Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Chen Cai,Jiayin Chen,Wei Fu,Shuying Ning,Hao Zhou,Muhammad Kashif,Yaxin Su
The Ce-modified OMS-2 catalyst (Ce x -OMS-2) was synthesized by the hydrothermal synthesis method, after which its catalytic efficacy in the selective reduction of NO by CO was assessed. The experiments showed that Ce 0.08 -OMS-2 was capable of 100% NO conversion between 175 and 300 °C when 0.05%NO, 0.1%CO, 5%O 2 and N 2 were used as equilibrium gases, and the N 2 selectivity peaked at 93.2% at 175 °C. Additionally, Ce 0.08 -OMS-2 exhibits good sulfur resistance in the presence of 0.02% SO 2 and maintains more than 88% NO conversion at 175–275 °C. By using BET, XPS, H 2 -TPR, NH 3 -TPD, and In situ DRIFTS to characterize the catalysts, the effects of doping the active metal Ce on the physicochemical characteristics of OMS-2 catalysts were under investigation. In conclusion, the improvement of the low-temperature activity of the Ce x -OMS-2 catalyst is facilitated by lower agglomeration and crystallinity , larger specific surface area, smaller average pore size, enhanced surface oxygen vacancies, increased Mn 4+ concentration, and richer Brønsted acid. Reaction gas adsorbed species and intermediates on the catalyst surface were dynamically captured during In situ DRIFTS experiments. The CO-SCR reaction of the catalyst was found to follow the E-R mechanism below 200 ℃ and the L-H mechanism at 200–350 ℃.
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Scientific Reports
·
2022
·Vol. 12
·期 1
·1-13
·
IF 4.996
Wernroth Mona-Lisa,Peura Sari,Hedman Anna M.,Hetty Susanne,Vicenzi Silvia,Kennedy Beatrice,Fall Katja,Svennblad Bodil,Andolf Ellika,Pershagen Göran,Theorell-Haglöw Jenny,Nguyen Diem,Sayols-Baixeras Sergi,Dekkers Koen F.,Bertilsson Stefan,Almqvist Catarina,Dicksved Johan,Fall Tove
Although development of microbiota in childhood has been linked to chronic immune-related conditions, early childhood determinants of microbiota development have not been fully elucidated. We used 16S rRNA sequencing to analyse faecal and saliva samples from 83 children at four time-points during their first 2 years of life and from their mothers. Our findings confirm that gut microbiota in infants have low diversity and highlight that some properties are shared with the oral microbiota, although inter-individual differences are present. A considerable convergence in gut microbiota composition was noted across the first 2 years of life, towards a more diverse adult-like microbiota. Mode of delivery accounted for some of the inter-individual variation in early childhood, but with a pronounced attenuation over time. Our study extends previous research with further characterization of the major shift in gut microbiota composition during the first 2 years of life.
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MOLECULAR PHARMACEUTICS
·
2024
·
IF 4.5
Ningze Zheng,Shurui Liu,Jianheng Chen,Yue Xu,Wenyin Cao,Jinyi Lin,Guang Lu,Guigen Zhang
The development of biomolecule delivery systems is essential for the treatment of various diseases such as cancer, immunological diseases, and metabolic disorders. For the first time, we found that SARS-CoV-2-encoded nonstructural protein 2 (NSP2) can be secreted from the cells, where it is synthesized. Brefeldin A and H89, inhibitors of ER/Golgi secretion pathways, did not inhibit NSP2 secretion. NSP2 is likely secreted via an unconventional secretory pathway. Moreover, both secreted and purified NSP2 proteins were able to traverse the plasma membrane barrier and enter both immortalized human umbilical vein endothelial cells and tumor cell lines. After entry, the NSP2 protein was localized in only the cytoplasm. Cytochalasin D, a potent inhibitor of actin polymerization, inhibited the entry of NSP2. NSP2 can carry other molecules into cells. Burkholderia lethal factor 1, a monomeric toxin from the intracellular pathogen Burkholderia pseudomallei, has demonstrated antitumor activity by targeting host eukaryotic initiation translation factor 4A. An NSP2-BLF1 fusion protein was translocated across the cellular membranes of Huh7 cells and mediated cell killing. By using different approaches, including protein purification, chemical inhibition, and cell imaging, we confirm that NSP2 is able to deliver heterologous proteins into cells. NSP2 can act as a potential delivery vehicle for proteins.
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高影响因子
POLYMER TESTING
·
2021
·
IF 4.282
Haochuan Luo
An effective method to prepare crosslinked polybenzimidazole (PBI) via [2 + 3] Huisgen cycloadditions has been proposed. Propargyl modified PBI (PBI-PG) has been synthesized firstly. In the presence of diazido crosslinkers, PBI-PG can be thermally crosslinked by [2 + 3] Huisgen cycloadditions. Evidences from 1 H NMR and ATR spectra imply a small amount of grafting alkenyl structures on PBI-PG. The grafting alkenyl structures provide another crosslinking mechanism named as alkyne-alkene crosslink. The alkyne-alkene crosslink is highly efficient under heat to form crosslinking networks which display toughness, low tensile strengths, and large swelling ratios in phosphoric acid (PA) solutions. Influences of rigidities and chain lengths of crosslinkers on performances of crosslinked PBIs have been investigated. PBIs crosslinked by rigid crosslinkers behave as brittle materials while that crosslinked by flexible crosslinkers behave as tough materials. Addition of crosslinkers leads to decreased gel fractions but improved tensile strengths, which is attributed to competition results of crosslinking and plasticizing effects. PBI-R2-20, which is crosslinked by a long rigid crosslinker, exhibits the highest tensile strength of 102.33 MPa, which is 66.34 MPa higher than that of PBI-PG. With even lower PA uptakes, PBIs crosslinked by rigid crosslinkers display more thermally stable and higher conductivities than that crosslinked by flexible crosslinkers. After doping in 12 mol/L PA solution, PBI-R2-20, with an acid uptake of 163 wt%, displays the highest tensile strength of 8.1 MPa and the most thermally stable and the highest conductivity which reaches a maximum of 2.30 × 10 −2 S cm −1 at 188 °C among all crosslinked membranes.
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CHEMICAL PAPERS
·
2014
·Vol. 68
·期 8
·1132-1136
·
IF 1.193
Tao Hong-Wen,Wang Xia,Yi Ping-Gui,Deng Zhi-Hong,Yu Xian-Yong,Li Xiao-Fang
A class of stereo-isomerically-pure alkanediol monoglycosides, 2-hydroxyethyl per- O -acetyl pyranosides ( IIIa-IIIf ), was conveniently prepared by a one-pot reaction of per- O -acetylated pyranoses ( Ia-If ) and 2-( tert -butyldimethylsilyloxy)ethanol ( II ) with catalysis by BF 3 ·OEt 2 . The α -( IIIa ) or β -linked glycosides ( IIIb-IIIf ) with 1,2- trans -configuration were obtained from glycosyl donors with participation of the neighbouring 2- O -acetyl group. BF 3 ·OEt 2 , along with hydrogen fluoride released from BF 3 ·OEt 2 under the experimental conditions used, facilitates the subsequent de-protection of siloxane to successfully afford 2-hydroxyethyl per- O -acetyl-pyranosides.
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Chemistry-An Asian Journal
·
2017
·Vol. 12
·期 17
·2304-2310
·
IF 4.083
Wei Su,Kui Zhou,Fanglin Cai,Cheng Chen,Bibimaryam Mousavi,Somboon Chaemchuen,Francis Verpoort
Graphical Coordination configuration matters : A Ru dimer, [Ru(NC NHC O)(pic) 2 ] 2 2+ ( 2 ), which transforms to two single-site Ru-OH 2 species to initiate water oxidation, was prepared and fully characterized. Complex 2 could catalyze water oxidation electrochemically, chemically and photochemically, exhibiting an excellent reactivity and stability. A dinuclear ruthenium complex [Ru II (NC NHC O)(pic) 2 ] 2 2+ ( 2 ) was firstly prepared and characterized spectroscopically and electrochemically. Instead of the conventional ligand exchange, complex 2 dissociates in situ to afford two single-site Ru aqua complexes, [Ru II (OH 2 )(NC NHC O)(pic) 2 ] + , which mediates water oxidation through proton-coupled electron transfer events. In electrokinetic studies, complex 2 demonstrated a TOF of 150.3 s −1 comparable to those state-of-the-art catalysts at neutral conditions. TONs of 2173 and 217 were attained in chemical and photochemical water oxidation when 2 was used as a catalyst, exhibiting good stability. Notably, a TOF of 1.3 s −1 was achieved at CAN-driven water oxidation, which outperformed most of the reported single-site Ru complexes, indicating that complex 2 is one of most active water oxidation catalysts (WOCs) to date. The unique coordination configuration and outstanding catalytic performance of complex 2 might shed light on the design of novel molecular WOCs.
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PLoS One
·
2018
·Vol. 13
·期 10
·e0204324
·
IF 2.766
Fangfang Li,Yidan Liu,Diwei Wang,Chaosheng Zhang,Zhihui Yang,Siqi Lu,Yangyang Wang
A halotolerant bacterial consortium capable of degrading di-(2-ethylhexyl) phthalate (DEHP) was enriched from activated sludge. Community analysis revealed that LF contained seven families and seven genera of bacteria. The predominant species was Gordonia sp. (54.93%), Rhodococcus . sp. (9.92%) and Achromobacter sp. (8.47%). The consortium could degrade 93.84% of 1000 mg/l DEHP after 48 h incubation. The optimal temperature and pH for LF to degrade DEHP were 30 °C and 6.0, respectively. LF degraded more than 91% of DEHP with salt concentrations ranging from 0–3%. The inoculum size had great effects on DEHP degradation (incubation time < 24h). LF could degrade high concentrations of DEHP (from 100 to 2000 mg/l) with the degradation ratio above 92% after 72 h incubation. Kinetics analysis revealed that the degradation of DEHP by LF was best fitted by the first-order kinetics when the initial concentration ranged from 100 to 2000 mg/l. The main intermediates (2-ethylhexyl pentyl phthalate, butyl (2-ethylhexyl) phthalate (BEHP), mono-ethylhexyl phthalate (MEHP), mono-hexyl phthalate (MHP), mono-butyl phthalate (MBP)) in DEHP degradation process were identified using gas chromatography–mass spectrometry (GC-MS), and a new complex biochemical pathway was proposed. Furthermore, LF could also degrade dimethyl phthalate (DMP), diethyl phthalate (DEP), di- n -butyl phthalate (DBP), di- n -octyl phthalate (DOP) and phthalic acid (PA).
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2017
·
IF 3.791
Luqing Ren,Jianjian Tao,Huaicheng Chen,Yang Bian,Xi Yang,Gaozhi Chen,Xin Zhang,Guang Liang,Wencan Wu,Zongming Song,Yi Wang
Retinal ischemia-reperfusion (I/R) injury is a common pathological process in many eye disorders. Oxidative stress and inflammation play a role in retinal I/R injury. Recent studies show that toll-like receptor 4 (TLR4) is involved in initiating sterile inflammatory response in retinal I/R. However, the molecular mechanism by which TLR4 is activated is not known. In this study, we show that retinal I/R injury involves a co-receptor of TLR4, myeloid differentiation 2 (MD2). Inhibition of MD2 prevented cell death and preserved retinal function following retinal I/R injury. We confirmed these findings using MD2 knockout mice . Furthermore, we utilized human retinal pigment epithelial cells (ARPE-19 cells) to show that oxidative stress-induced cell death as well as inflammatory response are mediated through MD2. Inhibition of MD2 through a chemical inhibitor or knockdown prevented oxidative stress-induced cell death and expression of inflammatory cytokines. Oxidative stress was found to activate TLR4 in a MD2-dependent manner via increasing the expression of high mobility group box 1. In summary, our study shows that oxidative stress in retinal I/R injury can activate TLR4 signaling via MD2, resulting in induction of inflammatory genes and retinal damage . MD2 may represent an attractive therapeutic target for retinal I/R injury.
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MOLECULES
·
2024
·Vol. 29
·期 8
·1721
·
IF 4.2
Shoudong Wang,Lei Zhou,Hongyun Qin,Zixu Dong,Haoyuan Li,Bo Liu,Zhilu Wang,Lina Zhang,Qiang Fu,Xia Chen
Hydrofluorocarbons (HFCs) have important applications in different industries; however, they are environmentally unfriendly due to their high global warming potential (GWP). Hence, reclamation of used hydrofluorocarbons via energy-efficient adsorption-based separation will greatly contribute to reducing their impact on the environment. In particular, the separation of azeotropic refrigerants remains challenging, such as typical mixtures of CH2F2(HFC-23) and CHF3(HFC-32), due to a lack of adsorptive mechanisms. Metal–organic frameworks (MOFs) can provide a promising solution for the separation of CHF3–CH2F2mixtures. In this study, the adsorption mechanism of CHF3–CH2F2mixtures in TIFSIX-2-Cu-i was revealed at the microscopic level by combining static pure-component adsorption experiments, molecular simulations, and density-functional theory (DFT) calculations. The adsorption separation selectivity of CH2F2/CHF3in TIFSIX-2-Cu-i is 3.17 at 3 bar under 308 K. The existence of similar TiF62−binding sites for CH2F2or CHF3was revealed in TIFSIX-2-Cu-i. Interactions between the fluorine atom of the framework and the hydrogen atom of the guest molecule were found to be responsible for determining the high adsorption separation selectivity of CH2F2/CHF3. This exploration is important for the design of highly selective adsorbents for the separation of azeotropic refrigerants.
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高影响因子
Advanced Optical Materials
·
2024
·
IF 8
Muhammad Arif,Xu Liu,Zijian Li,Hangwei Jia,Yansheng Jiang,Zhihua Yang,Xueling Hou,Shilie Pan
Salts and co-crystals composed of planar π -conjugated functional units represent a fascinating class of materials, featuring both enlarged birefringence and a strong SHG effect. Herein, the optical properties of π -conjugated (C 4 H 7 N 3 ) 2+ functional unit within 2-aminopyrimidine (2-AP) family are investigated for the first time. Furthermore, twelve novel compounds are successfully synthesized by applying four different strategies. In these strategies, (C 4 H 7 N 3 ) 2+ , (C 4 H 6 N 3 ) + , and (C 4 H 5 N 3 ) functional units are introduced into the crystal structure, both solely and in combination, to analyze the alteration in birefringence. Remarkably, a birefringence rule with (C 4 H 7 N 3 ) 2+ < (C 4 H 6 N 3 ) + < (C 4 H 5 N 3 ), stating that an increase in net charge over π -conjugated functional unit leads to a reduced birefringence, is discovered. Consequently, the inclusion of a charge-neutral (C 4 H 5 N 3 ) functional unit within the crystal structure along with coplanar arrangement is a promising approach to enhance birefringence. Furthermore, D-2 [(C 4 H 5 N 3 )(H 3 C 3 N 3 O 3 )] realizes Δn calc = 0.412 maximum in the (2-AP) family. Notably, both A-1 [(C 4 H 7 N 3 )(CF 3 SO 3 ) 2 ] and B-1 [(C 4 H 6 N 3 ) 2 (IO 3 ) 2 (H 2 O)] crystalize in the non-centrosymmetric space groups, with B-1 exhibiting SHG efficiency of ≈1.4 × KDP @ 1064 nm, with the shortest λ PM at 384 nm. This work provides new insight into discovering novel birefringent and non-linear optical materials with high performances in the wide chemical space.
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IEEE SENSORS JOURNAL
·
2024
·
IF 4.3
Yunjie Cao,Xijie Feng,Wenbo Sui,Yufei Shi,Zihan Xie,Xinyan Xian,Jun Wu,Jun Zhou,Jie Dong,Changyu Shen
Mercury is a toxic heavy metal that can easily cause serious harm to human health and the environment. To quickly and sensitively measure the concentration of mercury ions (Hg
2+
), a fiber optic sensor based on Polyacrylamide/2-Thiophenecarboxaldehyde(PAM-TH)-functionalized Mach-Zehnder interferometer (MZI) is proposed and demonstrated experimentally. The prepared modified polyacrylamide and 2-Thiophenecarboxaldehyde are combined by Schiff base reaction to form a three-dimensional network hydrogel with specific binding properties for Hg
2+
. The ultra-sensitive Hg
2+
detection is realized by coating hydrogel on the surface of highly sensitive MZI based on polarization maintaining photonic crystal fiber. The experimental results verify a limit of detection of approximately 0.87 fM, which is two orders better than that of the reported fiber-based Hg
2+
sensors. Through the desorption of mercury ions in the sensor film by ethylenediaminetetraacetic acid (EDTA), the proposed sensor demonstrates good reusability under a wide dynamic detection range from 0.01 pM to 10 nM.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 49
·2305359
·
IF 19
Ke Su,Lefu Mei,Qingfeng Guo,Pengfei Shuai,Yujia Wang,Yukun Liu,Yang Jin,Zhijian Peng,Bo Zou,Libing Liao
Optical manometry is a highly promising method for measuring pressure. However, its wider application is limited by the lower sensitivity and influenced by environmental factors. Herein, multi-mode optical pressure sensors based on Eu 2+ -doped Li 4 SrCa(SiO 4 ) 2 phosphors suitable for a variety of complex pressure-measuring environments are designed. The phosphors contain two separate luminescence centers at 443 nm (Eu Sr ) and 584 nm (Eu Ca ), respectively. In the lower pressure range, the emission peak undergoes a massive redshift of 5.19 nm GPa −1 of Eu Ca , which is 14× better than commercially available ruby sensors. In order to improve the pressure response range and the accuracy of pressure measurement, for the first time, a new approach in the pressure readout method in which single Eu 2+ ions doping based on fluorescence intensity ratio (FIR) pressure measurement is realized in designed materials. Meanwhile, the measured full width at half maximum (FWHM) as an indicator of pressure sensor performance also reveals that the sensing performance is d FWHM /d P ≈ 1.23 nm GPa −1 and d FWHM /d P ≈ 0.84 nm GPa −1 for Eu Sr and Eu Ca positions, respectively. Additionally, the structural stability of the phosphor is confirmed by in situ Raman spectrum. The above results indicate that the Li 4 SrCa(SiO 4 ) 2 :0.04Eu 2+ phosphor is a good candidate for multi-mode optical pressure sensors.
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