RENEWABLE ENERGY
·
2022
·
IF 8.634
Rui Chen,Qinpan Qiu,Xiao Peng,Chao Tang
Natural ester is regarded as a potential alternative to mineral insulating oil and has a wide range of applications in power system , but its electrical properties and thermal conductivity still need to be improved. Nano modification technology can improve the performance of natural ester to ensure the stability and reliability of natural ester in power equipment. In this study, nano modified natural ester is prepared with APTES surface modified h-BN, and the mechanism of enhancing the properties of natural ester is explored from the microscopic perspective by molecular simulation. The experimental results showed that nano h-BN had good dispersion stability in natural ester after surface modification with APTES. The electrical properties and thermal conductivity of the nano modified natural ester have been greatly improved, and the relative optimal doping concentration of nanoparticles is 0.03 g/L. The simulation results show that the interfacial thickness between nanoparticles and natural ester is larger and more tightly bound after surface modification, which is beneficial to reduce thermal resistance and improve thermal conductivity of natural ester insulating oil. The traps at the interface between nanoparticles and natural ester can capture free electrons in the oil, thus improving the breakdown voltage of natural ester insulating oil.
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Nanoscale
·
2023
·Vol. 15
·期 7
·3199-3211
·
IF 6.7
Feng-Rui Wang,Xiao-Xiao Sheng,Min Zhang,Min Miao,Jin-Ku Liu,Ji-Chang Liu,Yun-Sheng Ma,Peng-Peng Liu
Zinc molybdate (ZMO) is a safe and effective grafting material for anticorrosion. Herein, we reported the synthesis of ZMO/h-BN with the labyrinth of capillary pores owing to the in situ growth of ZMO on flake hexagonal boron nitride (h-BN) using the hydrothermal method. The special morphological structure provided a tortuous path for aggressive species to the steel substrate, which extended and blocked the transmission of aggressive species, enhancing the physical corrosion barrier performance. In addition, the capillary pores of ZMO contributed to the competitive adsorption of Cl− in an electrolyte and reduced the diffusion of aggressive species, thus further delaying the corrosion process. Moreover, the capture of oxygen by forming a B–O bond with h-BN and the formation of a molybdate passive film are beneficial for the inhibition of cathodic and anodic reactions. As verified by electrochemical impedance spectroscopy (EIS), the anticorrosion performance of ZMO/h-BN coating increased by 49.58% and 130.72% compared with ZMO and epoxy resin (EP) coatings after immersing in a NaCl aqueous solution (3.50 wt%) for 72 h. This coating matrix provides an avenue for molybdate-based corrosion remediation.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Zhiqiang Wang,Siqi Duan,Ruiting Zhang,Lin Ma,Ke Lin
Chiral molecules play a very important role in biological systems, and more and more chiral drugs are used in the treatment of diseases. Mandelic acid (MA) is an important chiral starting substance or the key intermediate of some chiral drugs, and the rapid detection of its chiral purity is very important in the synthesis, separation and detection of drugs. In this study, we developed a method for rapid determination of chiral purity of MA by Raman spectroscopy, and measured a series of Raman spectra of different chiral MA. Through the analysis, it is found that the OH stretching vibration peak can be used to identify the components of chiral molecules, and the enantiomeric excess ( ee value) obtained is in good agreement with the real value, and the error is about 5%. The experimental detection speed is fast and the efficiency is high. Our work firstly provides a new idea for the purity detection of chiral molecules by the original Raman spectrum.
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高影响因子
FASEB JOURNAL
·
2022
·Vol. 36
·期 10
·e22530
·
IF 5.834
Chengyu Yang,Yang Liu,Ziyan Wang,Minmin Lin,Chao Liu
Despite the best treatment, approximately 10% of fractures still face undesirable repair and result in delayed unions or non-unions. Dynamic mechanical stimulation promotes bone formation, when applied at the correct time frame, with optimal loading magnitude, frequency, and repetition. Controlled mechanical loading significantly increases osteogenic cells during the matrix deposition phase of bone repair. In the bone defect, the blood vessel network guides the initial bone formation activities. A unique blood vessel subtype (Type H) exists in bone, which expresses high levels of CD31 and endomucin, and functions to couple angiogenesis and osteogenesis. However, how this form of controlled mechanical loading regulates the Type H vessels and promotes bone formation is still not clear. Sphingosine 1-phosphate (S1P) participates in the bone anabolic process and is a key regulator of the blood vessel. Its receptor, sphingosine 1-phosphate receptor 1 (S1Pr1), is a mechanosensitive protein that regulates vascular integrity. Therefore, we hypothesis that controlled anabolic mechanical loading promotes bone repair by acting on Type H vessels. To study the effect of S1Pr1 on loading induced-bone repair, we utilized a stabilized tibial defect model, which allows for the application of anabolic mechanical loading. Mechanical loading upregulated S1Pr1 within the entire defect, with up to 80% expressed in blood vessels, as observed by deep tissue imaging. Additionally, S1Pr1 antagonism by W146 inhibited the anabolic effects of mechanical loading. We showed that mechanical loading or activating S1Pr1 could induce YAP nuclear translocation, a key regulator in the cell's mechanical response, in endothelial cells (ECs) in vitro. Inhibition of S1Pr1 in endothelial cells by siRNA reduced loading-induced YAP nuclear translocation and expressions of angiogenic genes. In vivo, YAP nuclear translocation in Type H vessels was up-regulated after mechanical loading but was inhibited by antagonizing S1Pr1. S1Pr1 agonist, FTY720, increased bone volume and Type H vessel volume, similar to that of mechanical stimulation. In conclusion, controlled anabolic mechanical loading enhanced bone formation mainly through Type H vessels in a S1Pr1-dependent manner.
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高影响因子
Crystals
·
2022
·Vol. 12
·期 7
·985
·
IF 2.67
Yuhan Feng,Yumin Zhang,Jipeng Liu,Ye Zhang,Yongshuai Xie
Due to its high thermal and chemical stability, excellent dielectric properties, unique optical properties, corrosion resistance, and oxidation resistance, the two-dimensional hexagonal boron nitride (h-BN) is often used in a thermal conductor protective layer in deep ultraviolet light-emitting detector fields. However, due to the complicated growth conditions of h-BN, it is often necessary to prepare h-BN by the CVD method in a high vacuum environment, which is limited to a certain extent in terms of film size and production cost. In order to solve this problem, we proposed a method to prepare h-BN thin films by atmospheric CVD (APCVD). This method does not need a vacuum environment, which reduces energy consumption and cost, and makes the operation simpler and the experimental environment safer. The preparation of high-quality h-BN film was carried out using a Cu-Ni alloy as the growth substrate. The growth process of h-BN film was studied, and the influence of growth parameters on the structure of the h-BN film was explored. The morphological features and elemental composition pairs of the samples were characterized and analyzed, which confirmed that the high-quality h-BN film could be successfully grown on the Cu-Ni alloy substrate by APCVD. The UV detection device prepared by using the prepared h-BN film as the photoresponse material had good photoresponse characteristics and performance stability. It provides a new idea for the low-cost preparation of large-scale h-BN.Keywords:APCVD;h-BN;film;photoelectric devices
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 13
·6274-6282
·
IF 3.925
Xiu Xing,Yan Liu,Ming-Liang Shi,Kun Li,Xin-Yue Fan,Zhong-Liu Wu,Na Wang,Xiao-Qi Yu
Controllable and mild photoenzymatic production of chiral alcohols was realized by coupling a versatile photochemical NAD(P)H regeneration system with (R)- or (S)-selective ketoreductases. The efficiency of NAD(P)H regeneration was improved using a Rhodium functionalized metal organic framework, namely Rh-UiO-67, to adjust and control electron transport and electron utilization. Furthermore, six different ketoreductases could be successfully immobilized on Rh-UiO-67 and combined with the light-driven NAD(P)H regeneration system to produce chiral aryl alcohols. Various chiral alcohols with complementary (R)- and (S)-conformations can be constructed by this method with high yields (97%) and excellent stereoselectivity (>99% ee).
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高影响因子
ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Chen Ning,Yixin Dong,Kun Yang,Xun Li,Fei Wang,Yu Zhang
The biocompatible protein nanocarrier with homogeneous particle size is a promising candidate material for the delivery of targeted drugs to tumors. Doxorubicin (DOX) is a commonly prescribed anthracycline antitumor drug, although it may cause nephrotoxicity and cardiotoxicity. The Chinese herbal remedy ursolic acid (UA), a pentacyclic triterpenoid with anticancer action, has been used as a potential drug sensitizer to increase the effectiveness of chemotherapy and pharmacological therapy. Therefore, the dose of DOX can be reduced by compatibility with UA to lower its side effects. Ferritin binds to tumor cells through an interaction with the transferrin receptor 1 (TfR1), which is overexpressed in human cancer cells. In this study, the hydrophobic drug UA and the hydrophilic drug DOX were successfully encapsulated into the ferritin inner cavity using the thermal treatment method incubated at 60 °C for 4 h. The results demonstrated that loaded ferritin could specifically enter breast cancer cells MCF-7 and non-small-cell lung cancer cells A549 in comparison with free UA and DOX, enhancing their therapeutic effects. The loading ratio of two drugs was optimized in the constructed nanocarriers, and the effectiveness of the constructed nanodrugs in inhibiting tumor proliferation was verified by cell apoptosis and three-dimensional (3D) tumor spheroids studies. For the first time, the hydrophilic and hydrophobic drugs were loaded simultaneously within unmodified ferritin without other addition of additives, which would reduce the toxic side effects of DOX and enhance its therapeutic effect. This study also showed that the ferritin-based nanocarrier has potential for drug delivery to tumors.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
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IF 8.128
Lili Deng,Ningjie Fang,Shilin Wu,Song Shu,Yinghao Chu,Jiaxiu Guo,Wanglai Cen
Constructing highly efficient and cost-effective photocatalyst system has been a big challenge for photocatalysis . Herein, CdS nanosphere ( N -CdS), hollow CdS (H-CdS) and a series of H-CdS@NiCoP core–shell nanospheres have been successfully prepared via a facile hydrothermal method . The activity test showed that H-CdS exhibited higher photocatalytic activity (3.34 mmol g -1 h −1 ) compared with N -CdS (0.99 mmol g -1 h −1 ) under visible light irradiation (λ ≥ 420 nm), suggesting that hollow structure could effectively improve photocatalytic activity. Moreover, the H-CdS@NiCoP-7 wt% displayed a maximum photocatalytic H 2 evolution rate of 13.47 mmol g -1 h −1 , which was about 4 times and 2.5 times higher than that of pristine H-CdS and H-CdS@Pt-3 wt%, respectively. Furthermore, H-CdS@NiCoP-7 wt% exhibited a good stability during 20 h test. The physicochemical properties were characterized by XRD , SEM , TEM, XPS , UV–vis DRS , PL and photoelectrochemical technique. The results showed that NiCoP addition can construct p-n junction with H-CdS and effectively promote the charge transfer from CdS to NiCoP, which improved the photocatalytic hydrogen evolution activity. This work revealed that NiCoP could react as an excellent co-catalyst for enhancing H-CdS photocatalytic activity.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yao Xu,Jack Yang,Ting Liao,Riyue Ge,Yang Liu,Jiujun Zhang,Ying Li,Mingyuan Zhu,Sean Li,Wenxian Li
Molybdenum carbide (Mo 2 C) exhibits unique competitive advantages in electrochemical water splitting due to its physicochemical properties . The high intrinsic activity is essential for the high-efficient Mo 2 C catalysts. Herein, transition metal (Ni, Co, or Fe)-Mo 2 C-embedded in N-doped carbon sheets grown on Ni foam (TM/Mo 2 C-NCSs) are synthesized to enhance the intrinsic activity of Mo 2 C by optimizing the Mo-H bonding energy through the interfacial interactions between Ni, Co, or Fe, and Mo 2 C. Owing to the superior intrinsic activity, fast ternary channels, and abundant active sites, the Ni/Mo 2 C-NCSs possess the lowest overpotential for HER (131 mV) and the Fe/Mo 2 C-NCSs show the lowest overpotential for OER (293 mV) at a current density of 100 mA cm −2 in 1 M KOH. The results analyzed with the Density function theory (DFT) calculation indicate that the most superior H adsorption site is at the interface between Mo 2 C and Ni hybrid. H was adsorbed on interface Mo&Ni@Ni/Mo 2 C with proper hydrogen adsorption free energies (ΔG H* ), achieving a fast desorption process in HER. This mechanism is absent in the pristine Mo 2 C catalysts. An alkaline electrolyzer with a cathode of Ni/Mo 2 C-NCSs and anode of Fe/Mo 2 C-NCSs demonstrates a small voltage of 1.66 V at a current density of 100 mA cm −2 . This work offers an elaborated strategy of interface engineering to enhance the intrinsic catalytic activity of Mo 2 C by accelerating H 2 desorption in HER and enhancing the catalytic kinetics of OER simultaneously.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Shuang Ren,Yingshuai Wang,Jiawen Liu,Jiaru Guo,Yifan Wang,Yanting Qin,Xukang Liang,Di Qin,Yong Zhang,Yuanyuan Gao,Tongyi Sun
Acid-responsive thick nanosheets for knee osteoarthritis therapy. • Dual delivery of H₂ gas and Mg 2+ ions in inflammatory joints. • H₂ scavenges ROS and reduces pro-inflammatory cytokines. • Mg 2+ contributes to chondroprotection and cartilage matrix maintenance. • A gas-ion synergistic strategy to reprogram the joint microenvironment. The inadequacy of current Knee Osteoarthritis (KOA) therapies lies in the challenges of effectively overcoming oxidative stress and repairing damaged joint cartilage. To address these challenges, we developed an innovative “gas-ion synergistic delivery” treatment strategy using two-dimensional magnesium boride thick nanosheets (MBNs). The MBNs, prepared via solvent-assisted exfoliation, continuously release hydrogen gas (H₂) and magnesium ions (Mg 2+ ) in the mildly acidic microenvironment of KOA (pH 6.5), providing a dual therapeutic effect. Hydrogen shows strong antioxidant properties, effectively scavenging free radicals 2,2-azino -bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH)), reducing intracellular ROS levels. Furthermore, MBNs significantly suppress the expression of pro-inflammatory cytokines IL-1β and TNF-α. This strategy leverages “gas antioxidation-ion regeneration” dual-mode synergy, offering low cost and exceptional biocompatibility. It presents an innovative solution with clear translational potential for microenvironment reprogramming and targeted therapy of KOA.
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高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Shengyang Qi,Zixuan Niu,Weizhong Yuan
The rapid progress in technology has led to widespread adoption of electronic devices. However, this increased usage has brought about concerns regarding both environmental impact and human health. As a result, there is a growing demand for the development of intelligent devices that can address both electromagnetic interference (EMI) shielding and effective thermal management simultaneously. In this work, we introduce a simple approach for the fabrication of flexible conductive phase change materials (FCPCMs). By combining hollow ZIF-67 (H-ZIF) nanoparticles with a high encapsulation efficiency alongside conductive carbon cloth, we found that the hollow nanoparticles provide excellent encapsulation capabilities. Unlike traditional PCMs, this FCPCM exhibits a unique ability to efficiently convert, store, and release heat energy when stimulated by both light and electricity. Furthermore, the distinctive composite structure of this material enables shape memory, allowing for an EMI shielding switch that responds to changes in temperature. This study not only contributes to the advancement of multifunctional flexible PCMs but also explores the convergence of thermal management and electromagnetic shielding, paving the way for further research and applications in this field.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Kaiwu Zhang,Xuan Wang,Caicheng Long,Jin Xu,Zixin Jiang,Bo Feng,Peng Zhang,Junjie Fei,Taiping Qing
DNA templated fluorescent copper nanoclusters (DNA-CuNCs) have demonstrated enormous potential for biochemical analysis. However, most of them are focused on DNA-related sensing. Here, we designed a hairpin DNA/RNA chimeric chain for the formation of fluorescent CuNCs and further applied it to detect reverse transcription-associated ribonuclease H (RNase H). The DNA/RNA chimera templated copper nanoclusters (DNA/RNA-CuNCs) exhibited similar spectral properties with DNA-CuNCs. In the presence of RNase H, the RNA segment in chimera is hydrolyzed and release short oligonucleotides, which fail to synthsize fluorescent CuNCs. The capabilities for RNase H detection from complex samples and screening of inhibitors were verified. This strategy exhibited high sensitivity for RNase H with a detectable minimum concentration of 5.5 × 10 −4 U mL -1 , which is lower than the developed fluorescent methods. This work will open up new thoughts to design new template for metal nanoclusters and broaden their application in RNA-related sensing.
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高影响因子
危险品化学品经营许可证（带存储）