BIOMATERIALS
·
2024
·
IF 12.8
Mengyao Chen,Xiaohan Tong,Yanting Sun,Chunyan Dong,Chen Li,Chunhui Wang,Minyi Zhang,Yixuan Wen,Pinting Ye,Ruihao Li,Jie Wan,Shujing Liang,Shuo Shi
As an iron dependent regulatory cell death process driven by excessive lipid peroxides (LPO), ferroptosis is recognized as a powerful weapon for pancreatic cancer (PC) therapy. However, the tumor microenvironment (TME) with hypoxia and elevated glutathione (GSH) expression not only inhibits LPO production, but also induces glutathione peroxidase 4 (GPX4) mediated LPO clearance, which greatly compromise the therapeutic outcomes of ferroptosis. To address these issues, herein, a novel triple-enhanced ferroptosis amplifier (denoted as Zal@HM-PTBC) is rationally designed. After intravenous injection, the overexpressed H 2 O 2 /GSH in TME induces the collapse of Zal@HM-PTBC and triggers the production of oxygen and reactive oxygen species (ROS), which synergistically amplify the degree of lipid peroxidation (broaden sources). Concurrently, GSH consumption because of the degradation of the hollow manganese dioxide (HM) significantly weakens the activity of GPX4, resulting in a decrease in LPO clearance (reduce expenditure). Moreover, the loading and site-directed release of zalcitabine further promotes autophagy-dependent LPO accumulation (enhance effectiveness). Both in vitro and in vivo results validated that the ferroptosis amplifier demonstrated superior specificity and favorable therapeutic responses. Overall, this triple-enhanced LPO accumulation strategy demonstrates the ability to facilitate the efficacy of ferroptosis, injecting vigorous vitality into the treatment of PC.
研究领域:
癌症生物学
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药理学
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治疗学
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DOI
PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 26
·14982-14989
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IF 3.049
Pian Wu,Ping Ding,Xiaosheng Ye,Lei Li,Xiaoxiao He,Kemin Wang
Multimetallic nanomaterials have aroused special attention owing to the unique characteristics of chemical, optical and enhanced enzyme mimetic capabilities resulting from the synergistic effect of different metal elements. In this work, we present a facile, gentle, fast and one-pot method for preparing Cu/Au/Pt trimetallic nanoparticles (TNPs), which possess intrinsic and enhanced peroxidase-like activity as well as excellent stability, sustainable catalytic activity, and robustness to harsh environments. Kinetic analysis indicated that Cu/Au/Pt TNPs exhibited strong affinities with H2O2 and 3,3,5,5-tetramethylbenzidine (TMB) as the substrates. To investigate the feasibility of Cu/Au/Pt TNPs-based strategy in biological analysis, H2O2 was chosen as a model analyte and a sensitive and specific detection for H2O2 was acquired with a detection limit of 17 nM. By coupling with glucose oxidase (GOD), this assay could also achieve a sensitive and selective detection of glucose with a detection limit of 33 μM, indicating the versatility of the method. In view of the potential combination with diverse enzyme-related reactions, the Cu/Au/Pt TNPs-based strategy is promising as a universal platform for biosensors.
研究领域:
纳米生物学
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分析化学
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生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2014
·
IF 3.107
Haiming Shi,Dongsheng Xie,Ruoling Yang,Yaqian Cheng
Twenty-one caffeic acid phenethyl ester (CAPE) derivatives were synthesized, and characterized by IR, HR-MS, 1H and 13C NMR analyses. All compounds were evaluated for their cytoprotective effects against H2O2-induced cytotoxicity and neuritogenic activities in the neurite outgrowth in PC12 cells. Compounds 1 and 20 exhibited stronger cytoprotective activities than their parent compound CAPE at 4 nM. Compounds 1, 4, 12 and 13 showed potential neuritogenic activities at 0.5 nM, while compounds 19 and 20 induced neurite outgrowth at 10 nM. The results from this study suggested that CAPE and its derivatives may be potential functional food ingredients for the prevention of neurodegenerative diseases.
研究领域:
药理学
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神经科学
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有机化学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Jinhui Wei,Xiangchuan Wu,Chengyuan Wu,Fan Hou,Lina Wu,He Huang
Aflatoxin B 1 (AFB 1 ), a naturally produced toxin existing in major food crops, is highly toxic and carcinogenic to human and animals. In this study, a reusable material, Pd@PCN-222 with great adsorption performance and peroxidase-like activity was synthesized for the removal of AFB 1 . Pd@PCN-222 exhibited great adsorption performance owing to hierarchical porous structure. Pd@PCN-222 also could catalyze the AFB 1 in the presence of H 2 O 2 due to the Fe-tetrakis (4-carboxyphenyl) porphyrin and Pd as effective peroxidase active site, which improved the removal efficiency of AFB 1 . Pd@PCN-222 was applied for the removal of AFB 1 with a removal rate of 96.52% in 2 h. Owing to the advantages of high removal efficiency and reusability, Pd@PCN-222 had great application potential in AFB 1 removal.
研究领域:
材料科学
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毒理学
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食品安全
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 37
·8599-8606
·
IF 5.344
Zhen Lin,Linlin Zheng,Wensong Yao,Shijun Liu,Yemei Bu,Qi Zeng,Xiaomin Zhang,Haohua Deng,Xinhua Lin,Wei Chen
Nanozymes have emerged as enzyme-mimicking nanomaterials to overcome the low stability and high cost of some natural enzymes. The design and fabrication of nanozymes with superior performance to natural enzymes are in urgent demand. Single-atom catalysts offer the unique characteristics of maximum atomic utilization, and are an excellent candidate for nanozymes. However, most of the reported synthesis methods for single-atom catalysts require the preparation of supports for single-atom catalysts in advance, which requires multiple steps and calcination in a high temperature atmosphere. Herein, Cu–N–C single-atom nanozymes (Cu–N–C SAzymes) were successfully designed via a one-pot solvothermal method. Cu–N–C SAzymes exhibited excellent peroxidase-mimicking activity that is superior to some other related nanoparticles. The mechanism study revealed that H2O2 was catalyzed by Cu–N–C SAzymes to generate reactive oxygen species. Furthermore, based on the excellent peroxidase-mimicking activity of the Cu–N–C SAzymes, a simple and sensitive detection method for H2O2 and glucose has been developed.
研究领域:
纳米技术
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催化
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生物化学
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分析化学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Xiaoyue Li,Penghui Li,Yingjie Li,Haitang Liu,Zongzheng Yang,Yanyan Chen,Xiaoyuan Liao
In situ generation of H 2 O 2 by photocatalyst with sterilization is an environmentally friendly method. In this work, we prepared three kinds of Zn-based ZIFs materials, i.e., MAF-6, ZIF-11 and ZIF-71, and systematically investigated their application in the area of photocatalytic H 2 O 2 production, and antibacterial efficiency. It is found that MAF-6 had the best ability of generate H 2 O 2 (1005 μmol h -1 g -1 ), 1.6 times more than ZIF-11, while ZIF-71 produced almost no H 2 O 2 . The sterilization rate of MAF-6 against Staphylococcus aureus and Escherichia coli can reach 97% and 91% in 3 h, respectively. It is worth noting that the more photo-generated reactive oxygen species (∙OH and ∙O 2 - ) are produced, the better sterilization effect . This work provides new material and insights into photocatalytic sterilization by in situ H 2 O 2 generation.
研究领域:
环境科学
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材料科学
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微生物学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Shenyan Xu,Hongxiang Chu,Xin Qin,Bei Jiang,Ruofan Li,Taikang Jia,Wenjing Wang,Chunyu Che,Yongsheng Wu,Ling Zhang,Chuanqi Zhang,Wenzhong Wang
The photocatalytic production of hydrogen peroxide from water and oxygen using solar energy presents a promising approach. Nevertheless, challenges persist regarding the efficiency of this process and the clarification of the underlying catalytic mechanisms. In this study, we synthesized a donor-acceptor type photocatalyst, modified resorcinol-formaldehyde resin. FT-IR and XPS analyses confirmed the successful incorporation of an additional electron donor unit, N, N-dimethylaniline, which interacts with the electron acceptor unit to facilitate the directed migration of photogenerated electrons. Furthermore, this modification creates an electron-rich carbonyl active center, enhancing its capacity to adsorb and reduce O 2 , thereby improving the photocatalytic production of H 2 O 2 . In situ EPR and DRIFT analyses identified key intermediates, substantiating a two-step, single-electron oxygen reduction pathway and providing insights into the catalytic mechanism. Importantly, without the use of sacrificial agents or additional aeration, the photocatalytic production rate of H 2 O 2 reached 22.8 μmol·h −1 , underscoring its potential as an effective photocatalyst. This study elucidates the reaction mechanism during the photocatalytic process, offering valuable insights for future material design aimed at enhancing hydrogen peroxide production rates.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Journal of Materiomics
·
2024
·
IF 8.4
Xin Zhou,Chenbin Ai,Xiaojing Wang,Zhen Wu,Jianjun Zhang
Pure ZnO exhibits low photocatalytic H 2 O 2 production activity due to the rapid charge recombination. To realize the spatial separation of photogenerated electrons and holes, constructing an electron transfer channel on the ZnO surface is an effective approach. This study successfully modified the surface of ZnO using F – (ZnO/F) by introducing NH 4 F in an aqueous phase photocatalytic system. The F – is adsorbed on the ZnO surface by Coulombic force and significantly improves the photocatalytic H 2 O 2 production performance of ZnO, with the highest efficiency of 4137.2 μmol·g –1 ·L –1 ·h –-1 . The photocatalytic performance enhancement mechanism of ZnO/F is explained in terms of electron transfer dynamics by femtosecond transient absorption spectroscopy (fs-TAS) measurements. F – surface modification constructs a new ultrafast electron transport pathway from the ZnO CB to F – , and the optimal ZnO/F exhibits the fastest interfacial electron transfer lifetime of 5.8 ps. The F – surface modification effectively facilitates the charge separation, thereby increasing the number of electrons available for photocatalytic H 2 O 2 reaction. This study has revealed the roles of F – surface modification in the photocatalytic H 2 O 2 production by ZnO and provides guidance for ionic modification to improve photocatalytic performance.
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Solomon Sime Tessema,Hongzhan Liu,Shiyu Xia,Tadele Eticha,Mohammed Yahya Suleiman,Yu Tian,Guobao Xu
A chemiluminescence (CL) system with high intensity and long-lasting emission is crucial for accurate CL measurements. The luminol/hydrogen peroxide (H 2 O 2 ) CL system has recently attracted significant attention. However, the CL emission from the luminol/H 2 O 2 system is typically weak, which limits its application for quantitative measurements. In this study, we synthesized a high-entropy metal–organic framework nanosheet (HE-MOFs) containing five homogeneous and nearly equally dispersed metal ions using a solution-phase strategy at room temperature. The resulting HE-MOFs exhibited exceptional peroxidase-mimicking catalytic activity. Their intrinsic peroxidase-like properties allowed HE-MOFs to efficiently catalyze H 2 O 2 , generating reactive oxygen species (ROS) and producing a strong, efficient, and stable CL emission in the luminol/H 2 O 2 /HE-MOFs system. The remarkable enhancement of CL emission can be attributed to the synergistic effects of the multi-metal ions in the unique crystal structure of HE-MOFs. Consequently, we developed a fast, sensitive, and selective luminol/H 2 O 2 /HE-MOFs CL sensor to detect dopamine (DA), leveraging the potential inhibitory effect of DA on CL emission. This sensor effectively detected dopamine and demonstrated good linearity over a 10–500 nM concentration range, with a low detection limit (LOD) of 3.90 nM (S/N = 3). As a proof of concept, we applied the method to detect DA in real samples, achieving excellent recoveries ranging from 95 % to 105 % (RSD < 1.19 %, n = 3). Our findings provide a new perspective on designing high-entropy-based MOFs nanozymes and lay the groundwork for developing highly sensitive CL biosensors for real-time bioassays.
研究领域:
分析化学
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生物传感
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材料科学
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DOI
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2023
·Vol. 148
·期 17
·8849-8859
·
IF 4.4
Liu Long,Tian Yanan,Bai Ruibing,Li Yue,Su Ze,Yao Yuan,Zhang Yanqiang
IL-H 2 O 2 bicomponent hypergolic propellant is a new type of green and environmentally friendly hypergolic propellant, but its ignition delay time needs to be further reduced. In this paper, an iodine-containing ionic liquid of 1-methyl-4,5-diiodoimidazolium iodide ([Dmim]I) was synthesized and applied to the spontaneous combustion system of methylimidazolium borane (MIMB) and H 2 O 2 . When a small amount of [Dmim]I was added, the spontaneous combustion of MIMB was enhanced and the flame color becomes brighter as well as the ignition delay time can be reduced from 250 to 109 ms; the accelerator of [Dmim]I had less effect on the maximum specific impulse of MIMB, but the combustion mechanism of MIMB in 95% H 2 O 2 was changed may be by lowering the Gibbs free energy of the dehydrocoupling reaction between the H 2 O 2 and the MIMB. Thermal behavior of MIMB, [Dmim]I, and MIMB containing 2 mass% [Dmim]I were studied by thermogravimetric analysis. The decomposition temperature of MIMB is greatly delayed after adding 2 mass% of [dmim]I, and the maximum temperature delay is about 30 °C; the thermal decomposition of MIMB includes two thermal mass loss processes and the corresponding decomposition activation energy are increased with the addition of [Dmim]I; these indicate that MIMB is compatible with [Dmim]I without oxidizing agent, and [Dmim]I has a stabilizing effect on MIMB.
研究领域:
推进剂化学
·
材料科学
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DOI
高影响因子
JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Yulu Xu,Zixin Li,Xia Hu,Xiang Wu,Wei Chen,Shujing Zhou,Jinjing Li,Chenze Qi,De-Kun Ma
CuBi 2 O 4 (CBO) semiconductor composed of low cost and environmentally friendly Cu, Bi, and O elements possesses relatively narrow band gap, appropriate energy band position, and very positive photocurrent onset potential, which make it promising for photoelectrochemical (PEC) O 2 reduction reaction (ORR). However, low separation and transfer efficiency of photogenerated carriers and poor product selectivity limit its further application in PEC ORR toward H 2 O 2 production. In this work, we report F − ions doped CuBi 2 O 4 (F-CBO) nanorod arrays with enhanced PEC ORR performance for H 2 O 2 generation. PEC ORR activity of CBO nanorod arrays was obviously enhanced through decreasing the sizes of nanorods. Furthermore, the doping of F − ions into CBO lattice promoted the separation and transfer of photogenerated carriers and significantly improved the selectivity of ORR toward H 2 O 2 path. As a result, 0.85 mmol/L of H 2 O 2 could be achieved on the F-CBO photocathode within 45 min under simulated AM1.5G sunlight illumination (100 mW cm −2 ), which is 2.8 times higher than that obtained on the pristine counterpart. The roles of fluorine doping were revealed based on experimental results and density functional theory (DFT) calculations. The combination of morphology and surface doping engineering provides a new strategy for designing highly efficient photocathod for PEC ORR to H 2 O 2 production.
研究领域:
材料科学
·
能源化学
·
环境科学
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DOI
高影响因子
MINERALS ENGINEERING
·
2025
·
IF 5
Xiaoyu Jiang,Sikai Zhao,Jie Wang,Haiyi Lv,Weizhen Bai,Wenbao Liu,Qiang Zhao,Yanbai Shen
Tetracycline (TC) persistence in aquatic systems poses significant ecological and human health risks, due to its toxicity and resistance to conventional biodegradation. In this study, sulfur and nitrogen modification strategies were employed to enhance the catalytic performance of spinel ferrite MnFe 2 O 4 for TC degradation via H 2 O 2 and peroxymonosulfate (PMS) activation. The catalysts were characterized using SEM, XRD, VSM, CV, and ICP-OES to elucidate the effects of heteroatom modification on morphology, crystal structure, magnetic separability, and metal leaching behavior. S modification markedly enhanced both H 2 O 2 and PMS activation capabilities. The optimized S/MnFe 2 O 4 -5/H 2 O 2 system removed 82 % TC (50 mg/L) within 20 min, an eightfold increase in the reaction rate compared to the unmodified MnFe 2 O 4 /H 2 O 2 . This system maintained high efficiency across a broad pH range (3–11). In contrast, nitrogen modification selectively improved PMS activation, with the optimal N/MnFe 2 O 4 -3/PMS system degrading 74 % TC in 30 min, twice the degradation rate of MnFe 2 O 4 /PMS, and exhibiting minimal metal leaching with excellent recyclability. Scavenger studies confirmed that ·OH constitutes the dominant reactive oxygen species (ROS) in S/MnFe 2 O 4 -5/H 2 O 2 systems, while both ·OH and ·SO 4 - contribute significantly in N/MnFe 2 O 4 -3/PMS systems. Sulfur species act as electron mediators, facilitating the Fe/Mn redox cycle and enhancing ROS generation, whereas zero valence iron (Fe 0 ) formed during nitrogen modification serves as an efficient electron donor to activate PMS. Degradation pathway analysis and toxicity predictions confirmed a substantial reduction of TC environmental hazards. This work provides fundamental insights into the structure–activity relationships of heteroatom-modified MnFe 2 O 4 catalysts, and establishes practical design principles for robust advanced oxidation process catalysts in antibiotic remediation.
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高影响因子
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