Photodiagnosis and Photodynamic Therapy
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2019
·
IF 2.589
Asif Jan,Chengcheng Liu,Hong Deng,Jiao Li,Wenpeng Ma,Xiaoyan Zeng,Yanhong Ji
Background and aim The extensive use of antifungal drugs has led to resistance from Candida albicans . The search for alternative treatment against drug-resistant C. albicans is highly desirable. Antimicrobial photodynamic therapy (aPDT) is an emerging and promising approach for treating localized and superficial C. albicans infections. The aim of this study was to investigate the photodynamic inactivation (PDI) effects of hypocrellin B (HB) on azole-sensitive and resistant C. albicans in vitro . Methods The PDI efficacies of HB on standard C. albicans strain (ATCC 10231), azole-sensitive clinical isolate of C. albicans , and azole-resistant clinical isolate of C. albicans were assessed. The uptake of HB in C. albicans cells was investigated by confocal laser scanning microscopy (CLSM). The PDI effects on cellular structure and surface characteristics were investigated by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Results HB exhibited no significant dark toxicity, but inactivated the azole-sensitive and resistant C. albicans in a light-dose and PS concentration-dependent manner. CLSM images indicated that PDI treated C. albicans cells showed stronger fluorescence compared to untreated cells. TEM images suggested that significant damage to the cell wall, membrane, and cytoplasm were induced by HB-mediated PDI. SEM analysis revealed that the surface of C. albicans cells became twisted and ruptured after PDI treatment. Conclusions Azole-sensitive and resistant C. albicans could be effectively inactivated by HB in the presence of light, and HB-mediated aPDT shows promise as an antifungal treatment for C. albicans .
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高影响因子
AICHE JOURNAL
·
2017
·Vol. 64
·期 2
·538-549
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IF 2.836
Yiyi Sheng,Yang Sun,Jing Xu,Jie Zhang,Yi-Fan Han
Cu-embedded mesoporous alumina, as a Fenton-like catalyst prepared via a sol-gel method, showed excellent activity and durability for the degradation of refectory compounds. The origin of active sites for the generation of hydroxyl radicals (•OH) were thoroughly studied using multitechniques. Cu, as the only active element, could be penetrated into the bulk of alumina and some Cu atoms were embedded into the framework. The dynamic structure of surface Cu species (the variety of Cu + /Cu 2+ ratio) during the reaction were determined as well. Furthermore, the structure plasticity of catalyst has proved by optimizing preparation and reaction conditions. A 98.53% degradation of RhB was recorded within 30 min, following a pseudo-first-order reaction rate expression. Electron spin resonance spectra and •OH scavenging experiments have confirmed that •OH is the main reactive oxidant for the elimination of RhB. By the surface-enhanced Raman spectroscopy and gas chromatography-mass spectrometer results, plausible pathways of RhB degradation were elaborated. © 2017 American Institute of Chemical Engineers AIChE J , 64: 538–549, 2018
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Advanced Sustainable Systems
·
2024
·Vol. 8
·期 12
·2400419
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IF 6.5
Dongxu Han,Zhi Song,Boxia Liu,Bofei Liu,Xiayan Zhang,Jialu Liu,Yeqiong Huang,Chuhan Xing
Because of its excellent catalytic activity and stability, perovskite materials are widely used in advanced oxidation processes to remove refractory organic pollutants. In this study, a series of catalysts Pr 0.6 Sm 0.4 Co x Mn 1-x O 3 (x = 0, 0.2, 0.4, 0.5, 0.6,0.8 and 1) with limited range effect are prepared by sol–gel method with the regulation strategy of injecting active metal Co at B site in the crystal lattice of perovskite catalyst Pr 0.6 Sm 0.4 MnO 3 . Under the optimal conditions, the Pr 0.6 Sm 0.4 Co 0.8 Mn 0.2 O 3 /PMS/RhB system showed superior catalytic performance, and the removal rate of Rhodamine B (100 mg L −1 ) is close to 100% within 40 min. In addition, the Pr 0.6 Sm 0.4 Co 0.8 Mn 0.2 O 3 catalyst has a wider pH (2-10) tolerance range and still has outstanding catalytic properties after multiple cycle tests. The quenching experiment and EPR test confirmed that a variety of active species are produced in the system, and the singlet oxygen as the leading path of a variety of active substances assisted to promote the efficient degradation of Rhodamine B in wastewater. This study provides a new reaction system and regulatory strategy of active structural sites for the design of Fenton-like catalytic systems based on novel perovskite oxides.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yifei Ye,Yuanyuan Cui,Li Yang,Jiaxu Zhang,Jianmin Sun
A novel external-skeleton B-containing ionic liquid modified SBA-15 catalyst BBN-Imi-SBA-15-I (BBN denotes borabicyclo[3.3.1]nonane, Imi represents imidazolium ionic liquid) was successfully constructed by a post-modification method for efficiently catalyzing CO 2 -epoxide coupling reaction under both metal- and solvent-free conditions. 5BBN-Imi-SBA-15-I (5 refers to the molar ratio of Si to B), thanks to its synergistic effects of Lewis acid, weak base sites from tertiary amine and quaternary ammonium, hydrogen bond group and nucleophilic group, displayed good catalytic activity with 97 % product yield and 99 % selectivity at 100 °C, 2 MPa in the absence of cocatalyst. The obtained catalyst demonstrated good recyclability during six consecutive catalytic runs, also presented generality for various mono-substitute epoxides. Through in-situ NH 3 diffuse reflectance infrared Fourier transform spectroscopy (NH 3 -DRIFTS) characterization, the Lewis acidity of organo-boron was verified. Besides, kinetics research also proved the positive effect of multiple active components on efficient catalysis under milder conditions over SiO 2 -based metal-free catalysts.
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REACTIVE & FUNCTIONAL POLYMERS
·
2016
·
IF 2.725
Luanluan Zhang,Hejun Gao,Yunwen Liao
A series of functional cross-linked polymer (Poly(AMPS- co -DVB)) were synthesized by 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and divinylbenzene (DVB). The physicochemical properties of the Poly(AMPS- co -DVB) were characterized by FT-IR, TGA , SEM, XRD , Zeta potential and UV–Vis. Those results showed that the Poly(AMPS- co -DVB) could provide mounts of adsorption sites from its special structure. The effects of the initial pH, dosage, contact time, and temperature on the adsorption of Rhodamine B (RhB) onto the Poly(AMPS- co -DVB) were investigated. It was found that the initial pH was an important factor for the molecules form of RhB and the surface formation of Poly(AMPS- co -DVB). With increasing of molar ratio of AMPS/DVB, the adsorption efficiency increased gradually. In the adsorption process , both physical and chemical mechanism is presence to adsorb RhB. The maximum adsorption capacity could get 407.9 mg/g within 2 h at room temperature .
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高影响因子
BULLETIN OF MATERIALS SCIENCE
·
2017
·Vol. 40
·期 1
·187-193
·
IF 0.899
GENG TONG-MOU,WANG XIE,ZHU FENG,JIANG HUI,WANG YU
The water-soluble polymeric chemosensor poly(AM-GRBD) has been synthesized by precipitation copolymerization with the functional monomer, GRBD, which was made of N \(^{\boldsymbol {\prime \prime }}\) -(rhodamine B-yl) diethylenetriamine and glycidyl methacrylate (GMA) and a hydrophilic co-monomer acrylamide (AM). The chemical sensor behaved as a fluorescent and chromogenic sensor towards various heavy metal cations and transition metal cations; particularly, Cr 3+ , Fe 3+ and Hg 2+ ions in completely aqueous media. The fluorescence of poly(AM-GRBD) was enhanced by Cr 3+ , Fe 3+ and Hg 2+ metal ions. Moreover, during titration of Cr 3+ , Hg 2+ or Fe 3+ to the aqueous solution of poly(AM-GRBD), the visual colour changed from colourless to pink or brown yellow under visible light.
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REACTIVE & FUNCTIONAL POLYMERS
·
2016
·
IF 2.725
Rong Ren,Yanhua Wang,Weilin Sun
Metal coordinated micelles based on the diblock copolymer PHEMA 82 -b-HQ 78 were synthesized. The block PHQ with 8-hydroxyquinoline groups can coordinate with metal ions to form the crosslinked core for micellization , while the other block PHEMA in the shell of the micelle improves its solubility. The morphological characteristics and the coordinating interaction between the metal ions and the core segment were characterized by DLS and TEM . The magnetic measurement found that the Curie-Weiss temperature T θ of the metalized micelle was 56 K and its hysteresis loop exhibited the typical ‘S’ shape with low H c and M r at 5 K, indicating that this micelle had the properties of soft ferromagnetic materials .
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 27
·22550-22554
·
IF 3.289
Jianbo Sun,Neng Jiang,Mengying Lv,Benqin Tang,Pei Wang,Jingyu Liang,Li Chen
Anstifolines A and B, two dimeric furoquinoline alkaloids with unique coupling patterns were isolated from the root bark of Dictamnus angustifolius. The biosynthetic pathway of anstifoline A was proposed. All of the isolates exhibited cytotoxicities and inhibition of superoxide anion generation and elastase release.
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高影响因子
Chinese Journal of Natural Medicines
·
2017
·
IF 1.667
Xiao-Xiao LU,Yi-Fan JIANG,Hong LI,Ying-Ye OU,Zhi-De ZHANG,Hong-Ye DI,Dao-Feng CHEN,Yun-Yi ZHANG
Lipopolysaccharides (LPS) contamination in herbal crude polysaccharides is inevitable. The present study was performed to explore the effect of polymyxin B on abolishing the influence of LPS contamination in mononuclear cells. LPS was pretreated with polymyxin B sulfate (PB) at different concentrations for 1, 5 or 24 h, and then used to stimulate RAW264.7 and mouse peritoneal macrophages (MPMs). The nitric oxide (NO) and tumor necrosis factor-α (TNF-α) in cell culture supernatant, as the indications of cell response, were assayed. Bupleurum chinensis polysaccharides (BCPs) with trace amount contamination of LPS was treated with PB. 30 μg·mL −1 of PB, treating LPS (10 and 1 000 ng·mL −1 in stimulating RAW264.7 and MPMs respectively) at 37 °C for 24 h, successfully abolished the stimulating effect of LPS on the cells. When the cells were stimulated with LPS, BCPs further promoted NO production. However, pretreated with PB, BCPs showed a suppression of NO production in MPMs and no change in RAW264.7. In the in vitro experiments, LPS contamination in polysaccharide might bring a great interference in assessing the activity of drug. Pretreatment with PB (30 μg·mL −1 ) at 37 °C for 24 h was sufficient to abolish the effects of LPS contamination (10 and 1 000 ng·mL −1 ).
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2017
·
IF 3.531
Qian He,Jia Ren,Junkai Ren,Kanglei Pang,Zhi Ma,Xingqi Zhu,Rui Song
Crystalline block copolymers tend to display a peculiar and intriguing behavior upon the external additives. In this work, we systematically investigated the self-assembly and crystallization behavior of polymethylene- b -poly (acrylic acid) crystalline diblock copolymer (PM- b -PAA, M 93 A 94 ) in the presence of calcium chloride (CaCl 2 ). When molar ratio between CaCl 2 and constituent deprotonated carboxyl group (COO − ) of M 93 A 94 (n, n = n CaCl2 /n COO − ) increased from 1:2 to 5:1, M 93 A 94 micelle gradually formed hexagonal and reticular aggregation. Further investigation of PM- b -PAA crystalline feature indicated that the crystallization of PM block was initially restrained by coordination interaction between calcium ion (Ca 2+ ) and carboxylate anion (COO − ), and then the crystallization of PM block was promoted when more Ca 2+ was added (n CaCl2 /n COO - reach to 5:1 and 13.5:1). Moreover, the conductivity measurement indicated that, when n (n CaCl2 /n COO − ) = 4, the coordination interaction between Ca 2+ and COO − was saturated, namely CaCl 2 /PAA formed tetradentate complex, and this information concerning the coordination geometry was highly consistent with the simulative calculation.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2016
·
IF 4.179
Jian He,Hu Li,Yanxiu Liu,Wenfeng Zhao,Tingting Yang,Wei Xue,Song Yang
A series of mesoporous acid–base bifunctional Zr/B mixed oxides with different molar ratios were prepared by a sol–gel method, and developed for conversion of ethyl levulinate (EL) to γ -valerolactone (GVL) by using alcohol as hydrogen source. The morphological structures and physico-chemical characteristics of the synthesized materials were identified by various techniques. A high GVL yield of 88.5% was achieved from EL in 2-propanol when Zr 1 B 1 was used. And acid–base sites played a synergic role in synthesizing GVL from EL as evident by poisoning experiments. Furthermore, the catalyst could be reused several times without significant loss of its catalytic activity.
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JOURNAL OF THE CHINESE CHEMICAL SOCIETY
·
2016
·Vol. 63
·期 11
·924-929
·
IF 0.879
Tingting Wang,Xican Li,Yunrong Li,Jianrun Wu,Yuyin Huang,Gang Wei,Dongfeng Chen
As the main bioactive component of Chinese herbal medicine Danshen, salvianolic acid B (Sal B, or lithospermic acid B) was observed to maintain the viability of mesenchymal stem cells (MSCs) treated by Fenton's reagent in the study. Interestingly, at a higher concentration, Sal B could even increase the viability rate to 175.1%. In mechanistic analysis experiments, Sal B was found to resist DNA destruction by •OH radical, scavenge various radicals in vitro , reduce Cu 2+ → Cu + , chelate Fe 2+ to yield an absorption maximum at 710 nm. Based on these results, we concluded that, (1) Sal B can not only protect MSCs against •OH-induced damages, but also promote their proliferation. This extraordinary capacity makes Sal B an ideal candidate in MSCs transplantation especially when MSCs are polluted by iron-overload or other oxidative stress factors and, can partly be responsible for the versatile properties of Sal B in pharmacology. The possible mechanisms of its protective effect are hypothesized to include Fe 2+ chelating, and direct radical scavenging which is involved in electron transfer (ET) or hydrogen atom transfer (HAT) from the catechol moieties. Its proliferation-promoting effect is presumed to be from its ester group, carboxylic group, or benzofuran ring.
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