Journal of Science-Advanced Materials and Devices
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2022
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IF 7.382
Xiaoyan Xue,Yan Sun,Qiwen Sun,Weiren Bao,Zongsen Zhang,Liping Chang,Jiancheng Wang,Kechang Xie
As an atom economy technology, the direct esterification reaction of olefins plays a significant role in the production of organic esters. In this work, a series of resin-supported HPW catalysts were prepared using D101, D152, RM027, and A15 as the carriers, and they were used to prepare 1-methylpentyl acetate by the esterification of 1-hexene and acetic acid. The composition, structure, morphology, acid content, and other parameters of catalysts were characterized. In the esterification reaction, the activity order of catalysts is as follows: 20.0%HPW/A15 > 20.0%HPW/D101 ≈ 20.0%HPW/D152 > 20.0%HPW/RM027. It depends on the acid strength of the carrier, the interaction between the carrier and HPW, and the HPW content. Moreover, it can be concluded that the weak acid resin carrier is completely inactive for the esterification reaction of 1-hexene, and the ratio of acetic acid to 1-hexene has a significant influence on the product selectivity. When n (acetic acid)/n (1-hexene) = 2, the optimum 1-methylpentyl acetate selectivity is 38.2%. Results of repeated experiments confirm that the stability of the active constituent is related to the type of functional groups on the carrier.
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Polymers
·
2022
·Vol. 14
·期 12
·2470
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IF 4.967
Jing Yang,Xujiao Tang,Qingqing Wu,Panpan Ren,Yishu Yan,Wei Liu,Chun Pan
Heparin has shown benefits in severe acute pancreatitis (SAP) therapy, but the underlying mechanisms were unknown. Extracellular high-mobility group protein-1 (HMGB-1) has been regarded as a central mediator contributing to inflammation exacerbation and disease aggravation. We hypothesized heparin attenuated the disease by targeting HMGB-1-related pathways. In the present study, the possible therapeutic roles of heparin and its non-anticoagulant derivatives, 6-O-desulfulted heparin and N-acylated-heparin, were determined on mouse models induced by “Two-Hit” of L-arginine. The compounds exhibited potent efficiency by substantially decreasing the pancreatic necrosis, macrophage infiltration, and serum inflammatory cytokine (IL-6 and TNF-α) concentration. Moreover, they greatly reduced the rapidly increasing extracellular HMGB-1 levels in the L-arginine injured pancreases. As a result, multiple organ failure and mortality of the mice were inhibited. Furthermore, the drugs were incubated with the RAW264.7 cells activated with damaged pancreatic tissue of SAP mice in vitro. They were found to inhibit HMGB-1 transfer from the nucleus to the plasma, a critical step during HMGB-1 active secretion from macrophages. The results were carefully re-examined with a caerulein and LPS induced mouse model, and similar results were found. The paper demonstrated heparin alleviated SAP independent of the anti-coagulant functions. Therefore, non-anticoagulant heparin derivatives might become promising approaches to treat patients suffering from SAP.Keywords:heparin;severe acute pancreatitis;HMGB-1;macrophage
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CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Zhaohui Wu,Jihuai Wu,Shibo Wang,Chunyan Wang,Yitiani Du,Ying Wang,Jialian Geng,Yuhe Lin,Weihai Sun,Zhang Lan
The rapid development of perovskite solar cell (PSC) makes it a typical representative of the third generation PV technology. The large-scale manufacturing of the device still faces many challenges, such as enhancing efficiency and improving stability. The core problem is the suppression of various defects and the adjustment of energy levels among components. In this report, a multifunctional molecule of potassium nonafluoro-1-butanesulfonate (KFBS) is introduced into SnO 2 electron transport layer (ETL). Owing to the synergistic effect of potassium ion, sulfonic group and nonafluorobutane group in KFBS, the energy match between perovskite (PVK) and ETL is tuned, the PVK and ETL quality is improved, and the defects at interface, on grain boundaries and in bulk are passivated. Consequently, the power conversion efficiencies increase from 20.6% for pristine device to 23.21% for KFBS-modified device. Moreover, unpacked KFBS-modified device still maintains its initial efficiency of 90.5 % after storing at room temperature and relative humidity of 30 % in dark for 1000 h, showing an excellent environmental stability.
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MATERIALS & DESIGN
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2022
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IF 9.417
Lingling Pan,Dawei Jiang,Luqi Pan,Zhizhen Meng,Yangyang Zhuang,Yueyue Huang,Fanrong Ye,Changcan Shi,Jie Chen,Jingye Pan
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and causes high ratios of morbidity and mortality worldwide. Although many potential therapeutic targets have been reported, the therapeutic effect needs to be further improved. Herein, we report a strategy to specifically target inflammation site via anti-ICAM-1 antibody bonded antibacterial peptides polymeric nanoparticle. Antibacterial peptide (KR-12) grafted amphipathic PCL- b -P(OEGMA- co -AMA)- g -Cys-KR-12 block copolymer and PCL- b -P(OEGMA- co -AMA)- g -biotin block copolymer were synthesized by ring-opening polymerization and click chemistry. Then, antibacterial peptides polymeric nanoparticles (AMPNP) were prepared by co-assembly of amphipathic PCL- b -P(OEGMA- co -AMA)- g -Cys-KR-12 and PCL- b -P(OEGMA- co -AMA)- g -biotin in aqueous solution. Intercellular adhesion molecule-1 (ICAM-1) is highly expressed on the surface of inflammatory endothelial cells, and the anti-ICAM-1 antibody can specifically bind to it. To obtain the anti-ICAM-1-AMPNP nanoparticles, biotinylated anti-ICAM-1 antibodies were bonded on the surface of AMPNP nanoparticles through the biotin-avidin system. The anti-ICAM-1-AMPNP nanoparticles had low systemic toxicity and exhibited ideal antibacterial property against drug-resistant bacteria, Gram-negative bacteria and Gram-positive bacteria. The anti-ICAM-1-AMPNP nanoparticles exhibited favorable targeting capabilities to inflammation endothelial cells in vitro and significantly reduced the inflammatory response of CLP mice in vivo . The present investigation might provide a specific strategy for targeting combating sepsis with anti-ICAM-1-AMPNP nanoparticles.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2021
·Vol. 127
·期 12
·1-13
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IF 2.584
Li Wenchuan,Wu Heng,Ao Hong,Zeng Zhixin,Gao Rongli,Cai Wei,Fu Chunlin,Deng Xiaoling,Chen Gang,Wang Zhenhua,Lei Xiang
Multiferroic composite ceramics x Ni 0.15 Cu 0.25 Zn 0.6 Fe 2 O 4 -(1- x ) Ba 0.85 Ca 0.15 Zr 0.1 Ti 0.9 O 3 ( x = 0, 0.2, 0.3, 0.4, 0.5, 0.6, 0.9 and 1) were prepared by combining chemical co-precipitation method with sol–gel method; the microstructure, dielectric, ferroelectric, magnetic and multiferroic properties were comparatively investigated. XRD results show that all the specimens have obvious bi-phases structure. The grains with larger size are magnetic phase Ni 0.15 Cu 0.25 Zn 0.6 Fe 2 O 4 (NCZF), while that of smaller size can be attributed to ferroelectric phase Ba 0.85 Ca 0.15 Zr 0.1 Ti 0.9 O 3 (BCZT). The dielectric constant of the sample with x = 0.6 is the largest at low frequency but the specimen x = 0.2 has the highest value of dielectric constant in high-frequency region. When x = 0.9, the ceramic has the largest loss, while it presents the lowest loss value when x = 0.3. The height of the peak decreases with increase in the frequency, and the position of the peak moves to higher temperature range with the decrease in x . The dielectric loss increases sharply with temperature, especially when x = 0.9, when the temperature is higher than 300 °C, the dielectric loss reaches hundreds of times under low frequency. Al samples present apparent ferroelectric hysteresis loops, but further characterization shows that the hysteresis may be attributed to leakage current. The remnant polarization( P r ) and coercive field( E c ) do not monotonically change with x , P r is 0.1576 μC/cm 2 at 2 kHz when x = 0.6. The magnetization monotonically changes with the x , indicating that there is a strong interfacial interaction between the two phases. Under the action of an external magnetic field of 1 mT, the magnetoelectric (ME) coupling is the strongest (relative polarization change 37%) when x = 0.2.
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Cartilage
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2021
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IF 4.634
Yunliang Lei,Jiabin Peng,Zhu Dai,Ying Liao,Quanhui Liu,Jian Li,Yonghui Jiang
ObjectiveThis study was undertaken to elucidate the mechanism of improved chondrocyte migration after juvenile articular cartilage fragmentation.DesignIn vitro organ culture with rabbit cartilage fragments and cell culture with rabbit chondrocytes were performed. In part A, minced juvenile cartilage fragments (~0.5 × 0.5 × 0.5 mm) from rabbits, planted in gelatin sponge and fibrin glue, were cultured for 2, 4, or 6 weeks in vitro and compared with the cartilage chunks (~4 × 4 × 1 mm) and membrane type 1 matrix metalloprotease (MT1-MMP) inhibitor groups. Chondrocyte outgrowth was evaluated on histology and confocal laser scanning microscopy. MT1-MMP expression was compared between the cartilage fragment group and the cartilage chunks group. In part B, articular chondrocytes were harvested from juvenile rabbits, MT1-MMP was transfected into the cells, and cell migration was evaluated using the Transwell and wound healing tests.ResultsThe histology and confocal microscopy results revealed that cell accumulation occurred at the edge of cartilage fragments, and outgrowth was better in the cartilage fragment group than those in the cartilage chunks group. Similar results were observed for MT1-MMP expression. After MT1-MMP inhibition, cells did not accumulate at the edge of the cartilage fragments, and chondrocyte outgrowth did not occur. Furthermore, overexpression of MT1-MMP enhanced the migration of articular chondrocytes.ConclusionsJuvenile articular cartilage fragmentation improved chondrocyte migration by upregulating MT1-MMP.
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SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Yingli Han,Yuehua Wang,Fangyu Zhou,Yuyang Jiang,Feng Liu
Human apurine/apyrimidine endonuclease (APE) is a multifunctional enzyme that affects the occurrence and development of cancer through DNA repair and redox regulation. It has been identified as a tumor marker for detection and prognosis and drug target due to its overexpression in a variety of cancers. However, the accurate detection of APE 1 activity is still a huge challenge. Traditional approaches exist some disadvantages, including low sensitivity, complex operation and professional equipment requirements. Therefore, it is necessary to develop a fast, sensitive and simple biosensor to detect APE 1 activity in vivo and in vitro. In this report, a new tetrahedral molecular beacon (TMB) probe is designed for the detection of APE 1 activity. This probe not only has the advantage that the tetrahedron can enter the cells without a transfection agent, but also has the advantages of simple operation and low cost. The extracellular detection limit of TMB is as low as 0.0026 U/mL, and this program has successfully achieved APE 1 intracellular imaging to distinguish cancer cells overexpressing APE 1 from normal cells. In addition, the probe which is an effective mean for screening APE 1 inhibitor can also monitor the response of APE 1 to different drugs. All in all, our probe can be successfully applied to detect APE 1 activity in vivo and vitro, and can achieve living cells drug screening. And this probe also provides a general method for the detection of other endogenous biological targets in living cells.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2021
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IF 5.316
Zhe Hu,Hanqing Dai,Wenjie Zhou,Jinxin Wei,Hongbin Zhang,Zhaoqi Ye,Yi Qiu,Yuanyuan Chen,Zhongtao Duan,Jing Wang,Wanlu Zhang,Fengxian Xie,Ruiqian Guo
The aggregation-induced quenching (AIQ) properties of the solid-state carbon dots (CDs) limit their wide-scale actual applications. Herein, a novel corrosion resistant solid-state CDs@Silicalite-1 (CDs@S-1) composite was synthesized via in situ embedding CDs into the S-1 matrix. Owing to the confinement effect, CDs are immobilized into the interrupted defects of the three-dimensional S-1 matrix. The as-prepared composite possesses high photoluminescence quantum yield (63%) and extra-high stability in common organic solvents and various pH solutions (pH=2–14). Moreover, the feasibility of the CDs@S-1 composite as a fluorescent label on various substrates was investigated. The results demonstrate the images with well-defined papillary ridges under ultraviolet (UV) light and show great potential for latent fingerprints detection in forensic science.
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MOLECULAR PHARMACEUTICS
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2021
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IF 4.939
Sida Ruan,Guiying Yang,Yuanzhen Dong,Wenwen Shangguan,Weigen Lu
Hypoparathyroidism (HP) is a rare disease with clinical manifestations of hypocalcemia and hyperphosphatemia, resulting from deficient or absent parathyroid hormone (PTH) secretion. Conventional treatment for patients with HP involves extensive calcium and vitamin D supplementation. In 2015, PTH1–84 was approved by the United States Food and Drug Administration as an adjunct for HP patients who cannot be well-controlled on conventional treatment. However, PTH1–84 therapy requires a daily injection, leading to poor patient compliance. The purpose of this study was to develop a long-acting PTH1–34 analogue by increasing its affinity to albumin. Three PTH1–34 variants were generated by substituting two of the three lysine (Lys) residues with arginine, reserving a single Lys as the modification site in each sequence. A series of side chains, containing fatty acid, deoxycholic acid, or biotin groups, were synthesized to modify these PTH1–34 variants by using a solid–liquid phase synthesis approach. In vitro bioactivity and albumin affinity tests were used to screen these new PTH1–34 analogues. Finally, Lys27-AAPC was selected from 69 synthesized analogues as a candidate therapeutic compound because it retained potency and exhibited a high albumin-binding capacity. In pharmacodynamic experiments, Lys27-AAPC demonstrated enhanced and prolonged efficacy in serum calcium elevating relative to PTH1–84. Moreover, a lyophilized powder for injection containing Lys27-AAPC was developed for further testing and represented a potential long-acting HP treatment.
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INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
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2021
·Vol. 54
·期 2
·71-80
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IF 1.462
Yufei Yang,Yadong Zhang
In this work, a HPW/ZSM-5 catalyst was prepared by impregnating phosphotungstic acid (HPW) with carrier ZSM-5 zeolite and characterized by XRD, SEM, N 2 adsorption/desorption isotherm, NH 3 -TPD, and FT-IR techniques. The catalytic performance of HPW/ZSM-5 was investigated by using the decomposition reaction of cyclohexylbenzene-1-hydroperoxide (CHBHP) to phenol and cyclohexanone. The conversion rate of CHBHP was up to 97.28%. In addition, the reusability test exhibited that the high durability HPW/ZSM-5 as the conversion rate of CHBHP only decreased by 3.11% after five runs. The kinetic study of the decomposition reaction indicated it was a primary reaction. The apparent activation energy of the decomposition reaction was 102.39 kJ·mol –1 in the temperature range of 45–60℃. All results indicate that the HPW/ZSM-5 catalyst has good performance and promising applications in acid catalyzed organic chemistry.
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Molecular Catalysis
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2021
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IF 5.062
Mengzhe Li,Xiaohua Shen,Miaoqing Liu,Jianjun Lu
L-lysine is used as a crystallization regulator, and a two-step synthesis method is adopted in a concentrated gel system, which provides a new route to synthesize of nano-sized TS-1 zeolite. The new synthesis strategy was used to successfully synthesize TS-1 zeolite with a particle size less than 100 nm. The rate of crystal nucleation is faster than the crystal growth at the low temperature in the first step. Introduction of L-lysine can prevent crystal growth to form nano-sized TS-1 zeolite at the high temperature in the second step. Meanwhile, L-lysine decrease the pH value of the gel system, which is favorable for Ti atoms to incorporate the TS-1 framework. TS-1 nanozeolite can effectively reduce the diffusion resistance, and nanozeolite has a large specific surface area and high stability. Therefore, TS-1 nanozeolite exhibits the excellent catalytic performance during the hydroxylation of benzene. The conversion of benzene has been greatly improved and the types of by-products are effectively reduced. The conversion of benzene reached 50.2%, and the yield of phenol was 30.8% without by-product benzoquinone. TS-1 nano-zeolite as a catalyst for benzene hydroxylation shows great potential in industrial application.
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JOURNAL OF CHROMATOGRAPHY A
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2021
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IF 4.759
Tao Bao,Sicen Wang,Nan Zhang,Juan Zhang
Inspired by the outstanding functions of 3-aminopropyltriethoxysilane (APTES), which can be used for functionalization of both covalent organic frameworks (COFs) and substrate surfaces, herein, a proof-of-concept demonstration was carried out by one-step synthesis and immobilization of COF-1 in capillary. COF-1 was grown on the inner wall of capillary using APTES, which played a triple role of catalyst, stabilizer, and connecting arm during the process. The immobilization of COF-1 on silicon surface was confirmed by scanning electron microscopy. Moreover, COF-1 modified capillary (COF-1@capillary) column exhibited excellent performance in the electrochromatographic separation of amino acids . High resolution and separation efficiency (225,378 plates/m for 4-methylbiphenyl) were successfully achieved. Separation of methylbenzene , styrene , ethylbenzene , chlorobenzene , 1,2-dichlorobenzene, 1,2,4-trichlorobenzene, 4-methylbiphenyl, naphthalene , and 4-vinylbipheny in the electro-driven mode confirmed the successful growth of COF-1 on the inner wall of capillary. The developed facile method for the immobilization of COF-1 may pave the way for further application prospects of boron-based COFs.
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