Scientific Reports
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2026
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IF 4.9
Liu Jiaying,Liu Nan,Ye Yiting,Ye Zhandong,Jiang Dongxu,Huang Song
Precancerous gastric lesions (PLGC) represent a critical transitional stage toward gastric cancer, yet effective interventions to halt progression remain limited. Vitexin, a naturally occurring flavonoid, exhibits anti-cancer potential; however, its molecular targets and mechanisms in PLGC have not been fully defined. This study aimed to elucidate the targets and mechanisms of vitexin against PLGC using an integrative strategy combining network pharmacology, molecular docking/molecular dynamics (MD), and cellular validation. Putative targets of vitexin and PLGC-associated genes were intersected to obtain 33 common targets, followed by protein–protein interaction network construction and pathway enrichment analyses. Molecular docking was performed against core targets, and MD simulations were conducted to assess the stability of the EGFR–vitexin complex. In vitro validation was carried out in MNNG-induced MC cells using cell viability, migration, and invasion assays, phase-contrast imaging, and immunofluorescence staining of EGFR and E-cadherin. Network analysis highlighted CCND1, EGFR, and ABL1 as central nodes and implicated oncogenic programs including cell-cycle regulation and PI3K–Akt signaling pathway. Docking suggested favorable binding of vitexin to the core targets. MD simulations further supported a stable binding mode of vitexin within the EGFR pocket over 100 ns with preserved global compactness; a late-stage conformational adaptation accompanied by hydrogen-bond network reorganization was observed without signs of global unfolding. Functionally, vitexin reduced MC cell viability in a dose-dependent manner, reaching ~ 50% inhibition at 20 μM, and significantly suppressed cell migration and invasion. Immunofluorescence demonstrated decreased EGFR expression and altered membrane localization, together with restored E-cadherin expression and membrane localization, suggesting a shift toward an epithelial phenotype. Vitexin inhibits PLGC-associated malignant phenotypes through multi-target modulation. Among the identified candidates, EGFR may serve as a putative and functionally relevant target, while modulation of EGFR-associated signaling together with restoration of E-cadherin may contribute to the reversal of EMT-related phenotypes. These findings provide mechanistic and structural support for the further preclinical evaluation of vitexin in preventing gastric cancer progression.
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Nature Communications
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2026
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IF 18.1
Wang Zihao,Cheng Quhan,Zhou Mengxue,Feng Kexin,Chen Qi,Yuan Yi,Zhang Shengmin,Kong Deling,Wang Kai,Wang Jianglin
Erythrocytes and erythrocyte membrane vesicles have shown promise for personalized drug delivery through passive immune evasion, yet their active role in immune phagocytosis remains largely unexplored. Here, we introduce a paradigm based on phosphatidylserine-everted erythrocyte membrane vesicles that trigger efferocytosis, enabling immune-mediated tissue regeneration rather than immune evasion. Incorporation of these phosphatidylserine-everted erythrocyte membrane vesicles into small-diameter vascular grafts markedly enhances endothelialization, suppresses calcification, and improves long-term patency in a rabbit carotid artery replacement model. Preclinical evaluation in a large canine model further demonstrates superior performance compared with clinically used expanded polytetrafluoroethylene grafts. This study establishes engineered phosphatidylserine-everted erythrocyte membrane vesicles as a versatile, customizable, and cost-effective biointerface for vascular grafts and other blood-contacting devices, providing a compelling strategy to harness innate immune mechanisms for regenerative medicine.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Xiao Le,Zheng Yuanyuan,Jiang Xingyi,Wang Manyi,Luo Yanbo,Pang Yongqiang,Wang Hongjuan,Chen Di
This study presents a liquid-filled stick microextraction method with a built-in acidifier (LFSME-BA) that enables ready-to-use, pH-adjustment-free extraction of non-steroidal anti-inflammatory drugs (NSAIDs) from complex herbal matrices. Similar to an alcohol swab, the device contains an H 3 PO 4 -saturated hydrophobic deep eutectic solvent (DES) loaded inside a hollow plastic stick and a polypropylene fabric tip. Upon use, the acidified DES is released and absorbed by the fabric tip. When immersed in the sample solution, H 3 PO 4 gradually diffuses outward and, in the aqueous model solution used in this study, reduces the sample pH to approximately 1.97. This in situ acidification converts the NSAIDs from their ionized forms to their neutral molecular species, markedly increasing hydrophobicity, thereby facilitating their diffusion into the DES phase. Following desorption with 0.4 mL acetonitrile and LC–UV analysis, the LFSME-BA method provided excellent linearity ( R 2 ≥ 0.994, 20–2000 ng/mL), low detection limits (3.04–5.80 ng/mL), and satisfactory accuracy (93.7–102.5%) and precision (RSD ≤ 8.3%). Application to herbal oral liquids and granules yielded relative recoveries of 85.1%–108.8%, further confirming the method’s reliability. This ready-to-use, disposable platform combines extraction and pH self-regulation in one step, offering a simple and efficient approach for screening adulterated pharmaceuticals in herbal products. Graphical
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Yang Yi,Song Jun-Mei,Wang Tian-You,Wu Shu-Wei,Zhou Yu-Hang,Gu Zhi-Peng,Guo Ling-Hong,Jiang Xian
Sanshool is a promising skin photoprotective agent with strong UV absorption and great antioxidative activity. However, it faces challenges including poor stability, skin penetration-associated systemic toxicity, and efficacy loss upon chemical modification. To address these issues, amphiphilic hyaluronic acids (HHA) were synthesized and self-assembled to integrate with sanshool via hydrophobic interactions, significantly boosting its photostability by 24% and enhancing its antioxidative activity. In HaCaT cells, HHA-sanshool nanoparticles (NPs) reduced UVB-induced reactive oxygen species, decreased cell apoptosis, and lowered G2/M phase arrest from 42% to approximately 31% (close to the normal level), while also inhibiting excessive autophagy. Moreover, in a mouse model, HHA-sanshool NPs alleviated UVB-induced skin damage, reducing skin thickening by up to 50% and mitigating erythema, protected collagen/elastic fibers, and suppressed proinflammatory factor, with no dermal penetration in vivo . This strategy provides a simple, efficient and safe platform for natural active molecular clinical translation in skin photoprotection.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Zhao Mengyuan,Liu Xiaofei,Liu Yang,Li Wanxuan,Zhang Xiangrong
The aim of this study was to encapsulates cinnamaldehyde (CA) using the complex coacervation technique with soybean protein isolate (SPI) and maltodextrin (MD) as the wall matrix. The physical characteristics of cinnamaldehyde microcapsules (CM) were analyzed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), molecular docking, and thermogravimetric analysis (TG). The results demonstrate that SPI and MD successfully encapsulated CA via hydrogen bonding and electrostatic interactions. The composite exhibited a smooth surface without voids, thereby preventing the rapid volatilization of CA. The thermal stability of CM was significantly improved compared with free CA. CA could be sustainedly released over a period of 10 days under different conditions. On the 10th day, the cumulative release rates of CM stored at 4 ℃, 25 ℃ and 46 ℃ were 39.99%, 48.16% and 76.36%, respectively. Meanwhile, the cumulative release rates of the microcapsules stored at 33%, 52% and 77% relative humidity were 45.97%, 61.51% and 65.90%, respectively. Its release followed the first-order kinetic. CM also inhibited the growth of E. coli, S. aureus, and Aspergillus niger. The shelf life of chilled chicken breast was effectively extended by 9 days upon CM treatment. Compared with the control group, chicken breast treated with CM showed lower pH, reduced thiobarbituric acid reactive substances (TBARS) to 0.14 mg/kg, and decreased total volatile base nitrogen (TVB-N). The research provides a valuable information to prepare CA to preserve meat.
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AQUACULTURE INTERNATIONAL
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2026
·Vol. 34
·期 5
·140
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IF 3.5
Shehata Akram Ismael,El Basuini Mohammed F.,Shija Vicent Michael,Bakky Md. Akibul Hasan,Tran Ngoc Tuan,Zhang Ming,Li Shengkang
This study probed the impacts of dietary octacosanol supplementation at 0 (control), 6, 12, and 18 mg/kg diets on the growth parameters, intestinal enzyme activities, biochemical, antioxidant status, gene expression pattern, and hypoxia tolerance of whiteleg shrimp ( Litopenaeus vannamei , initial weight 1.49 ± 0.01 g, n = 3, total shrimp = 360) during a 60-day feeding trial. To assess growth efficiency, final weight, weight gain, and specific growth rate were recorded, which were significantly ( p < 0.05) improved with octacosanol supplementation, with optimal responses observed at 12 mg/kg. Feed conversion ratio decreased quadratically, reaching optimal efficiency at approximately 10.83 mg/kg. Intestinal enzyme activities (amylase, lipase, and protease) and antioxidant indicators (SOD, CAT, GPx, and TAC) were markedly enhanced at 12 mg/kg, while lipid peroxidation (MDA) was minimized. Hemolymph biochemical indices, including total protein, albumin, globulin, HDL-c, and lysozyme, increased significantly ( p < 0.05), whereas AST and ALT decreased. Furthermore, transcriptional expression of immune- and antioxidant-related genes ( Mn-SOD , CAT , GSH-Px , LYZ , and ProPO ) was upregulated, coinciding with elevated antioxidant capacity and immune responses. Shrimp fed octacosanol diets exhibited enhanced hypoxia tolerance, with LT 50 extended by approximately 30–40 min compared to the control. Collectively, the results demonstrate that dietary octacosanol at 12 mg/kg optimizes growth, physiological health, and stress resilience in L. vannamei , supporting its potential as a natural dietary additive for sustainable shrimp farming. Future studies are needed to explore octacosanol’s long-term effects on shrimp under various stress conditions, its molecular mechanisms, and its impact on other species, as well as its synergy with other feed additives.
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Nature Communications
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2026
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IF 18.1
Shi Yuanji,Yang Minghao,Mu Hongxin,Hu Haidong,Ren Hongqiang
The global shift in per- and polyfluoroalkyl substance (PFAS) crisis towards (ultra-)short-chain congeners highlights the urgent need to design adsorbents with hydrophilic functions. However, current functional group immobilization modifications fail to balance efficiency with regeneration, limiting access to affordable (ultra-)short-chain PFAS-free potable water. Herein, we present a non-immobilized dynamic hydroxyl cycling strategy that uses only water to circularly drive commercial zeolite adsorption-regeneration processes, efficiently and sustainably removing various (ultra-)short-chain PFASs (C-F number: 1-6) from potable water. The enhanced nanopore accessibility and the formation of a “zeolite framework-confined water” dual-binding mode make the modified zeolite one of the highest capacity adsorbents reported (233.82-733.13 mg g -1 ). Notably, this methodology offers a potential low-cost, in-situ upgrade for existing purifiers, potentially providing healthy water to underdeveloped regions through 179 days of full-scale purification.
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CELLULAR & MOLECULAR BIOLOGY LETTERS
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2026
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IF 12.2
Xiaoxuan Zhao,Yang Zhao,Yuepeng Jiang,Yiming Ma,Jing Ma,Hongli Zhao,Xiaoling Feng
Background Unexplained recurrent spontaneous abortion (URSA) is characterized by defective endometrial stromal cell decidualization, with cellular senescence emerging as a key contributor. However, the metabolic–epigenetic mechanisms linking glycolysis to senescence-driven decidualization failure remain unclear. This study elucidates how hexokinase 2 (HK2)-mediated glycolytic reprogramming promotes histone lactylation-dependent stromal senescence and decidualization impairment in URSA. Methods We employed multi-omics profiling (RNA-seq, metabolomics, and CUT&Tag) of primary stromal cells from patients with URSA and controls to map the histone H3K18 lactylation (H3K18la)–cut-like homeobox 1 (CUX1)–senescence-associated secretory phenotype (SASP) axis. Subsequently, this axis was validated both in vitro decidualization models and URSA murine models. Results Decidual tissues from patients with URSA exhibited stromal cell senescence and impaired decidualization. Mechanistically, HK2-driven glycolysis elevated lactate production, which in turn promoted H3K18la at the CUX1 promoter. CUX1 then directly activated the transcription of key SASP factors, thereby propagating the senescence state. Critically, CUX1 depletion or glycolysis inhibition rescued these senescence and decidualization deficiency in vitro. Furthermore, CUX1 knockdown in the URSA murine model reduced stromal senescence and improved decidualization. Conclusions Our findings define a novel HK2–H3K18la–CUX1–SASP signaling axis that drives URSA pathogenesis by linking metabolic reprogramming with epigenetic regulation. This work highlights CUX1 as a potential therapeutic target for correcting decidualization deficiency in URSA. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1186/s11658-026-00879-y.
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Nature Communications
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2026
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IF 18.1
Wang Xinghuo,Huang Yaru,Wang Hui,Yin Shiheng,Xu Chuanhui,Wang Zuankai,Chen Yukun
Constrained by materials, structures, and interface, achieving high sensitivity, wide strain range, and linearity simultaneously remains an impossible triangle for flexible sensors. Herein, we propose 3D super-interface strategy based on patterned rubber substrate-conductive crack layer, successfully developing a microcrack super-interface flexible sensor (MSFS) with ultra-sensitivity (0–10% strain, GF 1.1 × 10⁸ and linearity 0.98). The 3D super-interface relies on the synergistic micro/nano level physical anchoring, and hydrogen bonding interfacial interactions between the rubber matrix and conductive crack layer, achieving strong interlayer bonding. During the sensing process, the crack structure endows the sensor ultra-sensitivity within 0–10% strain range; while the 3D super-interface ensures continuous electrical conductivity under >50% strain conditions. MSFS holds potential application value in monitoring expansion in silicon anode batteries. When the battery expansion reaches 2%, its resistance change can be as high as 22-fold. This approach enables the customized design of flexible sensors for ultra-sensitivity applications.
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Nature Communications
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2026
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IF 18.1
Liu Wenchao,Duan Lian,Zhang Xiangyu,Zhu Xinyi,Ge Yongxin,Xu Guoheng,Si Zhixiao,Dai Jiqing,Chang Wenbo,Zhang Miliang,Lan Ronghua,Hu Zhijun,Chen Ruotian,Hengphasatporn Kowit,Shigeta Yasuteru,Xiao Kai
Biological vision acquires external information through light-induced transmembrane ion transport, generating electrical impulses. Emulating the dual visual functions of photoreceptors and photosynapses through light-modulated ion transport presents a significant challenge. Herein, we present a bioinspired light-regulated nanofluidic iontronic device that can mimic biological visual functionalities, realized through an engineered carbon nanotube and molybdenum disulfide (CNT/MoS 2 ) heterostructure. This bioinspired device combines two key functionalities of photoreceptor-like optical sensing and photosynaptic signal processing with dynamically adjustable polarity-switching behavior, achieved via bias voltage–modulated transient photoresponse speeds. Both theoretical and experimental results prove that light-modulated ion transport originates from the heterointerface-induced asymmetric photovoltage generation across CNT/MoS 2 nanotube. Furthermore, we demonstrate its implementation for both accurate orientation recognition and reliable fingerprint detection under varying incident light angles. The device’s bidirectional photoresponsiveness highlights its unique advantages for adaptive visual simulation systems.
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Nature Communications
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2026
·Vol. 17
·期 1
·1818
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IF 18.1
Huang Wenge,Lori Mohammad Shamsodini,Yang Anchenyi,Zhuang Kai,Cheng Yuanhao,Chen Mojun,Sun Chao,Ming Tingzhen,Cui Huachen,Cheng Jiangtao
Self-propelled droplet jumping has widespread applications in surface cleaning, condensation heat transfer, hydrogen production, and triboelectric nanogenerator due to the passive yet effective cross-interface transfer of mass, momentum, energy and charge, whose rates generally increase with droplet size. However, as droplet size increases, gravity inevitably impedes droplet’s mobility, imposing a capillary length constraint of 2.7 mm for water droplet, beyond which self-propelled jumping remains a persistent challenge. Here, we report passive jumping of water puddle in the unprecedented centimeter scale from a superhydrophobic surface through the burst of an entrained bubble, breaking the capillary length limitation for droplet jumping. By virtue of direct and localized impact at droplet base, the bubble-burst-induced capillary waves play a paradigm-shifting role in shortening the impact duration, depressing droplet spreading, and facilitating momentum transfer. With >90% conversion to droplet jumping momentum, the impacting momentum of capillary waves scales linearly while droplet jumping height scales quadratically with bubble radius. Through studying the synergistic interplay between bubble bursting, fluidic jetting and droplet jumping, this work reveals a previously unexplored mechanism of capillary wave impact in fluid-structure interactions and offers a promising strategy for droplet actuations and the directional printing of particles in additive manufacturing.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Guo Ningli,Shi Jiayi,Zhang Xinyu,Xu Hui,Ji Tongyao,Qiu Fengkai,Li Kai,Wu Zhenyi,Ma Ji,Weng Qiaoyou,Qiu Rongfang,Shu Gaofeng,Chen Zhang,Chen Jingfeng,Wang Xiaojing
Inflammatory bowel disease (IBD) is a persistent intestinal inflammation driven by epithelial barrier dysfunction, immunological imbalance, and microbial dysbiosis. The restoration of gut homeostasis through biomaterial-based strategies offers a potential avenue for alleviating inflammation in IBD. Herein, an alginate-based hydrogel incorporating astaxanthin-loaded mesoporous catechin nanoparticles (AST@MCN-Gel) was designed to relieve inflammation and rebalance gut homeostasis. The mesoporous framework of MCN enabled effective encapsulation of the hydrophobic AST, thereby increasing its water solubility and bioavailability. In lipopolysaccharide-induced macrophages, AST@MCN exhibited superior ROS-scavenging capacity and anti-inflammatory activity relative to either AST or MCN. Mechanistically, AST@MCN modulated macrophage phenotype from pro-inflammatory (M1) to anti-inflammatory (M2) state through regulation of the MAPK/NF-κB pathway. On the other hand, the alginate-based hydrogel effectively enhanced the intestinal retention of AST@MCN, resulting in a marked improvement in oral therapeutic efficacy. In a DSS-induced IBD mouse model, oral administration of AST@MCN-Gel significantly alleviated the clinical symptoms and restored intestinal barrier integrity. Analysis of the gut microbiome further indicated that AST@MCN-Gel ameliorated gut dysbiosis by restoring microbial diversity and suppressing the proliferation of pathogenic species. Collectively, these underscore the potential of AST@MCN-Gel as an effective biomaterial-based therapeutic approach for restoring intestinal homeostasis and improving IBD therapy.
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