ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Liu Wang,Kang Wang,Xiaohui Wang,Ruyan Niu,Xiaohui Chen,Ying Zhu,Zixin Sun,Jichun Yang,Guoxiang Liu,Yang Luo
An early and accurate cancer diagnosis holds the potential to improve treatment and prognosis. Nevertheless, the complexity of the biological system limits the selectivity of existing approaches and makes tumor imaging in vivo particularly challenging. In this study, tumor-specific fluorescence imaging was achieved by building intelligent dual-lock deoxyribonucleic acid automatons (IDEAs) that employed a DNA walking system standing on ZrMOF@MnO2 multifunctional nanocomposites for controllable molecular recognition. The IDEAs exhibited significantly enhanced fluorescence signals only in the coexistence of both miRNA and GSH of tumor cells, enabling accurate distinguishing of tumor cells from healthy ones. Furthermore, the feasibility and specificity of IDEAs were also validated in vivo with tumor bearing mice successfully. This work highlights the potential of the proposed IDEA strategy for tumor-specific imaging, paving the way for successful precision diagnosis and treatment.
研究领域:
生物医学工程
·
分子生物学
·
癌症研究
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Xing Huang,Yanfei Zhang,Jun Chen,Lang Zhang,Yuzhi Xu,Wen Yin,Yakun Shi,Si-Yang Liu,Xiaoyong Zou,Zong Dai
Imaging of tumor-associated microRNAs (miRNAs) can provide abundant information for cancer diagnosis, whereas the occurrence of trace amounts of miRNAs in normal cells inevitably causes an undesired false-positive signal in the discrimination of cancer cells during miRNA imaging. In this study, we propose a dual-locked (D-locked) platform consisting of the enzyme/miRNA-D-locked DNAzyme sensor and the honeycomb MnO2 nanosponge (hMNS) nanocarrier for highly specific cancer cell imaging. For a proof-of-concept demonstration, apurinic/apyrimidinic endonuclease 1 (APE1) and miR-21 were chosen as key models. The hMNS nanocarrier can efficiently release the D-locked DNAzyme sensor in living cells due to the decomposition of hMNS by glutathione, which can also supply Mn2+ for DNAzyme cleavage. Ascribing to the smart design of the D-locked DNAzyme sensor, the fluorescence signal can only be generated by the synergistic response of APE1 and miR-21 that are overexpressed in cancer cells. Compared with the miRNA single-locked DNAzyme sensor and the small-molecule (ATP)/miRNA D-locked DNAzyme sensor, the proposed enzyme (APE1)/miRNA D-locked DNAzyme sensor exhibited 2.6-fold and 2.4-fold higher discrimination ratio (Fcancer/Fnormal) for cancer cell discrimination, respectively. Owing to the superior performance, the D-locked strategy can selectively generate a fluorescence signal in cancer cells, facilitating accurate discrimination of cancer both in vitro and in vivo. Furthermore, this D-locked platform is easily adaptable toward other target molecules by redesigning the DNA sequences. The outstanding performance and expansibility of this D-locked platform holds promising prospects for cancer diagnosis and related biomedical applications.
研究领域:
生物化学
·
分子生物学
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2021
·
IF 6.057
Nan Jiang,Peng Li,Shihao Sun,Wei Wei
Since 5-hydroxymethylfurfural (HMF) becomes a neo-forming contaminant with latent harm to human health, development of new method for highly sensitive detection of HMF is extremely desirable. Herein, a novel ratiometric fluorescence sensor based on strand displacement reaction and magnetic separation was designed for sensitive and selective detection of HMF with the help of MnO 2 nanosheets . The aldehyde-functionalized DNA (S0–CHO) and HMF competed for binding to amino-functionalized magnetic beads (NH 2 -MBs). Then, S0–CHO was collected from supernatant by magnetic separation. In the presence of HMF, the obtained S0–CHO induced the formation of T-shaped DNA by strand displacement reaction (SDR), lighting the fluorescence of FAM. In the absence of HMF, no S0–CHO was present to ignite T-shaped DNA. In this situation, fluorescence of Cy5 was turned on. Thus, a ratiometric fluorescence sensor for high-sensitive detection of HMF was developed. The sensor has a wide linear range from 5 nM to 5 μM. It also exhibited high selectivity against other potential interfering substances. It has been successfully applied to analyze HMF in food samples. The method has potential to be expanded to detect other molecules containing aldehyde groups and further be applied in food safety, environment and other fields.
研究领域:
生物化学
·
分析化学
·
食品安全
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Aimal Khan,Kaikai Zhang,A Taraqqi-A-Kamal,Xiaoguang Wang,Yong Chen,Yanrong Zhang
ε-MnO 2 effectively activates peroxymonosulfate (PMS) for the efficient degradation of emerging pollutants. ε-MnO 2 was synthesized by a facile thermal-treatment method and its long-term stability and efficiency for the elimination of emerging pollutants, including sulfamethoxazole (SMX), sulfachloropyridazine (SCP), sulfamethazine (SMT), ciprofloxacin (CIP), and azithromycin (AZI), from aqueous media were evaluated. ε-MnO 2 was found to activate PMS more efficiently than α-MnO 2 , β-MnO 2 , or δ-MnO 2 , owing to its high − OH-group content, unique structure, and high surface area. Sulfate (SO 4 •− ), hydroxyl (•OH), and superoxide (O 2 •− ) radicals, as well as singlet oxygen ( 1 O 2 ) were generated, with O 2 •− acting as the 1 O 2 precursor. The ε-MnO 2 /PMS system proved to be effective in the pH range of 3.5–9.0 and the rate of SMX degradation was not significantly affected by the presence of inorganic anions or natural organic matter. The proposed pathway for the activation of PMS by ε-MnO 2 includes inner-sphere interactions between ε-MnO 2 and PMS, and electron transfer to PMS via the MnIII ↔ MnIV redox cycle, which generates reactive oxygen species. These findings provide new insight into PMS activation by less-toxic metal oxides as catalysts and demonstrate that Mn-based materials can be used to effectively treat water matrices containing emerging pollutants.
研究领域:
环境科学
·
催化材料
✓ 已验证
DOI
PubMed
高影响因子
Journal of Analysis and Testing
·
2025
·
IF 7
Gao Zihui,Wang Yuling,Ma Shuhui,Cao Juntao,Liu Yanming
A highly efficient photoelectrochemical (PEC) biosensor for glutathione (GSH) assay was constructed based on the target-triggered etching of CdS@MnO 2 nanocomposites (NCs). The core–shell CdS@MnO 2 NCs were prepared by a hydrothermal method and coated on the indium tin oxide (ITO) electrode as a PEC sensing platform. The PEC sensing platform gave a near-zero PEC signal due to the excellent light absorption ability of MnO 2 nanosheet coating on the CdS nanoparticles. In the presence of GSH, the etching of MnO 2 on the CdS@MnO 2 NCs was triggered because of the unique etching reaction between MnO 2 and GSH, leading to the exposure of inner photoactive nanomaterials, i.e., CdS in this system. This inevitably causes an obvious increase in the photocurrent response, which is related to the GSH concentration. Thanks to the excellent quenching effect of MnO 2 on the PEC signal of CdS, acceptable PEC performance of CdS, and the specific interaction between GSH and MnO 2 , the targets-triggered etching strategy exhibited excellent analytical performance for GSH detection with a detection limit of 0.05 μmol/L and a linear range from 0.2 to 100 μmol/L. The PEC biosensor has advantages such as good selectivity, excellent stability, and low background. This work contributed a fresh idea to detect GSH sensitively through the PEC sensing method.
研究领域:
分析化学
·
生物传感
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Ying Qin,Yu Wu,Guojuan Chen,Lei Jiao,Liuyong Hu,Wenling Gu,Chengzhou Zhu
Generally, the photoactive materials are always tightly fixed on the photoelectrode of photoelectrochemical (PEC) sensors to produce excellent photocurrent response, while obvious and constant background currents will appear as well and then hamper the ultrasensitive sensing of target molecules. In this work, ultrasensitive detection of organophosphorus pesticides (OPs) is successfully fulfilled by using dissociable photoelectrode based on CdS nanocrystal-functionalized MnO 2 nanosheets . With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO 2 nanosheets, resulting in the dissociation of MnO 2 –CdS from the photoelectrode. Benefiting from the dissociation of photoactive materials, the background photocurrent induced by semiconductor itself dramatically decreases. OPs, as a specific inhibitor for AChE activity, can prevent the generation of TCh and the dissociation of MnO 2 nanosheets, building a relationship between OPs concentration and photocurrent. Under the optimized test conditions, the PEC sensor for the detection of paraoxon displays a wide linear range from 0.05 to 10 ng/mL with a detection limit of 0.017 ng/mL. Furthermore, the PEC sensor shows good sensitivity, stability, and promising application in practical samples.
研究领域:
分析化学
·
环境科学
·
生物传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Mingxia Yang,Senqing Fan,Jiaojiao Chen,Yu Chen,Chuang Li,Jiaxin Meng,Haijie Qing,Yangchao Liu,Zeyi Xiao
An electrocatalytic membrane structured reactor (EMSR) fabricated by loading MnO 2 catalyst in Ti membrane pores for oxidation of n-propanol coupled with hydrogen evolution. During the process of n-propanol oxidation coupled with hydrogen evolution by MnO 2 @Ti EMSR via flow-through mode, the conversion rate of n-propanol was increased by 44%, the selectivity of propionic acid was increased by 33%, and the Faraday efficiency was increased by 59%, compared with those of MnO 2 /Ti membrane with MnO 2 immobilized on the membrane surface. Enhanced contact and mass transfer are two contributors for the catalytic performance improvement by MnO 2 @Ti EMSR via flow-through mode. Besides, the cell voltage during n-propanol oxidation coupled with hydrogen production is decreased by 305 mV with energy consumption reduced by 0.73 kWh Nm H2 -3 , compared with those of hydrogen evolution by water splitting with oxygen evolution reaction. The achievements of this work provide a promising strategy for coproduction of propionic acid and hydrogen.
研究领域:
化学工程
·
环境科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Ziyang Cai,Mengqi Zhou,Weiliang Sun,Yanqiong Li,Huilin Pan
Rechargeable aqueous zinc-manganese dioxide (Zn-MnO2) batteries are one of the most promising candidates for large-scale energy storage due to their advantages of high safety, a high operating potential, and low cost. However, the unstable interface reactions and low electrical conductivity of the MnO2 cathode hold significant obstacles for the electrochemical performance of Zn-MnO2 batteries. Herein, we report a unique interfacial engineering approach to cooperatively tackle with Mn2+/MnO2 chemistry and build a conductive network at the electrode–electrolyte interface for the MnO2 cathode through dual-layer coating of ZIF-8/polypyrrole on MnO2 (ZPM). The outer ZIF-8 coating layer helps maintain a dynamically stable dissolution/deposition of Mn2+, whereas the electronic conductive polypyrrole inner layer establishes a robust conductive network. As a result, the ZPM cathode demonstrates an exceptional rate performance and a prolonged lifespan of 5000 cycles with a low attenuation of 0.00925% per cycle at 10C. The ampere-hour pouch cell of the ZPM cathode achieves a total capacity of 1068.4 mAh under a high areal capacity of 2.5 mAh cm–2, validating its practical viability. This dual-layer interfacial engineering strategy integrating Mn2+ dissolution/deposition regulation and electronic conductivity optimization provides an insightful pathway for addressing the complex issues of aqueous Zn-MnO2 batteries.
研究领域:
储能
·
电化学
·
材料科学
·
电池技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Clean Technologies
·
2025
·Vol. 7
·期 4
·102
·
IF 4.7
Yaxuan Peng,Meiyan Wang
Chlorobenzoic acids (CBAs) are a group of chlorinated persistent environmental pollutants with hard biodegradability, high water solubility, and well-documented carcinogenic and endocrine-disrupting properties. Electrocatalytic hydrodechlorination (ECH) is a highly efficient method under mild conditions without harmful by-products, but the ECH process commonly requires adding precious metal catalysts such as palladium (Pd). To address the economic constraints and more effective utilization of Pd, a palladium/manganese dioxide (Pd/MnO2) composite catalyst was developed in this study by chemical deposition. This method utilized the excellent electrochemical activity of MnO2as a carrier as well as the hydrogen storage and activation capacity of Pd. The test showed the optimal Pd loading was 7.5%, and the removal percent of 2,4-dichlorobenzoic acid (2,4-DCBA), a typical CBA, reached 97.3% using 0.5 g/L of Pd/MnO2after 120 min of electrochemical reaction. Under these conditions, the dechlorination percent can also be as high as 89.6%. A higher current density enhanced the dechlorination efficiency but showed the lower current utilization efficiency. In practical applications, current density should be minimized on the premise of compliance with the water treatment requirement. Mechanistic studies showed that MnO2synergistically promoted hydrolysis dissociation and hydrogen spillover and facilitated Pd-mediated adsorption of atomic hydrogen (H*) for dehydrogenation of 2,4-DCBA. The presence of MnO2can effectively disperse the loaded Pd and reduce the amount of Pd via the above process. The catalyst exhibited excellent stability over multiple cycles, and the 2,4-DCBA removal could still reach more than 80% after the five cycles. This work establishes electrocatalytic strategies for effectively reducing Pd usage and maintaining high removal of typical CBAs to support CBA-related water treatment.
研究领域:
环境催化
·
电化学
·
水处理技术
·
纳米材料
·
污染物降解
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Nano
·
2025
·
IF 8.2
Yunze Xu,Xiongya Li,Xiaochen Feng,Xiaochang Lu,Jiawei Lin,Dingguo Luo,Ranjith Kumar Kankala,Shibin Wang,Aizheng Chen,Chaoping Fu
The rise of antibiotic resistance and the slow pace of new antibiotic discovery highlight the urgent need for alternative antimicrobial strategies. Antimicrobial photodynamic therapy (aPDT) is a promising candidate, but its efficacy is limited by shallow light penetration and hypoxic microenvironments in deep-seated infections such as abscesses and biofilms. Here, we developed a self-oxygenating nanocomposite (HTCC-MnO 2 -Ce6, HMC) to overcome these barriers. Quaternized chitosan (HTCC) provided intrinsic antibacterial activity and facilitated electrostatic interactions with bacterial membranes. MnO 2 nanoparticles catalyzed endogenous hydrogen peroxide (H 2 O 2 ) into O 2 , thereby alleviating hypoxia and sustaining reactive oxygen species (ROS) generation under light irradiation. Ce6 acted as a photosensitizer to induce oxidative damage, while the HTCC matrix further promoted bacterial membrane disruption. In vitro , HMC displayed excellent cytocompatibility and achieved over 95% bacterial reduction under hypoxic conditions. In a methicillin-resistant Staphylococcus aureus ( MRSA ) abscess model, treatment markedly decreased bacterial burden, attenuated inflammation, and accelerated wound closure within 14 days. Collectively, this self-oxygenating nanoplatform integrates catalytic oxygen generation, membrane-targeted antibacterial activity, and photodynamic therapy, offering a potent non-antibiotic approach for managing multidrug-resistant infections and promoting abscess healing.
研究领域:
纳米医学
·
抗菌治疗
·
光动力治疗
·
材料科学
·
感染性疾病
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2021
·
IF 5.302
Feng Luo,Zhimin Li,Jiyuan Chen,Yangxi Yan,Dongyan Zhang,Maolin Zhang,Yue Hao
BiFeO 3 –BaTiO 3 –based solid solutions are promising candidates for high–temperature piezoelectric devices because of their high Curie temperature ( T C ) and considerable electrical properties. Here, we reported an optimum composition of 0.7Bi(Fe 0.999 Mn 0.001 )O 3 –0.3BaTiO 3 ceramic with a large piezoelectric constant ( d 33 ) of 230 pC/N and a high T C of 505 °C, which was attributed to the intentional introducing of the ceramic with MnO and MnO 2 mixture. Furthermore, an in situ d 33 measurement was carried out, demonstrating excellent thermal stability for the 0.7Bi(Fe 0.999 Mn 0.001 )O 3 –0.3BaTiO 3 specimen. The d 33 remained above 200 pC/N in the temperature range of 25 °C–400 °C and its fluctuation was less than ± 15 %. It was determined that the high d 33 in the 0.7BiFe 0.999 Mn 0.001 )O 3 –0.3BaTiO 3 ceramic originated from a synergistic effect of rhombohedral distortion, intrinsic response, and ferroelectric order. The findings establish a solid correlation between electrical properties and phase/domain structure, and provide a novel approach to improve the piezoelectric properties for BiFeO 3 –BaTiO 3 –based ceramics.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
CHINESE SCIENCE BULLETIN
·
2012
·Vol. 57
·期 32
·4210-4214
·
IF 1.321
Zhang LeiLei,Wang ZhongLi,Xu Dan,Xu JiJing,Zhang XinBo,Wang LiMin
Lithium-air (Li-air) batteries have attracted worldwide attention due to their high energy density (11140 Wh kg −1 ) comparable to gasoline. In this work, we have synthesized the α-MnO 2 hollow clews via a simple method and characterized them by X-ray diffraction and scanning electron microscope. Interestingly, cycle performance of Li-air batteries is improved greatly when using the α-MnO 2 hollow clews as the catalyst. The first discharge capacity is 596 mAh g −1 , and the charge capacity is 590 mAh g-1 at the current density of 0.1 mA cm −2 between 2.0 and 4.2 V using the Vulcan XC-72 as the carbon material. Additionally, by re-assembling new batteries with the used lithium foil, separators and cathode separately, we find that the cathode is the key role to end the Li-air battery life.
研究领域:
材料科学
·
电化学
·
储能技术
·
纳米材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）