KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2026
·
IF 3.4
Dai Yanmei,Teng Jiayu,Zhang Qingyu,Sun Dongchang,Tao Zijuan,Huang Changshun,Luo Liangli,Liu Bo,Ou Zhimin
9α-Hydroxyandrost-4-ene-3,17-dione (9α-OH-AD) is a valuable intermediate for the manufacture of steroid drugs such as hydrocortisone. Its bioproduction from 4-androstene-3,17-dione (4-AD), however, is limited by the low efficiency of the two-component steroid 9α-hydroxylase (KSH) system and insufficient cofactor regeneration during whole-cell catalysis. In this work, RvKshA and RvKshB were mined and heterologously expressed, and plasmid screening identified E. coli BL21/pET28a + -RvKshA/pETDuet-1-RvKshB as the best-performing strain. Structural analyses based on molecular docking and molecular dynamics simulations clarified the cooperative catalytic mechanism of KshA and KshB, providing guidance for rational system construction. More importantly, to address the NADH supply bottleneck, we established a dual-enzyme coupling strategy by introducing formate dehydrogenase (FDH) for in situ cofactor regeneration. This design enabled efficient steroid hydroxylation, giving a 98.3% conversion at 20 mM 4-AD. When combined with high-density fermentation and fed-batch feeding, the engineered strain achieved a substrate processing capacity of 80 mM and a spatiotemporal yield of 42.8 mM/(L·day). This study provides an integrated enzymatic and bioprocess solution for improving whole-cell steroid hydroxylation efficiency and offers a practical basis for the scalable biosynthesis of 9α-OH-AD.
✓ 已验证
DOI
高影响因子
CHEMISTRY AND TECHNOLOGY OF FUELS AND OILS
·
2026
·
IF 0.8
Wen Wu,Zhi Shitao,Wang Wenwen,Zhu Hao,Niu Cheng
In this study, a series of solvent extraction experiments were conducted to evaluate the effects of different single solvents and p-xylene-assisted composite solvents on heavy oil recovery, sand surface wettability, and the interfacial interaction mechanism. Results showed that p-xylene exhibited a distinct synergistic effect with aromatic solvents, particularly toluene, improving heavy oil recovery by up to 3.3%, whereas its combination with n-pentane caused a significant reduction in recovery due to the precipitation of heavy components such as asphaltenes. Contact angle measurements further confirmed that hybrid solvent systems enhanced the hydrophilicity of sand surfaces, with the [p-xylene]-n-pentane system showing the greatest decrease (14°) in contact angle. Zeta potential analysis revealed that sand particles possess a positive charge, while bitumen droplets carry a negative charge, confirming the electrostatic interaction that contributes to their adhesion. This work provides new insights into the synergistic mechanism of mixed solvents in bitumen extraction and highlights the potential of aromatic-assisted solvent systems for improving the efficiency of heavy oil separation. MD simulations further revealed that toluene most effectively promoted the dispersion and diffusion of heavy-oil SARA fractions. Mean square displacement analysis showed that saturated and asphaltene molecules exhibited the highest mobility in toluene, while colloids remained the least diffusive. Radial distribution function results confirmed strong π–π interactions between toluene and aromatic/asphaltene components, facilitating their structural disaggregation. Concentration and conformational analyses demonstrated that all four heavy-oil components gradually transitioned from aggregated states to dispersed equilibrium under toluene solvation. These molecular-scale insights corroborate experimental observations and elucidate the mechanism by which aromatic-assisted solvent systems improve the efficiency of heavy-oil separation.
✓ 已验证
DOI
高影响因子
Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·344
·
IF 38.5
Liu Xianyuan,Zhao Yang,Zhang Yali,Cui Xuechun,Xue Ying,Lu Xianyong,Gu Junwei
The development of intelligent electromagnetic skins demands scalable films integrating gigahertz (GHz)-terahertz (THz) wave absorption, electromagnetic interference (EMI) shielding, and programmable actuation. Here, we report a bioinspired bamboo-like layered-gradient system fabricated via scalable vacuum filtration, in which two types of films are constructed with distinct functionalities: a low-poly(3,4-ethylenedioxythiophene) (PEDOT) content film for microwave absorption and a high PEDOT content film for conductive network-enabled EMI shielding.The films precisely assemble Al-Fe 3 O 4 nanosheets, aramid nanofibers, and PEDOT into an asymmetric architecture. A monotonic through-thickness gradient in composition creates a tailored impedance profile and strong anisotropy while minimizing conductive filler content. This design achieves effective microwave absorption at low PEDOT loading (minimum reflection loss: − 56.6 dB at 2.2 mm in the X-band). With increased PEDOT content, a percolative network is constructed, enabling Joule heating (233 °C at 20 V) and efficient EMI shielding (42.0 dB in the GHz band and 57.8 dB in the THz band). Beyond electromagnetic performance, the gradient architecture enables programmable, ethanol-triggered anisotropic actuation via differential swelling. The films also exhibit excellent thermal stability, mechanical robustness, and flexibility, ensuring reliability in harsh environments. Collectively, this gradient architecture provides a scalable platform for intelligent electromagnetic skins integrate magnetic-dielectric coupling, conductive network tuning, and stimuli-responsive actuation.
The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
PubMed
高影响因子
CELLULOSE
·
2026
·
IF 4.6
Yang Wei,Wang Cong Cong,Zheng Cunbang,Yang Fan,Wu Shengji,Che Lei
Effect of acid impregnation and mechanical milling on the hydrolysis behavior and products distribution of chitin in subcritical water was investigated by a “temperature-programmed hydrolysis process”, in the present study. The acid impregnation and mechanical milling efficiently destroyed the glycosidic and hydrogen bonds in chitin, leading to a loss of crystal structure and significantly increased water solubility. The loss of crystal structure rendered the pretreated chitin substrates more susceptible to hydrolysis in subcritical water compared to raw chitin, thereby reducing the activation energy required to initiate the hydrolysis reaction. The main compounds in hydrolysate were analyzed to be reducing sugar, antioxidant compounds, 5-hydroxymethylfurfural, isopropyl acetate, acetamide and propanoic acid ethyl ester. The possible mechanism of acid impregnation and ball milling for hydrolysis of chitin in subcritical water was also proposed. This work suggested that acid-mechanical milling is an efficient pretreatment process for accelerating the liquefaction of chitin to valuable chemicals in subcritical water. Graphical abstract The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
高影响因子
Nature Energy
·
2026
·
IF 70.1
Zhang Zhenguo,Zhang Qi,Li Wen,Liu Wen,Zhang Jialin,Zhang Jin,Wang Haining,Xiang Yan,Lu Shanfu
High-temperature polymer electrolyte membrane fuel cells offer inherent impurity tolerance and simplified thermal/water management. However, conventional phosphoric acid-doped membranes must be relatively thick (typically >50 μm) to counteract H 3 PO 4 -induced mechanical degradation, leading to ohmic losses that limit fuel cell performance. Here we report a 20-μm-thin, mechanically robust phosphoric acid-doped membrane incorporating dynamic Cu-ion crosslinking for high-power-density high-temperature polymer electrolyte membrane fuel cells. The dynamic Cu-polymer coordination establishes dynamic crosslinking networks that provide exceptional toughness and extensibility, alongside spontaneous self-healing capability. Simultaneously, the Cu ions improve H 3 PO 4 retention and proton dissociation through electrostatic interactions and polarization of O–H bonds in H 3 PO 4 molecules. The resulting thin membranes exhibit minimal ohmic resistance (0.06 Ω cm 2 ) while maintaining low H 2 crossover current density (0.95 mA cm −2 ). Fuel cells incorporating this membrane achieved a peak power density of 3.08 W cm −2 at 200 °C (H 2 /O 2 ), with negligible degradation over 503 h at 1.0 A cm −2 and 160 °C.
✓ 已验证
DOI
高影响因子
Nature Synthesis
·
2026
·
IF 22.6
Zhang Hao,Liu Ziming,Li Di,Wu Chenxin,Hua Lei,Li Haiyang,Yi Yanhui,Huang Rui,Yu Liang,Deng Dehui
Direct co-conversion of earth-abundant N 2 and CH 4 to high-value C–N–O compounds is a promising synthetic method but remains challenging, as the activation of N 2 and CH 4 typically requires high-energy conditions that can cause product decomposition. Here we report a plasma-cascade process for synthesizing cyclohexanone cyanohydrin (Cy(OH)CN) via direct coupling of N 2 and CH 4 plasma with cyclohexanone. This catalyst-free process achieves a Cy(OH)CN formation rate of 0.60 mmol h −1 with a high selectivity of 95.8% towards the cyclohexanone-derived products under mild conditions, concurrently generating ammonia as a valuable coproduct. Comprehensive mechanistic studies reveal that plasma-generated ·CH x and hydrogen radicals enable direct α-carbonyl functionalization of cyclohexanone to α-CH x cyclohexanol intermediates, which then coupled mainly with excited-state N 2 and are further activated by hydrogen radicals to generate Cy(OH)CN. This plasma-cascade strategy decouples the activation of inert molecules from the formation of relatively unstable C–N–O compounds, enabling selective cyanohydrin synthesis that avoids using high-cost NH 3 and toxic HCN. The alternative text for this image may have been generated using AI.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Wang Yigang,Yang Sixie,Liu Yiwen,Wang Chang,Pan Hui,Zhang Zhenjie,He Ping,Zhou Haoshen
The global surge in lithium demand poses growing challenges for supply security and sustainability, yet vast lithium reserves in seawater remain largely untapped due to extremely low Li⁺ concentrations and high levels of competing ions. Here, we present an integrated electrochemical system coupling direct lithium extraction from seawater with in situ energy storage and hydrogen co-production. A reversible Ni(OH) 2 /NiOOH redox electrode replaces conventional anodic seawater electrolysis, storing electrical energy that would otherwise be wasted and enabling its recovery on demand through a Zn-NiOOH battery configuration. Meanwhile, a NiS 2 /MoS 2 catalyst lowers the overpotential for hydrogen evolution at the cathode, generating approximately 807 mL of hydrogen gas per gram of lithium extracted. This synergistic design reduces net energy consumption to 6.40 Wh g –1 Li , upgrades seawater from a low-quality brine (0.183 mg L –1 Li + ) to a Li-rich solution (306.2 mg L –1 ) and lowers the Mg/Li ratio by seven orders of magnitude without additional reagent. This approach demonstrates a practical, sustainable route to unlock seawater as a viable high-grade lithium resource for a secure energy future.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Food Measurement and Characterization
·
2026
·
IF 3.6
Wang Xin,Peng Huainan,Chang Menghan,Liu Qianqian,Wang Ziyu,Zhang Xinshuai,Fan Meijing,Yue Chonghui
The synergistic effects of long-chain inulin and ferulic acid in regulating the rheological properties of wheat dough and gluten network formation was comprehensively investigated. In this study, dynamic rheological analysis, texture profile analysis, low field nuclear magnetic resonance (LF-NMR), differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy, zeta potential and particle size analysis, fluorescence spectroscopy, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and scanning electron microscopy (SEM), laser confocal microscopy (CLSM) observation, etc. The results showed that the 2.5FXL-1FA treatment reduced the hardness of the dough from 385.71 N to 354.35 N compared to the 1FA treatment, while increasing the disulfide bond (SS) content from 18.10 µmol/L to 25.56 µmol/L. This combination treatment also elevated both storage modulus (G′) and loss modulus (G″), indicating enhanced dough elasticity and viscosity. Furthermore, the combination treatment increased the peak temperature (Tp) and enthalpy change (ΔH) values of dough, suggesting improved dough stability during heating. At lower concentrations, the FXL-FA combination reduced the zeta potential and fluorescence intensity of gluten, which was associated with improved gluten stability and a more compact network structure. However, higher doses of FXL-FA were found to negatively affect dough quality and gluten protein network stability, indicating that optimal doses are critical for maximizing the benefits of FXL-FA in dough formulation. This highlights the critical importance of optimizing the FXL-FA dosage to maximize the benefits of this combination in dough formulation.
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2026
·
IF 4.9
Yin Lingxuan,Pang Shutong,Li Xianping,Deng Guoxian,Shao Wei,Xia Xiaowen,Zhu He,Yan Junan,Yao Jiwei
Voluntary urination—the conscious control over urine release based on internal and external cues—is essential for social functioning and physiological homeostasis, yet the neural mechanisms underlying this behavior remain poorly understood. Effective mechanistic dissection requires genetically tractable models with robust naturalistic behaviors. However, C57BL/6J mice, despite their rich genetic toolkit, exhibit weak scent-marking unless subjected to prolonged social isolation, whereas BALB/c mice display robust marking but lack genetic accessibility. To bridge this gap, we employed F1 hybrid males (C57BL/6J × BALB/c) to combine these complementary strengths and established a 10-minute odor-driven paradigm in which both group-housed and socially isolated F1 males exhibited robust scent-marking toward estrous female urine. To facilitate efficient and accurate analysis of urine deposition from this behavioral paradigm, we trained a YOLOv8-based deep learning model for automated quantification, achieving high accuracy. Furthermore, whole-brain c-Fos mapping revealed significant activation in the prefrontal cortex, brainstem, and other key regions implicated in regulating this voluntary voiding behavior. Thus, our study establishes a novel behavioral paradigm for odor-induced voluntary urination, providing a genetically accessible model system to dissect the neural circuits governing physiological voiding and neurogenic lower urinary tract dysfunction.
✓ 已验证
DOI
PubMed
高影响因子
BioNanoScience
·
2026
·Vol. 16
·期 5
·320
·
IF 4
Ma Yingying,Xue Linying,Wang Yancai
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the leading clinical cause of dementia. Magnolol has promising therapeutic potential for AD. However, its poor aqueous solubility and the challenge of achieving brain-targeted delivery have severely hindered its clinical usage. This study designed a thermosensitive in situ hydrogel nasal spray for co-delivery of magnolol nanosuspensions and berberine, targeting AD treatment via nose-to-brain delivery. The magnolol nanosuspensions were prepared via a wet-milling approach to improve the drug’s solubility. A thermosensitive hydrogel based on poly(N-isopropylacrylamide) (PNIPAM) was synthesized and formulated as an in situ nasal spray to enable brain-targeted co-delivery of the two drugs. In vitro PC12 cells AD models and in vivo mice was used to evaluation the thermosensitive multifunctional in-situ hybrid gel effectiveness and distribution. Morphological characterization confirmed successful preparation of magnolol nanosuspensions with a mean particle size of 220 ± 10 nm, which exhibited a high dissolution rate of 82.36 ± 1.62% within 300 min. The nanosuspensions were embedded in the hydrogel, which has a lower critical solution temperature (LCST) of approximately 32 °C - allowing rapid phase transition in the nasal cavity (local temperature ~ 35 °C). On PC12 cells and mice AD models, the thermosensitive hydrogel co-delivery system increased cell survival by 27.13% and significantly enhanced drug accumulation in the brain. This multifunctional drug delivery system provides an efficient strategy for the brain-targeted delivery of magnolol nanosuspensions and berberine, offering a promising approach for AD treatment.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 12
·942
·
IF 3.2
Guo Chaofan,Du Yiping,Guan Haoyang,Zhu Jinglong,Ma Lin,Yan Zhengguang,Xiao Jiawen
Narrowband photodetectors exhibit considerable potential for high-resolution imaging and encrypted communication systems owing to their high spectral resolution capabilities. In this study, a composite perovskite single-crystal heterojunction (SCH) consisting of MAPbBr 3 and MAPbI 3 was fabricated by epitaxially growing MAPbI 3 on a MAPbBr 3 single crystal substrate. A carbon paste light-window electrode was applied to the MAPbI 3 surface following a spatially modulated electrode strategy. The resulting device demonstrates outstanding narrowband detection performance, featuring a full width at half maximum ( FWHM ) of 21 nm, a spectral rejection ratio ( SRR ) of 137, a specific detectivity of 1.24 × 10 11 Jones (cm Hz 1/2 W −1 ), a responsivity of 0.56 A W −1 , and a fast response time (34.86/42.81 μs). The exceptional narrowband detection capabilities of this single-crystal heterojunction device would broaden the application prospects of perovskite-based photodetectors in the field of optoelectronics.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Shen Xiang,Lan Zixun,Zhu Yaqiong,Zhong Tingting,Li Bozhang,Chen Jiaheng,Zhu Yanglong,Ye Jing,Wang Xiaolei
The core pathological mechanism of osteoporosis (OP) resides in the imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Furthermore, the accumulation of reactive oxygen species (ROS) and pro-inflammatory factors in bone tissue induces disorders in the immune microenvironment, which substantially elevates the risk of fracture. Inspired by the biological behaviors of sea cucumbers, we designed and constructed a bone-targeting platform (BA@PDA-PA) based on black phosphorus (BP) and amorphous calcium carbonate (ACC). This platform enables precise targeted therapy for diseased bone tissue while improving drug bioavailability. Upon reaching the target site, BA@PDA-PA can respond to the acidic microenvironment of OP lesions, and then release BP and calcium ions (Ca 2+ ) on demand. Specifically, BP efficiently scavenges local excessive ROS and improves the immune microenvironment. Meanwhile, the Ca 2+ released from ACC degradation, along with the low phosphorus oxides derived from BP breakdown, work together to promote osteoblast proliferation and differentiation while inhibiting osteoclast activity. This establishes a synergistic therapeutic mechanism involving “targeted delivery, microenvironment regulation, and bone metabolism remodeling.” In vivo experimental results demonstrate that this platform significantly improves the pathological bone microstructure of OP mice, thereby providing a promising therapeutic strategy for OP treatment. Graphical abstract The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）