MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Meiyun Shang,Juan Hu,Mengjia Shi,Yunpeng Fan,Yuan Zou,Yong Wang,Jinhong Guo,Cuiping Mao
Anti-cyclic citrullinated peptide (anti-CCP) antibodies are key biomarkers for rheumatoid arthritis and vital for its early diagnosis and monitoring. Conventional chemiluminescence immunoassays (CLIA) rely on streptavidin-functionalized magnetic beads (SA-MBs), which suffer from limited binding capacity and require labor-intensive chemical conjugation steps. Here, we report a MBs carrier modified with zirconium (Zr)-based metal-organic frameworks (MB@MOF), enabling rapid and efficient SA functionalization via one-step physicochemical adsorption. Compared to the conventional EDC/NHS method, our approach shortens the modification time by at least sixfold and eliminates the need for chemical crosslinkers. The MB@MOF carrier was constructed by anchoring Zr-MOF nanoparticles, synthesized with TCPE as the organic ligand, onto MBs. This carrier supports stable and dense SA loading while preserving native SA activity, thereby allowing highly sensitive detect anti-CCP antibodies. The developed MB@MOF carrier-based CLIA method achieved a detection limit of 0.1 RU/mL and a linear range of 0.5–200 RU/mL. Clinical validation using 36 clinical serum samples showed strong agreement with results from standard clinical analyzers, achieving an overall diagnostic accuracy of 91.7 %. This strategy significantly simplifies the assay workflow and holds strong potential for high-performance and rapid diagnostics of rheumatoid arthritis in clinical application.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Zhongchao Fu,Zhuojun Hou,Cen Shao,Nan Wu,Haibo Long,Enjin Liu,Zhaoxia Hou,Tomala Robert,Wieslaw Strek,Le Zhang
Large-size Y 2 O 3 ceramics are important materials for optical windows, semiconductor etching substrates, and related technologies. However, the batch production of its transparent ceramics with high optical and mechanical properties remains a challenge, these include technical limitations of small-scale production of powder with high sinterability and complicated processing which involves pre-sintering in vacuum plus HIP with high cost and limited dimensions. In this paper, an industry-compatible way namely dry-pressing combined with vacuum sintering was adopted with commercial powders as starting material to achieving its transparent ceramics. Furthermore, four Zr precursors (ZrO 2 , zirconium acetate, nitrate, and basic carbonate) were doped as sintering additive for the regulation of Zr distribution from powder pretreatment to forming and sintering. Both agglomerates and pore clusters were suppressed, and a homogeneous microstructure was achieved when zirconium basic carbonate was used as the sintering additive. Hence, a large-size (100 × 100 × 2 mm) ceramic was fabricated, with both the in-line transmittance (80.2 % at 800 nm) and Vickers hardness (7.48 ± 0.08 GPa) optimized simultaneously. The study not only provides references and guidance towards the optical quality enhancement and microstructure control but also provides insights for the fabrication of large-size Y 2 O 3 transparent ceramics.
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2026
·
IF 3
Long Jing,Zheng Liu,Mengyu Su,Qirong Lu,Xiangfei Kong,Guo-Cheng Han,Xiaoyan Wang
On-site rapid food safety testing is an important means of market supervision. A "Dual-response-Reverse" (one signal increases while the other decreases) type biomass carbon quantum dots(G-BCQDs)/Zr-MOFs ratiometric fluorescent paper-based sensor was designed for the visual detection of spermine concentration (SPM, a representative of biological amines).G-BCQD (emitting at 477 nm) and Zr-MOF (emitting at 537 nm) exhibit reverse fluorescence responses to spermine, namely quenching and enhancement, respectively, thus enabling fluorescence ratio detection. The smartphone was connected with the ratiometric fluorescent paper-based sensor to quantitatively detect the concentration of spermine. The results showed that there was a linear relationship between the concentration of spermine in the range of 0.1-220.0 μM and the R' value of RGB values, and the linear equation was R' = 0.3740CSPM + 141.75 (R2 = 0.9913). The detection limit of the method was 19.93 μM. Shrimp samples were selected to evaluate the practicability of the ratiometric fluorescent paper-based sensor for detecting spermine concentration. The results of the spiked recovery experiment showed that the recovery rate of the shrimp samples was in the range of 90.97-101.14%, and the relative standard deviation was less than 2.15%, indicating that the ratiometric fluorescent paper-based sensor had high accuracy and precision and was shown to be applicable for detecting SPM in spoiled samples and thus for monitoring spoilage.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Tao Kong,Zhimin Hao,Qingquan Wang,Junying Yin,Kang Wu,Bing Wang,Zhijie Gao,Hai-Wen Li
Garnet-type solid-state electrolytes are celebrated for their exceptional stability against lithium metal, a property that is crucial for developing high safety all solid-state batteries. However, the practical adoption of this electrolyte is hindered by low ionic conductivity and poor interface contact. In this paper, we propose a novel strategy for fabricating the garnet-type high-entropy oxide solid-state electrolyte Li 6 La 3 Zr 0.5 Ti 0.5 Cr 0.5 Sn 0.5 O 12 (LLZTCSO) by low-cost partial substitution of Zr with Ti, Cr, Sn in the LLZO. By the lattice distortion effect generated by Zr substitution, LLZTCSO achieves rapid lithium ion migration, high air stability, and excellent mechanical properties. As a result, Li/Ag@LLZTCSO/Li symmetric cell shows lower interfacial impedance (100.5 Ω cm 2 ) and higher critical current density (1.428 mA cm −2 ) than LLZO. The LiFePO 4 (LFP)/Ag@LLZTCSO/Li full cell also exhibits good rate capability (145.06 mA h g −1 at 0.5C) and cycling performance (capacity degradation of 12.13% after 100 cycles at 0.1C). This study outlines a novel approach for the synthesis of high-performance garnet-type electrolytes for all-solid-state lithium metal batteries, providing important references for the design of garnet-type solid-state electrolytes in the future.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Hongchuan Jiang,Xiang Li,Guodong Zhang,Cai Liang
Solar-driven calcium-looping offers a promising pathway for efficient storage and utilization of concentrated solar energy. However, the large-scale application of calcium-based heat carriers is hindered by low solar absorptance, poor sintering resistance, and slow reaction kinetics. Moreover, the energy conversion characteristics and particle behavior under direct irradiation remain poorly understood. In this study, Mn-Zr co-doped CaO composite particles were synthesized via an extrusion-spheronization method, achieving high absorptance, strong sintering resistance, and rapid reaction kinetics. Specifically, the co-doping of Mn and Zr significantly enhances absorptance to 67.7% while effectively reduces cracking. The stable framework of CaMnO 3 and CaZrO 3 maintains abundant mesoporous channels and suppresses sintering. The composite particles exhibit outstanding cycling stability, maintaining an energy storage density of 1148 kJ/kg after 40 cycles with only 22.9% degradation, far outperforming pure CaO materials (64.9% degradation after 20 cycles). Direct irradiation experiments confirm their high solar-thermal conversion efficiency, with particle temperature within the light spot reaching 1600 °C in 3 s. The irradiation-induced particle inhomogeneous sintering mechanism was preliminary proposed. Meanwhile, the effect of non-uniform irradiation on energy storage characteristics and particle behavior is revealed. Non-uniform irradiation led to localized hotspots and increased thermal stress, which aggravated particle breakage and sintering within the light spot.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Jintian Zhong,Zhaoyang Qi,Yiyan Liu,Yixi Zhu,Jie Chen,Changshen Ye,Ting Qiu
Fuels with extremely low sulfur content are highly desirable as a result of the growing environmental concerns. In this work, a simple and novel method to connect a ZrIV open site with polyoxometalates (POM) was introduced, which was used as an effective heterogeneous catalyst for oxidative desulfurization of fuel oil. ZrPTAX-BTC composites were synthesized conveniently and rapidly at room temperature and atmospheric pressure using pyromellitic acid (BTC) as a linker. The products were characterized by XRD, TGA, FT-IR, NMR, SEM, and N2 adsorption–desorption, which verified the successful preparation of ZrPTAX-BTC composite. ZrPTAX-BTC catalyst has high content of active components, and has excellent catalytic activity in oxidative desulfurization reaction. It achieves rapid and complete desulfurization under mild reaction conditions (T = 50 °C, O/S = 4, t = 30 min, DBT removal rate reaches 100%). Further studies show that the synergistic catalysis of a ZrIV open site and PTA molecule is the reason for its high catalytic activity, in which the ZrIV open site promotes the decomposition of H2O2 into O2·, PTA molecules combine with O2· to form peroxytungstate (W(O2)n), and the close distance between the ZrIV open site and PTA in ZrPTAX-BTC allows H2O2 to be efficiently utilized. In addition, ZrPTAX-BTC can be easily recovered and reused for at least five times, and only a slight decrease in catalytic activity has occurred. Therefore, ZrPTAX-BTC has high catalytic activity, high stability, and good reusability, which is a potential catalyst that can realize the application of fuel ultradeep desulfurization.
研究领域:
催化化学
·
环境化学
·
材料科学
·
能源工程
·
化学工程
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Jun-Liang Chen,Hengquan Yang,Chengyan Liu,Jisheng Liang,Lei Miao,Zhongwei Zhang,Pengfei Liu,Kenta Yoshida,Chen Chen,Qian Zhang,Qi Zhou,Yuntiao Liao,Ping Wang,Zhixia Li,Biaolin Peng
Half-Heusler alloys, which possess the advantages of high thermal stability, a large power factor, and good mechanical property, have been attracting increasing interest in mid-temperature thermoelectric applications. In this work, extra Zr-doped TiZrxNiSn samples were successfully prepared by a modified solid-state reaction followed by spark plasma sintering. It demonstrates that extra Zr doping could not only improve the power factor on account of an increase in the Seebeck coefficient but also suppress the lattice thermal conductivity originated from the strengthened phonon scattering by the superlattice nanodomains and the secondary nanoparticles. As a consequence, an increased power factor of 3.29 mW m–1 K–2 and a decreased lattice thermal conductivity of 1.74 W m–1 K–1 are achieved in TiZr0.015NiSn, leading to a peak ZT as high as 0.88 at 773 K and an average ZT value up to 0.62 in the temperature range of 373–773 K. This work gives guidance for optimizing the thermoelectric performance of TiNiSn-based alloys by modulating the microstructures on the secondary nanophases and superlattice nanodomains.
研究领域:
材料科学
·
热电材料
·
固态化学
·
纳米材料
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 3
·184
·
IF 5.4
Tan Long,Xiao Rui,Wu Di,Hu Lianzhe,Zhang Yan,Qi Wenjing
A fast fluorescent dual-emission platform for sensitive detection of sodium dehydroacetate (SDHA) in food is established utilizing bimetallic organic frameworks (Eu@Zr-MOFs). Eu@Zr-MOFs show two fluorescent emissions at 430 nm and 616 nm under single excitation wavelength of 290 nm. Two peaks separated by 180 nm help to eliminate environmental interference and improve the accuracy. In the presence of SDHA, fluorescent intensity at 430 nm and 616 nm shows fluorescent quenching within 1 min. Fluorescent lifetime results show that fluorescent quenching is a static quenching mode. Fluorescent quenching may be ascribed to the diketone structure of SDHA coordinated with Eu 3+ and internal filtering effect. The logarithm of fluorescent intensity (lg I 430 nm * I 616 nm ) has linear relationship with the concentration of SDHA from 0.1 µM to 200 µM with a limit of detection of 31.6 nM. More conveniently, it also achieves visual detection of SDHA through fluorescent color by portable UV lamp and smartphone “color capture” mode. The platform is applied to detect SDHA in fermented and baked food samples. Thus it is an efficient and sensitive fluorescent ratio method for SDHA detection with fast response, high selectivity and accuracy. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Energy & Environmental Materials
·
2026
·
IF 13.8
Jin Hu,Yuhan Ma,Yihao Cheng,Chunsheng Shi,Biao Chen,Liying Ma,Jianli Kang,Fang He,Naiqin Zhao,Chunnian He
Recently developed halide solid-state electrolytes (SSEs) have become promising alternatives for the next generation inorganic SSEs, primarily due to their comparatively favorable ionic conductivity, desirable deformability, and economic feasibility. Nevertheless, their practical application is still limited by inadequate ionic transport capability and poor moisture stability in the ambient environment. Herein, a simple yet effective Ta 5+ doping strategy is proposed to simultaneously improve the ionic conductivity and moisture stability of Li 2 ZrCl 6 (LZC). Specifically, the optimized Ta 5+ -doping SSEs, Li 2–x Zr 1–x Ta x Cl 6 (x = 0.3, denoted as LZT0.3C), exhibit an improved ionic conductivity of 1.31 mS cm −1 at room temperature (RT). Notably, LZT0.3C retains its structural integrity and high ionic conductivity even after exposure to 10% relative humidity. When implemented in ASSLBs with LiCoO 2 or single-crystalline LiNi 0.8 Mn 0.1 Co 0.1 O 2 cathodes, LZT0.3C delivers significantly improved long-term cycling stability. The combination of high ionic conductivity and enhanced moisture stability renders this halide SSE a scalable and cost-effective candidate for future energy storage systems.
✓ 已验证
DOI
高影响因子
CRYSTAL RESEARCH AND TECHNOLOGY
·
2014
·Vol. 49
·期 6
·383-392
·
IF 1.164
Xiufang Liu,Wei Liu,Xueying Zhang,Lu Han,Cong Zhang,Yanzhao Yang
Zirconium-doped ceria hollow slightly-truncated nano-octahedrons (HTNOs) (Ce 1-x Zr x O 2 ) were synthesized by a one-pot, facile hydrothermal method. The morphology and crystalline structure were characterized with powder X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and the high resolution transmission electron microscopy (HRTEM). The composition and chemical valence on the surface of the as-prepared Ce 1-x Zr x O 2 powders were detected by X-ray photoelectron spectroscopy (XPS) and energy dispersive spectrometry (EDS). The surface area and pore size distribution of as-obtained Zr-doped ceria HTNOs were measured by N 2 adsorption-desorption measurement. Mechanisms for the growth of Zr-doped ceria HTNOs are proposed as both oriented attachment and Ostwald ripening process and the formation of the hollow structure is strongly dependent on the addition of Zr 4+ ions. Furthermore, the as-obtained Zr-doped ceria HTNOs revealed superior catalytic activity and thermal stability toward CO oxidation compared to pure ceria. It may provide a new path for the fabrication of inorganic hollow structures on introducing alien metal ions.
研究领域:
材料科学
·
催化化学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 7
·2923
·
IF 4.6
Enmin Zong,Xuanren Wang,Lirong Zhang,Jiayao Yang,Xiaohuan Liu
The application of lignin-based adsorbents in the efficient removal of phosphate from wastewater has attracted much attention and been intensively studied in recent years. However, most currently reported lignin-based adsorbents are difficult to recover and recycle. Herein, we have developed a recyclable, nanostructured bio-adsorbent, poly(ethyleneimine) (PEI)-modified lignin (LG) integrated with Fe3O4and Zr-La dual-metal hydroxide (LG-NH2@Fe3O4@Zr-La), by the Mannich reaction followed by the chemical coprecipitation method. Multilayer adsorption existed on the surface of LG-NH2@Fe3O4@Zr-La based on the isotherm fitting curve, and its adsorption capacity reached 57.8 mg P g−1, exhibiting a higher phosphate uptake than most reported metallic oxide-based composites. The adsorption process was dominated by inner-sphere complexation of ligand-exchange and electrostatic interactions. Moreover, LG-NH2@Fe3O4@Zr-La exhibited excellent selectivity against coexisting anions, and the adsorption was more efficient under acidic conditions. When the phosphate concentration was 2.0 mg P L−1, the removal efficiency of phosphate reached 99.5% and the residual concentration was only 10 μg P L−1, which meets the United States Environmental Protection Agency (USEPA) standard for eutrophication prevention. In addition, the LG-NH2@Fe3O4@Zr-La displayed excellent reusability, maintaining 91.8% of removal efficiency after five cycles. Importantly, owing to the magnetic properties of the loaded Fe3O4, the resulting composite could be separated within 30 s under an external magnetic field. Thus, the separable and recyclable biobased magnetic adsorbent developed in this work exhibited promising application in phosphate capture from real sewage. This research study provides a new perspective for lignin valorization in lignocellulose biorefineries and establishes an approach for developing an economical and efficient bio-adsorbent for phosphate removal from wastewater.Keywords:lignin;magnetic adsorbent;Zr hydroxides;La hydroxides;phosphate;recycle
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2023
·
IF 11.1
Junchao Wang,Yongbo Chen,Jinwei Zhang,Gongyan Liu
Zirconium tanning agent, which is mainly composed of low-toxic tetravalent zirconium (Zr 4+ ) salts, has been considered the most promising eco-friendly tanning agent for leather manufacturing, due to its comparable tanning performance with trivalent chrome. However, in the initial penetration stage of the zirconium tanning process, macromolecular multinuclear complexes are commonly formed because of the rapid coordination between hydrated Zr 4+ , which can easily cross-link with active groups of neighboring collagen fibers and thus block subsequently even penetration of zirconium tanning agents, resulting in surface over-tanning and ununiform tanning effects. Herein, to address the aforementioned issues of conventional zirconium tanning, inert-surface modification of collagen fibers was proposed by using PEGylated epoxy copolymers (PEGMA-co-GMA, defined as PPG) to pretreat bated hide, based on the covalent reactions and hydrogen-bond interactions of PPG with amino and carboxyl groups on collagen fibers, respectively. After modification, the surface reactivity of skin collagen was significantly reduced, which was able to delay the cross-linking interactions with zirconium tanning agents and thus promote uniform penetration. Simultaneously, the extra hydroxyls produced from the ring-open reactions of epoxy groups could also mitigate the excessive coordinated complexation of hydrated Zr 4+ , leading to efficient penetration of zirconium tanning agents. Compared with conventional zirconium tanning, research results showed that this inert-surface modification strategy could comprehensively improve the overall leather performance with both efficient and uniform tanning effects. Moreover, the resultant leather qualities, including thermal stability, physical and mechanical properties, and organoleptic properties , are very comparable with chrome-tanned leather. In addition, attributing to the reaction between collagen amino and PPG, the use of sodium chloride was avoided, resulting in a cleaner salt-free pickling process. Altogether, this inert-surface modification strategy represents a significant step forward for effective and cleaner tanning technology , which will accelerate the wide application of Zr(IV) in place of traditional chrome tanning agents.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）