Frontiers in Bioengineering and Biotechnology
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2023
·
IF 5.7
Ruru Zhang,Kuan Lu,Li Xiao,Xuelan Hu,Wu Cai,Linjiang Liu,Yan Liu,Weihua Li,Hui Zhou,Zhiyuan Qian,Sixia Wang,Can Chen,Jianfeng Zeng,Mingyuan Gao
Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging its noninvasiveness, high spatial resolution, and lack of ionizing radiation. Ultrasmall iron oxides, when modified with polyethylene glycol, exhibit prolonged blood circulation and passive targeting toward plaque sites, rendering them conducive for MRI. In this study, we synthesized ultrasmall iron oxide nanoparticles of approximately 3 nm via high-temperature thermal decomposition. Subsequent surface modification facilitated the creation of a dual-modality magnetic resonance/fluorescence probe. Upon intravenous administration of the probes, MRI assessment of atherosclerotic plaques and diagnostic evaluation were conducted. The application of Flash-3D sequence imaging revealed vascular constriction at lesion sites, accompanied by a gradual signal amplification postprobe injection. T1-weighted imaging of the carotid artery unveiled a progressive signal ratio increase between plaques and controls within 72 h post-administration. Fluorescence imaging of isolated carotid arteries exhibited incremental lesion-to-control signal ratios. Additionally, T1 imaging of the aorta demonstrated an evolving signal enhancement over 48 h. Therefore, the ultrasmall iron oxide nanoparticles hold immense promise for early and noninvasive diagnosis of plaques, providing an avenue for dynamic evaluation over an extended time frame.
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ACS Nano
·
2023
·
IF 17.1
Hongwei Liao,Shengfei Yang,Zeyu Liang,Lin Xiao,Shangzhi Xie,Peihua Lin,Fan Xia,Chunyan Fang,Qian Chen,Daishun Ling,Fangyuan Li
Replication stress (RS) induced by DNA damage plays a significant role in conferring the anticancer effects of radiotherapy and is tightly associated with radioresistance of cancer cells. Amplification of RS represents an effective approach to improving the efficacy of radiotherapy, although the development of selective RS amplifiers remains an unexplored frontier. We herein present an RS nano amplifier (RSNA) consisting of a catalytic FePt nanoparticle loaded with the chemotherapeutic doxorubicin (DOX), which selectively exacerbates RS in cancer cells by promoting replication fork (RF) catastrophe. RSNA converts the excessive reactive oxygen species (ROS) in cancer cells into oxygen, enhancing the DNA-damaging effects of radiotherapy to create more template lesions that impede RF progression in coalition with DOX. After radiation, ROS scavenging by RSNA accelerates RF progression through damaged template strands, increasing the frequency of RF collapse into double-strand breaks. Moreover, pretreatment with RSNA accumulates cancer cells in the S phase, exposing more RFs to radiation-induced RS. These effects of RSNA convergently maximize RS in cancer cells, effectively overcoming the radioresistance of cancer cells without affecting normal cells. Our study demonstrates the feasibility of selectively amplifying RS to boost radiotherapy.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yuming Sun,Yue Hao,Xinyu Lin,Zhonghuan Liu,Hongyang Sun,Shuhan Jia,Yahui Chen,Yongsheng Yan,Xuefei Li
The efficiency of the photocatalytic reaction is mainly determined by the effective separation of photogenerated electron (e - ) and hole (h + ). As a high electrical conductivity, two-dimensional (2D) Ti 3 C 2 MXene is widely used as an electronic transmission intermediary with a large surface area and active terminal. In this work, 1D CuZnInS are loaded on the surface of 2D Ti 3 C 2 MXene nanosheets to compound 1D/2D CuZnInS/Ti 3 C 2 nanocomposites with effective inhibition of charge-carrier recombination. The H 2 production rate of optimized 1D/2D CuZnInS/Ti 3 C 2 composite reached 15.24 mmol h −1 g −1 , which is 4.5 times than that of pure CuZnInS (3.38 mmol h −1 g −1 ), and the apparent quantum efficiencies (AQEs) of composite photocatalysts can reach 0.39% and 0.24% under light irradiation at 365 nm and 420 nm wavelength, respectively. In addition, 1D/2D CuZnInS/Ti 3 C 2 has high stability after 10 cycles. The enhanced photocatalytic performance is attributed to the large specific surface area of 2D Ti 3 C 2 nanosheets, which facilitates the separation and transfer of photogenerated e - and h + pairs.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Yinjun Shi,Yushun Zhao,Tianqi Hou,Chengcheng Liao,Dengyun Li
The introduction of wide-band semiconductor devices has led to the development of electronic components with a high degree of integration and power density. The use of dielectric polymers can guarantee the performance of electronic components while maximizing their operational reliability. However, this polymer performance is often enhanced at the expense of its electrical insulation properties and processability. Herein, we report the synthesis of epoxy resin composites filled with boron nitride nanosheets (BNNSs) functionalized with copper nanowires (Cu NWs). Through encapsulation within a polydopamine coating, Cu NWs and BNNSs exhibit excellent electrical insulation properties and high dispersion, and their 1D and 2D interconnected networks enable effective charge and heat transfer. Hence, these epoxy resin composites showed a thermal conductivity of 1.2 W/m K at a filler loading rate of 26 wt %, marking a staggering 486% increase compared to pure epoxy resin. These composites also showed low dielectric loss, enhanced electrical insulation properties, matched thermal expansion coefficients, and low water absorption. Experimental analyses and simulations indicated that the composites had strong heat dissipation capability, meeting the technical specifications for electronic packaging materials, and are thus expected to find use in electronic device packaging.
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Applied Materials Today
·
2023
·
IF 8.3
Zizhao Fu,Hanxu Lu,Hong Liu,Yifeng Xing,Zhiyan Piao,Hanqing Dai,Wanlu Zhang,Ruiqian Guo
Due to their unique optical properties, I-III-VI alloyed quantum dots (QDs) have attracted significant attention. By cationic alloying and composition adjusting, quaternary and quintuple alloyed QDs could be synthesized and the optical properties could be further investigated by adjusting the synthesis parameters. In this study, we synthesized CuZnGaSSe (CZGSSe) QDs using a one-pot method and the photoluminescence quantum yield (PL QY) could reach 72.2%. The effects of the capping ligands, the halogen ions in Zn precursors and the reaction temperatures were explored and the growth mechanism of the CZGSSe QDs was discussed. Finally, by adjusting the S/Se ratio and Cu/Ga ratio, the prepared QDs exhibited tunable emission wavelengths ranging from 469 nm to 599 nm. This study is of significance for researching the growth sequence and guiding the synthesis of efficient quintuple QDs.
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Journal of Physical Chemistry C
·
2023
·
IF 3.7
Huiling Zhu,Cuixia Hao,Xin Li,Yao Qi,Xuesong Zhu,Yucheng Miao,Rui Liu,Jianxu Ding
Black phase CsPbI3 quantum dots (QDs) have garnered significant research interest due to their remarkable properties in optoelectronic applications. However, their inherent instability and low phase stability often lead to an undesired transformation into an orthorhombic yellow phase. In this study, we propose an innovative approach to synthesize Ag+ doped CsPbI3 QDs in a nonvacuum environment. The theoretical calculations and experimental results demonstrate that Ag+ doping substantially increases the formation energy and Goldschmidt tolerance factor, resulting in an enhanced thermodynamic stability and photoluminescence quantum yield (PLQY). The resulting Ag+ doped CsPbI3 QDs exhibit an impressive PLQY of up to 97% and maintain their black phase for over 60 days. This novel nonvacuum synthesis approach holds great potential for producing high-quality all-inorganic perovskite CsPbX3 QDs. To demonstrate the practical applications, we fabricate a white light-emitting diode (WLED) using the Ag+ doped CsPbI3 QDs, achieving Commission Internationale de I’Eclairage (CIE) color coordinates of (0.36, 0.26). These findings highlight the broad prospects of CsPbI3 QDs in lighting and display technologies.
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Molecular Medicine Reports
·
2023
·Vol. 28
·期 4
·1-13
·
IF 3.4
Qi Nie,Wenqing Chen,Tianmei Zhang,Shangrong Ye,Zhongyu Ren,Peng Zhang,Jian Wen
In recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effects of this material on the NCI‑H446 human small cell lung cancer and brain M059K malignant glioblastoma cell lines. First, a CCK‑8 assay was performed to determine cell viability, and then the combination index for evaluating drug combination interaction effect was evaluated. Intracellular reactive oxygen species (ROS) and lipid peroxidation levels were monitored using a DCFH‑DA fluorescent probe and a C11‑BODIPY™ fluorescent probe, respectively. Furthermore, western blotting assay was performed to determine the expression of autophagy‑ and iron death‑related proteins. The experimental results showed that, compared with either IONP monotherapy, PTX monotherapy, or IONP + PTX, IONP@PTX exerted a synergistic effect on the viability of both cell types, with significantly increased total iron ion concentration, ROS levels and lipid peroxidation levels. IONP@PTX significantly increased the expression of autophagy‑related proteins Beclin 1 and histone deacetylase 6 (HDAC6) in both cell lines (P<0.05), increased the expression of light chain 3 (LC3)‑II/I in NCI‑H446 cells (P<0.05) and decreased that of sequestosome1 (p62) in M059K cells (P<0.05). Moreover, the addition of rapamycin enhanced the IONP@PTX‑induced the upregulation of Beclin 1, LC3‑II/I and HDAC6 and the downregulation of mTORC1 protein in both cell lines (P<0.05). Moreover, rapamycin enhanced the IONP@PTX‑induced downregulation of p62 protein in NCI‑H446 cells (P<0.05), suggesting that IONP@PTX induces ferroptosis, most likely through autophagy. Collectively, the present findings show that IONP works synergistically with PTX to induce ferroptosis via the autophagic pathway.
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Light-Science & Applications
·
2023
·Vol. 12
·期 1
·1-9
·
IF 19.4
Lu Po,Li Ting,Lu Min,Ruan Cheng,Sun Siqi,Wu Zhennan,Zhong Yuan,Zhang Fujun,Gao Yanbo,Huang Yaowei,Wang Yang,Hu Junhua,Yan Fengping,Zhang Yu
Considering the multi-functionalization of ligands, it is crucial for ligand molecular design to reveal the landscape of anchoring sites. Here, a typical triphenylphosphine (TPP) ligand was employed to explore its effect on the surface of CsPbI 3 perovskite nanocrystals (PNCs). Except for the conventionally considered P-Pb coordination, an P-I supramolecular halogen bonding was also found on the NC surface. The coexistence of the above two types of bonding significantly increased the formation energy of iodine vacancy defects and improved the photoluminescence quantum yield of PNCs up to 93%. Meanwhile, the direct interaction of P and I enhanced the stability of the Pb-I octahedra and dramatically inhibited the migration of I ions. Furthermore, the introduction of additional benzene rings (2-(Diphenylphosphino)-biphenyl (DPB)) increased the delocalized properties of the PNC surface and significantly improved the charge transport of the PNCs. As a result, the DPB passivated CsPbI 3 NCs based top-emitting LEDs exhibite a peak external quantum efficiency (EQE) of 22.8%, a maximum luminance of 15, 204 cd m −2 , and an extremely low-efficiency roll-off of 2.6% at the current density of 500 mA cm −2 .
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Kaixu Yu,Ying Chen,Lu Zhang,Yongqiang Zheng,Jinlin Chen,Zhenhua Wang,Xiaogang Yu,Kehan Song,Yimin Dong,Fanxiu Xiong,Zijian Dong,Hao Zhu,Gaohong Sheng,Meipeng Zhu,Xi Yuan,Hanfeng Guan,Jiaqiang Xiong,Yi Liu,Feng Li
Ferroptosis is characterized by iron accumulation and lipid peroxidation. However, a clinical dose of Fe3O4 nanoparticles could not cause effective ferroptosis in tumors, and the mechanism is yet to be completely understood. In this study, using RNA-seq data, we found that tumor cells could feedback-activate the antioxidant system by upregulating Nrf-2 expression, thus avoiding ferroptosis caused by Fe3O4 nanoparticles. We also found that DHJS (a probe for ROS generation) can antagonize Nrf-2 expression when it synergizes with Fe3O4 nanoparticles, thus inducing ferroptosis in tumor cells. Considering these findings, we created a biomimetic hybrid cell membrane camouflaged by PLGA-loaded Fe3O4 and DHJS to treat osteosarcoma. The hybrid cell membrane endowed the core nanoparticle with the extension of blood circulation life and enhanced homologous targeting ability. In addition, DHJS and Fe3O4 in nanoparticles prompted synergistically lethal ferroptosis in cancer cells and induced macrophage M1 polarization as well as the infiltration of CD8(+) T cells and dendritic cells in tumors. In summary, this study provides novel mechanistic insights and practical strategies for ferroptosis induction of Fe3O4 nanoparticles. Meanwhile, the synthesized biomimetic nanoparticles exhibited synergistic ferroptosis/immunotherapy against osteosarcoma.
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CHINESE JOURNAL OF CATALYSIS
·
2023
·
IF 16.5
Lijuan Sun,Weikang Wang,Ping Lu,Qinqin Liu,Lele Wang,Hua Tang
Catalysts play a vital role in photocatalytic water-splitting by converting solar energy into storable chemical energy. In this study, we successfully synthesized an HCN/HEA heterostructure by rationally combining the Pt 18 Ni 26 Fe 15 Co 14 Cu 27 nano-high-entropy alloy (HEA) as an effective cocatalyst with protonated g-C 3 N 4 (HCN) nanosheets , via an electrostatic self-assembly method. The resulting HCN/HEA exhibited remarkable performance in both photocatalytic H 2 production and selective oxidation of benzyl alcohol to benzaldehyde. The integration of HEA into HCN leads to the formation of Schottky junctions, which can significantly accelerate charge migration and reduce the recombination of charge carriers. Further investigations using in situ surface photovoltage imaging demonstrated that the reducing cocatalyst HEA can act as a photogenerated electron trap. The best HCN/HEA heterojunction exhibited excellent photocatalytic hydrogen production activity, reaching 2.4 mmol g −1 h −1 and an impressive benzaldehyde production rate of 5.44 mmol g −1 h −1 . These values were 958 and 6.6 times higher than those achieved with pristine HCN, respectively. This study offers promise for the rational design of high-performance cocatalysts to improve the transport, separation, and utilization of light-release charge carriers.
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TALANTA
·
2023
·
IF 6.1
Yuanchao Lu,Yingcheng Tang,Ningxiang Yu,Xiaohua Nie,Xianghe Meng
Sensitively, accurately, and rapidly evaluating edible oils’ peroxide value (PV) is significant for safeguarding food quality and safety. However, the conventional detection methods are challenging to meet the above demands due to their complex operation, poor reproducibility, and professional personnel. The colorimetric method is an emerging technique to rapidly and on-site determine the PV of edible oils . CsPbBr 3 NCs, as a novel fluorescent-sensing material, have been applied in the chemical colorimetric analysis . However, the heavy use of high-toxic solvents (toluene, chloroform) in the CsPbBr 3 NCs colorimetric system significant-negatively influences the environment. This study evaluated the performances of CsPbBr 3 NCs in nine low-toxic solvents and investigated the potential response mechanism to PV. The results presented that CsPbBr 3 NCs in ethyl acetate displayed the highest photoluminescent intensity and the most uniform distribution. The results performed that the micro-morphology and crystal structure of CsPbBr 3 NCs in ethyl acetate were similar to that in toluene, demonstrating the potential excellent performance. Under optimum conditions, three methods, including photoluminescence (PL)-decreased, wavelength-shifted, and phone-based colorimetric methods, were established to evaluate PV with the LOD of 0.0034 g/100 g. The PV recovery rates in Soybean oil, Camellia oil, Linseed oil, and Olive oil were from 75.0% to 100.0%, with a relative error below 25%. Furthermore, it was believed that the decreased PL and shifted wavelength originated from the halogen substitution with the crystal-structure destructions and the surface-defect formations. Thus, developing the low-toxic colorimetric CsPbBr 3 NCs system with ethyl acetate could reduce the environmental influence and even enlighten the rise of other green detection methods for PV in edible oils.
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Science China-Materials
·
2023
·Vol. 66
·期 10
·4090-4099
·
IF 8.1
Yang Kaidong,Yang Yating,Sun Dongquan,Li Shihua,Song Xiaorong,Yang Huanghao
X-ray nanoscintillator-based photoresponsive therapy is emerging as a promising strategy to treat in vivo tumors, necessitating the development of nanoscintillators with X-ray-excited luminescence in the ultraviolet region (UV-XEL) for the photoactivation of therapeutic precursors. However, it remains a challenge to achieve high-efficiency X-ray-activated tumor therapy due to the limited UV-XEL efficacy. Herein, we developed novel Gd 3+ /Ce 3+ -codoped LiLuF 4 nanoscintillators with strong UV-XEL for in vivo tumor therapy. Significantly, through optimization of host materials, dopants, and energy transfer process, the developed nanoscintillators enabled effective enhancement of UV-XEL (up to 18-fold) as compared with the traditional Ce 3+ -doped counterparts. As a proof-of-concept study to evaluate the in vivo therapeutic applications of the nanoscintillators, we integrated them with nitric oxide (NO) precursors for controllably generating NO upon the X-ray exposure, achieving superior in vivo antitumor effect upon X-ray-induced synergetic NO therapy and radiotherapy. Moreover, X-ray-activated NO therapy can inhibit tumor metastasis into liver to suppress tumor regrowth and prolong mice survival. This work might motivate future development of X-ray nanoscintillators for treating diseases in deep tissue.
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