Frontiers in Cellular and Infection Microbiology
·
2021
·
IF 5.293
Zhang Qi,Chen Zhiqiang,Huang Chenxiao,Sun Jiuyuan,Xue Minfei,Feng Tingting,Pan Wen,Wang Kezhen,Dai Jianfeng
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide and has infected more than 250 million people. A typical feature of COVID-19 is the lack of type I interferon (IFN-I)-mediated antiviral immunity in patients. However, the detailed molecular mechanisms by which SARS-CoV-2 evades the IFN-I-mediated antiviral response remain elusive. Here, we performed a comprehensive screening and identified a set of SARS-CoV-2 proteins that antagonize the IFN-I response. Subsequently, we characterized the mechanisms of two viral proteins antagonize IFN-I production and downstream signaling. SARS-CoV-2 membrane protein binds to importin karyopherin subunit alpha-6 (KPNA6) to inhibit interferon regulatory factor 3(IRF3) nuclear translocation. Further, the spike protein interacts with signal transducer and activator of transcription 1 (STAT1) to block its association with Janus kinase 1 (JAK1). This study increases our understanding of SARS-CoV-2 pathogenesis and suggests novel therapeutic targets for the treatment of COVID-19.
研究领域:
病毒学
·
免疫学
·
分子生物学
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DOI
PubMed
高影响因子
Nano Energy
·
2018
·
IF 13.12
Yi Lu,Xiu Cheng,Ge Tian,Heng Zhao,Li He,Jie Hu,Si-Ming Wu,Ying Dong,Gang-Gang Chang,Silvia Lenaerts,Stéphane Siffert,Gustaaf Van Tendeloo,Zhao-Fei Li,Ling-Ling Xu,Xiao-Yu Yang,Bao-Lian Su
Hierarchical semiconductors are the most important photocatalysts , especially for visible light-induced hydrogen production from water splitting. We demonstrate herein a hierarchical electrostatic assembly approach to hierarchical CdS/m-TiO 2 /G ternary photocatalyst, which exhibits high photoactivity and excellent photostability (more than twice the activity of pure CdS while 82% of initial photoactivity remained after 15 recycles during 80 h irradiation). The ternary nanojunction effect of the photocatalyst has been investigated from orbitals hybrid, bonding energy to atom-stress distortion and nano-interface fusion. And a coherent separation mechanism of charge carriers in the ternary system has been proposed at an atomic/nanoscale. This work offers a promising way to inhibit the photocorrosion of CdS and, more importantly, provide new insights for the design of ternary nanostructured photocatalysts with an ideal heterojunction .
研究领域:
材料科学
·
能源科学
·
纳米技术
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DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Mingjun Cui,Yujie Qiang,Wei Wang,Haichao Zhao,Siming Ren
In this work, nitrogen doped carbon dots (NCDs) were prepared with citric acid monohydrate (CA·H 2 O) and ethanolamine (EA) via microwave method. In combination with electrochemical techniques, weight loss and SEM, it is found that nitrogen doping in carbon dots effectively suppresses the corrosion of Q235 carbon steel in HCl solution owing to the presence of pyrrolic N in NCDs. Especially for NCDs (1:10), the optimum inhibition efficiency is about 89% after 1 h of immersion in 0.1 M HCl solution with 500 ppm of concentration. By further calculation, the Δ G ads 0 value for NCDs (1:10) is -26.65 kJ·mol -1 , indicating the adsorption of NCDs on Q235 carbon steel surface involves both chemisorption and physisorption. In addition, NCDs still remain superior corrosion inhibition performance with the prolonged immersion time and ascending temperature.
研究领域:
材料科学
·
腐蚀与防护
·
电化学
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Chaocheng Liu,Xucai Kan,Feng Hu,Xiansong Liu,Shuangjiu Feng,Jiyu Hu,Wei Wang,Khalid Mehmood Ur Rehman,Mudssir Shezad,Cong Zhang,Haohao Li,Shengqiang Zhou,Qiuyue Wu
Herein, we have systematically illustrated the specific impact of Ce-Zn co-substituted M-type strontium hexaferrites on its microstructure and magnetic properties . An evident phase pattern change process and performance improvement are observed from a series of systematic measurements. The results of X-ray diffraction show that the single phase can be obtained when x = 0.00–0.30, the other unexpected diffraction peaks of hematite ( α -Fe 2 O 3 ) will appear in the patterns as x > 0.3. Scanning electron microscopy exhibits that all samples formed the uniform plane hexagonal structures with different substitution contents. FT-IR spectra verify the confirmation that M-type hexagonal structure has been formed thoroughly. M ( T ) curve displays the ferrimagnetic behavior of temperature dependent magnetization. And vibrating sample magnetometer indicates both M s and H c can be improved significantly, indicating an excellent performance in novel recording devices.
研究领域:
材料科学
·
磁学
·
陶瓷学
·
固态化学
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DOI
高影响因子
Open Access Rheumatology-Research and Reviews
·
2024
·
IF 1.7
Le-Ying Ni,Cheng-Biao Ding,Ji-Min Deng,Zheng-Wei Wu,Yun Zhou
Background Rheumatoid arthritis fibroblast-like synovial cells (RA-FLS) have become the core effector cells for the progression of rheumatoid arthritis due to their “tumor-like cell” characteristics, such as being able to break free from growth restrictions caused by contact inhibition, promoting angiogenesis, invading surrounding tissues, and leading to uncontrolled synovial growth. In recent years, cold air plasma (CAP) has been widely recognized for its clear anticancer effect. Inspired by this, this study investigated the inhibitory effect of CAP on the tumor-like biological behavior of RA-FLS through in vitro experiments.Methods Treatment of RA-FLS with CAP at different time doses (0s, 30s, 60s, 120s). 5-ethynyl-2’-deoxyuridine (EdU) proliferation assay was used to determine the cell viability. Analysis of cell migration and invasion was performed by wound-healing assay, transwell assay and immunofluorescent staining for f-actin, respectively. Flow cytometry technique was used for analysis of cell cycle and determination of reactive oxygen species (ROS). Hoechst staining was used for analysis of cell apoptosis. Protein expression was analyzed by Western blot analysis.Results Molecular and cellular level mechanisms have revealed that CAP blocks RA-FLS in the G2/M phase by increasing intracellular reactive oxygen species (ROS), leading to increased apoptosis and significantly reduced migration and invasion ability of RA-FLS.Conclusion Overall, CAP has significant anti proliferative, migratory, and invasive effects on RA-FLS. This study reveals a new targeted treatment strategy for RA.
研究领域:
风湿病学
·
等离子体医学
·
细胞生物学
·
炎症性疾病
·
癌症生物学
✓ 已验证
DOI
高影响因子
Inorganic and Nano-Metal Chemistry
·
2026
·
IF 1.7
Heng-Feng Du,Jia-Tian Shang,Hong-Biao Tang,Shi-jie Wang,Xing Li
Functionalized Au nanomaterials have significant potential in colorimetric detection of fatal toxic metals. In this work, a simply colorimetric sensor was designed and prepared for visual detection of Hg(II) ions based on gold nanoparticles (AuNPs) modified by 5-(m-aminophenyl)tetrazole (APT) and characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and UV − vis absorption spectroscopy. The colorimetric sensor exhibited the fine anti-interference and selectivity in an environment with the presence of other interfering ions. The limit of detection (LOD) is 0.6 µmol/L by the naked eye, and 0.21 µmol/L by UV-vis spectroscopy, indicating that the sensor of AuNPs modified with APT (APT@ AuNPs) could be used for the quantitative determination of Hg2+. Based on the above peculiarity, the sensor could be used to detect Hg2+ in real samples.
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DOI
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2022
·
IF 4.966
Shiran Huang,Ming Huang,Sinuo Tian,Zhiyuan Meng,Sen Yan,Miaomiao Teng,Zhiqiang Zhou,Jinling Diao,Wentao Zhu
Imazalil (IMZ) is a highly effective fungicide employed in crop production. It has been consistently detected in aquatic environments . The main environmental metabolite of IMZ is imazalil-M (IMZ-M). Limited studies have focused on the toxicity of IMZ and IMZ-M in aquatic organisms . This study systematically evaluated the developmental toxicity of IMZ and IMZ-M on zebrafish ( Danio rerio ) embryos and explored the potential mechanisms involved. The results showed that IMZ and IMZ-M caused developmental toxicity, characterized by decreased heart rate, hatching inhibition, and pericardial cyst in zebrafish embryos. Subsequently, acridine orange (AO) staining revealed cell apoptosis in the area around the heart regions of zebrafish larvae. Besides, the expression levels of apoptosis-related genes also varied significantly. Furthermore, 1 H NMR-based metabolomics analysis showed that IMZ and IMZ-M exposure could induce metabolic profiles disorder in zebrafish larvae. Importantly, zebrafish exposure to IMZ and IMZ-M significantly affected the metabolism of branched - chain amino acids, energy, and ketone bodies , which are related to cell apoptosis. Overall, the toxicity of IMZ and IMZ-M in zebrafish embryos and larvae was characterized, suggesting a theoretical basis for the potential environmental risks of IMZ and its metabolite IMZ-M on non-target organisms.
研究领域:
环境科学
·
毒理学
·
生物化学
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Liang Zeng,Ling Xiao,Xiaowen Shi,Mingyu Wei,Jinying Cao,Yangke Long
Herein, Prussian blue analogues@poly(m-phenylenediamine) nanoparticles (PBA@PmPDs) with well-defined core-shell structure were synthesized. The successful coating of poly(m-phenylenediamine) (PmPD) on the surface of Fe y Co 3-y [Co(CN) 6 ] 2 (Fe-Co-Co PBA) was confirmed by SEM, TEM , XRD , TGA , FT-IR and XPS . The catalytic performance of Fe-Co-Co PBA@PmPDs was evaluated by activation of peroxymonosulfate (PMS) for degradation of Rhodamine B (RhB), the effects of different influence factors on the RhB degradation efficiency were investigated, including PMS concentration, temperature, initial solution pH, and co-existing inorganic salts. Cobalt ions leaching and stability of the catalysts were studied, Co ions concentration dissolved into the solution from the solid catalysts at 60 min is reduced by half after the Fe-Co-Co PBA is coated with PmPDs. The RhB removal efficiency is higher than 90% even after four cycles and the nanoparticles still maintain the core-shell structure, indicating that Fe-Co-Co PBA@PmPDs is stabile and reusable. Radical quenching experiments and electron paramagnetic resonance spectra indicate that both SO 4 − and OH are generated during the PMS activation process and SO 4 − is the dominant reactive species. In virtue of its superior catalytic activity, excellent reusability and stability, low metallic ion leaching, Fe-Co-Co PBA@PmPDs could be a promising catalyst for the remediation of contaminated water.
研究领域:
环境科学
·
材料科学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Xi Tang,Yilin Wang,Zhifang Liu,Maoheng Fei,Ronghuan Gao,Yixi Xie,Xiayi Hu,Pengcheng Zhao,Junjie Fei
Characterized by high toxicity and difficult degradation, m-nitrophenol (3-NP) is an environmental pollutant that endangers the environment and biological systems. Therefore, the development of analytical techniques for the detection of low concentrations of 3-NP is critical for the environment and human health. In this work, spherical CdIn 2 S 4 and tiny ZnS particles were prepared by a hydrothermal method , and the Z-type ZnS/CdIn 2 S 4 heterojunction material was obtained by ultrasonically assembling ZnS onto CdIn 2 S 4 . The Z-type ZnS/CdIn 2 S 4 heterojunction possesses a better photocurrent response and a good electron transport capacity, and it can efficiently separate the photogenerated electron-hole pairs. Therefore, a photoelectrochemical sensor for accurate detection of 3-NP in water was constructed based on the Z-type ZnS/CdIn 2 S 4 heterostructure. The sensor has a detection range from 5 × 10 −12 M to 1 × 10 −8 M and an extremely low limit of detection (1.28 ×10 −12 M), which is rare among other sensors. Meanwhile, the sensor showed excellent performance in real samples, indicating that it can effectively monitor 3-NP in real water samples. The validation of the sensor using UV–visible spectra also yielded satisfactory results.
研究领域:
环境分析化学
·
材料科学
·
分析化学
·
光催化
·
传感器技术
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DOI
高影响因子
Small Methods
·
2023
·Vol. 7
·期 8
·2300054
·
IF 12.4
Lu Chen,Youbing Li,Kun Liang,Ke Chen,Mian Li,Shiyu Du,Zhifang Chai,Michael Naguib,Qing Huang
Two-dimensional (2D) transition metal carbides and/or nitrides, MXenes, are prepared by selective etching of the A-site atomically thin metal layers from their MAX phase precursors. High entropy MXenes, the most recent subfamily of MXenes, are in their infancy and have attracted great interest recently. They are currently synthesized mainly through wet chemical etching of Al-containing MAX phases, while various MAX phases with A-sites elements other than Al have not been explored. It is important to embody non-Al MAX phases as precursors for the high entropy MXenes synthesis to allow for new compositions. In this work, it is reported on the design and synthesis of Ga-containing medium/high entropy MAX phases and then their corresponding medium/high entropy MXenes. Gallium atomic layer etching is carried out using a Lewis acid molten salt (CuCl2). The as-prepared (Ti 1/4 V 1/4 Nb 1/4 Ta 1/4 ) 2 CT x exhibits a Li + specific capacity of ≈400 mAh g −1 . For (Ti 1/5 V 1/5 Nb 1/5 Ta 1/5 Mo 1/5 ) 2 CT x a specific capacity of 302 mAh g −1 is achieved after 300 cycles, and high cycling stability is observed at high current densities. This work is of great significance for expanding the family members of MXenes with tunable chemistries and structures.
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产品关联
DOI
PubMed
高影响因子
Journal of Superconductivity and Novel Magnetism
·
2023
·Vol. 36
·期 2
·711-719
·
IF 1.8
Huang Danqiang,Wen Xinchao,Dai Jianfeng,Wang Qing,Liu Hui,Li Zengpeng
In this study, SrFe 12 O 19 @MFe 2 O 4 (M = Co, Ni, Zn) core–shell nanofibers were fabricated by coaxial electrostatic spinning. The composites obtained at an annealing temperature of 900 °C are composed of SrFe 12 O 19 in pure phase and MFe 2 O 4 (M = Co, Ni, Zn) in different spinels. X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), and transmission electron microscope (TEM) were used to describe the structure and morphology of nanofibers. Magnetic Property Measurement Systems (MPMS) are used to characterize the magnetic properties of nanofibers. Sr@Ni and Sr@Zn fibers all exhibit a unique core–shell structure, while Sr@Co fibers are connected by a lamellar structure. The single-phase hysteresis lines for each composite indicate the presence of exchange coupling effects between the hard/soft magnetic composite phases. The magnetic properties of the composites change as the soft magnetic material in the shell layer changes. Sr@Co has the highest M s (69.43 emu/g) and M r (33.82 emu/g), whereas Sr@Zn has the highest H c (2927 Oe). The switching plant curves indicate that the best exchange coupling of the three groups of samples is for Sr@Co. The magnetic properties of the composites are explained in terms of the nanofiber diameter, the exchange coupling between the two phases, and the nature of the soft magnetic phase itself. It is shown that the exchange coupling of composites is closely related to the type of composite.
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产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 25
·9728-9734
·
IF 4.569
Dong Zhang,Shen-Jing Ji,Yu Cao,Nian-Tzu Suen
In this work, we have demonstrated that one can control the intrinsic activity of Ni metal toward the hydrogen evolution reaction (HER) by simply alloying Ni with different elements (i.e. Ti, Ge or Sn). The HER activities of Ni3M (M = Ti, Ge and Sn) series and Ni metal follow the order of Ni3Ti (η10 = 68 mV) > Ni3Sn (η10 = 122 mV) > Ni3Ge (η10 = 161 mV) > Ni (η10 = 273 mV). After normalizing their HER performances based on the roughness factor (RF), it was realized that Ni3Ti and Ni3Sn both exhibit higher intrinsic HER activities than that of Ni metal while Ni3Ge displays the worst HER performance. This trend was later rationalized by using density functional theory (DFT) calculation, which showed that blending Ni with Ti, Ge or Sn elements will alter the corresponding electronic structure and bonding scheme. Such a change in the bonding scheme (i.e. bonding state or antibonding state) will influence the adsorption energy of the H atom (ΔGHad) on an active site and is the main cause of the synergetic effect that results in the different HER efficiencies of Ni3M (M = Ti, Ge and Sn). Through the present case study, it was recognized that alloying is a simple yet effective strategy to promote the HER activity of an electrocatalyst. With a suitable combination between elements, it helps single metals (e.g. Co or Ni metal) exceed the limits on their intrinsic HER activities and has the potential to replace noble metals (e.g. Pt, Ir and Ru) in the future.
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产品关联
DOI
PubMed
高影响因子
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