MOLECULES
·
2022
·Vol. 27
·期 15
·5035
·
IF 4.927
Fengmao An,Xinran Xuan,Zheng Liu,Ming Bian,Qingkun Shen,Zheshan Quan,Guowei Zhang,Chengxi Wei
Alzheimer’s disease (AD) is a major neurodegenerative disease, but so far, it can only be treated symptomatically rather than changing the process of the disease. Recently, triazoles and their derivatives have been shown to have potential for the treatment of AD. In this study, the neuroprotective effects of 4-(4-(heptyloxy)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (W112) against β-amyloid (Aβ)-induced AD pathology and its possible mechanism were explored both in vitro and in vivo. The results showed that W112 exhibits a neuroprotective role against Aβ-induced cytotoxicity in PC12 cells and improves the learning and memory abilities of Aβ-induced AD-like rats. In addition, the assays of the protein expression revealed that W112 reversed tau hyperphosphorylation and reduced the production of proinflammatory cytokines, tumor necrosis factor-α and interleukin-6, both in vitro and in vivo studies. Further study indicated that the regulation of mitogen-activated protein kinase/nuclear factor-κB pathways played a key role in mediating the neuroprotective effects of W112 against AD-like pathology. W112 may become a potential drug for AD intervention.Keywords:triazoles;Alzheimer’s disease;amyloid beta-peptides;neuroinflammation;mitogen-activated protein kinase/NF-kappa B signaling pathways
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JOURNAL OF SEPARATION SCIENCE
·
2019
·Vol. 42
·期 15
·2482-2490
·
IF 2.516
Lingping Cheng,Jianfeng Cai,Qing Fu,Yanxiong Ke
6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone is a key synthetic intermediate for cardiotonic agent levosimendan. Very few studies address the use of chiral stationary phases in chromatography for the enantioseparation of this intermediate. This study presents two efficient preparative methods for the isolation of ( R )(−)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone in polar organic solvent chromatography and supercritical fluid chromatography using polysaccharide-based chiral stationary phases and volatile organic mobile phases without additives in isocratic mode. Under optimum conditions, Chiralcel OJ column showed the best performance ( α = 1.71, Rs = 5.47) in polar organic solvent chromatography, while Chiralpak AS column exhibited remarkable separations ( α = 1.81 and Rs = 6.51) in supercritical fluid chromatography with an opposite enantiomer elution order. Considering the sample solubility, runtime and solvent cost, the preparations were carried out on Chiralcel OJ column and Chiralpak AS column (250 × 20 mm i.d.; 10 µm) in polar organic mode and supercritical fluid chromatography mode with methanol and CO 2 /methanol as mobile phases, respectively. By utilizing the advantages of chromatographic techniques and polysaccharide-based chiral stationary phases, this work provides two methods for the fast and economic preparation of ( R )(−)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone, which are suitable for the pharmaceutical industry.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Wanlun Li,Shutao Wang,Huize Fan,Ziwei Wang,Yingying Liu,Hong You
Fluorinated liquid crystal monomers (FLCMs) are widely employed in liquid crystal display (LCD) panels. As emerging environmental contaminants with persistent, bioaccumulative, and toxic properties, FLCMs were proven to accumulate in liver, raising great concern regarding potential hepatotoxicity. 1-Ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl) benzene (EDPrB), as one representative FLCM, was chosen to investigate the hepatotoxicity in adult zebrafish (Danio rerio) at environmentally relevant concentrations (1, 10, and 100 μg/L) with long-term exposure (21 days). EDPrB caused morphological abnormalities, elevated transaminase activities, and inhibited antioxidant levels in zebrafish liver. The contents of total cholesterol and triglyceride were reduced by 2.3- and 1.82-fold, respectively, at 100 μg/L of EDPrB. Transcriptomic analysis revealed that EDPrB disrupted the lipid and glucose metabolisms, protein processing in endoplasmic reticulum (ER), and P53 signal pathway by dysregulating genes, such as fasn, acaca, acsl1b, hkdc1, xbp1, and ero1lb. EDPrB induced ER stress by activating PERK-eIF2α pathway, leading to hepatic metabolic dysfunction. PERK-eIF2α and P53-Bax/Bcl2 pathways were involved in EDPrB-induced apoptosis. Additionally, molecular simulation confirmed that EDPrB had a strong binding affinity to some lipid metabolism proteins (-8.9~-6.7 kcal/mol) and stress proteins (-9.3~-5.8 kcal/mol). The findings elucidate EDPrB-induced hepatotoxicity and underlying mechanisms, which contribute to assessing the ecological risk and pollution control of FLCMs.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Kuang Wang,Zhanqiang Fang
In this work, a cost-effective ball-milling technique was employed to synthesize submicron oxalated zero-valent iron co-doped with graphite and nickel (G@Fe OX bm /Ni), aiming to enhance the removal efficiency of the recalcitrant pollutant 2, 2′, 4, 4′ – tetrabromodiphenyl ether (BDE-47) while minimizing secondary risks. The incorporation of graphite significantly improved the debromination efficiency of BDE-47, with a rate constant of 0.26 day −1 in a tetrahydrofuran/water system, which represents a 59.88 % increase over the oxalated zerovalent Fe/Ni without graphite (0.16 day −1 ). The determination of Ni leaching showed that no nickel ions were detected post-reaction over a broad pH range (3–11). Moreover, the reactivity of G@Fe OX bm /Ni was largely unaffected across the pH range (0.26–0.49 day −1 ), exhibiting excellent resistance to acidic and alkaline conditions. In both ultrapure water and real groundwater matrices, the degradation rate constants for BDE-47 increased to 2.98 day −1 and 0.79 day −1 , respectively, achieving debromination yields of 97.86 % and 50.18 % for the final product, diphenyl ether. Based on the established degradation pathway and electrochemical analysis, the debromination of BDE-47 follows a catalytic debromination and hydrogenation process by adsorbed atomic hydrogen (H* ADS ). The graphite doping enhanced the debromination of BDE-47 by increasing the production of H* ADS . The adsorption effect of graphite on metal ions effectively controlled secondary pollution and improved the material’s tolerance to acidic and alkaline environments. This work offers an efficient method for the degradation of low brominated diphenyl ether pollutants at a low cost and without secondary risks.
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CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Xiaowen Xie,Xiaoguo Ma,Lihui Guo,Yinming Fan,Guolong Zeng,Mengyuan Zhang,Jing Li
A novel multi-templates molecularly imprinted polymer (MIP) was prepared on the surface of mesoporous silica coated magnetic graphene oxide (MGO@mSiO 2 ), and applied for the rapid and selective detection of alkylphenol compounds including bisphenol A (BPA), 4-tert-octylphenol (4-tert-OP) and 4-nonylphenol (4-NP) in water. The synthesized composite was characterized by Fourier transform infrared spectrometer, vibrating sample magnetometer, transmission electron microscopy and Brunauer-Emett-Teller surface area analyzer. The MIP showed high adsorption capacity, good selectivity and fast kinetic for these alkylphenols. The maximum adsorption capacities of the MIP for BPA, 4-tert-OP and 4-NP were 16.81, 35.97 and 61.73 mg g −1 , respectively, which were significantly higher than those of the non-molecularly imprinted polymer (NIP) due to the imprinting effect. The adsorption of alkylphenols reached equilibrium within 30 min, and followed pseudo-second-order kinetic model and Langmuir model well. The MIP exhibited good sorption selectivity towards BPA, 4-tert-OP and 4-NP, and could be reused 5 times. Furthermore, a new method for ultrasensitive determination of BPA, 4-tert-OP and 4-NP in water by high performance liquid chromatography was developed, using MIP-based magnetic solid-phase extraction coupled with dispersive liquid-liquid microextraction. Under the optimum conditions, the limits of detection (LODs) for BPA, 4-tert-OP and 4-NP were 0.013, 0.010 and 0.010 μg L −1 , respectively. The proposed method was used to the detection of BPA, 4-tert-OP and 4-NP in real water samples, with spiked recoveries of 81.5–104.1% and relative standard deviations (RSDs) of 1.0–7.6%, indicating the multi-templates MIP could be a promising adsorbent for separation and analysis of alkylphenols.
研究领域:
环境科学
·
分析化学
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Nanomaterials
·
2022
·Vol. 12
·期 12
·2062
·
IF 5.719
Wenlei Zhang,Hongwei Yin,Zhichao Yu,Xiaoxia Jia,Jianguo Liang,Gang Li,Yan Li,Kaiying Wang
Metal-organic frameworks (MOFs) have attracted significant research interest for supercapacitor applications due to their high-tunable conductivity and their structure’s pore size. In this work, we report a facile one-step hydrothermal method to synthesize nickel-based metal-organic frameworks (MOF) using organic linker 4,4′-biphenyl dicarboxylic acid (BPDC) for high-performance supercapacitors. The pore size of the Ni-BPDC-MOF nanostructure is tuned through different synthesization temperatures. Among them, the sample synthesized at 180 °C exhibits a nanoplate morphology with a specific surface area of 311.99 m2·g−1, a pore size distribution of 1–40 nm and an average diameter of ~29.2 nm. A high specific capacitance of 488 F·g−1has been obtained at a current density of 1.0 A·g−1in a 3 M KOH aqueous electrolyte. The electrode shows reliable cycling stability, with 85% retention after 2000 cycles. The hydrothermal process Ni-BPDC-MOF may provide a simple and efficient method to synthesize high-performance hybrid MOF composites for future electrochemical energy storage applications.Keywords:metal organic framework;4,4′-biphenyl dicarboxylic acid;one-step hydrothermal method;tunable pore size;nanoplate structure;supercapacitors
研究领域:
材料科学
·
能源存储
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MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Jian-Bo Chen,Xueyan Zhao,Zhenqi Zhang,Ya Chen,Xiaolin Fu,Yu Liu
Recently, 3,3-diamino-4,4-azoxyfurazan (DAAF) as one of most promising energetic furazan compounds has been widely studied because of its excellent explosive performances. Nowadays, the Oxone oxidation method is regarded as a main pathway to synthesize DAAF. However, several unknown impurities are yielded when the Oxone method is used to prepare DAAF. The identification of DAAF’s impurities is beneficial to optimize synthetic route of DAAF and then improve its purity. In this study, chemical structures of DAAF and its main impurities were analyzed by developing an unknown analysis workflow based on ultrahigh-performance liquid chromatography-tandem diode array detector -tandem high resolution mass spectrometry (UHPLC-DAD-HRMS). They were fully separated by UHPLC after the optimization of chromatographic conditions. HRMS based on a Q-Orbitrap system was performed to elucidate chemical structure of the impurities by determining exact mass of the impurities and their MS/MS fragments. Besides DAAF, eight unknown impurities were detected under negative ion mode ([M-H] - ) of HRMS with a heated electrospray ionization. Comprehensive analysis of UHPLC-DAD-HRMS provided more information including the retention time, UV–Vis spectrum, elementary composition and MS/MS fragments, and then possible structures of the impurities were proposed in this work. Further, the ion at m / z 211.0328, impurity I and impurity V were confirmed to be DAAF, DAF and DAAzF, respectively, through 1 H NMR and 13 C NMR after synthesizing their reference materials. In addition, the source of these impurities during the synthesis of DAAF has been analyzed. The impurities were originated from the precursor, the intermediate and byproduct of preparing DAAF through the hydrazine, the isomerism and the nitrosation.
研究领域:
化学
·
材料科学
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FirePhysChem
·
2022
·
IF 0
Kunkai Wang,Xiangzhi Li,Kaidi Yang,Huan Huo,Qi Xue,Bozhou Wang,Fuqiang Bi
1,1,4,4-Tetramethyl-2-tetrazene (TMTZ), a potential candidate for replacing 1,1-dimethylhydrazine (UDMH), has excellent properties including a high specific impulse, non-toxicity and non-volatility. However, most synthetic methods depicted in the literature use stoichiometric oxidative coupling, and the oxidizing agents are usually heavy metals or halogens, leading to low synthetic efficiency and high environmental pollution. In order to overcome these problems, it is necessary to explore more environmentally friendly and catalytic synthetic methods. In this paper, a method of photocatalytic oxidative coupling for the preparation of TMTZ was reported for the first time. By using an organic photocatalyst Eosin Y, TMTZ was synthesized rapidly and efficiently. The thermal decomposition properties of TMTZ were studied, and different performance characteristics between TMTZ and UDMH were determined and analyzed, which provided a basis for the application of TMTZ based new liquid propellant.
研究领域:
有机化学
·
催化化学
·
能源材料
·
推进剂化学
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Feng Wang,Xianhong Bi,Yun Cui,Kewei Lin,Charles Brennan,Soottawat Benjakul,Gengsheng Xiao,Lukai Ma
Toxic compounds in fried food products attract increasing attention, but studies regarding the levels of common toxins, such as malondialdehyde (MDA), 4-hydroxy-2-hexenal (4-HHE), and 4-hydroxy-2-nonenal (4-HNE), in fried starch-based food (FSBF) are scarce. Herein, we investigated the formation and distributions of these aldehydes in FSBF, and the frying oil and FSBF retained higher levels of low-molecular-weight aldehydes. The highest aldehyde concentrations were observed in French fries. Simulated frying experiments revealed that the distributions of the toxic aldehydes in FSBF were mainly determined by the amylose content. Molecular dynamics simulations indicated that amylose interacted strongly with 4-HNE, but its interactions with MDA and 4-HHE were weaker. The migration of MDA, 4-HHE, and 4-HNE into FSBFs was primarily attributed to the interactions between the toxic aldehydes and amylose. This study should provide a novel basis for the control and elimination of toxic aldehydes in fried food.
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DALTON TRANSACTIONS
·
2025
·
IF 3.3
Sourav Mondal,Ya-Shan Huang,Zhong-Ming Sun,John E. McGrady
We report here the synthesis and structural characterisation of the [Ru@Sn12]4- anion, a new member of the icosahedral M@E12 family of endohedral Zintl clusters. The cluster is approximately icosahedral, but a signicant variance in the Ru-Sn and Sn-Sn bond lengths is a result of back-bonding from the Ru center to the Sn12 cage. We use density functional theory to place the structural chemistry of [Ru@Sn12]4- into the wider context of the M@E 12 family.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xia Wei,Pengcheng Huan,Xiaming Chen,Guang Ji,Song Li
The interfacial electron interactions in heterogeneous catalysts are critical determinants of their catalytic efficiency. In this study, a Ni-Co alloy coating with a precisely controlled Ni/Co of 6:4 was synthesized on nickel foam (denoted as Ni-Co-6–4/NF) using NaH 2 PO 2 as a reducing agent. The resulting surface exhibited negligible phosphorus incorporation. The Ni-Co-6–4 coating featured a unique crystalline-amorphous interfacial structure. As expected, Ni-Co-6–4/NF demonstrated outstanding catalytic activity toward hydrazine oxidation, achieving a current density of 169.1 mA·cm −2 at 0.3 V versus the reversible hydrogen electrode (RHE) without i R compensation. Moreover, it maintained 100 % of its catalytic performance over 24 h of continuous electrolysis, placing it among the most durable non-noble Ni-based electrocatalysts reported for hydrazine oxidation. Density functional theory (DFT) calculations revealed that this improved performance stems from electron redistribution at the crystalline-amorphous interface, which enhances N 2 H 4 adsorption. These findings highlight the effectiveness of crystalline-amorphous interface engineering as a powerful strategy for the rational design and optimization of high-performance electrocatalysts.
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HYDROMETALLURGY
·
2016
·
IF 2.29
Zhang Peng,Dong Linfei,Zhang Dongxiang,Lei Shi,Hongmei Yang,Jinying Li,Wang Yaling,V.V. Tarasov
Calix[4]arene derivatives including diethyl phosphite groups were used for the first time for separating Nd(III) from nitrate media. Calix[4]arene derivatives were synthesized and characterized by infrared spectroscopy (IR), mass spectroscopy (MS), and 1 H NMR. Four calix[4]arene derivatives, CalixF (①), DCalixF (②), PCalixF (⑤), and POCalixF (⑥), were used in a solvent extraction method. The effects of aqueous acidity, diluent, temperature, shaking time, and Nd(III) concentration were investigated. The results showed that the extraction ability of ⑤ and ⑥ with a phosphate functional group at the upper rim were best for the extraction of Nd(III). Derivative ⑥ had better complexing capacities than ⑤ for the generation of a phenolic hydroxyl group at the lower rim. The enthalpy (∆ H O ), Gibbs free energy (∆ G O ), and entropy (∆ S O ) changes for the extraction were obtained from a thermodynamic study. The results showed that the extraction of Nd(III) from a nitric acid system might be an endothermic reaction since the process was naturally spontaneous and increasing the temperature during extraction was determined to be thermodynamically feasible. The extraction of Nd(III) was governed by a two-stage chemical reaction and diffusion process. In the first stage, the process was controlled by a fast chemical reaction at the liquid-liquid interface. The composition of the Nd(III)-calix[4]arene derivative complex was determined to be [Nd(NO 3 ) 3 ] 2 [L]. The second stage was the diffusion of extracted products towards equilibrium. Calix[4]arene derivative ⑥ was found to be an efficient extractant for the separation of Nd(III) and would be a potential extractant for the disposal of radioactive waste in spent fuel .
研究领域:
化学
·
核能科学
·
环境科学
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