Food Analytical Methods
·
2025
·Vol. 19
·期 1
·35
·
IF 3
Hu Wei,Jiang Donglei,Xiang Xinyue,Chen Chao,Wang Nanwei,Jiang Hui,Zhang Na,Wang Lifeng
This study presents the development of an electrochemical sensor based on nanochannels for the sensitive detection of the fungal toxin zearalenone (ZEN). The sensor incorporates gold nanoparticles (AuNPs) and multi-walled carbon nanotubes (cMWCNTs) onto anodic aluminum oxide (AAO), with nickel oxide (NiO) modification on the reverse side of the AAO, thereby forming a NiO-AAO@AuNPs-cMWCNTs/SPCE electrode system. The NiO modification facilitates the initial oxidation of ZEN, resulting in the generation of distinctive electrochemical oxidation peaks. To investigate the reaction mechanism of ZEN oxidation, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) were employed. In the concentration range of 1 ~ 40 μg/mL, the sensor showed a clear linear correlation between ZEN concentration and the impedance response, expressed by the regression equation: R EIS (Ω) = 40.8 + 2.7 C ZEN (μg/mL) (R 2 = 0.997, n = 3). The limit of detection (LOD) was determined to be 0.1 μg/mL. This nanochannel-based electrochemical platform provides a reliable and efficient strategy for ZEN detection, demonstrating the potential of nanostructured materials in food safety monitoring.
研究领域:
食品安全
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电分析化学
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纳米材料
·
环境监测
·
毒理学
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产品关联
DOI
高影响因子
Journal of Translational Medicine
·
2025
·Vol. 23
·期 1
·1363
·
IF 7.5
Li Mengyun,Zhang Xiaobing,Lu Jiafeng,Xiang Junjie,Wu Jie,Zheng Matao,Yang Siwei,He Lingyan,Shao Xian
Background Increasing evidence implicates the gut microbiota in the pathogenesis of Parkinson’s disease (PD). Microbiota-targeted interventions may be a promising therapeutic approach. Isoliquiritigenin (ISL), a natural flavonoid and primary pharmacological constituent of licorice (Glycyrrhiza), has neuroprotective effects. Whether this neuroprotection involves modulation of the gut microbiota is unclear. Purpose The study assessed whether ISL mediates neuroprotective in PD by modulating the gut microbiota, and investigated the functional involvement of Parabacteroides distasonis ( P. distasonis ) in this process. Methods Mice with chemically-induced PD were first treated with ISL via oral gavage to assess its therapeutic effects. To investigate the microbiota-mediated mechanisms, fecal microbiota transplantation (FMT) from ISL-treated donors and direct gavage of live or heat-killed P. distasonis were performed in separate cohorts. Behavioral performance, dopaminergic neuron integrity, intestinal barrier function, neuroinflammation, gut microbiota composition, and serum metabolomic profiles were systematically evaluated. Results ISL and FMT significantly improved motor deficits and protected dopaminergic neurons in the substantia nigra. ISL treatment compositionally reshaped the gut microbiota by suppressing pro-inflammatory genera and enriching beneficial bacteria, such as Parabacteroides . Oral administration of live P. distasonis fully reproduced the neuroprotective effects of ISL, including improved motor function, reduced neuroinflammation, restoration of blood–brain barrier integrity, and attenuation of intestinal mucosal damage. Heat-killed P. distasonis had no significant effects. Metabolomic analysis revealed that ISL and live P. distasonis jointly regulate neuroprotective pathways and metabolites related to the gut–brain axis. Conclusion ISL alleviates PD-related pathology partly through gut microbiota remodeling, with P. distasonis as a potential mediator.
研究领域:
神经科学
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微生物组研究
·
药理学
·
代谢组学
·
胃肠病学
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·
IF 15.7
Ren Yue,Zhang Yongfeng,Su Han,Zhao Yeyun,Yan Wenya,Dai Wenbo,Zhu Luojie,Wang Tao,Shi Jianbing,Zhi Junge,Tong Bin,Sun Peng,Cai Zhengxu,Dong Yuping
Near-infrared room-temperature phosphorescent (NIR-RTP) materials feature the advantages of large Stokes shift, long emission lifetime, and high penetration ability, and have been broadly applied in bio-medical imaging, fiber optic telecommunication, and night vision-readable display. Developing organic NIR-RTP materials heavily relies on the long-conjugated chemical structures. The large conjugation could result in aggregation caused quenching, complex synthesis, poor processability, and high biological toxicity. Herein, by solution blending poly(iminofuran-spiro-pyrrolone) (PISP) with polystyrene (PS), we construct a nonconventional NIR-RTP polymer alloy without significantly extensive conjugation. The PISP was synthesized via a catalyst-free multicomponent polymerization in air with high molecular weights (up to 41000 g/mol) and decent yields (up to 84%). Although lacking classical luminescent segments and largely extended conjugation, PISPs exhibit the clusterization-triggered cryogenic phosphorescence. More importantly, upon solution blending PISP with PS, the resultant polymer alloy shows a NIR-RTP emission up to 715 nm with a Stokes shift of 375 nm. This work will be of interest for developing luminescent materials for the optoelectronic devices, in vivo imaging, and flexible electronics.
研究领域:
材料科学
·
有机光子学
·
聚合物化学
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光电子器件
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生物医学成像
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·10501
·
IF 15.7
Zhu Qiong,Su Jingjing,Lin Guoan,Li Guisheng,Zhuo Zhiwen,Wang Weiyi,Li Jialin,Xu Xiaoxiang
Photocatalytic oxygen reduction reaction (ORR) represents a green and cost-effective means to produce the high-value industrial compound H 2 O 2 . However, the efficient H 2 O 2 synthesis awaits in-depth knowledge of the ORR mechanisms for the design of highly active photocatalysts. In this work, surface indium vacancies (denote hereafter as V In ) have been introduced into In 2 S 3 , which significantly boosts the photocatalytic activity for H 2 O 2 production, with an optimal H 2 O 2 generation rate of 4.77 ± 0.05 mmol·h −1 ·g cat. −1 under visible light illumination (λ ≥ 420 nm) and an apparent quantum efficiency (AQE) of 7.49 ± 0.01% at 420 ± 20 nm. Mechanistic analysis reveals the multifunctionality of V In , such as enlarging the chemisorption capacity of O 2 , enriching photo-generated electrons for ORR, endorsing high reducing power to photo-generated electrons, and promoting H 2 O 2 desorption. These findings justify that surface cation vacancies open up new possibilities for H 2 O 2 photosynthesis by leveraging their reaction dimensions in ORR.
研究领域:
材料科学
·
光催化
·
环境化学
·
能量转换
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产品关联
DOI
PubMed
高影响因子
npj Science of Food
·
2025
·
IF 7.8
Cao Liguang,Li Guojin,Liu Kai,Gao Wenrui,Dong Yifei,Yang Zifeng,Luo Jianchun,Lei Lin,Du Xiliang,Song Yuxiang,Li Xinwei,Gao Wenwen,Liu Guowen
Deoxynivalenol (DON) and fumonisin B1 (FB1) are prevalent mycotoxins commonly found together in dairy cow feed, posing significant risks to cow health and food safety. This study investigates combined toxic effects of DON and FB1 on bovine mammary epithelial cells (BMECs), and role of AMPK-Caspase 6 axis in mycotoxin-induced apoptosis in BMECs and mouse model. We showed that even subcytotoxic doses of DON, combined with FB1, induced synergistic or additive toxic effects, reducing cell viability, increasing LDH release, and promoting apoptosis. This combination also impaired milk triglyceride synthesis and downregulated genes involved in milk fat and protein production. Silencing Caspase 6 via siRNA, inhibiting with Z-VEID-FMK, or activating AMPK with AICAR alleviated apoptosis. Conversely, overexpressing Caspase 6 diminished AMPK’s protective effects. In vivo, inhibiting Caspase 6 alleviated apoptosis in mammary tissues. These findings highlight therapeutic potential of targeting the AMPK-Caspase 6 pathway to mitigate combined toxicity of DON and FB1.
研究领域:
毒理学
·
分子生物学
·
兽医学
·
食品安全
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·10080
·
IF 15.7
Yang Bowen,Zhou Enpei,Lv Wenhao,Wang Zhenxi,Lv Song
As building energy consumption and carbon emissions continue to rise, minimizing energy loss through windows—major heat exchange pathways—has become an urgent challenge. To reduce building energy consumption by improving windows’ thermal insulation and light modulation, this study develops a thermoresponsive hydrogel named PDH, based on a poly(N-isopropylacrylamide) backbone, for use as a window coating. The hydrogel exhibits considerable visible light transmittance (97.92%) and high solar modulation ability (81.70%), along with favorable mechanical properties, which enable its stable and direct application onto single-pane glass surface, thereby simplifying the conventional glass–hydrogel–glass structure in smart windows. In practical building applications, PDH hydrogel shows significant thermal regulation, with an average daytime indoor temperature reduction of 6.95 °C and energy savings of 384.04 kJ m −2 . Furthermore, a global energy-saving and carbon-reduction model is developed using climate data to support the assessments and applications of PDH hydrogels across various climate regions.
研究领域:
材料科学
·
智能材料
·
建筑节能
·
可持续技术
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Wang Shanshan,Zhang Kai,Taran Oxana P.,Li Siqi,Sun Fubao,Yan Hong,Li Fen
Lignin quantum carbon dots (CQDs) were prepared using basic lignin as the carbon source. They were loaded onto Z-type ZnIn 2 S 4 /WO 3 heterojunction semiconductor materials by a one-step hydrothermal method to construct a ternary composite photocatalyst. Taking the photocatalytic water hydrogen evolution reaction performance as an indicator, it was found that the 33% CQDs/ZnIn 2 S 4 /WO 3 composite photocatalyst exhibited the highest hydrogen evolution reaction rate of 15.355 mmol·h −1 ·g −1 , which was twice as high as that of ZnIn 2 S 4 /WO 3 (7.522 mmol·h −1 ·g −1 ). This study successfully constructed CQDs/ZnIn 2 S 4 /WO 3 tenary heterojunction photocatalyst with excellent and stable hydrogen production performance, which fully demonstrated the feasibility of loading lignin-based CQDs to enhance the photocatalytic performance of ZnIn 2 S 4 for high-value utilization of lignin.
研究领域:
材料科学
·
光催化
·
可再生能源
·
纳米材料
·
可持续化学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·
IF 15.7
Wang Yanqiu,Tan Lu,Yang Yi,Duan Hongli,Liu Chao,Zhao Jing,Zhou Yue,Li Changqing,Liu Minghan
Intervertebral disc degeneration is a major cause of low back pain and is driven by a vicious cycle of reactive oxygen species (ROS), ferroptosis, and inflammation, afflicting millions of people worldwide. Breaking this cycle represents a significant therapeutic challenge. Here, we develop a ROS-responsive hydrogel loading a resident nanozyme system composed of nucleus pulposus cell membrane-coated black phosphorus@cerium oxide to disrupt this degenerative cascade. Specifically, the nanozyme exhibits a self-sustaining cerium redox cycle due to the incorporation of black phosphorus nanosheets into cerium oxide, conferring durable antioxidant capacity for scavenging ROS. Furthermore, it suppresses the inflammatory cytokine IL6 by inhibiting HuR-mediated mRNA stabilization, thereby blocking the pro-inflammatory and pro-ferroptotic IL6/STAT3 axis. Together, this dual mechanism enables our nanozyme-functionalized hydrogel to break the ROS-ferroptosis-inflammation feedback loop, thus effectively promoting structural and functional disc repair.
研究领域:
生物医学工程
·
纳米医学
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骨科
·
再生医学
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炎症生物学
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氧化还原生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2025
·
IF 4.9
Feng Ya,Guo Xinyuan,Tan Rui,Ren Junchao,Huang Mengde,Chen Jianlong,Zhang Qingfa
Achieving a balance among degradation behavior, mechanical performance, and thermal stability is critical for meeting application requirements and ensuring sustainability, particularly for composites with inherent property limitations. Straw derived hydrothermal carbon microspheres were proposed to reinforce citrate ester composites and the ultimate goal was to seek an approach to achieve the balance between properties and sustainability of biocomposites. The results showed that the network structure within the composites was formed through strong ester and hydrogen bonding, which was directly responsible for their enhanced tensile properties. The resultant composites exhibited better degradation properties because the addition of hydrothermal carbon microspheres accelerated the degradation of citrate ester in both aqueous and phosphate-buffered saline environments. Adding hydrothermal carbon microspheres decreased the glass transition temperature due to the increase of the free volume and interfacial pathways, and increased the thermal stability due to the delay of maximum decomposition peak temperature of citrate ester. Among all the composites samples, the composite containing 3% HCS exhibited the most balanced and superior overall properties with the degradation rate of 37.56%, tensile strength of 1.25 MPa, tensile modulus of 0.23 MPa, and elongation at break of 52.69%. The mentioned composite is expected to provide referable process and properties in the composites field with specific requirements.
研究领域:
材料科学
·
聚合物复合材料
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可降解材料
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可持续材料
·
热分析
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产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·10264
·
IF 15.7
Li Boyu,Ma Jiabin,Yang Ke,Li Yuhang,Ng Maggie,Ma Yuetao,An Xufei,Cheng Xing,Mi Jinshuo,Tang Man-Chung,He Yan-Bing,Kang Feiyu
The limited proton transfer kinetics within organic positive electrodes restricts the proton storage capacity and hinders achieving high energy density in aqueous zinc-organic batteries. Herein, we obtain superharmonic motion of proton by crosslinking short hydrogen-bonds network within the positive electrode matrix to achieve fast proton transfer. Specifically, the pyrazino[2, 3-g]quinoxaline-5, 10-dione owing strong electrostatic and hydrogen-bond interactions with hydrogen ions is synthesized, which could attract concentrated hydronium and trigger local proton enrichment. Spatially confined water-hydronium domains are therefore formed to generate short hydrogen bonds around pyrazino[2, 3-g]quinoxaline-5, 10-dione molecules. Moreover, the 4,4’-diaminodiphenylamine and polytetrafluoroethylene binder exhibits a mutual affinity with pyrazino[2, 3-g]quinoxaline-5, 10-dione due to the strong hydrogen-bond interactions of them, which reduce the intermolecular distance within positive electrode and construct a highly interconnected state of water-hydronium domains, thereby establishing the short hydrogen bonds network throughout the electrode matrix. The rapid proton transport through short hydrogen bonds consequently reduces the polarization of aqueous zinc-organic batteries (1.47 × 10 −3 S cm −1 ). As a result, the composite positive electrode delivers specific energy of 400 Wh kg −1 at 0.1 A g −1 .
研究领域:
储能
·
电化学
·
材料科学
·
电池技术
·
有机电极材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Production Processing and Nutrition
·
2025
·Vol. 7
·期 1
·56
·
IF 5.7
Zhou Shiyang,Ren Fengming
In order to explore the in vitro hypoglycemic effect of lonicerae flos polysaccharides and its mechanism of action, the crude lonicerae flos polysaccharide was prepared by hot water extraction and ethanol precipitation. After sevage, dialysis, DEAE-52 and Sephadex G-100, the homogeneous component lonicerae flos polysaccharide was finally separated and purified. HepG2 cell experiment was used to investigate the hypoglycemic activity and mechanism of lonicerae flos polysaccharide, detecting the active polysaccharide components, and preliminarily analyze its monosaccharide composition, molecular weight and hypoglycemic pathway. The results showed that lonicerae flos polysaccharide was mainly composed of fucose (Fuc, 0.42%), rhamnoose (Rha, 7.81%), arabinose (Ara, 27.54%), galactose (Gal, 7.86%), glucose (Glu, 4.68%), xylose (Xyl, 0.33%) and galacturonic acid (Gal-UA, 51.36%). The results of total sugar, uronic acid, protein and molecular weight showed that total sugar content was 92.13% of lonicerae flos polysaccharide, the content of uronic acid was 48.66%, the protein content was 0.15%, weight average Mw was 121.994 k–Da and the Mn was 37.088 k–Da. In normal HepG2 cells, lonicerae flos polysaccharide could significantly promote glucose transport and increase glucose consumption in HepG2 cells. In insulin-resistant HepG2 cells, lonicerae flos polysaccharide could promoted the uptake of glucose, and there was a positive correlation with the mass concentration. The mechanism of hypoglycemic action showed that the lonicerae flos polysaccharide of 320 μg/mL could significantly regulate the abnormal expression of GLUT4, GSK-3β and IRS1 proteins in insulin-resistant HepG2 cells. This study provides a valuable scientific basis for the mechanism and effect of hypoglycemic action of the active components of lonicerae flos. Graphical
研究领域:
药理学
·
生物化学
·
天然产物研究
·
内分泌学
·
细胞生物学
✓ 已验证
DOI
高影响因子
Neuroscience Bulletin
·
2025
·
IF 5.8
Zhang Haifeng,Su Tiantian,Wu Xiaoke,Shi Mengmeng
There is a vicious cycle between brain metabolism and epileptic seizures that compounds the deleterious consequences of seizures. Human epilepsy samples implicate cholesterol 25-hydroxylase (CH25H) in linking lipid metabolism and immunity. CH25H expression increased in microglia after status epilepticus, with its product 25-hydroxycholesterol (25-HC) accumulating in the hippocampus and blood. Thus, we generated microglia-specific CH25H knockdown mice to study the role of CH25H specifically in epilepsy. CH25H knockdown inhibited the assembly and activation of NLRP3 inflammasome and restrained the loss of neurons in the hippocampal area in epileptic mice. More importantly, CH25H knockdown reduced the number of recurrent seizures and time in seizure by electroencephalogram recording, which was partly reversed after 25-HC treatment. Untargeted metabolomics showed that another lipid metabolite, arachidonic acid, might be a potential biomarker of CH25H-mediated epilepsy. These findings suggest that microglial CH25H regulated the status epilepticus in a hydroxylase-dependent mechanism.
研究领域:
神经科学
·
免疫代谢
·
神经炎症
·
癫痫研究
·
脂质代谢
·
分子神经生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）