SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Yaxiong Zeng,Zirong Song,Xianghong Gong,Aiyuan Ye,Jian Lou,Baohong Guan
Facile sol-gel fabrication of F@Al 2 O 3 rich in oxygen vacancies was achieved. • Oxygen vacancies facilitate the formation of hydrated -OH via water dissociation. • F doping narrows the band-gap of α-Al 2 O 3 and enhances electron transition ability. • The formed hydrated -OH effectively improves the selectivity of •OH generation. Hydroxyl radical (•OH) is a type of excellent reactive oxygen species (ROS) for the efficient degradation of organic pollutants, usually occurs in advanced oxidation processes (AOPs). The α-alumina (α-Al 2 O 3 ) is one of the few nanomaterials produced on a ton-scale and successfully utilized in large-scale water treatment. However, its role in AOPs has primarily been limited to serving as an inert support due to its insufficient active sites and gradual consumption of the surface hydroxyl groups, leading to the function-guide generation of •OH in AOPs is still challenging. Herein, we precisely regulate ROS generation in ozone (O 3 )-based AOPs by doping engineering to enhance the catalytic capability of α-Al 2 O 3 for efficiently eliminating organic pollutants. Fluorine-doped α-alumina (F@Al 2 O 3 ) facilitates O 3 activation via a radical pathway with 95.7% •OH, delivering boosted performance for degradation of atrazine from water, which is 5.6 and 2.1 times that of non-catalytic ozonation and O 3 /α-Al 2 O 3 , respectively, exceeding most reported O 3 -based catalysts. The lattice doping of F into α-Al 2 O 3 via F Al coordination effectively reduces the local electron density around Al sites to form hydrated hydroxyl groups, thus facilitating O 3 adsorption and lowering the energy barrier of the rate-limiting step during O 3 activation for •OH generation. The simple lattice-doping engineering doubles the catalytic capability of α-Al 2 O 3 by the precise regulation of ROS generation, which rendering α-Al 2 O 3 an extremely promising nanomaterial for advanced water treatment. Download: Download high-res image (153KB) Download: Download full-size image
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高影响因子
AQUATIC TOXICOLOGY
·
2026
·
IF 4.6
Sai Wu,Chunhui Zhang,Hongwen Sun,Cuiping Wang
Understanding the size-dependent behavior of iron oxide nanoparticles in crop systems is critical for assessing their environmental risks and application potential. In this study, α-Fe 2 O 3 materials with particle sizes of 25 nm, 200 nm, and 400 nm were successfully synthesized and systematically evaluated for their transport, transformation, and physiological effects on rice. Among these, the 25 nm α-Fe 2 O 3 exhibited a higher zeta potential, facilitating electrostatic interaction with the negatively charged rice surface. Exposure to α-Fe 2 O 3 increased the formation of iron plaque on root surfaces, with the most pronounced effect observed for the 25 nm particles. While iron plaque enhanced the immobilization of metal elements on the root surface, it concurrently hindered the uptake of both metal and non-metal elements by rice roots. Root exudates secretion was stimulated by α-Fe 2 O 3 exposure, with larger particles inducing a more pronounced secretory response at equivalent concentrations (TOC increased by 12.91-23.82%). Electron transfer interactions between α-Fe 2 O 3 and root exudates occurred in the rhizosphere, leading to the reduction of Fe(III) to Fe(II), large particle size α-Fe 2 O 3 induces more root exudates and more pronounced Fe (III)/Fe (II) transformation. Rice growth was promoted by exposure to 50 mg/L of 25 nm α-Fe 2 O 3 , but inhibited at 500 mg/L. In contrast, larger particles consistently promoted growth, albeit with diminished efficacy at higher concentrations. Exposure to α-Fe 2 O 3 , particularly the 25 nm particles, triggered significant increases in reactive oxygen species (ROS) levels, plasma membrane permeability, antioxidant enzyme activities, and lipid peroxide content in rice roots. These findings provide a mechanistic basis for understanding the size-dependent phytotoxicity and transformation behavior, and offering insights for its application in controlling pollutant migration in agricultural systems.
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DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
He Bo,Hu Yanhao,Liu Dongshan,Zang Xin,He Xu,Chen Wang,Yang Jingfang,Feng Mingfeng,Chen Ping,Wei Lirong,Li Yu,Yan Wei,Li Jun,Feng Zhike,Zhou Jiahai,Ye Yonghao
Dihydroxyacid dehydratase (DHAD), a key enzyme in branched-chain amino acid synthesis in plants, is a promising yet unexploited herbicide target. Inspired by the natural DHAD inhibitor aspterric acid, we design benzoxazinone derivatives with α-hydroxycarboxylic acid moieties as potential inhibitors and develop an eco-friendly α-C(sp³)-H hydroxylation method for accessing carbonyl compounds. Among the derivatives, 7-fluoro-2-hydroxy-3-oxo-4-propyne-3,4-dihydro-2 H -benzo[ b ][1,4]oxazine-2-carboxylic acid ( I-6e) completely inhibits Arabidopsis thaliana germination and suppress six weed species by > 50%, with 100% efficacy against Avena fatua and Setaria viridis at 150 g ai/ha. This broad-spectrum activity and rice crop safety highlight its potential as an herbicide lead compound. Compound I-6e exhibits stronger affinity for DHAD ( K d = 1 µM) than that of the natural substrate ( K d = 5.39 µM). The 2.19 Å cocrystal structure of the At DHAD– I-6e complex reveals a unique binding mechanism, confirming the critical role of the α-hydroxycarboxylic acid scaffold. This study provides a blueprint for rational DHAD inhibitor design.
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DOI
PubMed
高影响因子
ACS Food Science & Technology
·
2025
·
IF 2.8
Jun-Hui Du,Yu-Yun Xiao,Ying-Chao Guo,Wen-Qing Zhang,Guan-Ru Si,Zheng-Fang Wu,Chuan-Qiang Gao,Jie Mei,Yi-Long Ma,Zhao-Jun Wei
T2DM (Type 2 diabetes mellitus) is a chronic metabolic disease typically managed with medications that often cause undesirable side effects, highlighting the urgent need for safe and effective natural alternatives. In this study, Baijiu distillers’ grains (BDGs) from Xiaojiao Baijiu were used to screen and identify anti-α-glucosidase peptides. The fraction under 3 kDa of the hydrolyzate generated by alcalase demonstrated the most potent inhibitory activity. This fraction was subsequently separated by RP-HPLC, resulting in the most effective subfraction, F2–2, with an inhibitory rate of 77.33 ± 1.15%. Six potential antidiabetic peptides (AAPFYAL, LAYPQ, IRLPFNQI, INPALPW, ATPVFL, SSSSAVVG) were identified from F2–2, with AAPFYAL showing the highest inhibitory activity (IC50 = 363.77 μM). Molecular docking demonstrated that these peptides competitively bind to key residues of α-glucosidase (such as D327, D542) via hydrogen bonds, which was further confirmed by pharmacophore model analysis. Our findings demonstrate that Xiaojiao BDGs are promising hypoglycemic resources.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Xu Zhou,Yapeng Zhang,Huipeng Gao,Quan Zhang,Lei Qin,Yuesheng Dong,Chun Li,Yaqin Sun,Zhilong Xiu
α-Pinene, a promising advanced biofuel, has garnered significant attention in the field of synthetic biology. However, its high cytotoxicity and volatility pose substantial challenges for efficient recovery from fermentation broths. This study explores a novel solid–liquid phase microextractive adsorption (SLPMA) technique to achieve in-situ separation of α-pinene from fermentation broths using a recombinant yeast. The extractant was immobilized into a polystyrene (PS) skeleton through copolymerization to prepare six resins for in-situ microextractive adsorption of α-pinene in the fermentation broth. The optimal extractant, isopropyl myristate (IPM), incorporated into the PS resin (PS-IPM) exhibited acceptable biocompatibility. Comprehensive characterization of the PS-IPM resin using FTIR, SEM, nitrogen physisorption, and TGA confirmed the successful immobilization of IPM (41.39 wt%) and material suitability. Compared to traditional extractive fermentation methods, the SLPMA process significantly enhanced cell growth promotion efficiency by 4.5 times. This improvement is attributed to the immobilization of the extractant within the porous material, which increased the extraction interface area and induced a microextraction effect. This effect enriched the α-pinene concentration in the regular fermentation broth toward the IPM phase of the PS-IPM microextractor by 57.9-fold. It increased the α-pinene concentration by 2.3-fold compared to the IPM from the extractive fermentation system. Consequently, the PS-IPM resin exhibited outstanding performance and effectively mitigated product inhibition. The resin successfully facilitated multiple cycles of in-situ α-pinene separation during fermentation, achieving a recovery of up to 95.82%. Furthermore, the removal efficiencies for inorganic salts, pigments, and proteins in the fermentation broth exceeded 98%. A delayed resin addition strategy was also implemented, further enhancing operational efficiency. FTIR analysis, combined with quantum chemical calculations, revealed that the strong van der Waals interaction is the primary driving force behind the separation process. This interaction enables the PS-IPM resin to function as an effective microextractor during adsorption. The study highlights the considerable potential of the SLPMA process for in-situ α-pinene separation during fermentation, providing a valuable reference for addressing challenges in other product-inhibited fermentation systems.
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高影响因子
FirePhysChem
·
2024
·
IF 0
Jiashuai Wang,Bo Wu,Lingfeng Yang,Yuan Bian,Renjie Li,Ke Zeng,Juan Zhu,Liangyou Zhao,Jinpeng Shen,Chonghua Pei
Thermites are widely used in propellants, explosives and ignition materials because of their high heat release rate and good combustion efficiency. Structural control over thermites to achieve improved performance leads to a promising research area. Among these, core-shell structured composites have attracted wide attention due to their excellent properties and close contact among components. Herein, core-shell structured α -AlH 3 /Fe 2 O 3 thermites were prepared, which exhibit high heat-release and excellent combustion performance. At an equivalence ratio of 2.0, the core-shell structured α -AlH 3 /Fe 2 O 3 has the most heat release (1213.8 J/g) and the lowest reaction activation energy (147.5 kJ/mol). The ignited combustion performance of α -AlH 3 /Fe 2 O 3 was notably strengthened by the shorter ignition delay period (11 ms). Interestingly, the core-shell structured α -AlH 3 /Fe 2 O 3 was less sensitive to electrostatic discharge, which suggests that the core-shell structured α -AlH 3 /Fe 2 O 3 reaches the goal of high energy release and electrostatic safety. The core-shell thermite system with α -AlH 3 as metal fuel could provide an efficient alternative to hunt for thermites with high reactivity.
研究领域:
材料科学
·
化学工程
·
能源技术
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DOI
TETRAHEDRON-ASYMMETRY
·
2014
·Vol. 25
·期 23
·1520-1526
·
IF 2.165
Yong-Ming Sun,Zhong-Yuan Xu,Li-Juan Liu,Fan-Jie Meng,He Zhang,Bao-Ci Fu,Li-Jun Sun,Mei-Ju Niu,Shu-Wen Gong,Chang-Qiu Zhao,Li-Biao Han
The hydrophosphorylation of aldehydes with a P -stereogenic H -phosphinate was realized by heating two compounds in a neat state or catalyzed by a base , to afford P -retention α-hydroxyl phosphinates. The ( S P , S C ) and other diastereomers were isolated, and their structures were confirmed by NMR spectroscopy and crystallography.
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高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2010
·Vol. 48
·期 14
·3145-3151
·
IF 3.971
Kunyan Sui,Song Gao,Wenwen Wu,Yanzhi Xia
Poly(ethylene glycol)- grafted -multiwalled carbon nanotube (MWNT- g- PEG) was synthesized by a coupling reaction and formed inclusion complexes (ICs) after selective threading of the PEG segment of the MWNT- g- PEG through the cavities of α-cyclodextrins (α-CDs) units. The polypseudorotaxane structures of the as-obtained hydrogels were confirmed by 1 H NMR, X-ray diffraction and DSC analyses. The complexation of the PEG segments with α-CDs and the hydrophobic interaction between the MWNT resulted in the formation of supramolecular hybrid hydrogels with a strong network. Thermal analysis showed that the thermal stability of the hydrogel was substantially improved by up to 100 °C higher than that of native hydrogel. The resultant hybrid hydrogels were found to be thixotropic and reversible, and could be applied as a promising injectable drug delivery system. The mechanical strength of the hybrid hydrogels was greatly improved in comparison with that of the corresponding native hydrogels. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 3145–3151, 2010
研究领域:
高分子科学
·
材料化学
·
纳米技术
·
药物递送
·
超分子化学
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8
Mengli Geng,Dandan Ma,Zhaojun Wang,Qiuming Chen,Maomao Zeng,Jie Chen,Benu Adhikari,Hongyang Pan,Zhiyong He
Kaempferol (KAE) is a dietary flavonoid with recognized effects on glucolipid metabolism and oxidative stress, but its poor lipophilicity and low bioavailability limit its application. In this study, KAE derivatives with different fatty acid chain lengths (C2–C12) were synthesized using acylation catalyzed by lipozyme TL IM, and their biological activities were then systematically evaluated. In vivo assays in hyperglycemic zebrafish ( Danio rerio ) demonstrated that two medium-chain derivatives, 4’- O -octanoyl-kaempferol (C8-KAE) and 4’- O -decanoyl-kaempferol (C10-KAE), exerted superior effects on glucose regulation, lipid metabolism, and oxidative stress compared with KAE. RT–qPCR analysis showed that C8-KAE and C10-KAE more effectively coordinated the expression of key genes governing gluconeogenesis, glycogen synthesis, lipogenesis, and fatty acid oxidation, indicating multi-target regulation of glucolipid homeostasis. Subsequent in vitro tests confirmed their stronger α-glucosidase inhibitory activity than KAE, while molecular docking, molecular dynamics simulations, and MM/GBSA binding free energy analyses consistently indicated more stable and favorable binding interactions with the enzyme. These findings indicate that medium-chain acylation is an efficient strategy to upgrade KAE into more potent modulators of glucolipid metabolism and identify C8-KAE and C10-KAE as promising lead compounds.
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高影响因子
Journal of Food Measurement and Characterization
·
2026
·
IF 3.3
Liu Yong,Deng Yejun,Wang Xiang,Zhang Caihong,Huang Lixin,Xie Pujun
Inhibiting α-glucosidase activity by secondary metabolites has been confirmed as an effective strategy for treating type 2 diabetes mellitus (T2DM). α-Glucosidase inhibitory activity was determined by different parts of Gleditsia sinensis Lam. (GSL) extracts. The thorn of the GSL methanol extract exhibited the highest activity (IC 50 = 0.21 mg/mL). Eleven potential α-glucosidase inhibitors were detected by Ultra Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry, and fisetin was screened as the dominant compound (IC 50 = 0.211 µM) through virtual screening, correlation analysis, and inhibitory assay. Fluorescence quenching experiment explained that fisetin inhibited α-glucosidase through hydrogen bonds and hydrophobic forces in a reversible and non-competitive mode. Three-dimensional fluorescence and circular dichroism demonstrated that fisetin modified the amino acids’ microenvironment and disrupted the hydrogen-bonded network of α-glucosidase. α-Glucosidase was bounded with fisetin by hydrogen (Thr448, His515, Asp346, and Gln531) and hydrophobic residues (His515, Lys352, and Ala349) simulated by molecular docking. This study points out the fisetin’s inhibitory mechanism of α-glucosidase, indicating that it is a promising natural ingredient in T2DM treatment.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Jiao Li,Xin Wen,Bin Zhang,Jianheng Ren,Zhumei Liao,Yuanyi Hua,Xiaohong Li,Qin Wang
In rheumatoid arthritis (RA), circulating platelets (PLTs) migrate to the inflamed synovium and interact with inflammation-resident cells, thereby amplifying inflammatory cascades. Moreover, these PLTs become overactivated and rapidly release α-granule contents in response to an inflammatory stimulus. Thus, the preferential incorporation of therapeutics into α granules can facilitate inflammation-homing trafficking and on-demand drug release. Due to the close crosstalk between PLTs and multiple inflammation-resident cells, precise modulation of PLTs dysfunction holds potential to inhibit the pathological cellular interaction and inflammatory cascades. Owing to the high P-selectin expression on both PLT membranes and α granules, we synthesize a P-selectin-targeted and resveratrol (Res)-loaded nanoparticle BFNPs@Res. After intravenous administration, BFNPs@Res selectively bind to circulating PLTs and accumulate in α granules. These BFNPs@Res-incorporated PLTs subsequently migrate to the inflamed synovium and release therapeutic payloads stored in α granules responding to inflammatory stimulus. Meanwhile, after internalization by PLTs, BFNPs@Res effectively suppress pathological PLTs activation and disrupt their crosstalk with inflammatory cells. In arthritic rats, BFNPs@Res attenuate PLT-mediated inflammatory cell recruitment and effectively alleviate RA symptoms. To our knowledge, this is the first report of exploiting the inflammatory homing and stimulus-responsive α granule release of PLTs for inflammation-targeted delivery, providing new insight for RA therapy.
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高影响因子
Science China-Information Sciences
·
2019
·Vol. 62
·期 12
·1-8
·
IF 2.731
Yang Huai,Xiao Mengqi,Cui Yu,Pan Longfei,Zhao Kai,Wei Zhongming
Two-dimensional (2D) ferroelectricity is considered to have significant potential for information storage in the future. Semiconducting ferroelectrics that are stable at room temperature afford many possibilities for the assembly of various high-performance heterostructures and fabricating multifuntional devices. Herein, we report the synthesis of a stable van der Waals (vdW) single-crystal semiconductor α -In 2 Se 3 . Piezoresponse force microscopy (PFM) measurements demonstrated the out-of-plane ferroelectricity in ∼15 layers α -In 2 Se 3 at room temperature. Both ferroelectric domains with opposite polarization and the tested amplitude and phase curve proved that this semiconductor exhibits hysteresis behavior during polarization. In the α -In 2 Se 3 /WSe 2 vertical heterostructure device, the switchable diode effect and nonvolatile memory phenomenon showed a high on/off ratio and a small switching voltage. The distinct resistance switches were further analyzed by band alignment of the heterostructure under different polarizations by first principle calculations. Nonvolatile memory based on vdW ferroelectric heterostructure could provide a novel platform for developing 2D room-temperature ferroelectrics in information storage.
研究领域:
材料科学
·
纳米电子学
·
铁电器件
·
二维材料
·
非易失性存储
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DOI
高影响因子
危险品化学品经营许可证（带存储）