JOURNAL OF MEMBRANE SCIENCE
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2022
·
IF 10.53
Rui Chen,Liuyong Mao,Christine N. Matindi,Gansheng Liu,Jintao He,Zhenyu Cui,Xiaohua Ma,Kuanjun Fang,Biao Wu,Bhekie B. Mamba,Jianxin Li
An in-situ reaction controlled non-solvent induced phase separation (RC-NIPS) method was developed to tailor the morphology of polyvinyl chloride (PVC)/styrene-maleic anhydride (SMA) grafting polyethylene glycol (PEG) (SMA-g-PEG) blend ultrafiltration (UF) membrane. Herein, PVC and SMA was dissolved in dimethylacetamide (DMAc) solvent to prepare a casting solution (16 wt% polymer concentration) at 50 °C. Subsequently, PEG (20 kDa) as an additive and reactant was added to the casting solution at a mass ratio of PEG to the polymer 1/1 wt/wt. to enhance the hydrophilicity and mechanical elongation of the membrane. Results demonstrated that the casting solution with PVC/SMA = 3/1 wt/wt. was an entirely compatible system. The viscosity of the casting solution with adding PEG gradually increased from 692 mPa s to 1880 mPa s at the initial stage and 4780 mPa s at 42 h, then rose sharply to 27,320 mPa s at 84 h. This behavior was ascribed to the esterification reaction between PEG and SMA, leading to pre-gelation and gelation of the system. Whereafter, SMA-g-PEG graft polymers were obtained. Meanwhile, the degree of grafting (DG) increased from 0.40% at 12 h of the reaction to 2.61% at 42 h. Afterwards, a phase inversion using water as coagulation was used to prepare PVC/SMA-g-PEG blend membrane after a certain time of the esterification reaction. It was found that the morphology of resultant membranes systematically changed from asymmetric structure with a dense top layer and finger-like sublayer at the initial stage to a dense layer with a fully sponge-like structure after 18–42 h reaction. The PVC/SMA-g-PEG membrane obtained after the reaction of 42 h demonstrated better hydrophilicity, high pure water permeance and excellent toughness due to the internal plasticization of water molecules. The membrane also exhibited a high BSA rejection (>95%) and fouling recovery rate (FRR) (85.9%). Our work provides some insights on tailoring the UF membrane structure and simultaneously enhancing permeability, antifouling performance and toughness.
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高影响因子
Gels
·
2022
·Vol. 8
·期 5
·279
·
IF 4.432
Hang Yang,Xianyu Lan,Yuzhu Xiong
Although many advances have been made in medicine, traumatic bleeding and wound infection are two of the most serious threats to human health. To achieve rapid hemostasis and prevent infection by pathogenic microbes, the development of new hemostatic and antibacterial materials has recently gained significant attention. In this paper, safe, non-toxic, and biocompatible polyvinyl alcohol (PVA); carboxymethyl cellulose (CMC), which contains several carboxyl and hydroxyl groups; and polyethylene glycol (PEG), which functions as a pore-forming agent, were used to prepare a novel PVA/CMC/PEG-based composite hydrogel with a macroporous structure by the freeze-thaw method and the phase separation technique. In addition, a PVA/CMC/PEG@ZIF-L composite hydrogel was prepared by the in situ growth of zeolitic imidazolate framework-L (ZIF-L). ZIF-L grown in situ on hydrogels released Zn2+and imidazolyl groups. They elicited a synergistic antibacterial effect in hemostasis with PVA and CMC, rendering the PVA/CMC/PEG@ZIF-L hydrogel with a good antibacterial effect againstStaphylococcus aureus. At the same time, the macroporous structure enabled the rapid release of Zn2+and imidazolyl groups in ZIF-L and promoted cell proliferation at an early stage, enhancing the coagulation efficiency. A rat liver injury model was used to confirm its rapid hemostasis capacity.Keywords:in situ growth;macroporous structure;synergistic antibacterial;rapid hemostatic;carboxymethyl cellulose;wound dressing;hydrogel;ZIF-L;polyvinyl alcohol;phase separation technique
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高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2023
·
IF 3.6
Qinming Xu,Hui Chen,Junming Zhu,Xing Li,Jingang Yang,Xiaocui Deng,Qingmei Yuan
In this study, the PEG-Glu-Lys-Glu copolymer drug delivery system (GO/PEG-Glu-Lys-Glu) is prepared using glutamate-lysine-glutamate (Glu-Lys-Glu) modified polyethylene glycol (PEG) and connected graphene oxide nanosheets (GO). The multiple carboxyl groups of Glu-Lys-Glu and π–π interactions of GO can increase drug loading rate, and the fluorescence characteristics of GO could monitor the distribution of drug-loading systems in cells and the uptake of cells without the need for external dyes. Paclitaxel (PTX) is loaded via reduction-responsive disulfide bonds as a model medicine to examine the drug delivery potential of GO/PEG-Glu-Lys-Glu. The results showed that the drug loading content of PEG-Glu-Lys-Glu and GO/PEG-Glu-Lys-Glu to PTX is 7.11% and 8.97%, and the loading efficiency is 71.05% and 89.68%, respectively. It’s speculated that the π–π interaction between GO and PTX improved the drug-loading capacity and efficiency of GO/PEG-Glu-Lys-Glu. In vitro, in a simulated drug release test, at 48 h, the release of PTX was 85.51% at pH 5.0, 65.12% and 38.32% at pH 6.5 and 7.4, respectively. The cytotoxicity assay results showed that GO/PEG-Glu-Lys-Glu cell inhibition rate to MCF-7 cells was 7.36% at 72 h. The cell inhibition rate of GO/PEG-Glu-Lys-Glu/PTX system at 72 h was 92%, equivalent to free PTX. Therefore, the GO/PEG-Glu-Lys-Glu drug delivery system has the characteristics of good biocompatibility and sustainable release of PTX, which is expected to be applied in the field of tumor therapy.
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高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
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IF 4.845
Zhenjie Wang,Xinxin Lin,Dongxu Chi,Zhaochu Xu,Guimei Lin,Hongzhuo Liu,Jin Sun,Zhonggui He,Yongjun Wang
Along with the malignant proliferation of tumor requiring nutrients, the expression of L-type amino acid transporter 1(LAT1) and amino acid transporter B 0,+ (ATB 0,+ ) in cancer cells is up-regulated that can be used as new targets for active targeting of tumor. However, since normal cells also express amino acid transporters in small amounts, traditional ligand-exposure drug delivery systems are potentially toxic to the body. Therefore, we designed a smart-response drug delivery system that buries the tyrosine ligand in PEG hydration layer at normal tissues and exposes the ligand by cleaving the pH-sensitive bond of PEG at the tumor site. Irinotecan (CPT-11) is actively loaded into the inner aqueous phase of liposomes via a copper ion gradient mechanism which has high encapsulation efficiency and stable drug release profile. Smart-response liposomes showed the strongest cytotoxicity and the maximum cellular uptake in vitro , the largest amount of tumor site accumulation and the best antitumor effect in vivo , compared with non-targeted liposomes and non-sensitive liposomes. It is worth noting that smart-response liposomes not only achieved enhanced antitumor effect but also attenuated side effects compared to ligand-exposure liposomes. This provides a smart responsive drug delivery system for precise treatment and shows a good application prospect.
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高影响因子
Nanoscale Advances
·
2022
·Vol. 4
·期 19
·4169-4174
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IF 5.598
Yi Gao,Shaofeng Liang,Shuangliang Zhao,Wei Gao,Zequan Li,Muqun Wang,Hong Li,Xiangning He,Riyao Cong,Hailin Diao,Chuwang Su,Xiaoying Xie
The emergence of cooling technology has brought about huge social benefits to society, but it is also accompanied by the serious problem of energy consumption. In countries close to the equator, intense solar radiation is accompanied by unbearable high temperatures and strong ultraviolet radiation. Therefore, we prepared a simple hydrogel with good evaporative cooling, which can work continuously and has good UV absorption, to solve the indoor cooling and UV radiation problems. Polyacrylamide (PAM) in the hydrogel provides a mechanically strong backbone, and polyethylene glycol (PEG) slows water loss and provides the hydrogel with the ability to reflect infrared light. Lithium bromide (LiBr) is a highly efficient water vapor absorbent, which can provide the hydrogel with water regeneration capability. Carbon dots (CDs) can provide excellent UV absorption for hydrogels, and CDs (4.28 kJ kg−1 K−1) have a higher specific heat capacity than water (4.20 kJ kg−1 K−1), which can store more heat for a better indoor cooling effect. The composite hydrogel has a good prospect of application in the windows of residential and high-rise buildings.
研究领域:
材料科学
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环境科学
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化学工程
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能源技术
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高影响因子
JOURNAL OF COMPOSITE MATERIALS
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2023
·
IF 2.9
Tao Hai,Fahad Mohammed Alhomayani,Hussein Ajam,Ahmed S M Metwally
Impregnating fabrics with shear thickening fluid (STF) improves impact resistance. In this study modification of polyethylene glycol (PEG 200) was carried out to enhance the thickening behavior of STF. The rheological analysis shows tunned STFs by PEG modification with glutaric acid and oxalic acid increase the maximum viscosity by about 10.33 and 3.28 folds with respect to unmodified STF. Additionally, the alternations of a liquid dispersion medium (PEG) led to higher chain length in STFs, representing superior interaction between media and particles by profuse H-bonding. The results confirmed that increasing the molecular length of PEG-based on STF caused a significant improvement in the knife and spike stabbing impact resistance, quasi-static, and yarn pull-out performance of the neat fabric. In addition, it was realized, by increasing impact velocity the energy absorption ability of STF-treated fabric composite increases. Additionally, a regression analysis using artificial intelligence was applied to study the effect of the pull-out rate on the mechanical response of different materials. Using a third-order polynomial for AI regression model, it turned out that while the pull-out rate has the least influence on untreated E-glass fabrics (UEG) response, for other materials, the behavior changes significantly by increasing the rate from 100 to 400 mm/min.
研究领域:
材料科学
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纺织工程
·
人工智能应用
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高影响因子
LANGMUIR
·
2022
·
IF 4.331
Mingwei Guo,Zhifeng Zhao,Zhongyuan Xie,Weixin Wu,Wenjing Wu,Qinwei Gao
The isothermal crystallization behavior and corresponding morphology evolution of poly(d-lactic acid) (PDLA) blends with PLLA6.7k or MPEG-b-PLLA6.7k-g-glucose with different architectures and different PLLA-grafted copolymer contents were investigated. The formation of stereocomplexes (SCs) in between the chain branched structure of MPEG-b-PLLA6.7k-g-glucose and PDLA chains acting as the physical crosslinking points slows down the motion of PDLA chains, but the SCs could act as a heterogeneous nucleating agent for the late formation of homocrystals (HCs) in the blend system, accelerating the crystallization kinetics of HCs through enhancing the nucleation density. For PDLA/MPEG-b-PLLA6.7k-g-glucose blends, the mobility of SCs in the blend system and the nucleation density of SCs in the blends exhibit oppositional behavior during the isothermal crystallization at a Tc of 130 °C. The evolution of the crystal growth and structure during the isothermal crystallization process by rheometry has revealed the interesting role of the branched chains of MPEG-b-PLLA6.7k-g-glucose in the mechanism of the crystallization in PDLA blends.
研究领域:
材料科学
·
高分子化学
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Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 46
·24444-24452
·
IF 8.867
Xiaoxiao Ji,Huihui Zeng,Xianjing Gong,Fangchang Tsai,Tao Jiang,Robert K. Y. Li,Hengchong Shi,Shifang Luan,Dean Shi
Herein, a self-supporting comb-like Si-PEG copolymer with flexible Si–O–C bonds in the main chain and pending short PEG chains as the side chain was synthesized to improve the low temperature performance and overcome the quandary between good mechanical and electrochemical properties of the polymer electrolyte in lithium-ion batteries. The tensile strength of Si-PEG polymer electrolytes (SPH15) is 0.8 MPa at 30 °C, which is high enough to inhibit the growth of lithium dendrites. The ion conductivities of Si-PEG (SPH15) are 1.2 × 10−4 S cm−1 at 30 °C and 3.2 × 10−5 S cm−1 at 10 °C, which are one order of magnitude higher than those for PEG-based copolymer electrolytes without Si doping. The assembled LiFePO4/SPH15/Li half batteries can deliver the specific capacities of 84 mA h g−1 at 10 °C and present 75% capacity retention after 500 charge–discharge cycles at 0.5C.
研究领域:
材料科学
·
电化学
·
能源存储
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Lin Yang,Yudong Fu,Honghai Liu,Qiaojun Nie,Ming Zhang,Zhongrong Shen
Zinc (Zn) metal anodes have been extensively investigated in aqueous Zn-ion batteries (AZIBs). Nevertheless, severe dendrite issues caused by uneven ion diffusion and Zn deposition greatly influence the stability and safety of AZIBs. Herein, a novel three-electrode tubular cell assembled from simple materials is constructed for both electrochemical measurement and visual characterization. Measured by the tubular cell, a water-in-salt electrolyte (WiSE) exhibits excellent ionic conductivity (33.29 mS cm–1) and reduced corrosivity, which is prepared by incorporating cellulose and polyethylene glycol (PEG) into concentrated zinc chloride (ZnCl2) solution. The results reveal that the functional groups of cellulose and PEG in WiSE can regulate the solvation structure of Zn2+, thereby alleviating consecutive side reactions and inhibiting the formation of byproducts. The inherent ion channels formed by the polymer chains and the physical barriers constructed by PEG on the Zn surface further facilitated the uniform deposition of Zn2+ along the (002) crystal plane, enabling the Zn symmetric battery to achieve an ultralong cycle life of 1000 h at a current density of 2 mA cm–2.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2013
·
IF 3.554
Haitao Huang,Xiaolan Zhang,Jiahui Yu,Junping Zeng,Peter R. Chang,Haibo Xu,Jin Huang
This work is aimed at the development of a reduction-sensitive drug carrier for the delivery of the anti-cancer drug paclitaxel (PTX). N,N′-bis(acryloyl)cystamine (CBA) was reacted with ethanolamine (AEOL) via Michael addition to synthesize cationic poly(CBA-AEOL) (PCA) containing disulfide bonds. Subsequently, polycaprolactone (PCL) was grafted from PCA to form a novel reduction-sensitive copolymer (PCA-g-PCL). The PCA-g-PCL copolymer self-assembled as spherical micelles with a mean size of ca. 108 nm. The disulfide bonds in the PCA-g-PCL copolymer contributed to the reduction-sensitivity of the micelles, observed as stepwise aggregation under simulated reduction conditions. To improve the stability of PCA-g-PCL micelles in aqueous media, carboxyl-terminated poly(ethylene glycol) methyl ether (mPEG-COOH) was conjugated with the PCA-g-PCL copolymer via electrostatic interaction to produce polyion complex micelles with a hydrophilic PEG surface. The in vitro release of PTX from the mPEG@PCA-g-PCL micelle showed a reduction sensitive profile, namely the rate of drug release strongly depended upon the concentration of the reducing agent. Leakage of PTX was limited to below 30% under normal conditions while almost all the drug was released in 9 h under reduction conditions with 40 mM DTT. In conclusion, the assembled mPEG@PCA-g-PCL micelle with reduction-sensitive controlled release shows great potential for improving the therapeutic effect of paclitaxel.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Xiaodong Lv,Shi Wang,Yuhang Dong,Yafang Zhang,Xin Wang,Guoqing Yan,Jun Wang,Rupei Tang
To promote the highly selective synergistic chemotherapy, the pH-ultra-sensitive dynamic methotrexate nano-prodrugs with detachable PEGylation were successfully prepared via facile method, and the synergistic nanodrugs could be further constructed through encapsulating Doxorubicin (DOX) following the self-assembly process. The nano-prodrugs exhibited the low critical micelle concentration (CMC), negative zeta potential and stability for 5 days in PBS and FBS at physiological pH (7.4) for stable blood circulation, DePEGylation and dynamic size change at tumoral extracellular pH (6.8) for improved tumor accumulation and cellular internalization, and efficiently synergistic drug release at tumoral intracellular pH (5.0) for enhanced tumor apoptosis and cytotoxicity. Moreover, in vivo experiment suggested that the synergistic nanodrugs could significantly improve tumor accumulation and restrain tumor growth while decreasing adverse effects. Therefore, the dynamic methotrexate nano-prodrugs with detachable PEGylation are easy to clinically transform for highly selective synergistic chemotherapy.
研究领域:
药学
·
纳米技术
·
肿瘤学
·
药物递送系统
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高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 46
·6418-6426
·
IF 0
Wenyu Li,Peng Zhang,Kun Zheng,Qiaoling Hu,Youxiang Wang
Extracellular stability to protect DNA against nucleases and stimulus-triggered intracellular DNA release are key factors in designing non-viral gene vectors. In this study, the diselenide-linked polycation mPEG–SeSe–PEI was developed as a new type of PEG-detachable gene vector for redox-responsive gene delivery. The corresponding stable analog mPEG–PEI and the disulfide-linked polycation mPEG–SS–PEI were synthesized as controls. The results showed that all the PEGylated polycations could condense DNA into tightly packed spherical nanoparticles about 80 nm in size, which showed excellent stability under physiological conditions. The results of zeta-potential measurements, stability tests and DNA release ability assay indicated that at a GSH concentration of 0.3 mM, the diselenide bonds were more easily cleaved than disulfide bonds, which facilitated dePEGylation and DNA release. Meanwhile, it was interestingly found that mPEG–SeSe–PEI/DNA polyplexes showed higher gene expression than mPEG–SS–PEI/DNA polyplexes in both HEK293T and HepG2 cells. Confocal laser scanning microscope (CLSM) images revealed that mPEG–SeSe–PEI/DNA polyplexes showed more efficient endosomal escape ability than mPEG–SS–PEI/DNA polyplexes. Based on these results, the diselenide bonds as a novel strategy are more suitable to address the challenging problem of extracellular stability and intracellular DNA release.
研究领域:
基因递送
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聚合物化学
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分子生物学
·
生物医学工程
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