% (n = 25) and high speed of 10 s each assay. The SERS peak at 1295 cm −1 originated from N1-C6 stretching vibration mode of purine ring was selected for quantitating 6-thioguanine. The signals indicated a satisfied linear relationship with the concentrations of 6-thioguanine in the range of 0.010 μM to 10 μM, with a detection limit of 0.032 μM. The droplet-based microfluidic SERS system was successfully applied for credible and rapid analysis of 6-thioguanine in human serum, and is pretty promising for performing the therapeutic drug monitoring.
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JOURNAL OF POWER SOURCES
·
2014
·
IF 5.211
Guofu Ma,Jiajia Li,Kanjun Sun,Hui Peng,Jingjing Mu,Ziqiang Lei
A gel polymer PVA–KOH–K 3 [Fe(CN) 6 ] is prepared by potassium hydroxide and potassium ferricyanide doped polyvinyl alcohol, and a solid-state supercapacitor is assembled using the gel polymer as electrolyte and separator, activated carbons as electrode. The gel polymer exhibits flexible, high ionic conductivity and wide potential properties. The electrochemical properties of the supercapacitor are investigated using cyclic voltammetry , galvanostatic charge/discharge, and impedance spectroscopy techniques. The electrode specific capacitance of the supercapacitor can be as high as 430.95 F g −1 , and after 1000 cycles at a current density of 1 A g −1 it still remains higher than 380 F g −1 . The energy density and power density of the supercapacitor reach 57.94 Wh kg −1 and 59.84 kW kg −1 , respectively. These novel flexible gel polymers are desirable for applications in supercapacitor devices.
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RSC Advances
·
2014
·Vol. 4
·期 31
·16327-16332
·
IF 3.708
Wen Liang Fu,Shu Jun Zhen,Cheng Zhi Huang
In this contribution, a new simple and cost-effective strategy for the preparation of hybrids of graphene oxide (GO) and metal nanoparticles (MNPs) through the mediation of polyethyleneimine (PEI) molecules was reported. PEI molecules as cationic polymers could effectively attach onto the surface of GO for further negative MNP adsorption. By this process, gold and silver nanoparticles are assembled on GO with high efficiency. This method has also been successfully applied to the assembly of metal nanoparticles and carbon nanotubes (CNTs), indicating that this method is general. Furthermore, the as-prepared graphene oxide/silver nanoparticle (GO/AgNP) hybrids have been used as perfect surface enhanced Raman scattering (SERS) substrates with an enhancement factor of 1.5 × 105 and successfully applied for the sensitive and selective detection of 6-mercaptopurine (6MP) in pharmaceutical tablets with satisfactory results.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2015
·Vol. 308
·期 1
·287-295
·
IF 1.034
Jing P. F.,Liu H. J.,Zhang Q.,Hu S. Y.,Hu C.,Peng L.,Lei L. L.
The adsorption of thorium(IV) [Th(IV)] was studied using a novel 6-o-monotosyl-deoxy-β-cyclodextrin inclusion complex of dibenzoyl (inclusion complex), which was acquired by the reaction of dibenzoyl and 6-OTs-β-CD with the mole ratio of 1:2. The adsorption of Th(IV) onto inclusion complex were investigated as a function of pH value, contact time, temperature, interfering ions and Th(IV) concentration using batch adsorption technique. The maximum adsorption of Th(IV) and the equilibrium adsorption capacity were found to be 89 ± 1 % and 17.83 mg g −1 respectively at pH 3.0, equilibrium time 20 min and initial Th(IV) concentration 20 mg L −1 . Adsorption kinetics, adsorption isotherm and thermodynamics were carried out.
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JOURNAL OF RARE EARTHS
·
2013
·
IF 1.363
Hongzhen XIE,Guanzhong LU
Five lanthanide complexes of Ln 2 (dpdc) 2 (tpy) 2 (NO 3 ) 2 (H 2 O) 2 [Ln=La ( 1 ), Ce ( 2 ), Pr ( 3 ), Sm ( 4 ), Gd ( 5 ), H 2 dpdc=2,2’-biphenyldicarboxylic acid and tpy=2,2′:6′,2″-terpyridine] were prepared at room temperature and characterized by X-ray diffraction, FT-IR and thermo-gravimetric analysis. The results showed that complexes 1–5 were isostructural and consisted of dinuclear units [Ln 2 (dpdc) 2 (tpy) 2 (NO 3 )(H 2 O) 2 ] bridged by two dpdc 2− ligands. The dinuclear units with strong intramolecular hydrogen bonds were assembled into 2D supramolecular layers by the weak π … π staking interactions between pyridine rings of tpy. The TG analysis showed that the complexes 1 – 5 behaved higher thermal stability with no mass loss at < 320 °C. The lanthanide contraction effect and the solid state luminescence properties of complexes 1 – 5 were also investigated. The luminescence emission spectra of complexes 1 – 5 exhibited ligands emission bands and complex 3 and 4 had no typical emission in the visible region.
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INTERNATIONAL BIODETERIORATION & BIODEGRADATION
·
2015
·
IF 2.131
Lin-Na Du,Gang Li,Yu-Hua Zhao,He-Kun Xu,Yang Wang,Ying Zhou,Liang Wang
We investigated biodegradation of the azo dye methyl orange (MO) by Aeromonas sp. DH-6. Nearly 100% decolorization of MO (100 mg l −1 ) by the strain was observed at pH 3.0–7.0 and a broad temperature range (5–45 °C) after incubation for 12 h. Most of the tested carbon and nitrogen sources could significantly enhance MO decolorization, but of the metal ions , only Mg 2+ , Mn 2+ , and 1.5 mM of Ca 2+ could increase the decolorization. The strain still showed a high capacity for decolorizing MO even at a concentration of up to 1000 mg l −1 . Based on the gas chromatography-mass spectrometry analysis (GC-MS) and high performance liquid chromatography analysis (HPLC) data, N,N-dimethyl- p -phenylenediamine and 4-aminobenzenesulfonic acid were identified as the main intermediates of MO biodegradation, and a possible degradation pathway was proposed. Moreover, results of enzyme analysis indicated that laccase, NADH-DCIP reductase, and azo reductase were responsible for the degradation. Overall, high biodegradation efficiency at a broad range of temperatures and dye concentrations suggested that strain DH-6 would have high potential in the bioremediation of azo dyes.
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Yangjian Chen,Fujun Peng,Xiaoda Song,Jicheng Wu,Wenbin Yao,Xiangdong Gao
Polymer-based paclitaxel (PTX) conjugates have demonstrated application potentials to improve the water solubility and enhance the efficiency of drug delivery. In this study, a novel HA-based drug conjugate, HA-6-PTX, was designed and successfully synthesized by chemically grafting PTX to the C-6 position of N -acetyl- d -glucosamine (GlcNAc) of hyaluronic acid (HA) using hexanediamine as the linker. Leaving the carboxylate of HA chain unaffected, the conjugate with drug loading as high as 21.8% showed an excellent water solubility of 168 mg/mL and exhibited increased drug release in the presence of hyaluronidase. Compared to free PTX, HA-6-PTX demonstrated increased cytotoxicity and enhanced apoptosis-inducing effect against HepG2 and A549 cells due to the increased cellular uptake of drug via HA-receptor mediated endocytosis. It was concluded that the HA-6-PTX conjugate could be potentially utilized for further exploration as targeted drug delivery to enhance antitumor efficacy.
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