JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 4.9
Guolong Shi,Minglin Ji,Sedrati Manar,Jing Chen,Guohua Jiang
Antithrombotic medications, including antiplatelet drugs, anticoagulants, and thrombolytics, remain fundamental to the clinical management of thrombosis, as they are widely used in the treatment of cardiovascular diseases and other conditions to prevent and treat thrombotic events. Thrombolytic agents, such as urokinase and streptokinase, are pivotal in the treatment of acute thrombotic diseases by activating the fibrinolytic system to dissolve blood clots. However, these agents face challenges due to their limited targeting specificity, short half-life, and varying efficiency, which can result in suboptimal therapeutic outcomes. In this study, we developed cyclic RGD (cRGD)-functionalized liposomes (IR/LK@cLip) to encapsulate IR-780 and lumbrokinase (LK). Leveraging the affinity of the RGD sequence for activated platelet membrane glycoprotein IIb/IIIa receptors, we aimed to improve the targeted chemo-photothermal combined therapy for thrombi. The cRGD can specifically target GPIIb-IIIa receptors, which are overexpressed on activated platelets, enabling the fabricated liposomes to actively recognize thrombi. When exposed to near-infrared (NIR) laser irradiation, IR-780, acting as a photosensitizer, can induce the disintegration of liposomes and promote the release of LK, which enhances drug penetration efficiency by increasing thrombus porosity. In vivo studies have confirmed that IR/LK@cLip exhibits effective accumulation at the site of thrombus formation. Moreover, the IR/LK@cLip has demonstrated the ability to rapidly restore blood circulation at thrombosed locations, suggesting its potential as a powerful antithrombotic treatment.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Yong Huang,Tao Quan,Bowen Li,Chaohui Zhen,Haiqian Zhang,Zhiyao Li,Chongzhi Wu,Rui Liang,Lihe Sun,Xin Xie
Triple-negative breast cancer (TNBC), lacking effective therapeutic targets, is highly aggressive, prone to metastasis, and associated with poor prognosis, highlighting the necessity for innovative therapeutic strategies. Ferroptosis, an emerging form of iron-dependent programmed cell death, presents a promising treatment approach. However, its effectiveness is often hindered by adaptive resistance within the tumor microenvironment and inefficient drug delivery. To address these limitations, the glutathione (GSH)-responsive disulfide linker (-SS-) was utilized to engineer rhein (Rhe, chemotherapeutic agent) and ferrocene (Fc, ferroptosis booster) into the self-assembling small-molecule prodrug RSSF. Sorafenib (SOR), a ferroptosis inducer, was stably loaded into RSSF via a simple nanoprecipitation method, yielding the newly nanoprodrug designated as SOR@RSSF nanoparticles (NPs) for the combination therapy of TNBC. SOR@RSSF NPs exhibit markedly enhanced cellular uptake and enable the highly specific and synchronous release of Rhe, Fc, and SOR in response to intracellular GSH levels. Notably, Fc efficiently generates hydroxyl radicals (•OH) through the Fenton reaction, thereby inducing pronounced oxidative stress, while SOR concurrently impaired the cellular ferroptosis defense machinery. Combined with the chemotherapeutic activity of Rhe, the resulting lipid peroxide (LPO) accumulation and GSH depletion synergistically trigger both ferroptosis and apoptosis selectively in tumor cells. In a 4T1 tumor-bearing mouse model, SOR@RSSF NPs significantly inhibited tumor progression while maintaining a favorable biosafety profile. Overall, this study presents a promising ferroptosis-sensitizing strategy using a nanoprodrug delivery system for combination therapy against TNBC.
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Small
·
2026
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IF 12.1
Xianming Gao,Ting Wu,Xinyi Dong,Qibo Wang,Hao Liu,Yu Zhang
The treatment of infected bone defects remains a significant clinical challenge, necessitating rigorous infection control alongside effective bone reconstruction. To address this, we develop a pH-responsive, zeolitic imidazolate framework-8 (ZIF-8)-based delivery system for targeted psoralen (PSO) delivery, which provides dual functionalities: antibacterial activity and osteogenic modulation. These nanoparticles (NPs) are further functionalized with a polydopamine (PDA) coating, designated as PSO/ZIF-8@PDA NPs (PZP NPs), to achieve synergistically enhanced therapeutic efficacy through photothermal activity. Exploiting rapid degradation in the acidic microenvironment of infected bone defects and slow degradation in the neutral microenvironment, these PZP NPs undergo spatiotemporal transformation, enabling sequential antibacterial and osteogenic modulation at the defect sites through the concentration-dependent effects of PSO. In vitro optimisation of PSO loading establishes a balance between osteogenic potency, antimicrobial efficacy, and biocompatibility, defining an optimal therapeutic platform for nanocarrier performance. In vivo evaluation in polymicrobial ( Staphylococcus aureus and Escherichia coli )-infected rat calvarial defect models demonstrates effective pathogen eradication and enhanced osteogenic differentiation. This dual-functional nanoplatform represents a promising strategy for the clinical management of infected bone defects and broadens the potential of nanomedicine in regenerative applications for infected tissues.
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Advanced Healthcare Materials
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2026
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IF 9.6
Lishang Xu,Kan Shao,Yanfei Liu,Yongbo Liu,Yifu Tan,Yunqi Man,Zhirou Zhang,Zhongyu Cheng,Qian Wang,Zhihang Ren,Jian Wu,Qi-Wen Chen,Zhenbao Liu
Antigen-enriched tumor vaccines represent a promising strategy for cancer immunotherapy. Nevertheless, their clinical efficacy is often limited by insufficient antigen presentation and low immunogenicity. Here, a novel nanovaccine was developed that synergistically combines mitochondrial fission inhibition, tumor-dendritic cell fusion, and metal-phenolic nanoparticle technology. Tumor cells were pretreated with the mitochondrial fission inhibitor Mdivi‑1, yielding antigen‑enriched cell membranes (CM(M)). Subsequently, these CM(M) were fused with the dendritic cell membranes (DCM) overexpressing B7 biomolecules to create a tumor-dendritic cell fusion membrane (DCCM(M)). R848-loaded metal-phenolic nanoparticles (TF/R848) were further coated with the fusion membrane to create a dual-functional nanovaccine (TF/R848@DCCM(M)). This nanovaccine increases immunogenicity and optimizes antigen presentation. The nanovaccine promotes dual T-cell activation via direct antigen presentation and DC-mediated cross-presentation. TF/R848@DCCM(M) showed remarkable anticancer activity in melanoma-bearing mouse models, greatly reducing tumor development and extending longevity. Moreover, the nanovaccine enhanced the effects of immune checkpoint inhibitors, offering a promising strategy for combination immunotherapy. This study presents a novel, efficient platform for cancer immunotherapy, positioning a versatile and powerful approach for next-generation tumor vaccines.
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PROGRESS IN ORGANIC COATINGS
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2026
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IF 7.3
Hao Zhang,Tong Liu,Duo Qi,Ming Wu,Fuxin Liang,Dawei Zhang,Na Wang
Although multifunctional superhydrophobic surfaces exhibit broad application prospects, their practical application is constrained by complicated preparation, environmental pollution, demanding equipment requirements, and poor durability. Herein, we developed a fluorine-free, ultrarobust superhydrophobic coating comprising zeolitic imidazolate framework-71 (ZIF-71)-assembled CaCO 3 microspheres and an epoxy/polydimethylsiloxane dual-network resin. This coating could be applied to various substrates, exhibiting a water contact angle of 154.5° ± 0.8° and water sliding angle of 5.4° ± 0.5°. It retained its superhydrophobic properties after severe mechanical stresses, such as those from tape peeling (300 cycles), sandpaper abrasion (12 m), high-velocity water jetting (42 L), and quartz sand impact (4.0 kg). This exceptional durability was attributed to the stable hierarchical microscale/nanoscale structure formed by ZIF-71 nanoparticles on the surface of CaCO 3 microspheres and enhanced interfacial adhesion due to the interconnected pore structure of the microspheres. Additionally, the coating exhibited strong resistance to harsh corrosive environments (pH 1–14, 3.5 wt% NaCl, and saturated NaCl solutions) as well as self-cleaning properties, which effectively prevented dirt accumulation. Electrochemical impedance spectroscopy in a 3.5 wt% NaCl solution confirmed the superior durability of the composite coating, showing an impedance modulus of 1.02 × 10 10 Ω·cm 2 . Icing delay and cyclic freeze–thaw tests confirmed that the coating could considerably delay ice nucleation by up to 458 s and maintain hydrophobicity after 25 freeze–thaw cycles.
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Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 2
·121436
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IF 7.2
Lei Ni,Yuanyuan Li,Qichao Wang,Juncheng Jiang,Zhiquan Chen,Luping Gu,Na Li,Dongxiao Zhang
The green synthesis of adipic acid is prone to thermal runaway because of unstable peroxide bonds and high exothermicity. In this work, phase change microcapsules (PCMs) were employed as inhibitors to mitigate the potential hazard of uncontrolled thermal behaviour at the source of the reaction. Two PCMs—octadecane/MF (melamine–formaldehyde) and paraffin/MF—were synthesised and characterised systematically. Moreover, the inhibition performance of the phase change capsules under different operating conditions was studied through calorimetric reactions combined with the differential variance (DIV) criterion. The addition of 6.74 wt% octadecane/MF PCMs at the 73 °C reaction stage optimally suppressed thermal runaway, resulting in a maximum reduction in DIV to 0.071, a decrease in heat release of 52.6 kJ and a reduction in the maximum temperature of 19.8 °C. Adding 4.04 wt% paraffin/MF PCMs resulted in a maximum reduction in DIV to 0.087, a decrease in heat release of 28.9 kJ and a reduction in the maximum temperature of 18.7 °C. The results demonstrated that the introduction of phase change microcapsules significantly suppressed the risk of thermal runaway during adipic acid synthesis. In particular, the inhibitory performance of the n-octadecane/MF microcapsules was positively correlated with the dosage within the scope of this study.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 11.3
Xuedong Du,Junjie Chen,Li Feng,Jun Zhao,Hexuan Deng,Ziye Wang,Jufeng Li,Yinan Song,Qingrui Zhang
Biomass-derived non-metallic electrocatalysis offers a sustainable strategy for pollutant degradation; however, its practical implementation is often hindered by unclear activation mechanisms, limited selectivity, and weak catalytic activity. In this study, we developed an innovative approach to transform common biomass waste into amyloid-like fibrils process (ANFs), thereby maximizing the electrocatalytic performance of metal-free manner. The distinctive ultra-high aspect ratio of ANFs facilitates extensive exposure of active sites, while abundant amino acid-derived N/O-doped defects synergistically enhance the three-electron oxygen reduction pathway, enabling efficient generation of reactive oxygen species. When applied to real high-salinity aquaculture wastewater containing tetracycline (TC), the resulting ANF-based catalysts (ANFCs) demonstrated outstanding degradation efficiency (>85 %) across a wide pH range (3–9), achieving a TC oxidation rate three times higher than that of conventional carbon cloth. The ANFCs delivered a catalytic performance of 22.0 g TC g −1 catalyst A −1 h −1 , on par with many metal-based catalysts. Furthermore, compared to traditional electro-Fenton systems, the ANFC-enabled electro-assisted oxidation processes (ANFC-EAOPs) supported continuous treatment of marine aquaculture wastewater while reducing sludge generation by 90 %. A comprehensive life cycle assessment confirmed the system scalability and environmental sustainability, underscoring its potential as a robust, versatile, and metal-free solution for advanced wastewater treatment and diverse application.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Yiqin Chen,Xinyu Liu,Wan Zhu,Zi Wang,Jiaxin Wu,Zixin Ni,Hongjing Pan,Danqiu Li,Yuefei Wang,Jihong Zhou
Roasting is a pivotal step in Longjing tea processing that shapes its sensory quality, yet the molecular basis of the characteristic roasted aroma remains underexplored. In this study, we systematically investigated the impact of roasting durations (10–30 min) and temperatures (210–230 °C) on the sensory attributes, biochemical composition, and volatile organic compounds (VOCs) of Longjing tea, while elucidating aroma perception through molecular docking. Sensory evaluation revealed enhanced “roasted” and “burnt” notes, alongside increased astringency and bitterness, with intensified roasting treatment. These sensory shifts coincided with substantial degradation of umami-related free amino acids and soluble sugars, as well as oxidation and epimerization of catechins. Using headspace solid-phase microextraction-gas chromatography–mass spectrometry (HS-SPME-GC–MS/MS), we identified 1286 VOCs. Heterocyclic compounds, particularly pyrazines, were markedly enriched and closely correlated with the roasted aroma. Relative odor activity value (ROAV) analysis pinpointed 27 key aroma-active compounds, including 2-ethyl-3,5-dimethylpyrazine, 2,3-diethyl-5-methylpyrazine, 2,3,5-trimethyl-6-ethylpyrazine, 2-methoxy-3,5-dimethylpyrazine, and 2,6-diethylpyrazine. Molecular docking simulations further demonstrated that pyrazines bind stably to olfactory receptors OR1A1 and OR1D2, primarily through cooperative hydrophobic, hydrogen-bonding, and π–π stacking interactions. These findings elucidate the molecular basis of the roasted aroma in Longjing tea and provide scientific guidance for optimizing the roasting process.
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EUROPEAN POLYMER JOURNAL
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2026
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IF 6.3
Nan Li,Tao Liu,Xiangrong Shi,Xiangtao Yu,Bo Jiang
Despite significant efforts in developing high-performance epoxy adhesives, an inevitable trade-off persisted among strong adhesion, high toughness and reprocessability. Here, an epoxy adhesive with high toughness and reprocessability was developed through microphase separation and dynamic chemical structure, effectively addressing the aforementioned challenge. Specifically, the asynchronous ring-opening reactions of aromatic amines and aliphatic amines with epoxy groups resulted in the formation of a phase-separated microstructure in the cured epoxy resin, thereby endowing it with high toughness. Furthermore, the dynamic chemical structure, realized through B-N coordination and dynamic bond exchange of borate esters, enabled epoxy adhesives to have decent environmental stability and reprocessability. Therefore, the acquired epoxy adhesives exhibited superior toughness with a work of debonding of 32927.77 N/m, high adhesive strength of 24.87 MPa, decent environmental resistance (water, extreme temperatures and various solvents) and reprocessability. This strategy of incorporating microphase separation and dynamic chemical structure is expected to provide novel insights into the design of high-performance epoxy adhesives and to facilitate advancements in sustainable polymer materials.
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Frontiers in Plant Science
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2026
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IF 4.8
Zhiheng Feng,Peijun Li,Guang Yang,Yining Wang,Mengqi Li,Jiangting Wu,Nan Chao,Li Liu
Proanthocyanidins (PAs), polymers of flavan-3-ols, are crucial for the sensory quality and stress defense of mulberry (Morus spp.). The biosynthesis of their monomers, catechin and epicatechin, are catalyzed by leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR), respectively, representing key rate-limiting steps that determine PA composition and abundance. In this study, systematic functional analyses including phylogenetic analysis, quantified spatio-temporal expression profiles during fruit development (S1-S4 stages), in vitro enzymatic assay, knock-down using Virus-Induced Gene Silencing (VIGS) in mulberry leaves and heterologous overexpression in Arabidopsis thaliana were conducted to reveal their roles in proanthocyanidin biosynthesis in mulberry. Results showed that MaLAR (969 bp) and MaANR (1014 bp) were successfully cloned and phylogenetically conserved. Spatio-temporal expression analysis revealed distinct patterns: MaLAR expression continuously increased, reaching highest expression level at the fully ripe stage (S4), whereas MaANR showed highest expression level at the color-turning stage (S2). In vitro enzymatic assays confirmed that MaLAR catalyzed the formation of catechin from leucoanthocyanidin, and MaANR catalyzed the formation of epicatechin from anthocyanidin. VIGS-mediated silencing of either gene in mulberry leaves led to significant reduction in total PA content. Conversely, heterologous overexpression of MaLAR or MaANR in Arabidopsis resulted in significant increase of PA in the seed coat. Our findings confirm that MaLAR and MaANR are conserved, key positive regulators of PA biosynthesis in mulberry. The differential expression patterns during fruit ripening suggest they play distinct, temporally regulated roles in determining the final PA composition and content. These results provide an important theoretical basis and represent important targets for the metabolic engineering and molecular breeding of mulberry for improved fruit quality.
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CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 13.2
Mengyuan Pu,Changqing Fang,Xing Zhou,Xupeng Wang,Mannan Yang,Jian Su,Xinyao Tang,Yuerong Chen,Yijiang Shang
Polyurethane (PU) adhesives hold significant promise for interfacial applications due to their tunable soft-hard segment design. However, the sustainability of conventional PU adhesives is constrained by their reliance on petroleum-derived feedstock, while their adhesion strength is significantly undermined in humid or underwater environments due to competitive interfacial water. Herein, we report a two-step strategy that integrates the glycolysis of waste polyethylene terephthalate (PET) with bio-inspired dopamine grafting to fabricate a catechol-functionalized polyurethane adhesive with robust and repeatable wet adhesion. Waste PET was first glycolyzed and the product was purified via silica gel column chromatography. The resulting glycolytic liquid product (GLP) was employed as a chain extender. Dopamine was then grafted onto the PET-based polyurethane backbone to introduce catechol functionalities, yielding a dopamine-grafted adhesive (C-GPUD). The catechol groups not only interact with urethane groups via hydrogen bonding but also undergo conformational adaptation, oxidative cross-linking, and metal chelation. These synergistic effects collectively enhance both the cohesive strength and the interfacial bonding. The optimized C-GPUD 10 adhesive exhibited rapid and robust adhesion on various substrates in underwater scenarios. It demonstrated excellent repeatable adhesion in tap water, retaining a lap shear strength of 0.21 MPa after ten peeling cycles, which corresponds to 45.7% retention of the initial strength. This outstanding performance enables C-GPUD to effectively seal liquid and gas leaks, demonstrating considerable potential for applications in emergency sealing and underwater repair.
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INORGANIC CHEMISTRY COMMUNICATIONS
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2026
·
IF 5.4
Mei Wang,Shan Mou,Xiaofang Tian,Meijie Xie,Xinyu Luo,Pei Zhang,Yingjuan Wang,Boyan Zheng,Qingqing Zou,Qianchun Zhang
Sunset yellow (SY) is a widely used artificial food coloring that can pose health risks when consumed in excess. In this study, a fluorescent sensor for the quantitative analysis of SY content in complex foods was reported. Using ammonium fluoride and sorbic acid as precursors, fluorine-doped carbon quantum dots (F-CDs) were synthesized via solvothermal method. The prepared F-CDs were characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). The results revealed that F-CDs had a uniform morphology and fluorine-rich structure, with an average particle size of 2.15 nm. In addition, we found that F-CDs exhibited excellent selectivity for SY, mainly due to the fluorescence quenching effect of SY on F-CDs. Therefore, a fluorescent sensor based on F-CDs was constructed with a linear detection range of 0.010–75 μM ( R 2 = 0.997) and a detection limit of 30 nM. The sensor's practical applicability was demonstrated by analyzing of SY in hard candy, tangerine peel sugar, peach jelly, beer, and bread, with recoveries of 92.1%–115% and RSDs of 1.0–4.8%. What's more, the fluorescence detection results were closely related to the HPLC-DAD validation results (relative deviation ≤0.17), highlighting the accuracy of the method. F-CD-based fluorescence detection platforms offer the advantages of simplicity, sensitivity, and reliability, providing a promising tool for routine SY monitoring in food safety applications.
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