Analytical Methods
·
2015
·Vol. 7
·期 4
·1471-1477
·
IF 1.821
Siyuan Wang,Wen Zhang,Xia Zhong,Yaqin Chai,Ruo Yuan
A nanohybrid based on reduced graphene oxide functionalized by poly(amido-amine), multi-walled carbon nanotubes and Au nanoparticles (RGO–PAMAM–MWCNT–AuNPs) for simultaneous electrochemical determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) was reported in this paper. The RGO–PAMAM–MWCNT–AuNP-modified electrode showed a high selectivity towards the oxidation of AA, DA, and UA, and resolved their overlapped oxidation peaks into three well-defined peaks. The RGO–PAMAM–MWCNT–AuNP nanohybrids were characterized by scanning electron microscopy (SEM). Several important parameters that control the performance of the electrochemical sensor were investigated and optimized. Under optimal conditions by a differential pulse voltammetry (DPV) method, the linear response ranges for the determination of AA, DA, and UA are 20 μM to 1.8 mM, 10 μM to 0.32 mM, and 1 μM to 0.114 mM in the co-existence systems, respectively. The corresponding detection limits are 6.7 μM, 3.3 μM and 0.33 μM (S/N = 3), respectively.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2015
·
IF 1.03
Hai-Ting Lu,Xin-Hua Cao,Zi-Juan Yang,Sen Chen,Yang Fan
A novel nanocomposite composed of copper nanoparticles encapsulated in a hollow carbon shell was prepared. The thin, porous carbon shell ensured efficient mass and electron transport and provided a confined environment for electrochemical reactions. The Cu@C nanocomposite exhibited favorable electrocatalytic activity toward glucose and superior electrochemical sensing performance toward glucose, with a low limit of detection (1 µM) and a wide linear dynamic range (0.0–6.1 mM). Good selectivity, reproducibility, and stability were obtained. The application of the sensor for the determination of glucose in human serum demonstrated its use for practical analysis.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2013
·Vol. 37
·期 7
·2174-2178
·
IF 2.966
Xing Liu,Qi Wang,Yu Zhang,Lichun Zhang,Yingying Su,Yi Lv
In this paper, a novel and simple colorimetric method for the determination of glutathione (GSH) was developed. The BSA–MnO2 NPs possess oxidase-like activity that can catalyze the oxidization of 3,3′,5,5′-tetramethylbenzidine (TMB), and the existence of GSH can cause reduction of oxidized TMB along with a visual color variation. A good linear relationship can be obtained from 0.26 to 26 μM with a limit of detection of 0.1 μM. Furthermore, the good recoveries for serum samples indicated that the present colorimetric methodology was feasible, simple and sensitive, with a promising application in routine analysis of biosamples.
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2013
·Vol. 5
·期 9
·2335-2342
·
IF 1.855
Bingbing Xu,Qijun Song,Haijun Wang
A novel protocol for simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) based on double-walled carbon nanotubes (DWNTs)/choline (Ch) modified glassy carbon electrode (GCE) was presented. Ch was covalently immobilized on the GCE through oxygen atoms. The Ch monolayer provides a positively charged monolayer, which could attract negatively charged DWNTs through electrostatic interaction. In the simultaneous determination of aforementioned three analytes using CV, the electrochemical signals were well separated into three oxidation peaks with peak potential differences of 0.182 V (AA–DA), 0.146 V (DA–UA) and 0.328 V (AA–UA). In amperometric studies of AA, DA and UA, the modified electrode exhibited wide linear ranges of 0.10–777 μM, 0.06–314 μM and 0.25–344 μM and low detection limits of 0.03, 0.03, and 0.05 μM, respectively. Amperometric responses of AA, DA and UA were within 1 s. Moreover, this modified electrode was further applied to determine AA, DA and UA in real samples with satisfactory results.
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2013
·
IF 0.769
Yu-Rong TANG,Yu ZHANG,Rui LIU,Ying-Ying SU,Yi LÜ
The poly(acrylic acid) functionalized NaYF 4 :Yb,Er nanoparticles (NPs) were found to possess intrinsic peroxidase-like activity, which could catalyze oxidization of 3,3′,5,5′-tetramethylbiphenyl (TMB) by H 2 O 2 to produce a color variation. Using TMB as substrate, we systematically studied the effect of a series of conditions, such as temperature and pH, on the catalytic activity of NaYF 4 :Yb,Er NPs. When combined with uricase, the proposed colorimetric method could be successfully used for the determination of uric acid. Under the optimum conditions, the linear range of this method was from 1.0 × 10 −5 M to 2.0 × 10 −4 M with the detection limit down to 5.3 × 10 −6 M. Moreover, the developed method was applied to detect uric acid in serum samples and the results were in good agreement with those reported by the hospital.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2013
·
IF 3.554
Lin Jiang,Shuqing Gu,Yaping Ding,Daixin Ye,Zhen Zhang,Fenfen Zhang
An electrochemical sensor based on tricobalt tetroxide nanoparticles–graphene nanocomposite film modified glassy carbon electrodes (GCEs) for sensitive determination of l -tyrosine (L-Tyr) was presented here. The nanoparticles were fabricated by electro-polymerization technology. Scanning electron microscopy was implemented to characterize morphology of the nanocomposite film. The electron transfer behavior of modified electrodes was investigated in 5 mM K 3 [Fe(CN) 6 ]/K 4 [Fe(CN) 6 ] solution using cyclic voltammetry and electrochemical impedance spectroscopy (EIS). The electrochemical response of modified electrodes toward L-Tyr was investigated by cyclic voltammetry (CV), square wave voltammetry (SWV), amperometry in detail. The results indicated that synergistic effect of Co 3 O 4 NPs and graphene film dramatically improved the conductivity and sensitivity of the sensor. Under optimal conditions, a wide linear relationship between the responses and L-Tyr concentrations ranging from 1.0 × 10 −8 to 4.0 × 10 −5 mol L −1 was obtained with a comparatively low detection limit of 1.0 × 10 −9 mol L −1 . Furthermore, the sensor also displays excellent sensitivity and high stability. To further study the practical applicability of the fabricated sensor, it was applied to detect real samples and the received results were satisfactory.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2012
·
IF 5.602
Bo Liang,Lu Fang,Guang Yang,Yichuan Hu,Xishan Guo,Xuesong Ye
A glucose biosensor based on direct electron transfer of glucose oxidase (GOD) self-assembled on the surface of the electrochemically reduced carboxyl graphene (ERCGr) modified glassy carbon electrode has been reported. X-ray photoelectron spectroscopy (XPS) analyses of ERCGr indicate most of the oxygen-containing groups such as epoxy/ether groups and hydroxyl groups in the carboxyl graphene were eliminated, while carboxylic acid groups remained. GOD was immobilized on the ERCGr modified glassy carbon electrode via self-assembly. The cyclic voltammetric result of the electrode shows a pair of well-defined and quasi-reversible redox peaks with a formal potential of −0.467 V and a peak to peak separation of 49 mV, revealing that the direct electron transfer between GOD and the electrode has been achieved. The proposed biosensor exhibits a linear response to glucose concentrations ranging from 2 to 18 mM with a detection limit of 0.02 mM. Moreover, this facile, fast, environment-friendly and economical preparation strategy of ERCGr may be extended for the preparation of other graphene based enzyme electrode biosensors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 3
·期 4
·556-561
·
IF 0
Ni Hui,Wenting Wang,Guiyun Xu,Xiliang Luo
A highly stable and sensitive nonenzymatic glucose sensor was successfully constructed through a facile electrodeposition method. Graphene oxide (GO) doped poly(3,4-ethylenedioxythiophene) (PEDOT) was first electrodeposited onto a glass carbon electrode using cyclic voltammetry and copper nanoparticles were then electrodeposited onto the rough surface of the PEDOT/GO nanocomposite through electrochemical reduction in a solution containing copper cations. The modified electrode was used for reliable nonenzymatic electrochemical detection of glucose, and under optimized conditions, it exhibited a high sensitivity of up to 909.1 μA mM−1 cm−2 and a very fast response time of less than 1 s, with a wide linear range of 0.1 μM to 1.3 mM and a low detection limit of 47 nM. This nonenzymatic glucose sensor was, furthermore, highly stable and unresponsive to potentially interfering substances, and it could be used for the assay of glucose in real human serum samples. These enhanced sensing performances were ascribed to the close contact of copper nanoparticles onto the rough surface of the PEDOT/GO conducting polymer nanocomposite, which has good conductivity and very high surface area that can act as an excellent substrate for the growth and support of copper nanoparticles. All these results indicate that this electrochemical sensor is highly promising for nonenzymatic glucose detection.
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2014
·Vol. 45
·期 2
·131-138
·
IF 2.147
Fan Yang,Yang Xin,Cao Zhen,Chen Shufang,Zhu Bing
Mesoporous CuO microspheres with core-in-hollow-shell structure were synthesized by one-pot hydrothermal method, using dicyandiamide as hydrolysis agent and poly(vinylpyrrolidone) as soft template. The as-synthesized CuO microspheres were characterized by powder X-ray diffraction, field-emission scanning electron microscopy and N 2 sorption measurements. The core-in-hollow-shelled CuO microspheres exhibit greatly enhanced amperometric response towards glucose as compared to that of the simple hollow counterpart. The as-developed non-enzymatic glucose sensor exhibited favorable performance with wide linear range (0.005–7.95 mM), sensitivity of 622.2 μA mM cm −2 and low detection limit of 1 μM.
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Jianjun Liao,Shiwei Lin,Yue Yang,Kai Liu,Wencai Du
In organic electrochemical transistor (OECT) based glucose sensors Pt-based electrodes are usually used as the gate electrodes due to its excellent electrocatalytic activity. In this paper, a cheap and biocompatible material, TiO 2 nanotube arrays (TNTAs), was used as the gate electrode of the OECT device for the first time. It is encouraging that the sensing performance of OECTs using TNTAs-based gate electrodes is comparable to or better than those of the previously reported OECTs using Pt-based gate electrodes. Highly sensitive and selective OECT devices can be obtained by modifying TNTAs electrodes with Pt nanoparticles (Pt-NPs) and enzyme (glucose oxidase). The device shows a linear response to the logarithm of glucose concentration over the range from 100 nM to 5 mM, and the detection limit as low as 100 nM was achieved, which is three orders of magnitude lower than that of a conventional electrochemical measurement with the same electrode. On the other hand, the glucose can be selectively detected in the presence of interferences, such as ascorbic acid and uric acid, when the gate electrode is modified with Nafion. Moreover, the device presents a good stability and reproducibility. By modifying with other specific enzymes and nanomaterials, it is expected that many other type of enzyme sensors with high sensitivity and selectivity could be realized.
✓ 已验证
产品关联
DOI
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2014
·Vol. 32
·期 4
·498-504
·
IF 0.537
Ying Li,Lianhai Zu,Guanglei Liu,Yao Qin,Donglu Shi,Jinhu Yang
In this paper, a novel strategy with a new growth mechanism for fast and large-scale growth of Au long nanowires on high-curvature SiO 2 nanospherical surfaces has been developed. The synthesis includes three steps, i.e., amino modification of SiO 2 nanospheres, Au seed loading on aminated SiO 2 nanospheres and subsequently, Au seed-mediated nanowire growth on SiO 2 nanospheres. The prepared Au nanowires (Au NWs) (exhibit long length, high aspect ratio, and good flexibility, and can naturally form the dense nanowire film, which is promising as a stable conductive electrode. In addition, the effect of synthetic conditions such as reactant feeding order, Au seeds and SiO 2 @Au seeds on the morphology of Au nanostructures (nanowires, nanoteeth, and nanoflowers) has been investigated. It is found that Au seeds and high-curvature SiO 2 nanospherical surfaces are necessary conditions for the successful preparation of Au NWs and nanowire films. The different growth mechanisms for Au NWs and nanoteeth have been proposed and discussed. Moreover, the novel nonenzymatic H 2 O 2 sensor based on Au NWs exhibits much enhanced performance such as higher sensitivity, stability, and selectivity, wider linear range and lower detection limit, compared with that of Au nanoparticles-based H 2 O 2 sensor.
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Chunjing Zhang,Shihui Si,Zhengpeng Yang
Combining the surface modification and molecular imprinting technique, a novel photoelectrochemical sensing platform with excellent photochemical catalysis and molecular recognition capabilities was established for the detection of uric acid based on the magnetic immobilization of Fe 3 O 4 @C nanoparticles onto magnetic glassy carbon electrode (MGCE) and modification of molecularly imprinted TiO 2 film on Fe 3 O 4 @C. The developed biosensor was highly sensitive to uric acid in solutions, with a linear range from 0.3 to 34 µM and a limit of detection of 0.02 μM. Furthermore, the biosensor exhibited outstanding selectivity while used in coexisting systems containing various interferents with high concentration. The practical application of the biosensor was also realized for the selective detection of uric acid in spiked samples. The study made a successful attempt in the development of highly selective and sensitive photoelectrochemical biosensor for urine monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）