CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Jing Gong,Shunhua Wang,Jie Liu,Yaowen Zhang,Jiyao Li,Hao Yang,Kunneng Liang,Yi Deng
Periodontitis, a chronic inflammatory condition associated with bacterial infection, is the leading cause of tooth loss in adults. Pathogenic bacteria that persist in deep periodontal pockets with hyperglycemic levels following traditional manual debridement can contribute to a persistent local inflammatory microenvironment, posing a significant challenge and highlighting the critical need for improved therapeutic approaches. In addition, the anaerobic environment during these treatments is beneficial to the colonization of anaerobes and may amplify inflammatory responses. Herein, we designed a glucose oxidase (GOx)-coating MXene-SnS 2 bio-heterojunctions (MS@G bio-HJs) for multi-modal and effective treatment of anti-bacteria and anti-inflammatory. Upon the hyperglycemic nidus in periodontal pockets, GOx catalyzes the conversion of glucose into hydrogen peroxide (H 2 O 2 ). Subsequently, the breakdown of H 2 O 2 into hydroxyl radicals through Sn 2+ /Sn 4+ -involved Fenton-like reactions enables in situ liberation of oxygen (O 2 ), contributing to relieve local hypoxia. The proposed bio-HJs presents a satisfactory bactericidal capability with anti-bacterial rates of more than 99 % upon near-infrared irradiation, in virtue of multi-modal therapies including photodynamic, photothermal and chemodynamic treatments. Furthermore, in vivo assays utilizing infectious rat models demonstrated that the proposed bio-HJs exhibits high biocompatibility and capacity to alleviate hypoxia and reduce pathogenic virulence factors, potentially contributing to periodontal tissue regeneration. These findings suggest that the versatile bio-HJs could be a promising therapeutic candidate for treating infectious periodontal diseases.
研究领域:
牙科学
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生物材料
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纳米技术
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治疗学
✓ 已验证
产品关联
DOI
高影响因子
FITOTERAPIA
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2024
·
IF 2.5
Ling Jiang,Cai-Bo Tian,Rui-Han Ye,Nian Shi,Xing-Chao He,Yun-Li Zhao,Xiao-Dong Luo
Drug-induced liver injury caused acute hepatic failure and hepatitis frequently. In this investigation, kakuol and asarinin reduced the levels of serum alanine transaminase (ALT), aspartate transaminase (AST) and malondialdehyde (MDA) dramatically, and ameliorated the pathological damage of liver tissues in APAP-induced mice. Furthermore, both compounds increased the viabilities of APAP-induced L-O2 cells and extracellular glutathione (GSH) levels accompanied significantly by reducing the level of intracellular ROS in vitro . In addition, HSP90AA1/CDK2/mTOR signaling pathway and five target proteins (CDK2, HSP90AA1, HRAS, MMP1, mTOR) were proposed from network pharmacology and molecular docking prediction, and then the up-regulation of protein expression of CDK2, mTOR and down-regulation of HSP90AA1, HRAS, MMP1 by kakuol and asarinin in western blotting supported their mechanism.
研究领域:
药理学
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分子生物学
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毒理学
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肝病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Jiadong Hou,Yufeng Liu,Chufei Cheng,Fuhao Cheng,Pengfei Qin,Yang Miao,Weihua Ji,Xiaomin Wang
The limited efficiency of traditional trial-and-error experiments has impeded the development and application of high-entropy fluorite oxides in thermal insulation coatings. To solve this problem, a novel entropy descriptor based on first principles is presented to help select candidate components for synthesizing high-entropy fluorite structure oxides. Results show that the compatibilities of 10 single-phase high-entropy fluorite oxides can be accurately predicted based on entropy formation ability. In the studied (Zr, Hf, Pr, La, X) O 2-δ system, a correlation between thermal characteristics and size/mass differences was established by designing the size and mass of X. Specifically, we found that the thermal conductivity is more strongly correlated with the difference in atomic mass, while the coefficient of thermal expansion is strongly correlated with the difference in atomic size. X-ray photoelectron spectroscopy (XPS) analysis shows that the concentration of oxygen vacancy can effectively reduce the thermal conductivity of high-entropy fluorite oxides. In addition, the values of hardness, elastic modulus and thermal conductivity of five single-phase fluorite oxides are successfully predicted by first principles calculation , and the differences between these values and the experimental results are small, which provides a prospective significance for the performance prediction of high-entropy fluorite oxides. Our findings provide a strategy for customizing high-entropy fluorite single-phase oxides with suitable properties to meet the performance requirements of thermal barrier coatings (TBCs).
研究领域:
材料科学
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热力学
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2016
·Vol. 6
·期 1
·1-15
·
IF 5.228
Zhang Qingzhe,Bao Nan,Wang Xinqiang,Hu Xinde,Miao Xinhan,Chaker Mohamed,Ma Dongling
In this article, a novel route for the synthesis of graphene/TiO 2 continuous fibers (GTF) using force-spinning combined with water vapor annealing method is reported for the first time. The morphology, structure and optical properties of the composite were fully characterized. With a single step of heat treatment process using steam at ambient conditions, we were able to initiate a series of chemical reactions, such as reduction of graphene oxide (GO), crystallization of TiO 2 , formation of C-Ti bond, and introduction of oxygen vacancies into TiO 2 . The incorporation of graphene in TiO 2 fibers facilitated bandgap narrowing and improved photo-induced charge separation in the photocatalyst. As a result of synergistic effects, TiO 2 fibers-2 wt% graphene (2%GTF) showed the highest photocatalytic activities in the degradation of X-3B under UV irradiation, superior to the benchmark photocatalyst P25. Under visible light irradiation, the same catalyst was about 4 times more efficient compared to pure TiO 2 fibers (PTF). A detailed study of involved active species (in particular, · , h + and ·OH) unraveled the mechanism regarding photocatalysis.
研究领域:
材料科学
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纳米技术
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环境科学
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
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2026
·
IF 10.4
Qiuya Ji,Kai Ye,Ran Meng,Sijie Wu,Ran Feng,Bao Zhang
To address the conflicting challenges of fat reduction, texture fidelity, and co-delivery of hydrophilic and hydrophobic bioactive compounds, this study explored an innovative O 1 /W/O 2 -microstructured bigel system, WGB(O 1 /W/O 2 ). The system was stabilized through whey protein aggregates rapidly adsorbing at dual interfaces as an amphiphilic mediator, along with hydrogen bonding formation with guar gum in hydrogel matrix. The extended multilayered structure enabled WGB(O 1 /W/O 2 ) demonstrated favorable cream cheese simulation performance in appearance, viscoelastic properties, melting behavior, and texture characteristics. Sequential degradation of each phase during digestion (O 2 -W-O 1 ) increased the intestinal release of PTS and GA by up to 3.3-fold and 1.8-fold, respectively, over conventional bigels (O/W or bicontinuous). Among the bigels, cream cheese texture similarity ranked O 1 /W/O 2 > bicontinuous>O/W. The delivery efficiency for hydrophobic PTS followed O 1 /W/O 2 > O/W > bicontinuous, while that for hydrophilic GA followed O 1 /W/O 2 > bicontinuous>O/W. This study highlights broad application prospects of WGB(O 1 /W/O 2 ) for fat-reduced and nutrient-enhanced dual-functional foods, while advances understanding of bigel microstructure evolution-properties relationships.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2011
·
IF 3.384
Hua Yang,Jia-Qi Chen,Jun Li,Ying Lv,Shuang Gao
Hydroxylation of benzene to phenol in the [(CH 3 ) 4 N] 4 PMo 11 VO 40 /ascorbic acid/TEMPO/O 2 catalytic system was carefully investigated. UV–vis, ESR and 1 H NMR studies showed ascorbic acid radicals were formed through the hydrogen exchange of ascorbic acid with TEMPO (2,2,6,6-tetramethyl-1-piperidine-N-oxyl radicals) during the reaction. In acetonitrile, the ascorbic acid would be partly oxidized to 2-hydroxy-2-buten-4-olide (α-tetronic acid, isotetronic acid, compound 1 ) without TEMPO. The interaction of TEMPO and ascorbic acid restrained the oxidative dissociation of ascorbic acid and promoted the rate of the hydroxylation. Aqueous acetic acid solvent can also restrain the oxidative dissociation of ascorbic acid. In aqueous acetic acid, the yield of phenol could reach 18.9% in the [(CH 3 ) 4 N] 4 PMo 11 VO 40 /ascorbic acid/TEMPO/O 2 catalytic system with sufficient ascorbic acid after 400 min.
研究领域:
催化化学
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有机化学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
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2018
·
IF 5.116
Chaoqun Niu,Mingke Zhang,Guangping Chen,Bokai Cao,Jiwei Shi,Jie Du,Yong Chen
Polyacrylate polymer is a promising polymer matrix for gel polymer electrolyte (GPE) in lithium-ion batteries . Herein, in-situ polymerized poly(ethylene glycol phenyl etheracrylate) (PEGPEA) based GPE combined with 1 M LiPF6 in ethylene carbonate/dimethyl carbonate/ethyl methyl carbonate (EC/DMC/EMC, 1:1:1 in volume) solvents was introduced. The maximum recoverable strain of the in-situ polymerized PEGPEA-GPE was up to 99%. The outstanding interfacial compatibility between PEGPEA-GPE and the lithium electrode was also obtained. Surprisingly, lithium dendrite was effectively suppressed in charge-discharge cycling because of polymer-enhanced solid electrolyte interphase (SEI) and excellent contact interface. Furthermore, the PEGPEA-GPE exhibited wide electrochemical stability window up to 4.9 V versus Li + /Li, and achieved an ionic conductivity of 3.35 × 10 −3 S cm −1 at 25 °C. When used as electrolyte, the Li[Ni 0.5 Co 0.2 Mn 0.3 ]O 2 /PEGPEA-GPE/Li batteries showed high discharge capacity retention rate of 97.5% after 70 charge-discharge cycles and considerable discharge rate capability, i.e., 155 mAh g −1 0.2C, 142 mAh g −1 0.5C, 120 mAh g −1 1C, 60 mAh g −1 2C. These results demonstrate that this highly elastic in-situ polymerized PEGPEA-GPE is a potential electrolyte system for high-performance polymer electrolyte lithium-ion batteries and has excellent application prospects in wearable and flexible batteries.
研究领域:
材料科学
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电化学
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电池技术
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 13
·6871
·
IF 4.9
Liang Hao,Jingfei Luan
This study presents a pioneering synthesis of a direct Z-scheme Y2TmSbO7/GdYBiNbO7heterojunction photocatalyst (YGHP) using an ultrasound-assisted hydrothermal synthesis technique. Additionally, novel photocatalytic nanomaterials, namely Y2TmSbO7and GdYBiNbO7, were fabricated via the hydrothermal fabrication technique. A comprehensive range of characterization techniques, including X-ray diffractometry, Fourier-transform infrared spectroscopy, Raman spectroscopy, UV-visible spectrophotometry, X-ray photoelectron spectroscopy, transmission electron microscopy, X-ray energy-dispersive spectroscopy, fluorescence spectroscopy, photocurrent testing, electrochemical impedance spectroscopy, ultraviolet photoelectron spectroscopy, and electron paramagnetic resonance, was employed to thoroughly investigate the morphological features, composition, chemical, optical, and photoelectric properties of the fabricated samples. The photocatalytic performance of YGHP was assessed in the degradation of the pesticide acetochlor (AC) and the mineralization of total organic carbon (TOC) under visible light exposure, demonstrating eximious removal efficiencies. Specifically, AC and TOC exhibited removal rates of 99.75% and 97.90%, respectively. Comparative analysis revealed that YGHP showcased significantly higher removal efficiencies for AC compared to the Y2TmSbO7, GdYBiNbO7, or N-doped TiO2photocatalyst, with removal rates being 1.12 times, 1.21 times, or 3.07 times higher, respectively. Similarly, YGHP demonstrated substantially higher removal efficiencies for TOC than the aforementioned photocatalysts, with removal rates 1.15 times, 1.28 times, or 3.51 times higher, respectively. These improvements could be attributed to the Z-scheme charge transfer configuration, which preserved the preferable redox capacities of Y2TmSbO7and GdYBiNbO7. Furthermore, the stability and durability of YGHP were confirmed, affirming its potential for practical applications. Trapping experiments and electron spin resonance analyses identified active species generated by YGHP, namely •OH, •O2−, and h+, allowing for comprehensive analysis of the degradation mechanisms and pathways of AC. Overall, this investigation advances the development of efficient Z-scheme heterostructural materials and provides valuable insights into formulating sustainable remediation strategies for combatting AC contamination.
研究领域:
材料科学
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环境科学
·
化学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
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