LANGMUIR
·
2018
·
IF 3.789
Xiangyu Ge,Jinjin Li,Chenhui Zhang,Zhongnan Wang,Jianbin Luo
The robust liquid superlubricity of a room-temperature ionic liquid induced by tribochemical reactions is explored in this study. Here, 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM]TFS) could realize stable superlubricity (μ < 0.01) with water at the interfaces of Si3N4/SiO2. A superlow and steady friction coefficient of 0.002–0.004 could be achieved under neutral conditions (pH of 6.9 ± 0.1) after 600 s of running-in process. Various factors that could affect superlubricity were explored, including concentration of [EMIM]TFS, sliding speed, applied load, and volume of the lubricant. The results reveal that superlubricity can be achieved with [EMIM]TFS aqueous solution under a broad scope of conditions. The results of surface analysis show that a steady composite tribochemical layer comprising [EMIM]TFS, silica, ammonia-containing compounds, and sulfides was formed by tribochemical reactions between [EMIM]TFS and Si3N4 during the running-in period. The film thickness calculation reveals that the achieved superlubricity is in a mixed lubrication regime that comprises boundary lubrication and thin film lubrication. The superlubricity state is governed by a firm composite tribochemical layer, a molecular adsorption layer (electric double layer of [EMIM]TFS), and a fluid layer. The liquid superlubricity achieved by the ionic liquid is helpful for the development of new ionic liquids with superlubricity characteristics and is of great significance for scientific understanding as well as engineering applications.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
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IF 5.7
Tong Zhou,Meigui Huang,Heping Cui,Shahzad Hussain,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The formation pathway and mechanism of various pyrazines were investigated during the thermal treatment of the alanine-xylose Amadori compound (Ala-ARP) and exogenous alanine (Ala). 15N-labeled Ala was used to coheated with Ala-ARP to clarify the nitrogen sources and the respective contributions of exogenous Ala and the regenerated Ala released from Ala-ARP to different pyrazine formation. It was found that exogenous Ala exhibited a priority in capturing glyoxal (GO) to form pyrazine during the thermal degradation of ARP. Compared to the Ala-methylglyoxal (MGO) model, a lower activation energy was required for the Ala-GO reaction, where the reaction dynamics of Ala-GO followed a zero-order model. In addition to forming pyrazine, the interaction between existing exogenous Ala and GO would accelerate the thermal degradation of Ala-ARP and retro-aldolization reaction of deoxyxylosones (DXs) to α-dicarbonyls. During this process, the release of regenerated Ala and MGO was promoted. Accordingly, as GO was expended by exogenous Ala during the initial stage of ARP-Ala degradation, the condensation between regenerated Ala and MGO became intensified, leading to the generation of methylpyrazine and 2,5-dimethylpyrazine. As a result, in the thermally treated mixture of Ala-ARP and exogenous Ala, 55% of the formed pyrazine originated from exogenous Ala, while 63% of the formed methylpyrazine and 57% of the formed 2,5-dimethylpyrazine were derived from regenerated Ala (120 °C, 30 min).
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高影响因子
JOURNAL OF ANALYTICAL CHEMISTRY
·
2025
·Vol. 80
·期 4
·718-730
·
IF 1.1
Jin Biao,Jin Zhiyin,Jin Dongri
(S)-2,5-Dioxypyrrolidine-1-yl-(5-(4-methylpiperazin-1-yl)-2,4-dinitrophenyl) pyrrolidine-2-carboxylate ( PPZ-Pro-NHS ) was used as the reagent for chiral derivatization to distinguish between amino acid enantiomers. PPZ-Pro-NHS, synthesized from (S)-1-(5-(4-methylpiperazin-1-yl)-2,4-dinitrophenyl) pyrrolidine-2-carboxylic acid, reacted with chiral amines under mild conditions to yield the corresponding organic derivatives. The optimal conditions for derivatization using PPZ-Pro-NHS were 25°C and 40 min in a medium containing triethylamine. A simple liquid chromatography–mass spectrometry ( LC − MS ) method was developed to separate chiral amino acids using reversed-phase chromatography. The amino acids were separated by isocratic or gradient elution on a Mightysil RP-18 GP column with a mobile phase containing H 2 O, methanol, and 0.1% (v/v) formic acid. The enantiomers of the amino acids were fully separated with high resolution ( Rs = 1.20–5.30) and high sensitivity (limit of detection: 85–4546 fmol) using PPZ-Pro-NHS derivatization and LC–MS analysis with both isocratic and gradient elution. The enantiomers of 16 amino acid mixtures were simultaneously separated in a single chromatographic run using a gradient mobile phase system. Thus, PPz-Pro-NHS can be used for chiral amine screening and authentication.
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ACS Applied Materials & Interfaces
·
2016
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IF 7.145
Bo Yuan,Xiao-Qian Yin,Xiao-Qin Liu,Xing-Yang Li,Lin-Bing Sun
Much attention has been paid to metal–organic frameworks (MOFs) due to their large surface areas, tunable functionality, and diverse structure. Nevertheless, most reported MOFs show poor hydrothermal stability, which seriously hinders their applications. Here a strategy is adopted to tailor the properties of MOFs by means of incorporating carboxyl-functionalized natural clay attapulgite (ATP) into HKUST-1, a well-known MOF. A new type of hybrid material was thus fabricated from the hybridization of HKUST-1 and ATP. Our results indicated that the hydrothermal stability of the MOFs as well as the catalytic performance was apparently improved. The frameworks of HKUST-1 were severely destroyed after hydrothermal treatment (hot water vapor, 60 °C), while that of the hybrid materials was maintained. For the hybrid materials containing 8.4 wt % of ATP, the surface area reached 1302 m2·g–1 and was even higher than that of pristine HKUST-1 (1245 m2·g–1). In the ring-opening of styrene oxide, the conversion reached 98.9% at only 20 min under catalysis from the hybrid material, which was obviously higher than that over pristine HKUST-1 (80.9%). Moreover, the hybrid materials showed excellent reusability and the catalytic activity was recoverable without loss after six cycles. Our materials provide promising candidates for heterogeneous catalysis owing to the good catalytic activity and reusability.
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高影响因子
RESPIRATORY RESEARCH
·
2026
·
IF 5.7
Zhou Weitao,Dai Dan,Chen Yao,Han Xiao,Dong Xinran,Liao Yunfei,Chen Tong,Wang Huixian,He Chen,Lu Yilei,Zheng Chenxin,Zhou Yufeng,Qian Liling
Biallelic isoleucyl-tRNA synthetase 1 ( IARS1 ) variants are associated with an IARS1 -related phenotype characterized by growth retardation, intellectual disability, muscular hypotonia, infantile hepatopathy, and interstitial lung disease. This rare, early-onset disorder is often lethal. Although several variants have been identified in recent years, their pathogenicity and underlying molecular mechanisms remain poorly understood. In this study, we generated Iars1 Y148C/R444* compound heterozygous mice, which exhibited pulmonary alveolar proteinosis - like lesions, growth retardation, and muscular hypotonia. Lipid metabolomic profiling of these mice revealed dysregulation of cholesterol metabolism pathways. Furthermore, the Iars1 mutation increased surfactant deposition in alveolar macrophages by impairing lysosomal degradation and disrupting lysosome-autophagosome fusion. We also found that partial loss of IARS1 activity interfered with the post-translational processing of cathepsin Z by inhibiting its ubiquitin-mediated degradation. Importantly, exogenous expression of cathepsin Z improved surfactant clearance in macrophages with partial loss of Iars1 activity. Collectively, our findings demonstrate that partial loss of IARS1 activity induces lysosomal dysfunction in alveolar macrophages and promotes pulmonary surfactant accumulation in the alveoli, thereby contributing to the development of pulmonary alveolar proteinosis.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2026
·
IF 4.4
Mingrui Zhang,Lulu Yan,Guangyao Ma,Ming Zhang,Zicheng Chen
Modified g-C 3 N 4 /HKUST-1/diatomite composite is rationally fabricated. • CN x , HKUST-1 and diatomite synergistically enhance adsorption and photocatalytic oxidation. • Light-induced ·O 2 − and ·OH participate in oxidation of formaldehyde. Effective removal of indoor formaldehyde (HCHO) is critical for improving indoor air quality and protecting human health. In this study, a ternary composite material CN x @DH-4 was constructed by rationally combining K-doped modified carbon nitride (CN x ), diatomite, and HKUST-1. This combination integrates adsorption enrichment with visible light-driven photocatalytic degradation. Structural and surface characterization analyses confirmed the uniform dispersion of CN x and HKUST-1 on the diatomite carrier, while XPS revealed the interface electronic interactions, which regulated the electronic structure. Owing to the optimized CN x loading, extended visible-light absorption, and abundant nitrogen vacancy sites acting as active centers, CN x @DH-4 achieved a HCHO removal efficiency of 83.34%. EPR measurements confirmed the light-induced generation of ·O 2 − and ·OH radicals, suggesting that reactive oxygen species play an important role in HCHO oxidation. CN x @DH-4 maintained its optical and structural stability during 10 cycles and exhibited excellent durability. This study provides a practical strategy for designing multifunctional adsorption-type photocatalysts, where the adsorption sites, defect engineering, and structural stability interact synergistically to achieve continuous and efficient indoor HCHO purification. Download: Download high-res image (184KB) Download: Download full-size image
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FUEL
·
2026
·
IF 7.8
Qianqian Chen,Subing Fan,Junmin Lv,Tiansheng Zhao
The purpose of the olefin hydroformylation-hydrogenation tandem reaction for alcohol synthesis is to design a highly efficient and stable heterogeneous catalyst. In this study, a novel heterogeneous magnetic nanoparticle-supported rhodium-cobalt bimetallic core–shell catalyst was prepared, which exhibits excellent synergistic catalytic performance and enables a one-step alcohol synthesis process. The magnetic support Fe 3 O 4 allows for rapid separation of the catalyst from reaction products under an external magnetic field. The 7.5Co0.5Rh/Fe 3 O 4 @SiO 2 magnetic core–shell catalyst was successfully prepared by loading active metals via a one-pot impregnation method and performing silica coating using the Stöber method. It shows outstanding olefin conversion (99.71%) and alcohol selectivity (91.17%). The effect of preparation conditions, process conditions, and the universality of substrates were investigated in detail. The catalyst was reused 5 times, and the performance differences between the core–shell catalyst and the traditional impregnated catalyst with the same support, as well as the differences in metal leaching during the reaction, were compared. In addition, the catalyst could participate in the reaction directly without prior reduction, avoiding the additional costs associated with subsequent reduction steps.
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JOURNAL OF FOOD SCIENCE
·
2026
·Vol. 91
·期 2
·e70878
·
IF 3.4
Naijun Dong,Nasha Wu,Shu Huang,Yuesheng Dong,Zhilong Xiu
Type 2 diabetes mellitus (T2DM), one of the most rapidly growing metabolic disorders globally, poses a substantial public health burden. In this study, a novel edible eutectogel was innovatively developed for the co-delivery of natural active ingredients, baicalein (Bai), and 1-deoxynojirimycin (DNJ). Utilizing a deep eutectic solvent (DES) system, the hydrophobic Bai and hydrophilic DNJ were co-dissolved and encapsulated within the eutectogel (Bai-DNJ/EG), enabling gastric protection and targeted intestinal release. Animal experimental demonstrated that the Bai-DNJ/EG significantly ameliorated multiple pathological features, including blood glucose reduction, improved insulin sensitivity, attenuated systemic inflammation, decreased fat accumulation, and mitigated organ damage. Compared with Bai/EG and DNJ/EG, Bai-DNJ/EG exhibited superior therapeutic efficacy across all parameters, indicating a synergistic effect between the Bai and DNJ. The dose of Bai in Bai-DNJ/EG was reduced by 50% relative to previous studies, and DNJ was 7.5 times less than that of clinical use in a Chinese herbal preparation for lowering blood glucose. In addition, comparison of lipid metabolism and inflammatory factors between Bai HG and Bai/EG groups indicated that DES enhanced the pharmacological activity of Bai by improving its solubility. Furthermore, 16S rRNA sequencing revealed that Bai-DNJ/EG positively regulates gut microbiota homeostasis and repairs the intestinal barrier. Bai-DNJ/EG inhibited deleterious bacteria including Methanobacteriaceae, Pseudomonadota , Campylobacterota , and Spirochaetota , while promoted the SCFA-producing bacteria, for example, Muribaculaceae and Butyricicoccaceae. This study presents a groundbreaking strategy for the synergistic delivery of natural bioactives and establishes a new paradigm for modernized traditional natural medicine formulations.
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高影响因子
CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Sandeep Karki,Sahil Malhotra,Muhammad Ijaz,Nicolas Rollet,Eoin D. O'Cearbhaill,Estela Bini,David J. Brayden
The buccal route has re-emerged as an alternative non-injectable route for peptide delivery. However, buccal peptide bioavailability is low, necessitating new formulation strategies. Pullulan, a water-soluble carbohydrate polymer, offers potential as a film-forming agent for buccal peptide delivery. Our aim was to co-administer a glucagon-like peptide-1 receptor agonist (GLP-1 RA) model analogue with an epithelial permeation enhancer, sodium glycodeoxycholate (GDC) in a bilayer film using a pullulan-based mucoadhesive layer. A pullulan–carboxymethyl cellulose mucoadhesive layer was selected, along with a backing layer made from an ammonio-methacrylate copolymer (Eudragit® RLPO). Physicochemical characterization confirmed the suitability of the pullulan-based film for buccal application. A Hilltop Chamber comprising an adhesive-backed cotton pad identified an optimal GLP-1 RA:GDC ratio for peptide permeation across ex vivo porcine buccal mucosae. 200 mM GDC (94.4 mg/mL) enabled ∼6% flux at 3 h using a donor concentration of 50 mg/mL GLP-1 RA (∼1:2). When these concentrations were incorporated into the prototype pullulan films, GLP-1 RA fluxes across mucosae reached ∼4.5% and ∼2% at 3 h for single mucoadhesive-layer and bilayer films, respectively, without overt tissue damage. Integrating GLP-1 RA and GDC into a pullulan–based bilayer film offers a promising carbohydrate polymer platform for enhancing buccal peptide delivery.
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BIOORGANIC CHEMISTRY
·
2026
·
IF 5.1
Yinghao Huang,Chentao Ding,Shaowei Wang,Shufang Qi,He Zhu,Yiyan Wang,Ren-shan Ge,Yi Liu,Jing Cheng
Biocide disinfectants are essential chemicals in infection control, but their use may cause adverse effects by inhibiting neurosteroid biosynthesis. In the current study we systematically examine the inhibitory effect of the biocide benzalkonium chloride (BAC), which is widely used for surface disinfection and as preservative in many consumer products, on human and rat 5α-reductase 1 (5α-R1) activity. The effects of BAC component (C1-C18) on brain 5α-R1 were investigated using HPLC-MS/MS measurement of steroid substrate testosterone and product dihydrotestosterone for enzyme inhibition screening assay and kinetics analysis, surface plasmon resonance (SPR) binding, intact cells, in silico docking and molecular dynamic simulations as well as structure-activity relationship (SAR)/3D-QSAR modeling. BAC component inhibited both human and rat 5α-R1, depending on alkyl chain length, with C10 + components exhibiting significant activity. C18 component emerged as the most potent inhibitor (IC₅₀ = 9.54 μM for human 5α-R1; 34.36 μM for rat 5α-R1). SPR assay showed that C18 had a high affinity binding with KD of 6.42 μM with a relatively slow dissociation rate, indicating stable target engagement once bound. Mechanistic studies identified mixed/noncompetitive inhibition of 5α-R1 by BAC components by competing with NADPH (SPR assay). In intact SF126 cells, C12-C18 components suppressed 5α-dihydrotestosterone formation at 10–100 μM. Pearson correlation analysis linked inhibitory strength to structural parameters (LogP, molecular weight, alkyl carbon count, heavy atoms, and rotatable bonds). A 3D-QSAR pharmacophore model highlighted hydrophobic interactions as critical for inhibition. Molecular docking further elucidated binding mechanisms, showing that BAC components occupy the NADPH-binding site via van der Waals forces, hydrogen bonds, hydrophobic contacts, and charge interactions. Our results suggest that BAC components have the potential to inhibit human and rat 5α-R1 activity and cause the neural disorders. These findings underscore BAC as potential endocrine disruptor by targeting neurosteroid biosynthesis, warranting further investigation into their neurotoxicological implications. This work was funded by the Zhejiang Nature and Science Foundation. The funders had no role in study design, interpretation or decision to publish.
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NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Qishan Chen,Hui Ding,Bo Zhu,Xu Li,Jinxiang Dong
The green and efficient epoxidation of long-chain linear α-olefins represents a crucial step in the synthesis of key industrial intermediates. Although the hydrogen peroxide/titanosilicate-1 (H2O2/TS-1) catalytic system is environmentally friendly, its broad industrial implementation has long been hindered by unsatisfactory epoxide selectivity and low H2O2 utilization efficiency, which limit large-scale and economical production. To overcome these limitations, a strategy employing tetrapropylammonium bromide (TPABr) as a crystallization modifier was developed to precisely engineer the active sites of TS-1 zeolites. By balancing the incorporation kinetics of titanium and silicon into the framework, uniform distribution of titanium species was achieved, accompanied by the enrichment of highly active Ti(OH)2(OH2)2(OSi)2 sites. The resulting TS-1-TPABr-40 catalyst delivered outstanding performance in the epoxidation of 1-hexene, exhibiting 97% epoxide selectivity, ∼76% effective H2O2 utilization, and good recyclability. These results highlighted how molecular-level coordination engineering in zeolite catalysts could simultaneously enhance catalytic efficiency and oxidant economy, providing a sustainable and scalable strategy for green chemical synthesis.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Yiwei Li,Xu Jiang,Chuntao Chen,Xiao Fu,Dongping Sun
The dense stromal barrier of pancreatic cancer (PC) severely limits chemotherapeutic efficacy. Although combination therapy is a standard clinical approach, it often exacerbates systemic toxicity. To address the dual challenges of localized drug delivery and immune activation, we developed an injectable, multifunctional hydrogel system for the synergistic codelivery of an anti-PD-1 antibody and chemotherapeutic agents (gemcitabine/albumin-bound paclitaxel). This system is based on a novel, fully natural-source composite material─methacrylated silk fibroin (SilMA) and methacrylated chitosan (CSMA). Its core innovations include: in situ gelation via a mild LAP-photoinitiation process preserves antibody bioactivity and bioactive degradation products derived from the natural polymers, which may help establish a favorable peritumoral microenvironment. In an orthotopic PC mouse model, a single peritumoral injection of this hydrogel (HLGP group) significantly enhanced tumor infiltration of CD8+ T cells, suppressed tumor growth, and outperformed all control groups, including the free-drug combination group. This study presents a unique, integrated local delivery strategy capable of simultaneously overcoming the stromal barrier, reducing systemic exposure and enhancing immunotherapy efficacy, thereby offering a promising translational pathway for the treatment of pancreatic cancer.
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