International Journal of Diabetes in Developing Countries
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2026
·
IF 0.8
Xu Mingxing,Wang Jing,Ge Xueqing,Wang Xu,Wang Huanqin,Sun Xinyi,Yang Junhong,Wang Shu
Background Diabetes is a chronic metabolic disease whose prevalence and progression are closely related to many factors, including genetics, environment, and lifestyle. Impaired fasting glucose (IFG) is an early manifestation of type 2 diabetes mellitus (T2DM), but the underlying mechanisms are not yet fully understood. In this study, we explored the differentially expressed metabolites in patients with IFG and T2DM by using an untargeted metabolomics approach. Objective In this study, we explored the differentially expressed metabolites in patients with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) by using an untargeted metabolomics approach. Methods Patients were assigned to three groups as follows: an IFG group, T2DM group, and normal control group. After matching baseline data that comprised sex, age, aminopherase, creatinine, and uric acid, we selected 16 cases in each group. Fasting serum metabolomes were profiled using ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS). Results The study population consisted of a cohort of 48 patients: 16 patients in the normal control group, 16 in the IFG group, and 16 in the T2DM group. Untargeted metabolomic analysis demonstrated 25 differentially expressed metabolites in the IFG group and 51 differentially expressed metabolites in the T2DM group. In the IFG group, differentially expressed metabolites were mainly enriched in glycerophospholipid metabolism, ether lipid metabolism, amino acid metabolism and biosynthesis, and pyruvate metabolism. In the T2DM group, the enriched pathways included glycerophospholipid metabolism, pyruvate metabolism, multiple amino acid-related pathways (glycine, serine, threonine, alanine, aspartate, glutamate, phenylalanine), phenylalanine-tyrosine-tryptophan biosynthesis, the citrate cycle, and butanoate metabolism. Conclusions This pilot metabolomic investigation suggests that changes in metabolic characteristics may already occurred early in the development of T2DM. There may still exist some metabolic differences between patients with IFG and those with T2DM, and differentially expressed metabolites were concentrated in the amino acid and lipid metabolism pathways. But this study is still in the exploratory stage; future work with larger, longitudinal cohorts is warranted to validate these findings and assess their clinical relevance.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.1
Yuxing Liao,Huiqiong Liang,Hongmei Huang,Shuangyan Su,Zilin Li,Lijin Huang,Ziyan Yang,Cuixiang Zhang,Han Wang,Guihua Wang,Guiyuan Chen,Xueying Li
Di-(2-ethylhexyl) phthalate (DEHP) and its metabolite mono-(2-ethylhexyl) phthalate (MEHP) are endocrine-disrupting chemicals linked to breast cancer progression, yet the underlying prognostic mechanisms are poorly elucidated. This study employed a bioinformatics approach, integrating computational target prediction, protein-protein interaction (PPI) network analysis, and transcriptomic data from The Cancer Genome Atlas (TCGA), to identify prognostic genes modulated by DEHP/MEHP. Through Cox and LASSO regression, we identified a novel gene signature primarily involved in lipid metabolism (PPARD, CPT1A, LPCAT1, AGPAT1,PLIN5) and mitochondrial complex I (NDUFAB1, NDUFV1, NDUFAF4, MT-ND1), which was associated with patient survival. Molecular docking and dynamics simulations were performed to assess the binding affinity between DEHP/MEHP and core targets, confirming stable, high-affinity interactions. In vitro experiments further showed that DEHP and MEHP promote the proliferation and migration of breast cancer cells (MCF-7 and MDA-MB-231), enhance lipid accumulation and mitochondrial function, and validate the altered expression of these prognostic genes at the transcriptional level, with MEHP exerting more pronounced effects. In conclusion, this study suggests that DEHP and MEHP may activate metabolic reprogramming in breast cancer, thereby contributing to disease progression and poorer prognosis, highlighting these genes as potential prognostic biomarkers and therapeutic targets.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124167
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IF 7.5
Chen Chen,Zhenyu Wang,Yasen Li,Jiayao Gao,Xin Chen,Mingjie Jia,Die Shao,Yiming Wang,Xuejian Li,Fuqiang Yu,Guangwen Xu,Junli Xu,Hong-bin Sun
Transition-metal borides have long been developed as promising electrocatalysts for the hydrogen evolution reaction (HER); however, the identity of their true active phase remains controversial. Here, in conjunction with our previous studies, by systematically investigating a series of cobalt- and nickel-boride-derived catalysts through a combined computational and experimental screening, we reveal that HER activity universally originates from the synergistic interaction between metallic sites and hydroxide matrices, enabled by lattice expansion, interfacial electronic transfer, and dynamic surface evolution. As a representative high-performance example, Pt-modified Co(OH) 2 derived from cobalt boride exhibits ultralow overpotentials of 11 mV at 10 mA cm −2 and 95 mV at 500 mA cm −2 , together with long-term stability. Importantly, the same reconstruction principle applies to Ni-boride systems, confirming the generality of this approach. Beyond water electrolysis, we further demonstrate that these HER catalysts are highly effective in Al-H 2 O batteries, where hydrogen evolution is coupled with electrical energy harvest. An alkaline Al-H 2 O battery employing the reconstructed catalyst delivers a power density of 21.96 mW cm −2 . This work establishes that the activity of “boride-based” HER catalysts fundamentally arises from reconstructed metal-hydroxide active centers, providing a development paradigm of transition-metal electrocatalysts.
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BIOORGANIC CHEMISTRY
·
2022
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IF 5.307
Hongjun Zhang,Zeguang Cheng,Litian Wei,Xinjun Yu,Zhao Wang,Yinjun Zhang
A gene encoding an esterase from Bacillus aryabhattai (BaCE) was identified, synthesized and efficiently expressed in the Escherichia coli system. A semi-rational protein engineering was applied to further improve the enzyme’s enantioselectivity. Under the guidance of the molecular docking result, a single mutant BaCE-L86Q and a double mutant BaCE-L86Q/G284E were obtained, with its E max value 6.4 times and 13.9 times of the wild-type BaCE, respectively. The recombinant BaCEs were purified and characterized. The overwhelming E value demonstrated that BaCE-L86Q/G284E was a promising biocatalyst for the biological resolution to prepare ( S )-indoline-2-carboxylic acid.
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ANALYTICAL LETTERS
·
2023
·
IF 2
Qian Gao,Yang Li,Xinyi Li,Huiqing Wang,Lin Tian,Hao Gong,Cuiping Ma,Chao Shi
A highly ultrafast and sensitive electrochemical sensor based on electrical potential-assisted hybridization was developed for the determination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The electrode was modified with multi-walled carbon nanotubes (MWCNTs) and Au nanoparticles (AuNPs) for excellent electrochemical performance. The constant electric field was applied to rapidly and efficiently enrich the capture probes to the electrode surface in 60 s. Meanwhile, pyrene as the backfill reagent resulted in a significant reduction of nonspecific adsorption. The electrochemical properties of the modified electrode were investigated via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The analytical response was measured by differential pulse voltammetry (DPV). The sensor achieved the ultrafast hybridization of nucleic acids at the electrode interface within 90 s, substantially reducing the reaction time from hours to minutes. Under optimal conditions, the sensor exhibited a superior detection limit of 60 fM and showed satisfactory specificity toward single-base mismatch. Additionally, the proposed sensor realized sensitive determination of SARS-CoV-2 in throat swabs. The enzyme-free and non-amplification sensing strategy showed promising potential for application in point-of-care testing (POCT).
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Qinhan Wu,Pengkun Zhang,Dong-Hau Kuo,Binghong Wu,Adugna Boke Abdeta,Zhengjie Su,Longyan Chen,Osman Ahmed Zelekew,Jinguo Lin,Xiaoyun Chen
Monoclinic lindgrenite (Cu 3 (MoO 4 ) 2 (OH) 2 )-like CuMoOS oxysulfide catalyst with high catalytic activity in the dark was synthesized by a facile method. Hydrazine reduced cations to increase Cu + and Mo 4+ proportions, sulfur doping was used to diminish the problem of poor stability caused by the excessive deviations of the catalyst from electric neutrality due to the high Cu + and Mo 4+ concentrations. The ratios of Cu + /Cu 2+ and Mo 4+ /Mo 6+ ions affected the catalytic activity of CuMoOS catalysts. The CuMoOS with a Cu + /(Cu + +Cu 2+ ) ratio of 0.708 showed abundant oxygen vacancies and the best catalytic reduction effect. Through controlling the Cu + content of the catalyst, its defective structure, and electron transfer resistance, the reduction reaction with NaBH 4 can be effectively adjusted. CuMoOS-3 catalyst shows a complete catalytic reduction of 4-NP (50 ppm) within 4 min 50 ppm MB, RhB and MO organic dyes were completely reduced within 4 min, 6 min, and 8 min, respectively. At the same time, Cr 6+ , as a model heavy metal ion , was completely reduced in 12 min, and its pseudo-first-order reaction kinetic constant reached 0.1709 min −1 . Good stability was kept after six cycling experiments. Therefore, the high-efficiency CuMoOS catalyst synthesized by green procedures displays the potential for industrial application.
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Gels
·
2023
·Vol. 9
·期 3
·246
·
IF 4.6
Abid Naeem,Chengqun Yu,Weifeng Zhu,Zhenzhong Zang,Yongmei Guan
Puerarin has been reported to have anti-inflammatory, antioxidant, immunity enhancement, neuroprotective, cardioprotective, antitumor, and antimicrobial effects. However, due to its poor pharmacokinetic profile (low oral bioavailability, rapid systemic clearance, and short half-life) and physicochemical properties (e.g., low aqueous solubility and poor stability) its therapeutic efficacy is limited. The hydrophobic nature of puerarin makes it difficult to load into hydrogels. Hence, hydroxypropyl-β-cyclodextrin (HP-βCD)-puerarin inclusion complexes (PIC) were first prepared to enhance solubility and stability; then, they were incorporated into sodium alginate-grafted 2-acrylamido-2-methyl-1-propane sulfonic acid (SA-g-AMPS) hydrogels for controlled drug release in order to increase bioavailability. The puerarin inclusion complexes and hydrogels were evaluated via FTIR, TGA, SEM, XRD, and DSC. Swelling ratio and drug release were both highest at pH 1.2 (36.38% swelling ratio and 86.17% drug release) versus pH 7.4 (27.50% swelling ratio and 73.25% drug release) after 48 h. The hydrogels exhibited high porosity (85%) and biodegradability (10% in 1 week in phosphate buffer saline). In addition, the in vitro antioxidative activity (DPPH (71%), ABTS (75%), and antibacterial activity (Staphylococcus aureus,Escherichia coli, and Pseudomonas aeruginosa)indicated the puerarin inclusion complex-loaded hydrogels had antioxidative and antibacterial capabilities. This study provides a basis for the successful encapsulation of hydrophobic drugs inside hydrogels for controlled drug release and other purposes.Keywords:hydrogel;flavonoids;antioxidant;inclusion complexes;oral formulation
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FOOD CHEMISTRY
·
2024
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IF 8.5
Yao Jin,Xiangwei Yuan,Lian Ou,Jiaying Wu,Jiangtao Hu,Kang Xue,Xiaoli Xiong
Formaldehyde is known to harm the respiratory, nervous, and digestive systems of people. In this paper, a novel dandelion-like electrocatalyst with core–shell heterostructure arrays were fast self-assembled prepared in situ using copper foam (CF) as support substrate and 2,3,6,7,10,11 hexahydroxy-triphenyl (HHTP) as ligand (Cu(OH) 2 @Cu 3 (HHTP) 2 /CF) by a simple two-step hydrothermal reaction. The 1D Cu(OH) 2 nanorods “core” and the 2D π-conjugated conducting metal–organic frameworks (Cu 3 (HHTP) 2 c MOF) “shell” with remote delocalized electrons give the dandelion-like heterogeneous catalysts excellent electrochemical activity such as a large specific surface area, high conductivity and a fast electron transfer rate. The Cu(OH) 2 @Cu 3 (HHTP) 2 /CF exhibited excellent electrocatalytic performance for formaldehyde under alkaline conditions with a linear range of 0.2 μmol/L – 125 μmol/L and 125 μmol/L – 8 mmol/L, a detection limit as low as 15.9 nmol/L (S/N = 3), as well as good accuracy, consistency, and durability, and it effectively identified FA in food.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2011
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IF 2.089
Xuejun Huang,Yao Chen,Changwei Wang,Hui Wang
Mutual solubility data of water + pentan-1-ol and liquid−liquid equilibrium of water + pentan-1-ol +2,6,6-trimethylbicyclo[3.1.1]hep-2-ene (α-pinene) and water + pentan-1-ol + 6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane (β-pinene) have been measured experimentally at (293.15, 303.15, 313.15, and 323.15) K under atmospheric pressure. The estimated uncertainty of phase composition and temperature were about (0.0005 and 0.05) K, respectively. The experimental ternary liquid−liquid equilibrium data have been simultaneously predicted and correlated by the extended and modified UNIQUAC models.
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Bioengineered
·
2021
·
IF 3.269
Shujun Xu,Bingxin Wu,Biying Zhong,Luoqi Lin,Yining Ding,Xiao Jin,Zhiwei Huang,Miaoyang Lin,Huanlin Wu,Danping Xu
Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion injury (MIRI). Naringenin (NAR), as a flavonoid, has a significant advantage in improving MIRI. But the regulatory effect and mechanism of NAR on ferroptosis in MIRI have not been reported. After the rats were given NAR and induced to form myocardial ischemia-reperfusion (MI/R) injury, Tetrazolium chloride (TTC) staining was used to detect the myocardial infarction area of rats, and Hematoxylin-eosin (H&E) staining was used to detect myocardial injury. The markers of tissue inflammation were detected by ELISA. Serum creatine kinase Serum creatin kinase (CPK), Lactate dehydrogenase (LDH), and lipid peroxide (LPO) and oxidative stress related levels were measured. In addition, iron detection kits were used to detect total iron and Fe2+ levels in cardiac tissues, and western blot was used to detect the expression of ferroptosis-related proteins and the expression of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and glutathione peroxidase 4 (GPX4). At the cellular level, H9C2 cardiomyocytes were induced by hypoxia/reoxygenation (H/R), and ferroptosis inducer Erastin was administered to detect cell viability, ferroptosis-related indicators, oxidative stress related indicators, and expressions of Nrf2 and GPX4, to explore the mechanisms involved. NAR alleviated MI/R-induced pathological damage, inflammation and lipid peroxidation in myocardial tissue of rats. NAR adjusted the NRF2 /System xc – /GPX4 axis and improved ferroptosis. At the cellular level, ferroptosis inducer Erastin reversed the protective effect of NAR on H/R-induced H9C2 cardiomyocytes. In conclusion, NAR can alleviate MIRI by regulating the Nrf2/System xc-/GPX4 axis to inhibit ferroptosis.
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ELECTROCHEMISTRY
·
2015
·Vol. 83
·期 3
·155-160
·
IF 1.033
Yan-qing LI,Ying LUO,Li-jun LI,Hao CHENG,Wen-yi HUANG
In order to establish a simple, sensitive and rapid method for the determination of azithromycin, the gold electrode modified with Silica sol/Nano-Au/PVP/Ru(bpy)32+ was prepared, and the electrochemiluminescence (ECL) method was developed for the determination of azithromycin based on the sensitizing effect of azithromycin on Ru(bpy)32+. Moreover, the electrochemical behaviors and the electrochemical luminescence behaviors of the Ru(bpy)32+ system and the Ru(bpy)32+- azithromycin system were investigated by ECL respectively. The results show that the proposed electrode showed very good electrochemical activity and electrochemiluminescence response to the Ru(bpy)32+- azithromycin system, under the optimum experimental condition, the linearity of azithromycin concentration to ECL intensity was achieved in the concentration of azithromycin from 1.0 × 10−7 to 1.0 × 10−4 mol L−1 and the detection limit (S/N = 3) was 1.33 × 10−9 mol L−1. Through the parallel determination of 1.0 × 10−5 mol L−1 azithromycin for 8 times, the RSD of results was 1.82%, and the recovery ranging from 97.9% to 101.6% was obtained in the detection of azithromycin tabelets and the RSD was 1.36% (n = 5). The proposed method showed high selectivity and sensitivity and simplicity, and it could be applied to the analysis of azithromycin with satisfactory results.
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Separations
·
2024
·Vol. 11
·期 4
·116
·
IF 2.5
Guijiang Li,Wenze Xu
The escalating demand for cobalt in modern industry necessitates the recycling or extraction of this resource for sustainable development. Despite the abundance of lignin in nature, its utilization remains low, highlighting the need to enhance its value-added potential. This study focuses on the synthesis of quaternary ammonium lignin (QAL) and 2-ethylhexyl phosphoric acid mono-2-ethylhexyl ester (P507) as ionic liquid (QP–IL) compounds for the extraction of metal ions. A comparison of the extraction behavior of Co(II) and Ni(II) from chloride solution between QP–IL and P507 revealed varying extraction ratios under different conditions, with QP–IL demonstrating a higher cobalt extractability than P507. Furthermore, under identical conditions, QP–IL exhibited superior Co/Ni separation performance (βCo/Ni) compared to P507. Ultimately, QP–IL proved to be more effective than P507 in separating cobalt from mixed solutions.
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