INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Shaochun He,Junting Li,Xundan Cao,Fei Xie,Hui Yang,Cheng Wang,Carla Bittencourt,Wenjiang Li
A novel reusable, high-compressible cotton regenerated cellulose/chitosan composite aerogel (RC/CSCA) was prepared using N -methylmorpholine-N-oxide (NMMO) as the green cellulose solvent, and glutaraldehyde (GA) as the crosslinking agent. The regenerated cellulose obtained from cotton pulp could chemically crosslink with chitosan and GA, to form a stable 3D porous structure. The GA played an essential role in preventing shrinkage and preserving the deformation recovery ability of RC/CSCA. Due to the ultralow density (13.92 mg/cm 3 ), thermal stability (above 300 °C), and high porosity (97.36 %), the positively charged RC/CSCA can be used as a novel biocomposite adsorbent for effective and selective removal of toxic anionic dyes from wastewater, showing an excellent adsorption capacity, environmental adaptability, and recyclability. The maximal adsorption capacity and removal efficiency of RC/CSCA for methyl orange (MO) was 742.68 mg/g and 95.83 %.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Song Chen,Hao Li,Yajia Bai,Jianan Zhang,Toshiyuki Ikoma,Di Huang,Xiaona Li,Weiyi Chen
Biopolymer/hydroxyapatite (HAp) composites are one type of the most promising materials for a variety of biomedical applications. In this study, hierarchical and urchin-like chitosan/HAp nanowire (HU-CS/HAp NW) microspheres were for the first time synthesized by in situ hydrothermal treatment of chitosan/HAp (CS/HAp) microspheres in the acetic acid solution. The results indicate that HU-CS/HAp NW microspheres were spherical in morphology with a diameter of 100–300 μm. Their surface was mainly constructed by numerous HAp NWs with the diameter of 80–120 nm and showed a hierarchical and urchin-like nanofibrous architecture. It was found that the acidic hydrothermal treatment caused an in situ conversion of HAp NPs to HAp NWs. In vitro biocompatible evaluation indicates that HU-CS/HAp NW microspheres showed an enhanced cell attachment and proliferation due to the presence of hierarchical and urchin-like architecture. Furthermore, HU-CS/HAp NW microspheres showed a good adsorption capacity for tetracycline hydrochloride (model drug, one of the most representative antibiotics) with a higher adsorption capacity than CS/HAp microspheres and well maintained their antibacterial efficacy to inhibit the growth of bacteria: Escherichia coli and Staphylococcus aureus . Thus, the present HU-CS/HAp NW microspheres would be applicable as novel drug-laden cell carriers.
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Food & Function
·
2023
·Vol. 14
·期 9
·4254-4266
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IF 6.1
Ronggang Liu,Yu Li,Chengfu Zhou,Mingqian Tan
Astaxanthin (AXT) is a lipid-soluble carotenoid with good anti-oxidation, hepatic steatosis reduction, anti-inflammation, and intestinal microbiota regulation ability, whose poor stability and pH vulnerability limit its bioavailability. Spirulina protein (SP) derived from spirulina has good emulsifying ability with potential application in nutraceuticals, medicines, and cosmetics. In this study, Pickering emulsions were prepared using a SP–chitosan (CS) complex as an emulsifier. The particle size, zeta potential, and three-phase contact angle of the SP–CS complex with different SP to CS ratios were investigated. A mass ratio of 1 : 2.5 SP–CS complex showed a good emulsifying ability in preparing Pickering emulsion. A higher storage modulus and viscoelasticity were observed with higher SP–CS complex concentrations and oil fractions. The SP–CS Pickering emulsion significantly improved the stability of AXT in different environments. The lipid release rate and AXT bioavailability after digestion of 3 wt% SP–CS complex-stabilized Pickering emulsion reached 70.54 ± 1.59% and 36.60 ± 3.44%, respectively. The results indicated that the SP–CS complex could act as a Pickering emulsion stabilizer and had the potential to deliver protective hydrophobic AXT.
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SURFACE & COATINGS TECHNOLOGY
·
2023
·
IF 5.4
Yanan Wei,Xiaofei Cao,Jun Hu,Neng Li,Li Sun,Weihua Li,Hongwei Liu
The hydration of wettable materials can help to improve their anti-biofouling effect, but their hydration stability under high salinity conditions is a challenge considering the future applications in natural marine environments. Inspired by the self-cleaning properties of crustaceans, chitosan (CS)/Poly (vinyl alcohol) (PVA) hydrogels have been prepared, and their anti-biofouling and salt tolerant mechanism were deeply investigated using surface analysis and molecular dynamics simulation . Interestingly, it is found that CS/PVA hydrogels can be controllably triggered at a low pH, and they can self-adjust to enhance anti-biofouling performance following the changes of environmental conditions. The hydration of CS/PVA hydrogels is enhanced in seawater because of a low salt sensitivity factor ( f ) of these hydrogels with a value of less than 0. Super hydrophilicity of CS/PVA hydrogels makes water drop achieve super spreading within 66.5 ms. Compared to PVA hydrogels, almost no crude oil, protein and algae can adhere to the surface of the prepared CS/PVA (0.2:1) hydrogel. The field tests in the south sea of China also demonstrate that CS/PVA (0.2:1) hydrogel has an excellent anti-biofouling ability after 6 months of testing. The anti-biofouling mechanism is also discussed according to the experimental results and molecular dynamics simulation.
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Biomolecules
·
2023
·Vol. 13
·期 3
·496
·
IF 5.5
Yingyuan Zhao,Zhaoxuan Wang,Shuxian Liu,Shiying Xie,Yinchun Xie,Ruifang Li,Hiroaki Oda
Astaxanthin is a carotenoid with excellent antioxidant activity. However, this small lipid-soluble molecule is insoluble in water and has low stability. Although this situation can be improved when astaxanthin is prepared as a nanosuspension, the aqueous form is still not as convenient and safe as the dry powder form for storage, transport, and use. The lyophilization process provides better protection for thermosensitive materials, but this leads to collapse and agglomeration between nanoparticles. To improve this situation, appropriate lyophilization protectants are needed to offer support between the nanoparticles, such as sugars, amino acids, and hydroxy alcohols. The purpose of this work is to screen lyophilization protectants by single-factor experiments and response surface optimization experiments and then explore the optimal ratio of compound lyophilization protectants, and finally, make excellent astaxanthin/BSA/chitosan nanosuspension (ABC-NPs) lyophilized powder. The work shows that the optimal ratio of the compounding lyophilization protectant is 0.46% oligomeric mannose, 0.44% maltose, and 0.05% sorbitol (w/v). The ABC-NPs lyophilized powder prepared under the above conditions had a re-soluble particle size of 472 nm, with a ratio of 1.32 to the particle size of the sample before lyophilization. The lyophilized powder was all in the form of a pink layer. The sample was fluffy and dissolved entirely within 10 s by shaking with water. Consequently, it is expected to solve the problem of inconvenient storage and transportation of aqueous drugs and to expand the application of nanomedicine powders and tablets.Keywords:lyophilization;astaxanthin nanoparticles;freeze-drying protectant
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高影响因子
Gels
·
2023
·Vol. 9
·期 4
·346
·
IF 4.6
Wenhui Wang,Jia-Horng Lin,Jiali Guo,Rui Sun,Guangting Han,Fudi Peng,Shan Chi,Ting Dong
Water pollution, which is caused by leakage of oily substances, has been recognized as one of the most serious global environmental pollutions endangering the ecosystem. High-quality porous materials with superwettability, which are typically constructed in the form of aerogels, hold huge potential in the field of adsorption and removal of oily substances form water. Herein, we developed a facile strategy to fabricate a novel biomass absorbent with a layered tubular/sheet structure for efficient oil/water separation. The aerogels were fabricated by assembling hollow poplar catkin fiber into chitosan sheets using a directional freeze-drying method. The obtained aerogels were further wrapped with -CH3-ended siloxane structures using CH3SiCl3. This superhydrophobic aerogel (CA ≈ 154 ± 0.4°) could rapidly trap and remove oils from water with a large sorption range of 33.06–73.22 g/g. The aerogel facilitated stable oil recovery (90.07–92.34%) by squeezing after 10 sorption-desorption cycles because of its mechanical robustness (91.76% strain remaining after 50 compress-release cycles). The novel design, low cost, and sustainability of the aerogel provide an efficient and environmentally friendly solution for handling oil spills.Keywords:chitosan;poplar catkin fiber;superhydrophobic aerogels;layered tubular/sheet structures;oil/water separation
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Polymers
·
2023
·Vol. 15
·期 7
·1688
·
IF 5
Xuemei Bai,Jingmin Luan,Tingting Song,Haifeng Sun,Yuhua Dai,Jianxiang Yu,Huafeng Tian
In this work, a series of chitosan (CS)-grafted carbon oxynitride (OCN) nanoparticles (denoted as CS-OCN) were successfully synthesized for the first time by thermal polycondensation and subsequent esterification. The structure and photocatalytic performance of CS-OCN nanoparticles were investigated. The XPS spectra of CS-OCN-3 showed the presence of amino bonds. The optimal photocatalytic degradation efficiency of the synthesized CS-OCN-3 could reach 94.3% within 390 min, while the photocurrent response intensity was about 150% more than that of pure OCN. The improved photocatalytic performance may be mainly attributed to the enhanced photogenerated carrier’s separation and transportation and stronger visible light response after CS grafting. In addition, the inhibition diameter of CS-OCN-3 reached 23 mm againstE. coliwithin 24 h under visible light irradiation, exhibiting excellent photocatalytic bactericidal ability. The results of bacterial inhibition were supported by absorbance measurements (OD600) studies ofE. coli. In a word, this work provided a rational design of an efficient novel metal-free photocatalyst to remove bacterial contamination and accelerate the degradation of organic dyes.Keywords:carbon oxynitride;CS grafting;MB degradation;antibacterial properties;photocatalytic activity
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2019
·
IF 6.361
Fangfang Xiao,Jianhua Cheng,Wen Cao,Cao Yang,Junfeng Chen,Zifen Luo
The use of chitosan combined with magnetic Loofah biochar (CMLB) was investigated for the removal of Cr(VI) and Cu(II) from aqueous solution. The modified biochar had higher Cr(VI) and Cu(II) adsorption capacity than that of pristine biochar. 40%-CMLB showed high Cr(VI) and Cu(II) adsorption capacity of 30.14 mg/g, and 54.68 mg/g, respectively. Adsorption reached equilibrium within 18 h. The study found that the experimental data showed the best fit for the pseudo-second-order kinetic model and Freundlich model. Additionally, after three reuse cycles, Cr(VI) and Cu(II) adsorption capacity by CMLB were 23.34 mg/g and 42.6 mg/g, respectively. XPS results indicated that ion exchange and surface complexation were the primary mechanisms for Cr(VI) and Cu(II) adsorption.
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Polymers
·
2019
·Vol. 11
·期 1
·95
·
IF 3.164
Chunhong Shi,Wenquan Sun,Yongjun Sun,Lei Chen,Yanhua Xu,Mengdan Tang
Carboxymethyl chitosan (CMCS), acrylamide, and methacryloxyethyltrimethyl ammonium chloride were used as co-monomers to produce a sludge dewatering agent carboxymethyl chitosan-graft-poly(acrylamide-methacryloxyethyltrimethyl ammonium chloride) (CCPAD) by UV-induced graft polymerization. Single-factor experiments and response surface methodology were employed to investigate and optimize the grafting rate, grafting efficiency, and intrinsic viscosity influenced by the total monomer concentration, CMCS concentration, cationic degree, pH value, and illumination time. The structure, surface morphology, and thermal stability of CCPAD were characterized by infrared spectroscopy, hydrogen nuclear magnetic resonance, X-ray diffraction, scanning electron microscopy, and differential thermal-thermogravimetry. The raw sludge with 97.9% water content was sourced from the concentrated tank of a sewage treatment plant and used in the sludge condition experiments. In addition, CCPAD was applied as the sludge conditioner to investigate the effects of cationic degree, intrinsic viscosity, and pH on the supernatant turbidity, moisture content, specific resistance to filtration, and sludge settling ratio. Moreover, the mechanism of sludge conditioning by CCPAD was discussed by examining the zeta potential and extracellular polymeric substance (EPS) content of the supernatant. The sludge dewatering results confirmed that CCPAD had excellent performance for improving sludge dewaterability.Keywords:chitosan-based flocculant;graft copolymerization;flocculation;sludge conditioning;dewaterability
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Enhui Zhang,Ronge Xing,Song Liu,Kecheng Li,Yukun Qin,Huahua Yu,Pengcheng Li
A gastric cancer angiogenesis marker peptide, GX1, is promising to be a desirable ligand for anti-angiogenesis targeted drug of gastric cancer treatment. In this study, GX1 was utilized to fabricate a multifunctional vascular targeting docetaxel (DCT)-loaded nanoparticle with N -deoxycholic acid glycol chitosan (DGC) as the carrier and GX1-PEG-deoxycholic acid (GPD) conjugate as the targeting ligand. The mean size of obtained GX1-DGC-DCT was 150.9 nm with a narrow size distribution and their shape was spherical with smooth surface texture. The in vitro drug release test revealed a sustained release manner and an acid pH could accelerate the release compared with the neutral pH. Furthermore, GX1-DGC-DCT showed stronger cytotoxicity against co-cultured gastric cancer cells and human umbilical vein endothelial cells (co-HUVEC) than DCT within 100 μM. In addition, GX1 efficiently enhanced the cellular uptake of nanoparticles in co-HUVEC cells as confirmed by confocal fluorescence scanning microscopy. Moreover, in vivo delivery of GX1-DGC-DCT was demonstrated to inhibit tumor growth in SGC791 tumor-bearing mice with tumor inhibition rate (TIR) of 67.05% and no weight loss of mice was observed. The anti-tumor effects were further confirmed by H&E and TUNEL analysis. Therefore, this new drug delivery system represents a potential strategy for gastric cancer therapy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Jingwei Wang,Zhiheng Guo,Jianxin Xiong,Datong Wu,Shan Li,Yongxin Tao,Yong Qin,Yong Kong
Modification of natural polysaccharides such as chitosan (CS), β‑cyclodextrin (β-CD), and alginic acid offers a promising strategy for the preparation of smart drug carriers, and latest innovations on such carriers are focused on stimuli-responsive biomaterials. In this study, highly hydrophilic three-demensional (3D) porous CS-grafted β-CD (CS-g-β-CD) was prepared through the Williamson ether synthesis reaction with epichlorohydrin (ECH) as the crosslinker and the consequent nucleophilic reaction between the epoxide ring of ECH and the primary amine of CS, which was then characterized by 1 H nuclear ( 1 H NMR), Fourier transform infrared (FT-IR) spectra, X-ray diffraction (XRD) analysis, scanning electron microscope (SEM), thermogravimetry (TG), and N 2 adsorption/desorption isotherms. When etoposide (VP16), an anti-cancer drug, was encapsulated in the CS-g-β-CD, the encapsulation ratio was up to 73.6%. Finally, the resultant CS-g-β-CD was successfully used as the responsive drug carrier for pH- and thermo-sensitive release of VP16. This work opens a new avenue for the preparation of stimuli-responsive drug carriers with modified natural polysaccharides.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2019
·
IF 3.714
Ying Ji,Xun Lin,Jicheng Yu
This study developed oxidized starch-chitosan complexes for the adsorption of procyanidins . Oxidized starch-chitosan complexes were prepared in two steps. Native cornstarch was first oxidized with a 2,2,6,6-tetramethyl piperidinyloxy (TEMPO) mediated reaction and then surface coated with chitosan to adsorb procyanidins. This study evaluated the morphologies and structures of starches in addition to the adsorption properties of procyanidins onto oxidized starch-chitosan complexes. The zeta potential revealed that the optimal weight ratio of oxidized starch and chitosan in the complexes was 1:0.4. The UV–visible spectrum of the complexes showed absorption spectra at about 255 nm, which has never been observed for oxidized starch. X-ray analysis and SEM indicated that the complexes changed the crystallinity and morphology of native starch. The ATR-FTIR spectra suggested that electrostatic interactions may be present between the -COO - of oxidized starch and –NH 3 + of chitosan. The adsorb experiments suggested that the oxidized starch-chitosan complexes could potentially be applied as carriers of bioactive compounds . This paper provides a good reference for an efficient adsorbent of polyphenols by oxidized starch-chitosan complexes.
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