Environmental Science-Nano
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2021
·Vol. 8
·期 9
·2618-2628
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IF 8.131
Ting Chen,Zhiliang Zhu,Yujie Bao,Hua Zhang,Yanling Qiu,Daqiang Yin
The effective construction of electron transport channels has essential significance for electron-transfer rate enhancement in REDOX processes during peroxymonosulfate (PMS) activation. This study focuses on the establishment of Cu-involved covalent bonds due to the unique electron configuration of Cu ions. The strategy was achieved by anchoring Cu atoms to an O-doped g-C3N4 (Cu–O–CN) matrix. The C–O–Cu linkage was successfully constructed, derived from the precise incorporation of oxygen. From XAFS, H2-TPR, and solid-ESR characteristic observations, the desired REDOX performance was verified. The constructed C–O–Cu linkages were treated as electron transport channels for electron transfer while reacting with PMS, effectively accelerating the REDOX circulation of the Cu(II)/Cu(I) redox couple and promoting the consecutive generation of active species. Consequently, nearly 100% bisphenol A (BPA) was degraded in the Cu–O–CN/PMS reaction system within 30 min. This demonstrates the effectiveness of Cu–O–CN for PMS activation. The prepared Cu–O–CN exhibited definite stability and potential reusability. This research not only highlights the tailored design of heterogeneous catalysts for PMS activation but also broadens its application in water purification.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2020
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IF 4.192
Li Hao,Xinchang Gao,Tingyi Zhou,Jinxuan Cao,Yangying Sun,Yali Dang,Daodong Pan
Umami peptides can help reduce the salt content in foods while still maintaining a savory taste. Few studies have reported the bioactivity of umami peptides after consumption. We studied the bioactivities of 12 umami peptides after gastrointestinal digestion. Three umami peptides exhibited angiotensin I-converting enzyme (ACE) inhibitory and antioxidant activity after digestion. Six novel peptides were identified from digestion solutions of the peptides by HPLC-MS/MS. Among them, CC, CCNK, and HCHT had both ACE inhibitory activity (IC50 values were 9.81, 9.00, and 114.99 μM, respectively) and antioxidant activity (strong 1,1-Diphenyl-2-pycryl-hydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) free radical scavenging activities). AHSVRF had strong ACE inhibitory activity. These peptides increased the nitric oxide concentration and decreased the content of endothelin-1 in a medium of human umbilical vein endothelial cells in a dose-dependent manner. Experiments with damaged HepG2 cells showed that peptides CC, CCNK, and HCHT had antioxidant activity through their cytoprotective effects and by reducing the reactive oxygen species content. The results indicated that umami peptides may provide many health benefits after consumption.
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PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
·
2023
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IF 2.9
Hua-Ping Zhou,Ding-Ran Wang,Chen-Lu Xu,Ye-Wang Zhang
Heparinase I (EC 4.2.2.7), is an enzyme that cleaves heparin, showing great potential for eco-friendly production of low molecular weight heparin (LMWH). However, owing to its poor catalytic activity and thermal stability, the industrial application of heparinase I has been severely hindered. To improve the catalytic activity, we proposed to engineer both the substrate and Ca2+ binding domains of heparinase I. Several heparinases I from different organisms were selected for multiple sequence alignment and molecular docking to screen the key residues in the binding domain. Nine single-point mutations were selected to enhance the catalytic activity of heparinase I. Among them, T250D was the most highly active one, whereas mutations around Ca2+ binding domain yielded two active mutants. Mutant D152S/R244K/T250D with significantly increased catalytic activity was obtained by combined mutation. The catalytic efficiency of the mutant was 118,875.8 min−1·µM−1, which was improved 5.26 times. Molecular modeling revealed that the improved activity and stability of the mutants were probably attributed to the formation of new hydrogen bonds. The highly active mutant had great potential applications in industry and the strategy could be used to improve the performance of other enzymes.
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REACTIVE & FUNCTIONAL POLYMERS
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2017
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IF 3.151
Xuhai Xiong,Xinghua Ma,Ping Chen,Lu Zhou,Rong Ren,Siyang Liu
New aryl-ether-imide/phthalide-containing bismaleimide oligomers (MPEIBMI) with different molecular weight were designed and synthesized by adjusting the addition amount of diamine compound derived from o -cresolphthaleine, and dianhydride 4,4′-(4,4′-isopropylidene diphenoxy)-bis(phthalicanhydride) (mole ratio: 1.25/1.5/2.0). The chemical structures of the oligomers and their intermediate compounds were confirmed by Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance ( 1 H and 13 C NMR) spectroscopy and elementary analysis. X-ray diffraction (XRD) results showed a blunt diffraction peak, suggesting an amorphous structure. The oligomers exhibited good solubility in a variety of common organic solvents . The heat flow curves of the oligomers measured by differential scanning calorimeter (DSC) displayed a broad curing exothermic peak. The thermal stability and thermal mechanical properties of the cured resins were investigated by thermogravimetric analysis (TGA) and dynamic mechanical analysis (DMA). The results indicated that the introduction of phthalide cardo structure and imide rings into the polybismaleimide network could effectively improve the thermal properties. The glass transition temperature and initial thermal decomposition temperature were above 260 °C and 423 °C, respectively, and the residual weight percentages at 700 °C were all > 58%. The mechanical tests revealed that the cured MPEIBMI films had excellent tensile strength and good retention at the temperatures above 200 °C.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2017
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IF 2.329
Honest N.E. Kessy,Kai Wang,Lei Zhao,Molin Zhou,Zhuoyan Hu
Enzyme-assisted extraction and biotransformation of phenolic compounds from litchi pericarps were investigated. Pectinase, β-glucosidase and tannase were used individually and sequentially. The effects of various enzymes and hydrolysis conditions on recovery and biotransformation of phenolic compounds were evaluated. The results indicated that the optimum conditions for enzymatic extraction were 3% (w/w) of pectinase, 1% (w/w) of tannase and 1% (w/w) of β-glucosidase, incubation time and temperature were 180 min and 35 °C, respectively. Under these conditions, pectinase treatment was more efficient in liberating phenolic compounds compared to tannase and β-glucosidase. Sequential enzyme treatment produced more phenolic compounds than the untreated litchi pericarps. As revealed by HPLC, apart from the phenolic compounds observed in pectin and pectin–tannase treated litchi pericarps, quercetin was observed in the pectinase-β-glucosidase and pectinase-β-glucosidase-tannase treated samples, indicating that flavonols probably underwent transformation from glycosylated (rutin) to deglycosylated (quercetin) during sequential enzymatic treatments. Ferric reducing antioxidant power, DPPH radical scavenging capacity, and angiotensin I-converting enzyme inhibition capacity of the enzyme produced extracts were significantly improved compared to the untreated sample. These results suggest that enzyme-assisted produced extracts could be a promising ingredient in developing natural functional foods, and in pharmaceutical products against hypertension in humans.
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CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Cheng Chen,Li Liu,Jing Guo,Lixiang Zhou,Yeqing Lan
Sulfur-doped copper-cobalt bimetallic oxides (S-CuYO) with abundant Cu(I) were successfully synthesized by a co-precipitation method and were for the first time utilized to activate peroxymonosulfate (PMS) for the degradation of chloramphenicol (CAP). For comparison purposes, sulfur-doped monometallic oxides (S-CuO and S-CoO) and non-doped copper-cobalt bimetallic oxide (CuCoO-1) were also prepared via the same processes. The results demonstrated that S-CuCoO had the highest catalytic activity among the catalysts. The sulfur-doped catalyst significantly improved the catalytic performance and stability. More than 98% of CAP (20 mg/L) was removed within 15 min at the initial pH = 5. The superior catalytic activity of S-CuCoO mainly resulted from the synergy of Cu(I) and Co(II). The presence of Cu(I) improved the conversion of Co(III) to Co(II), which maintained the high catalytic performance of S-CuCoO. In addition, the produced Cu(II) was further converted to Cu(I) by lattice oxygen (O 2− ), ensuring an adequate supply of Cu(I) in the catalyst. Radical quenching experiments revealed that both the SO 4 − and OH radicals were generated by the interaction of S-CuCoO with PMS, thereby contributing to the efficient degradation of CAP and the OH radicals played a larger role. The main intermediates of the CAP degradation were identified by high-performance liquid chromatography–mass spectrometry (HPLC-MS/MS). Theoretical calculations of the frontier electron densities (FEDs) were performed to determine the possible degradation pathways of CAP.
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Inorganic Chemistry Frontiers
·
2024
·
IF 6.1
Qingzheng Kong,Xiaomei Jiang,Ying Sun,Jianguo Zhu,Xutang Tao
Recently, low-dimensional copper(I)-based halide has been considered as a potential substitute for its lead-based counterpart due to its environmental friendliness, facile preparation and superior luminescence performance. In particular, as a representative efficient luminescent material, it shows great potential as a scintillator for X-ray detection. Herein, three organic copper(I) halide single crystals were grown by incorporating a conjugated organic cation (4-benzylpyridine, 4-bzpy) with copper(I) iodide modules. The three compounds exhibit distinct crystal structure and properties. Notably, the zero-dimensional cubane-like (4-bzpy)4Cu4I4 shows a broadband emission with near-unity photoluminescence quantum yield (∼99.7%) and a large Stokes shift (∼216 nm). More importantly, it demonstrates an obvious X-ray response with a high light yield (∼60 948 photons per MeV) and a perfect linear relationship with the dose rate under X-ray irradiation. The highly efficient emission of (4-bzpy)4Cu4I4 clusters mainly originates from the ligand-to-core charge transfer state. This work not only provides further understanding of the importance of crystal structure in the properties of organic copper(I) halides, but also facilitates the design and fabrication of high-performance X-ray scintillators.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Fanfan Guo,Yuanyuan Hu,Huiwen Zhou,Yuanjin Li,Jiadi Li,Guichuan Wei,Jing Long Han,Wenyue Gao,Sisi He,Wenxin Niu,Ling Zhang
NIR-I electrochemiluminescence (ECL) is emerging as highly sensitive detection strategy due to its low background at the ambient conditions. Nonetheless, the applications of current NIR-I ECL nanoprobes are limited to the harsh synthetic/testing condition, high toxicity, low signal, and poor biocompatibility. In this study, glutathione/lipoic acid-protected trimetallic Au 6 PtAg nanoclusters (GSH/LA/Au 6 PtAg NCs) are demonstrated as an efficient nanoprobe with strong ECL signals around 850 nm in the presences of triethylamine. Critically, the alloying of Ag + into the bimetallic Au 2.5 Pt NCs altered the electronic structures of Pt(II), valences of Au(0), and the zata potentials of NCs, promoting the ECL intensities at 850 nm by 1.0 time. Additionally, the partly ligand-exchange of GSH by LA further increased the ECL intensities at 850 nm by 2.2 times through accelerating electron transfer processes. Meanwhile, the NIR-I fluorescence ( λ emit = 910 nm) was enhanced. More importantly, the utilization of GSH/LA/Au 6 PtAg NCs μg −1 is enhanced by 3000 times after embedding into SiO 2 microspheres ( D , 318 nm). Because noradrenalin has substantial inhibition effects to NIR-I ECL of GSH/LA/Au 6 PtAg/SiO 2 , 1.0 nM−0.1 mM noradrenalin was detected with the low limit of detection as 0.04 nM (S/N = 3) selectively. Biomolecules, glucose, ascorbic acid, or uric acid didn't interrupt the detection of noradrenalin. The sensitivity of this ECL method to detect noradrenalin is much higher than those in previous reports, enabling the early diagnosis of neurogenic diseases.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Zhen-Ming Lu,Zi-Wen Qiu,Yan-Mei Li,Ke-Yan Zhang,Ye-Yang Wu,Ni Yan,Hong Cheng
Breast cancer cells are characterized by heightened autophagy, which impairs tumor-associated antigen presentation and represents a significant barrier to the antitumor immunity. In this study, a PD-L1-targeting autophagy modulator (PFC@CQ) is fabricated to activate the photoimmunotherapy against breast cancer. Specifically, the hydrophobic photosensitizer protoporphyrin IX (PpIX) is covalently linked to the hydrophobic peptide FFVLK and a PD-L1-targeting peptide sequence CLQKTPKQC, resulting in the formation of an amphiphilic photosensitizer-peptide conjugate (PpIX-FFVLK-CLQKTPKQC, called PFC), which is capable of encapsulating the autophagy inhibitor chloroquine (CQ). PFC@CQ can not only facilitate the targeted drug codelivery to PD-L1-overexpressing breast cancer cells, but also effectively disrupt their immune evasion by blocking PD-1/PD-L1 pathway. Upon light irradiation, the photodynamic therapy (PDT) of PFC@CQ induces tumor cell destruction and immunogenic cell death (ICD), causing the release of damage-associated molecular patterns (DAMPs). Simultaneously, PFC@CQ can inhibit autophagy pathway to mediate the upregulation of MHC-I, thereby enhancing antigen presentation. This cascade immunomodulation promotes the dendritic cell maturation and CD8+ T cell activation, leading to a synergistic suppression of both primary and metastatic tumors. This work introduces an innovative autophagy modulation strategy with potent immunomodulatory capability, demonstrating a potential to trigger systemic antitumor immune responses through local treatment.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Tianrui Li,Baoling Tang,Jiance Jin,Kai Han,Haoran Zhang,Hailian Zhao,Xuejie Zhang,Maxim Molokeev,Yuzhen Wang,Zhiguo Xia,Bingfu Lei
Cu(I)-based halide scintillators are promising candidates for X-ray detection due to excellent scintillation and low-cost solution processability. However, the rational design of Cu(I)-based halide scintillators remains challenging due to insufficient theoretical frameworks elucidating their structure-property correlations. In this work, two Cu(I)-based hybrid metal halides, Cu 2 I 4 -IC (Ionic compound) are designed and Cu 4 I 4 -CC (Coordination compound) via bonding mode control engineering. The Cu 2 I 4 -IC exhibits blue emission, and the Cu 4 I 4 -CC exhibits yellow emission, and the photoluminescence quantum yield (PLQY) of Cu 2 I 4 -IC and Cu 2 I 4 -IC are 91% and 100% respectively. The non-radiative transitions are reduced due to the high rigidity of Cu 4 I 4 , resulting in a light yield up to 67 500 photons MeV −1 and a detection limit as low as 47.3 nGy s −1 of Cu 4 I 4 -CC. Additionally, a high-performance scintillator hydrogel based on Cu 4 I 4 -CC with polyvinyl alcohol (PVA),H 2 O and dimethyl sulfoxide (DMSO) is innovatively developed. Owing to the high transmittance, the large-area scintillator hydrogel film (10 × 10 cm 2 ) achieves an X-ray imaging resolution of 14 lp mm −1 . Furthermore, the synergistic effects of hydrogen bonding and coordination bonding endow the hydrogel scintillator with excellent plasticity and flexible stretchability. The Cu 4 I 4 -CC@PVA hydrogel proves promising for X-ray imaging with excellent stability in harsh environments, matching state-of-the-art scintillators.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Xuefei He,Shuai Zhang,Yuzhen Wang,Kai Han,Zhiguo Xia
Hybrid luminescent metal halides has emerged as the state-of-the-art scintillators, while remaining challenges for enhancing light yield and X-ray imaging capability. Herein, halogen engineering is reported to optimize Cu(I)-based hybrid halides by enhancing the X-ray absorption cross-section, resulting in an increase of light yield by 188% to 79,770 photons MeV −1 from (C 12 H 30 N 2 ) 2 Cu 6 Cl 10 to optimized (C 6 H 15 N) 2 CuI 3 . The transparent glassy scintillation screen with optical transparency beyond 82% demonstrates good thermal stability and high mechanical flexibility. More importantly, the high X-ray imaging resolution of 20.5 lp mm −1 is achieved based on the Cu-I-based glassy scintillation screen. The combined merits of enhancing scintillation performance and X-ray imaging resolution provide a platform for developing halide glass scintillators and enriching their applications in radiology and security screening.
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Cell Reports
·
2025
·
IF 6.9
Li Chai,Chaoqun Li,Xuefeng Wang,Yanyang Qin,Hemin Sun,Jie Du,Liu Yang,Dongmei Hu,Jianan Xiong,Zhiyuan Zhao,Rong Gong,Tao Wu,Meng Wu,Meng Nie,Jialin Gao,Jihui Jia,Chengjiang Gao,Wei Zhao,Huan Zhou,Dongwei Kang,Mutian Jia
Perturbation of energy metabolism is an essential feature during infection and inflammation. TANK-binding kinase 1 (TBK1) is crucial for initiating the innate immune response against viral infection, although aberrant and ongoing TBK1 activation induces excessive production of type I interferons (IFN-I). Nonetheless, the mechanisms whereby energy metabolism controls TBK1 activation remain unclear. Here, we elucidate a mechanism linking energy metabolism to the inhibition of TBK1-induced IFN-I responses via the immune response gene 1 (IRG1)-itaconic acid axis. Mechanistically, itaconic acid and its derivatives alkylated TBK1 at Cys605, thereby disrupting TBK1 dimerization and rapid activation. IRG1, the enzyme that catalyzes itaconic acid production, is upregulated during late-phase viral infection and acts as a feedback regulator to restrain TBK1 activity. We developed itaconic acid-based compounds ITA-5/ITA-9 as alternative TBK1 inhibitors. ITA-5/ITA-9 effectively limited excess IFN-I-mediated hyperinflammation. These findings provide a promising therapeutic strategy for treating diseases mediated by aberrant TBK1 activation.
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