FITOTERAPIA
·
2025
·
IF 2.6
Mingxuan Guo,Huanxin Zhao,Nannan Song,Ping Huang,Man Li,Liwen Han,Ke-wu Zeng,Zhiyuan Lu
Sepsis-associated acute lung injury (SA-ALI), a critical complication of sepsis, is characterized by immune dysregulation-induced pulmonary dysfunction. Shenmai Injection (SMI) is a standardized herbal preparation consisting of Panax ginseng C.A.Mey (Hongshen) and Ophiopogon japonicus (Thunb.) Ker Gawl (Maidong), traditionally used for qi-replenishing, collapse-stabilizing, and lung-moistening therapy. Although clinically utilized in the management of SA-ALI, the specific mechanisms by which it acts against SA-ALI necessitate further investigation. The present study endeavors to comprehensively determine the therapeutic efficacy of SMI against SA-ALI through an integrated approach combining network pharmacology, metabolomics, metagenomic sequencing, and experimental validation. In this study, murine SA-ALI was established using lipopolysaccharide (LPS) and Poly(I:C). Results indicated that SMI administration significantly attenuated pulmonary inflammation, restored blood-gas barrier integrity, reduced serum pro-inflammatory cytokines and suppressed NF-κB pathway activation in SA-ALI mice. Network pharmacology elucidated the multi-targeted mechanism of SMI in modulating steroid hormone biosynthesis. Integrated metabolomics and target analysis revealed that ophiopogonin A/B and luteolin in SMI alleviates metabolic dysregulation by targeting key enzymes, including AKR1C3, HSD17B1/2, and SULT1E1. Metagenomic profiling demonstrated SMI-mediated gut microbiota remodeling, marked by suppression of pathogenic Chlamydiaceae (particularly Chlamydia abortus ) and enrichment of commensal Lactobacillaceae . Correlation analysis showed that intestinal androstenedione and androsterone levels during SMI treatment recovery were negatively correlated with Chlamydia abortus abundance. In conclusion, SMI enhances the recovery from sepsis-associated SA-ALI by dual modulation of gut microbial ecology and host metabolic homeostasis, thereby establishing its potential as a multi-mechanistic therapeutic candidate for sepsis-related organ injury.
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高影响因子
WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 15
·1-15
·
IF 3
Lv Tingting,Wang Hong,Li Ding,Li Ruihai,Yang Chengliang,Zhao Wei,Cui Zhenyu,Li Jianxin
Organophosphorus pesticide contaminated sites have been categorized as a global priority contaminated site type for remediation due to the excessive accumulation of persistent organic pollutants. This study investigated the removal effect of phorate (PHR) in polluted soil through co-solvent-assisted alkaline activation of persulfate (PS) system, and evaluated the contribution of the co-solvent to the desorption behavior and solubilizing effect of PHR. Results showed that a high PHR degradation rate of 56.1% was obtained on the second day under the following conditions: 40% (v/v) acetonitrile (ACN) as co-solvent, C PS = 382 mmol L –1 , pH 12, and a W L /W s ratio of 1:2. It was a significant improvement over the system without co-solvent (19.9%). Moreover, a degradation rate of PHR was up to 93.9% on the 21st day under the optimized operating conditions, which was significantly higher than that observed in the persulfate oxidation system (13.1%) and the alkaline hydrolysis system (33.6%). The critical active species, including sulfate radicals \(S{O}_{4}^{\bullet -}\) and hydroxyl radicals (•OH) for the oxidation of PHR in contaminated soil during the alkaline-activated persulfate system were identified using electron spin resonance (ESR) and radical quenching experiments. The degradation pathways involved both hydrolytic pre-activation and radical mineralization. Furthermore, the luminescent bacteria tests demonstrated that the luminescence inhibition rate of the PHR-contaminated soil decreased from an initial value of 100% (highly toxic) to 16.2% (low toxicity) after remediation. In summary, this study offers a promising approach for the remediation of organophosphorus pesticide-contaminated soils.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2025
·
IF 4.7
Xin Yao,Gongnv Xu,Bingchen Tan,Xuankai Deng,Yanhua Yu
Photoswitches with multiple fluorescent states known as photofluorochromism under light irradiation show practical applications in optical information storage, anticounterfeiting, and sensors. Despite considerable progress, current photoresponsive systems mainly operate in solution phase, with solid-state implementations remaining challenging. Herein, in this article, we reported three green fluorescent protein (GFP) chromophore like analogues (denoted as p -CBIE, m -CBIE and m -DCBIE) demonstrating photofluorochromic behavior in solid-state. Intriguingly, these compounds exhibited opposite photo responses between solution and solid states. In solution phase, UV irradiation induced fluorescence quenching through photoisomerization. Remarkably, the solid-state displayed light-activated fluorescence enhancement with chromatic shifts: p -CBIE and m -DCBIE exhibited green-to-blue emission switching with fluorescence quantum yield (Φ F ) enhancements from 8.2 % to 18.2 % and 11.3 % to 25.8 %, respectively. m -CBIE demonstrated blue emission increase with Φ F improvement from 4.8 % to 16.6 %. Mechanism studies revealed that light-induced molecular reorganization facilitated tighter packing and enhanced structural rigidity in the solid state, thereby suppressing non-radiative decay pathways. Moreover, p -CBIE, m -CBIE and m -DCBIE were successfully used for selective photoactivation imaging of SK-OV-3 cancer cells and photo-patterning.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zehao Wang,Huayu Chen,Yesheng Fu,Hang Yin,Dandan Yu,Junhui Liang,Yuexiang Huang,Liuqi Wang,Wei Gao,Da Chen,Yang Hou
Hydrogen production technology by water electrolysis highly relies on active and durable electrocatalysts for oxygen evolution reaction (OER). For Fe-containing electrocatalysts, the surface evolution during OER generally induces the dissolution of Fe into electrolyte. The excessive changed and dynamic surface quite puzzles the initial catalyst design, and moreover the excessive Fe loss could result in instability of the reconstructed surface, which might affect the formation of active species and the durability on the reaction interface. Here, we introduced a functional component of ethylenediamine-intercalated black phosphorus (eda-BP) to the Ni 1.5 Fe 0.5 B. Through electronic interaction between eda-BP and Ni 1.5 Fe 0.5 B, the excessive Fe loss during surface reconstruction process is effectively suppressed and the formation of Ni oxyhydroxide active species is facilitated, thereby enhancing the stability of the catalytic reaction interface. At the meantime, the ⁎ OH adsorption capacity on the reaction surface is regulated and the heterostructure catalyst exhibits significantly improved OER reaction kinetics. The Ni 1.5 Fe 0.5 B/eda-BP demonstrates a low OER overpotential ( η = 221 mV) at the current density of 10 mA cm −2 and sustainable activity. This work offers a facile strategy for improving the reactive interface for efficient and durable OER process.
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WATER RESEARCH
·
2025
·
IF 12.4
Haokun Bai,Peike Cao,Lanlan Liang,Shuo Chen,Xie Quan
Metal atomic cluster (AC) catalysts exhibit remarkable catalytic activity in environmental catalysis owing to their tunable structural and electronic properties regulated by electronic metal-support interactions (EMSI). Nevertheless, the precise size control of metal AC remains challenging owing to their inherent aggregation tendency under harsh synthetic conditions. Herein, we propose a confined synthesis strategy for fabricating cobalt AC within the interlayer channels of a two-dimensional molybdenum disulfide membrane (CoAC@MoS 2 membrane) for peroxymonosulfate (PMS) activation. The interlayer confinement of MoS 2 nanosheets enforces the in-plane assembly of metal precursors, yielding ultrafine CoAC (2.1 nm) with excellent Fenton-like activity (0.733 min -1 ), outperforming unconfined Co nanoparticles (29.3 nm, 0.291 min -1 ). Experiments and density functional theory calculations reveal that electrons transfer from sulfur vacancy and Mo sites in MoS 2 to Co 3d orbitals, generating electron-rich Co sites with an upshifted d -band center, which optimizes PMS adsorption and electron transfer to generate SO 4 ⚫- and ⚫OH radicals. The as-prepared CoAC@MoS 2 membrane achieved a sulfamethoxazole degradation rate of 5.33 × 10 6 μmol g metal -1 s -1 , which was 1-2 orders of magnitude higher than state-of-the-art nanoconfined catalytic membranes, and also proved effective in treating secondary pharmaceutical wastewater. This work establishes a universal paradigm for size and electronic structure engineering of metal catalysts through spatial confinement, advancing the development of high-performance Fenton-like catalytic systems for sustainable water remediation.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Shuyi Lu,Qian Wu,Shanshan Wang,Dongru Sun,Yan Liu,Shaohua Huang,Biling Huang
19F-labeled molecular probes offer significant advantages in chiral analysis, with their stereostructures playing a critical role in enantiodiscrimination. Rapid and accurate assignment of absolute configurations is particularly important for the pharmaceutical field and asymmetric synthesis. This work presents a comparative evaluation of two 19F-labeled probes as CDAs: aromatic P1 ((S)-1-(2-fluorophenyl)ethylamine) and aliphatic P2 (trans-2-fluorocyclohexanamine), focusing on their enantiomeric recognition of chiral carboxylic acids. The results demonstrate that P1 outperformed P2, particularly in analyzing carboxylic acids with chiral centers positioned several carbons away from the carboxyl group or possessing multiple chiral centers. Density functional theory calculations elucidated the underlying mechanisms, revealing that P1’s great recognition efficiency arises from a larger energy difference between diastereomers and the formation of hydrogen bonds between its fluorine atom and the analytes’ protons. These findings emphasize the importance of probe–analyte interactions in CDA-based enantiorecognition systems for achieving high-resolution discrimination. Moreover, P1 exhibited practical applications in determining ee values and analyzing various brands of ibuprofen capsules and tablets, highlighting its potential for pharmaceutical quality control. Furthermore, we introduced a novel online platform combining a P1-guided 19F NMR approach with machine learning for automated prediction of absolute configurations. This work sheds light on the differences between aromatic and aliphatic probes in enantiorecognition, while introducing an online predictive tool, in favor of the design of 19F molecular probes and the rapid assignment of absolute configurations.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qiang Tan,Zhonglin Chen,Jimin Shen,Pengwei Yan,Jing Kang,Binyuan Wang,Shengxin Zhao,Yang Shen,Yabin Li
A ZnFe-LDH-derived ZnFe-LDO with high surface hydrophilicity was synthesized for catalytic ozonation to achieve durable water purification. It showed high catalytic performance towards ozone (O 3 ) decomposition to generate hydroxyl radicals (·OH), as well as enhancing the decontamination efficiency compared to ozonation alone. The ZnFe-LDO catalytic ozonation system promoted the degradation ratio of diatrizoic acid (DTA) from 20.6 % (ozonation alone) to 100 % within 10 mins, and the observed degradation rate constant (k obs ) of DTA under O 3 /ZnFe-LDO system was 14.8 times that of O 3 alone system and 3.1 times that of O 3 /ZnFe-LDH system. The constructed ZnFe-LDO and ZnFe-LDH catalyzed ozonation systems for water purification were comprehensively evaluated. ZnFe-LDO showed excellent structure and catalytic stability during the long-lasting catalytic ozonation process. The hydrophilic surface of ZnFe-LDO benefited the adsorption of H 2 O, and O 3 was more readily adsorbed on the hydrated surface ( E ads = −1.89 eV) to react with -OH sites. The continuous flow technique based on the O 3 /ZnFe-LDO process was well adopted for the purification of raw water. In short, regulating the surface hydrophilicity of ZnFe-LDO was an effective strategy to achieve durable catalytic ozonation.
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Reaction Kinetics Mechanisms and Catalysis
·
2025
·
IF 1.7
Guo Lirong,Yang Xiaodie,Shao Huijuan,Zhang Xuzhi,Wang Yating,Jiang Tao
We have investigated the effect of different impurities (CO, CO 2 , CS 2 , CH 3 OH, H 2 O, C 4 H 4 S) on the silicon-bridged diphosphine(PNSiP)/CrCl 3 (C 4 H 8 O) 3 /modified methylaluminoxane ethylene tri-/tetramerization system. The results showed that the addition of trace impurities has a certain inhibitory effect on catalytic activity. The influence of impurities on the catalytic activity of the catalyst system was as follows: CO > CO 2 > CS 2 > CH 3 OH > H 2 O > C 4 H 4 S. CO showed the most significant inhibitory effect in reducing activity from 1.75 × 10 6 g/(mol Cr h) to 0.74 × 10 6 g/(mol Cr h) at an addition of 0.2 ppm. Through the analysis of nuclear magnetic resonance (NMR) and ultraviolet–visible spectrophotometry (UV–vis), we found that carbon monoxide mainly inactivates the catalytic system by coordinating with chromium active sites, while methanol and water reduce the catalytic activity by destroying the structure of modified methylaluminoxane. Furthermore, we also proposed a possible reaction path between carbon monoxide and the chromium active center. Graphical abstract
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Decai Yang,Qing Ye,Chao Qu,Lanyang Wang,Youguo Luo,Kexin Shi,Ying Zhang,Lefei Chen
The synergetic catalysis of metal single atoms and their nanoclusters is one of the innovative strategies to enhance the visible light driven H 2 production of graphitic carbon nitride (g-C 3 N 4 , CN). However, existing methods for co-anchoring metal single atoms and their clusters onto CN remain overly cumbersome. In this study, a carbon vacancies trap strategy is proposed to precisely control the type and location of Au species formation on CN. The resulting novel dual-active-site photocatalyst (Au SA+QDs /C v CN) achieves a breakthrough in H 2 production activity, with a rate of 1318.8 μmol h −1 g −1 under visible light irradiation. Various characterization techniques have been used to demonstrate that the catalyst optimizes the absorption of visible light and band structure, and significantly improves the efficiency of charge separation and transport. Complementary density functional theory (DFT) calculations further confirm that Au SA+QDs /C v CN optimizes carrier dynamics. Additionally, a synergistic effect between proton transport and electron transfer is observed between Au single atoms and quantum dots, while the H 2 spillover phenomenon is effectively inhibited. Overall, this study provides valuable insights and a critical reference for the design and development of dual-active-site photocatalytic materials for H 2 production.
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JOURNAL OF RARE EARTHS
·
2025
·
IF 7.2
Tingting Li,Jiyu Sui,Meixin Hong,Sheng-Rong He,Weinan Dong,Jingjing Xia,Guizhong Luo,Anran Ju,Cong Zhang,Yu Zhang,Zhennan Wu,Feng Jiang,Xue Bai
Near-infrared luminescent lanthanide materials hold significant importance in the fields such as optoelectronics and information processing. However, their luminescence efficiency is severely constrained by multiple factors, including vibrational quenching, crystal field effects, and structural symmetry. In recent years, emerging lanthanide clusters featuring atomically precise structures have offered promising pathways to overcome these constraints and achieve efficient near-infrared (NIR) luminescence. Here, we successfully synthesized two distinct crystalline compounds (Nd-1 and Nd-2) via a stepwise substitution strategy, allowing for the modulation of the luminescence behavior of Nd 3+ ions. Complete substitution with the pentafluorobenzoic acid ligand results in Nd-2 exhibiting higher structural symmetry and fewer nonradiative relaxation pathways. These structural optimizations lead to a significant improvement in luminescence efficiency, with Nd-2 exhibiting a solid-state near-infrared photoluminescence quantum yield (PLQY) of 1.12%, a substantial enhancement compared to conventional Nd 3+ -based complexes. The underlying modulation mechanism was elucidated through application of Judd-Ofelt theory, crystal field analysis, and temperature-dependent photophysical investigations. This work reveals the intrinsic relationship between the structure and the luminescence behavior, providing a novel approach for designing high-efficiency NIR luminescent materials.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jiawei Han,Weitao Fang,Huizhen Sun,Baimin Niu,Jiaxin Chen,Xiaoqian Liu,Jue Wang,Gaorong Wu
Over the past half century, the dissolution of poorly water-soluble drugs has long been a major challenge in pharmaceutics. As in-depth research on amorphization strategies progresses, in situ amorphization has emerged as an effective solubilization approach, avoiding production and stability concerns of other methods. This study aimed to design in situ co-amorphous combinations of ketoprofen (KET) with small-molecule coformers (L-lysine, L-arginine, meglumine) and explore the mechanism of humidity-mediated in situ co-amorphization. When these combinations contacted water, gradual co-amorphization was confirmed by PLM, PXRD, DSC and FTIR analyses. Results indicated that such co-amorphization process was significantly affected by the molar ratio of components, ambient temperature and pH of aqueous media, which were related to intermolecular interactions, molecular motion and reaction microenvironment. Compared to crystalline KET, the three combinations showed 6.08–7.02 times increase in apparent solubility as well as 2318.81–3620.48 times improvement in intrinsic dissolution rate. Moreover, they sustained long-term supersaturation, attributed to complexation reaction of KET and coformer validated via phase solubility and nucleation inhibition tests. Overall, this study proposes an in situ co-amorphous combination strategy induced by humidity and reveals such amorphization mechanism, efficiently addressing the poor water solubility of drugs.
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高影响因子
INTERNATIONAL DAIRY JOURNAL
·
2025
·
IF 3.4
Xi Cao,Caoqi Jiang,Haojun Han,Dongjie Zuo,Guiquan Zhang,Yikun Xian
To our knowledge, the triacylglycerol (TAG) composition of giant panda milk fats (GPMFs) and its variation across lactation stages remain uncharacterized. In this study, TAG profiles of GPMFs during different lactation stages were assayed using ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry. A total of 107 TAGs were identified in GPMFs, including those with acyl carbon number (ACN) of 26–62 and double bond (DB) of 0–10. TAG 52:2 (ACN:DB) showed the highest abundance (8.55 %–13.35 %), with oleic acid, palmitic acid, and linoleic acid as its components. Interestingly, TAG profiles at 23 d still exhibited transitional characteristics via multivariate analysis. In colostrum, TAGs had a higher degree of unsaturation. Compared to mature milk, colostrum exhibited significantly higher levels of TAGs with 3–6 DBs and those with ACN of 52 and 54. Uncovering variation in GPMFs during lactation can provide a foundation for developing specific milk fat substitutes.
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