CHEMISTRY-A EUROPEAN JOURNAL
·
2017
·Vol. 23
·期 62
·15721-15728
·
IF 5.317
Yuanyuan Hu,Dong Xie,Yang Wu,Nangui Lin,Aixin Song,Jingcheng Hao
Graphical Stacking gels : Factors affecting the self-assembly of supramolecular hydrogels composed of combining 5′-adenosine monophosphate and Ag + are discussed (see figure). The gelation capability was enhanced by increasing the concentration of Ag + or decreasing the pH. The gels are very sensitive to light and have potential applications as photosensitive materials. Supramolecular hydrogels obtained by combining 5′-adenosine monophosphate (AMP) with Ag + were fabricated in this work. Their gelation capability was enhanced by increasing the concentration of Ag + or decreasing the pH. The gels are very sensitive to light, which endows them with potential applications as visible-light photosensitive materials. Coordination between the nucleobase of AMP and Ag + , as well as π–π stacking of nucleobases, are considered to be the main driving forces for self-assembly. The hydrogels successfully achieved the encapsulation and enrichment of biomolecules. Hydrogen bonding between the amino group of guest molecules and silver nanoparticles along the nanofibers drives the enrichment and is considered to be a crucial interaction.
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JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Yan Dai,Jiali Zhang,Shimeng Zhang,Linhua Li,Chao Qu,Jiang Chen,Lei Lu
Bacterial keratitis is a major cause of blindness, hindered by the rising threat of antibiotic resistance. Although corneal bandage lenses (CBLs) are widely utilized in ophthalmic treatment, their effectiveness in treating bacterial keratitis remains limited due to risks of secondary infections, patient discomfort, and complications. In this study, we developed a novel biomimetic coating on CBLs by grafting Ag/Cu bimetallic nanoparticles (Ag/Cu-NPs) and thiol-functionalized heparin (Hep-SH) using a rapid polydopamine (PDA) deposition technique, effectively mimicking the ocular surface glycocalyx structure. The resulting Ag/Cu-NPs/Hep-SH coated CBLs (PNH-CBLs) exhibited significant antibacterial activity, with over 80 % reduction in Staphylococcus aureus ( S. aureus ) and 70 % in Escherichia coli ( E. coli ) due to the sustained release of Ag + and Cu 2+ , along with displaying favorable in vitro biocompatibility. Animal experiments conducted on New Zealand white rabbits with bacterial keratitis demonstrated successful treatment therapeutic outcomes, with PNH-CBLs leading to a significant decrease in clinical score. These biomimetic lenses also exhibited selective anti-protein adsorption properties, minimizing inflammation and promoting surface lubrication. Overall, this innovative approach addresses critical challenges in antibiotic resistance and offers a promising therapeutic strategy for managing ophthalmic infectious diseases.
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Advanced Materials Interfaces
·
2015
·Vol. 2
·期 13
·1500234
·
IF 0
Ben Wang,Yang Liu,Yabin Zhang,Zhiguang Guo,Hong Zhang,John H. Xin,Li Zhang
Fe 3 O 4 nanoparticles (NPs) with Ag NPs evenly distributed on the surface are fabricated by using polydopamine (PDA) as the intermediate layer. Silanization and thiol chemistry are used to firmly combine the Fe 3 O 4 @ PDA core and outer surface Ag NPs. The spherical and hybrid nanoparticles are termed Fe 3 O 4 @PDA@Ag NPs, which possess a core–shell and hierarchical structure. After surface modification with 1 H ,1 H ,2 H ,2 H -perfluorodecanethiol, the hybrid Fe 3 O 4 @PDA@Ag NPs become highly hydrophobic. Slight rolling of a water droplet on the as-prepared NPs causes the formation of a “liquid marble”, which is capable of performing remote actuation on various solid surfaces, such as glass sheet, paper, plastic, textile, and ceramic, and at the liquid–air interface using a permanent magnet. Liquid marbles with self-assembled NPs on the liquid surface have potential to act as a miniaturized reactor for manipulation of inner liquid droplet with high positioning precision. In addition, the Fe 3 O 4 @PDA@Ag NPs are multifunctional and can be applied for oil/water separation and antibacterial purpose.
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ACS Sustainable Chemistry & Engineering
·
2016
·
IF 5.267
Peng Tan,Yan-Hua Li,Xiao-Qin Liu,Yao Jiang,Lin-Bing Sun
Silver (Ag)-based nanoparticles are one type of highly effective antimicrobial widely used in medical devices, consumer products, and wound dressing. Although Ag(I) rather than Ag(0) is the active species in antibacterial processes, the use of Ag(I) as antibacterial materials is hindered by its instability toward light irradiation. In this paper, we report the fabrication of core–shell AgCl@SiO2 nanoparticles, which comprise a core of AgCl nanoparticles and a shell of porous silica, for antibacterial applications for the first time. The porous silica shells not only enhance the stability of AgCl by preventing the core from direct light irradiation but also allow active Ag(I) to pass through continuously to inhibit the growth of bacteria. It is worth noting that the synthesis is achieved by a facile one-pot method in which the surfactant hexadecyltrimethylammonium chloride used for the formation of AgCl nanoparticles also acts as a structure-directing agent in the subsequent creation of porous silica. Our results show that the obtained AgCl@SiO2 nanoparticles exhibit well-defined core–shell structure and are highly efficient in the growth inhibition of Escherichia coli. More importantly, the stability of Ag(I) toward light irradiation is greatly enhanced by the protection of the silica shell. The convenient fabrication, well-defined core–shell structure, and enhanced stability make AgCl@SiO2 nanoparticles highly promising for antibacterial applications.
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CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Zhong Lu,Jingting Gao,Qingfeng He,Jie Wu,Donghui Liang,Hao Yang,Rong Chen
Nano Ag/ZnO hybrid material has been considered to be a promising nanocomposites for biomedical application because it has enhanced antibacterial activity and low cytotoxicity. Here a sponge-like nano Ag/ZnO-loaded chitosan composite dressing was first synthesized via preparing a chitosan sponge by lyophilization process, followed by the incorporation of Ag/ZnO nanocomposites into chitosan sponge. The porosity, swelling, blood clotting and in vitro antibacterial activity against drug-sensitive and drug-resistant pathogenic bacteria were evaluated. The results demonstrate that the prepared composite dressing shows high porosity and swelling as well as enhanced blood clotting and antibacterial activity. Cytocompatibility test evaluated in vitro illustrates the very low toxic nature of the composite dressing. Furthermore, the in vivo evaluation in mice reveals that the chitosan-Ag/ZnO composite dressing enhances the wound healing and promotes re-epithelialization and collagen deposition. These results strongly support the possibility of using this novel chitosan-AgZnO composite dressing for wound care application.
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Scientific Reports
·
2017
·Vol. 7
·期 1
·1-9
·
IF 4.259
Wang Jingyun,Zhang Lei,Huang Youju,Dandapat Anirban,Dai Liwei,Zhang Ganggang,Lu Xuefei,Zhang Jiawei,Lai Weihua,Chen Tao
The probe materials play a significant role in improving the detection efficiency and sensitivity of lateral-flow immunochromatographic test strip (ICTS). Unlike conventional ICTS assay usually uses single-component, solid gold nanoparticles as labeled probes, in our present study, a bimetallic, hollow Au-Ag nanoparticles (NPs) labeled ICTS was successfully developed for the detection of clenbuterol (CLE). The hollow Au-Ag NPs with different Au/Ag mole ratio and tunable size were synthesized by varying the volume ratio of [HAuCl4]:[Ag NPs] via the galvanic replacement reaction. The surface of hollow Ag-Au NPs was functionalized with 11-mercaptoundecanoic acid (MUA) for further covalently bonded with anti-CLE monoclonal antibody. Overall size of the Au-Ag NPs, size of the holes within individual NPs and also Au/Ag mole ratio have been systematically optimized to amplify both the visual inspection signals and the quantitative data. The sensitivity of optimized hollow Au-Ag NPs probes has been achieved even as low as 2 ppb in a short time (within 15 min), which is superior over the detection performance of conventional test strip using Au NPs. The optimized hollow Au-Ag NPs labeled test strip can be used as an ideal candidate for the rapid screening of CLE in food samples.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2017
·
IF 3.133
Xueyan Li,Di Wu,Qingzhi Luo,Rong Yin,Jing An,Sijie Liu,Desong Wang
The novel ternary cyclized polyacrylonitrile (CPAN)/Ag/AgCl composites were successfully synthesized by a facile precipitation and photo-assistant reduction method. The CPAN/Ag/AgCl particles were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, UV–vis diffuse reflectance spectroscopy (UV–vis DRS), photoluminescence spectroscopy (PL), electrochemical impedance spectra (EIS) and photocurrent time (EI) measurement. The photocatalytic activities of the samples were investigated through the decomposition of methyl orange (MO) and rhodamine B aqueous solution under visible-light irradiation. The results showed that the CPAN/Ag/AgCl photocatalysts displayed much higher visible-light photocatalytic activity than Ag/AgCl, and the reaction rate constant of the MO degradation catalyzed by CPAN/Ag/AgCl is about 3 times of that by Ag/AgCl. It is proposed that the photogenerated holes h + and O 2 − played important roles in the photocatalytic degradation of MO in the presence of CPAN/Ag/AgCl composites under visible light irradiation.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2017
·
IF 3.133
Junjie Li,Xing Yu,Tielin Shi,Chaoliang Cheng,Jinhu Fan,Siyi Cheng,Tianxiang Li,Guanglan Liao,Zirong Tang
In this paper, we proposed a depressing bonding temperature method for Cu Cu bonding with nanoparticle paste. The paste was prepared by composting dominant Cu nanoparticles with Ag nanoparticles of lower sintering temperature , where the average nanoparticle size of Cu and Ag was 61.02 and 69.25 nm, respectively. The reliable bonding was successfully achieved at the temperature of 250 °C, the pressure of 1.12 MPa and the protection of Ar-H 2 gas mixture comparing with pure Cu nanoparticles paste. An optimal resistivity of sintered Cu-Ag composite nanoparticle paste can achieve 1.99 × 10 −7 Ω m with the 2:1 molar ratio of Cu to Ag, and the largest shear strength of the bonded Cu-Cu joint can reach 25.41 MPa. The underlying sintering mechanism of the composited nanoparticles was discussed. It suggests the compositing with Ag nanoparticles is a practical strategy towards lowering the bonding temperature for Cu-based interconnect. The experimental process can be easily implemented, the bonding temperature and the performance can satisfy the packaging requirements of current 3D-IC. The developed Cu-Ag composite nanoparticle paste is also promising for packaging of other thermal and force sensitive chips.
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APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Xia Yang,Yi He,Xueling Wang,Ruo Yuan
Mercuric ion (Hg 2+ ) is one toxic metal ion existed in aquatic ecosystems which would seriously damage human central nervous system and other organs. So developing an approach to sensitively detect Hg 2+ in our living environment is urgent and important. In this work, a novel surface enhancement Raman spectrum(SERS) sensor is fabricated for high selective and ultrasensitive detection of Hg 2+ in aqueous solution, based on a stable thymine-Hg 2+ -thymine (T-Hg 2+ -T) structure and the π - π interaction between single-stranded DNA (ssDNA) and single walled carbon nanotubes (SWCNTs). Herein, SWCNTs act as Raman labels to produce characteristic Raman peaks which can be a beacon to quantitative detect Hg 2+ . In the presence of Hg 2+ , the ssDNA can capture Hg 2+ forming T-Hg 2+ -T structure, which makes SWCNTs leave the hot spots of the SERS-based biosensor. With this design, the Raman intensity of SWCNTs decreased with the increasing concentration of Hg 2+ . At the same time, CoFe 2 O 4 @Ag as active SERS substrates can effectively enhance sensitivity and uniformity of the biosensor through aggregation by magnet. Under optimal conditions, this proposed biosensor can detect Hg 2+ at a range from 1 pM to 100 nM with a detection limit of 0.84 pM. With the advantages of good sensitivity, selectivity, simplicity and rapidity, the biosensor is potentially suitable for monitoring of Hg 2+ in environmental applications.
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JOURNAL OF HAZARDOUS MATERIALS
·
2016
·
IF 4.836
Jing Jiang,Chang Zhang,Guang-Ming Zeng,Ji-Lai Gong,Ying-Na Chang,Biao Song,Can-Hui Deng,Hong-Yu Liu
The fabrication of montmorillonite (Mt) decorated with lysozyme-modified silver nanoparticles (Ag/lyz-Mt) was reported. The lysozyme (lyz) was served as both reducing and capping reagent. Coupling the bactericidal activity of the lyz with AgNPs, along with the high porous structure and large specific surface area of the Mt , prevented aggregation of AgNPs and promoted nanomaterial-bacteria interactions, resulting in a greatly enhanced bactericidal capability against both Gram positive and Gram negative bacteria. This paper systematically elucidated the bactericidal mechanisms of Ag/lyz-Mt. Direct contact between the Ag/lyz-Mt surface and the bacterial cell was essential to the disinfection. Physical disruption of bacterial membrane was considered to be one of the bactericidal mechanisms of Ag/lyz-Mt. Results revealed that Ag + was involved in the bactericidal activity of Ag/lyz-Mt via tests conducted using Ag + scavengers. A positive ROS (reactive oxygen species) scavenging test indirectly confirmed the involvement of ROS (O 2 − , H 2 O 2 , and OH) in the bactericidal mechanism. Furthermore, the concentrations of individual ROS were quantified. Results showed that Ag/lyz-Mt nanomaterial could be a promising bactericide for water disinfection.
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RSC Advances
·
2016
·Vol. 6
·期 17
·14105-14111
·
IF 3.289
Hua-Zhou Zhao,Yi Xu,Chun-Yan Wang,Rong Wang,Song-Tao Xiang,Li Chen
A “sandwich” microfluidic surface enhanced Raman scattering (SERS) chip with Ag film@nanoAu prepared in a microchannel was proposed and fabricated in situ. The integrated composite Ag film@nanoAu was prepared in situ by way of chemical plating and self-assembly. Firstly, the preparation conditions were optimized. On the basis of that, the influence of the laser focus position along the vertical direction and the materials of the cover plates on the SERS effect were investigated and optimized in detail. The optimized SERS effect was observed when the laser was focused on the interface of the sample and the SERS substrate. The SERS intensity of Rhodamine 6G (R6G) decreased 2.5 times and 2.1 times when PDMS or glass was used as the cover plate separately. Compared to single gold and silver SERS substrates, the composite of Ag film@nanoAu integrated in the microfluidic channel resulted in the peak intensity increasing 3–5 times during the SERS detection of R6G at 1507 cm−1. The enhancing effect could be attributed to the change in the local electromagnetic field which was caused by the synergistic sensitizing effect between the Au nanoparticles and the underlying silver mirror film. It was illustrated that the detection limit for R6G was 10−8 M and the enhancement factor (EF) was 3.8 × 105 with a relative standard deviation (RSD) of approximately 10% in the as-prepared microfluidic SERS chip.
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CRYSTENGCOMM
·
2016
·Vol. 18
·期 45
·8756-8761
·
IF 3.849
Zhiqiang Cheng,Shengzhe Zhao,Zhaolian Han,Yingying Zhang,Xiaodong Zhao,Lijuan Kang
Hollow TiO2 nanotubes have been produced by combining electrospinning with a soaking process and controlled calcination method. Silver was successfully coated on the surface of the TiO2 tubes through the immersion burning method. Structure and components of TiO2 and Ag/TiO2 tubes were characterized by X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX) and X-ray photoelectron spectroscopy (XPS). Morphology was studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The photocatalysis properties were verified by degradation of methyl orange (MO) dye. From the results, the Ag/TiO2 hollow tubes could degrade methyl orange efficiently under UV light irradiation, showing excellent photocatalytic activity over pure TiO2. The synthesis mechanism of the Ag/TiO2 tubes and the mechanism for silver-enhanced photocatalytic activity have been conjectured.
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