JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 46
·45484
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IF 1.86
Teng Xue,Erjun Tang,Jian Zhou,Ruitao Han,Shaojie Liu
A coordinating ionic liquid (IL), 1-[(diethyl amine)amine]ethyl-3-methyl imidazolium chloride ([N 3 MIM]Cl), was prepared as an alternative to a simple organic ligand to coordinate to copper(I) bromide (CuBr). We, thereby, obtained a novel catalyst for atom transfer radical polymerization (ATRP) reactions. This catalyst was applied to the ATRP of methyl methacrylate in the IL 1-allyl-3-methyl imidazolium chloride ([AMIM]Cl). The chemical structures of the ILs obtained were confirmed by Fourier transform infrared spectroscopy, mass spectrometry, and 1 H-NMR analyses. The coordination ability of [N 3 MIM]Cl was assessed by cyclic voltammetry, and the redox potential of [N 3 MIM]Cl–CuBr was −0.507 V. The [N 3 MIM]Cl–CuBr complex was expected to be a markedly more active catalyst than the amine DETA–CuBr complex. The coordination mode toward CuBr was also examined. The [N 3 MIM]Cl–CuBr catalyst system showed good controllability in the aforementioned ATRP reaction in [AMIM]Cl. The Cu catalyst was easily separated from the obtained polymer with the coordinating IL as a ligand. Consequently, the coordinating IL overcame the shortcomings of traditional organic ligands, such as poor compatibility with IL media and poor separation of the catalyst from the polymer; this makes it highly promising for applications in the ATRP field. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45484.
研究领域:
高分子化学
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催化化学
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功能材料
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绿色溶剂
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配位化学
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电化学
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高影响因子
REPRODUCTION FERTILITY AND DEVELOPMENT
·
2021
·Vol. 33
·期 12
·700-712
·
IF 2.311
Xin Zhan,Yiran Xie,Liping Sun,Qi Si,Hongkai Shang,Xin Zhan,Yiran Xie,Liping Sun,Qi Si,Hongkai Shang
This study explored the molecular mechanism underlying the effects of dexamethasone (DEX, 1 µM) on glucose transporters (GLUT) in JEG-3 human placental choriocarcinoma cells. JEG-3 cells were treated with DEX, an expression plasmid encoding human glucocorticoid receptor α (GRα), pcDNA3.1-GRα, GRα short interference (si) RNA, LY294002, xanthine oxidase (XO)/hypoxanthine (HX), rapamycin, insulin-like growth factor (IGF) 1, N-acetylcysteine (NAC) or phosphatidic acid (PA), and cell proliferation, apoptosis, mitochondrial membrane potential (MMP), human chorionic gonadotrophin (hCG) content, human placental lactogen (hPL) content, glucose uptake, reactive oxygen species levels and signalling pathway modulation were evaluated. Treatment of JEG-3 cells with DEX (1 µM), GRα siRNA, LY294002 (50 µM), XO/HX (7.2 µM/36 nM) or rapamycin (80 nM) inhibited cell proliferation, induced apoptosis, significantly decreased MMP and hCG and hPL content and increased ROS levels. In addition, glucose uptake was decreased through downregulation of the mRNA and protein expression of GRα, GLUT1 and GLUT3. Treatment of JEG-3 cells with GRα siRNA, LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2. The effects of GRα overexpression and IGF1 (100 nM), NAC (5 nM) or PA (100 µM) treatment on JEG-3 cells contrasted with those of DEX treatment. DEX blocked glucose uptake by downregulating GRα expression, which reduced GLUT1 and GLUT3 mRNA and protein expression, which, in turn, may have inhibited the PI3K/AKT/mTOR pathway and activated the ROS/AMPK pathway.
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PubMed
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 21
·e01335
·
IF 2
Yu-cheng Jiang,Bao-guang Zhu,Xiang-li Long
Graphical The production of 1-(4-chlorophenyl)-1H-pyrazol-3-ol from the oxidation of 1-(4-chlorophenyl)-pyrazolidin-3-one by air under the catalysis of Co(II)@AC has been enhanced by modifying the activated carbon with H₂C₂O₄ solution to increase the acidic groups and micropores on the carbon surface. The production of 1-(4-chlorophenyl)-1 H -pyrazol-3-ol by oxidizing 1-(4-chlorophenyl)- pyrazolidin-3-one with H 2 O 2 suffers from some shortcomings. The oxidation of 1-(4-chlorophenyl)-pyrazolidin-3-one to 1-(4-chlorophenyl)-1 H -pyrazol-3-ol can be realized by air catalyzed with Co(II)@AC (prepared by supporting cobalt(II) on activated carbon). Air is a good substitute for H 2 O 2 because it can minimize the cost, hazards, and pollution, which is beneficial to the improvement of the production process for pyraclostrobin. In this study, activated carbon has been modified by H 2 C 2 O 4 solution to improve the catalytic performance of Co(II)@AC. The experiments indicate that the best carbon is made by heating the carbon at 300 °C for 3 h with a heating rate of 5 °C/min in N 2 after being soaked in 0.4 mol/L H 2 C 2 O 4 solution at 50 °C for 12 h with an L/S ratio of 40/1 mL/g. The 1-(4-chlorophenyl)-1 H -pyrazol-3-ol concentration obtained by Co(II)@AC immobilized on the optimized carbon is 39.39% over that catalyzed by Co(II)@AC loaded on the original carbon. Characterization results reveal that modification with H 2 C 2 O 4 increases the specific surface area and enhances the acidity on the carbon surface. The oxidation rate of 1-(4-chlorophenyl)-pyrazolidin-3-one is primarily determined by the physical structure. The selectivity toward 1-(4-chlorophenyl)-1 H -pyrazol-3-ol is mainly influenced by the chemical characteristics.
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ACS Omega
·
2024
·
IF 3.7
Tengjiao Fan,Lin Shen,Yaxin Huang,Xin Wang,Lijiao Zhao,Rugang Zhong,Peng Wang,Guohui Sun
Lung cancer ranks as the second most diagnosed cancer and the leading cause of cancer-related deaths worldwide. Novel chemotherapeutic strategies are crucial to efficiently target tumor cells while minimizing toxicity to normal cells. In this study, we proposed a combination strategy using energy blocker lonidamine (LND) and cytotoxic drug nimustine (ACNU, 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea) to enhance the killing of a human lung cancer cell line and investigated the potential chemo-sensitizing mechanism of LND. LND was found to remarkably increase the cytotoxicity of ACNU to A549 and H1299 cells without significantly affecting normal lung BEAS2B cells. The combination of LND and ACNU also produced significant effects on cell apoptosis, colony formation, cell migration, and invasion assays compared to single drug treatment. Mechanistically, LND decreased intracellular ATP levels by inhibiting glycolysis and inducing mitochondrial dysfunction. Furthermore, the combination of LND and ACNU could intensify cellular oxidative stress, decrease cellular GSH contents, and increase reactive oxygen species (ROS) production. Notably, LND alone dramatically downregulated the expression of DNA repair protein MGMT (O6-methylguanine-DNA methyltransferase), enhancing DNA interstrand cross-link formation induced by ACNU. Overall, LND represents a potential chemo-sensitizer to enhance ACNU therapy through energy inhibition, disrupting redox homeostasis and downregulating MGMT expression in human lung cancer cell line under preclinical and clinical background.
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PubMed
高影响因子
Journal of Materials Chemistry A
·
2025
·Vol. 13
·期 44
·37953-37961
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IF 9.5
Yao Dai,Yubo Luo,Yingchao Wei,Tianshun Xiong,Chengwei Sun,Wenjie Shu,Guanzheng Luo,Linyao Wu,Shuhui Zhang,Qinghui Jiang,Xin Li,Zheng Ma,Yao Luo,Yan Liu,Dan Zhang,Junyou Yang
Inorganic plastic thermoelectric materials have attracted much attention for breaking the brittle bottleneck of traditional inorganic thermoelectric materials. The Ag2(S, Se, Te) system is one of the most novel and promising thermoelectric semiconductors. To enhance its thermoelectric performance, substitution of Na for Ag is adopted to modulate the electrical and thermal transport properties of Ag2S1/3Se1/3Te1/3, through enhancing phonon scattering and effective mass. It enables us to achieve a record high average power factor (PF) of 7.4 μW cm−1 K−2 in the temperature interval of 300–500 K and a room-temperature thermoelectric figure of merit (ZT) of 0.50 and a peak ZT of 0.84 at 500 K in Ag2(S, Se, Te), respectively. In addition, the slip mode of Ag2S1/3Se1/3Te1/3 plastic deformation is also revealed for the first time, in which the crystal slip behavior is dominated by the {112}〈111〉 slip regime, instead of the conventional {110}〈111〉 view. The obtained high thermoelectric performance, as well as the maintained plastic performance, shows broad application prospects in waste heat recovery and wearable devices.
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Frontiers in Bioscience-Landmark
·
2026
·Vol. 31
·期 7
·
IF 4.1
Wenlong Li,Xinyue Pei,Yongpei Li,Yanji Lu,Xian Hong,Ming Sui,Qiang Li,Xueying Sun,Jingqiu Wang,Enming Zhang,Yihan Liu,Tao Wang,Jing Xu,Zhihui Deng
Background: Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown limited efficacy in gastric cancer, primarily due to the rarity of inherent homologous recombination (HR) deficiency. The nuclear Arp2/3 complex was recently implicated in DNA double-strand break repair via HR. Here, we investigate whether pharmacological inhibition of Arp2/3 can induce a functional HR-deficient state to synergize with PARPi in gastric cancer cells. Methods: HR repair efficiency was assessed using a direct repeat green fluorescent protein (DR-GFP) reporter assay in HEK-293T cells following Arp2/3 inhibition with CK666, siRNA-mediated knockdown, or CRISPR/Cas9-mediated knockout of ACTR2/ACTR3. HGC-27 and AGS gastric cancer cells were treated with CK666 alone and in combination with olaparib or niraparib. Cell viability and synergy were evaluated by Cell Counting Kit-8 (CCK-8) and clonogenic assays (n = 3 independent experiments). DNA damage and apoptosis were assessed by immunofluorescence for gamma H2A histone family member X (γH2AX) foci (≥100 cells per condition) and Western blot analysis for cleaved PARP. Results: Arp2/3 inhibition with CK666 significantly impaired HR repair efficiency in the DR-GFP assay (p < 0.01). This effect was recapitulated by genetic knockdown or knockout of ACTR2/ACTR3. CK666 alone exerted minimal cytotoxicity, but synergized with both olaparib and niraparib to suppress proliferation (Combination Index <1), reducing the half-maximal inhibitory concentration (IC50) of PARPi by approximately threefold. Combination treatment markedly enhanced γH2AX foci formation (p < 0.0001) and increased the level of cleaved PARP compared with either monotherapy. Conclusions: Inhibition of Arp2/3 compromises HR repair capacity, thereby creating a synthetic lethal interaction with PARP inhibition in gastric cancer cells. This combination strategy represents a promising therapeutic approach to broaden the clinical utility of PARPi in HR-proficient tumors and may also enable dose reduction to mitigate associated toxicities.
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PubMed
高影响因子
TETRAHEDRON
·
2026
·
IF 2.1
Jiahui Ma,Yiming Ma,Huida Qian,Yu Wang,Zhongxue Fang
A silver-catalyzed [3 + 2] cycloaddition of imines with isocyanoacetates was developed. This reaction represents a novel protocol for the efficient and practical synthesis of polysubstituted imidazolines bearing a broad range of substituents with good to excellent yields under mild conditions. The practicality of this cycloaddition was shown by a gram-scale synthesis.
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高影响因子
IMMUNITY
·
2026
·
IF 30.6
De Dong,Huiling Li,Yuwei Zhu,Zebin Lu,Junliang Zhu,Xinyu Tian,Zhiwei Huang
BTNL3 and BTNL8, butyrophilin-like (BTNL) family receptors, are predominantly expressed on intestinal epithelial cells. The BTNL3-BTNL8 complex selectively activates human Vγ4⁺ T cells, which play critical roles in intestinal immune homeostasis and tissue damage repair. Here, we report the structure of the BTNL3-BTNL8-Vγ4Vδ1 T cell receptor (TCR) complex. The structure reveals that BTNL3-BTNL8 forms an antigen-independent tetramer, in contrast to the phosphoantigen-driven association of BTN2A1-BTN3A1. Two BTNL3-BTNL8 heterodimers clamp a head-to-head TCR homodimer to form a 2:2:2 BTNL3:BTNL8:Vγ4Vδ1 TCR complex, with the Vγ4 HV4 and CDR2 loops jointly engaging BTNL3. Structural alignment indicates that the CD1d binding site on TCR overlaps spatially with one monomer within a TCR dimer, suggesting that TCR dimerization sterically precludes simultaneous engagement of CD1d molecules. Together, our results elucidate the structural mechanism of BTNL3-BTNL8-mediated engagement and activation of Vγ4Vδ1 TCR, offering insights into γδ TCR signaling initiation.
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高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2026
·Vol. 227
·期 3
·e00465
·
IF 2.8
Yufan Zhou,Yanan Li,Jie Zhang,Renming Pan,Xiaoyue Peng,Xinhang Jiang,Ying Li,Wenfang Zheng
Difluoroamino (–NF 2 ) is one of the ideal energetic functional groups for enhancing the overall performance of solid propellants. Its strong oxidizing properties reduce the average molecular weight of combustion products and increase the specific volume of combustion gases, thereby significantly boosting the energy release level of solid propellants and demonstrating tremendous application potential. In this study, hydroxyl-terminated polyether (HTPE) was copolymerized with 3-difluoroaminomethyl-3-methyloxetane (DFAMO) via cationic ring-opening copolymerization to form the PDFAMO-HTPE-PDFAMO triblock copolymer, which achieves coordinated optimization of energy and mechanical properties. PDFAMO-HTPE-PDFAMO retains the benefits of HTPE's low glass transition temperature and favorable thermal stability, with a peak decomposition temperature of 257.1°C and a corresponding decomposition enthalpy of 1385.64 J/g. Combined with three model-free kinetic calculation methods to obtain key thermal performance parameters such as activation energy and frequency factor. Furthermore, TG-FTIR technology was utilized to validate the thermal decomposition process and elucidate the decomposition mechanism, which is divided into a two-stage pyrolysis process: initial decomposition of the difluoroamino groups followed by scission of the polymer backbone. These results demonstrate the potential of PDFAMO-HTPE-PDFAMO tri-block copolymer as the energetic propellant binder.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Nasi Yu,Wenhua Li,Jiyou Zhong
Near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs) have an extensive range of applications within multiple fields, such as bioimaging, night vision and non-destructive examination. Therefore, developing broadband, low-cost, and efficient NIR phosphors capable of satisfying the demands of the above applications is desired. In this work, a series of inexpensive phosphate Na 2 AlTi(PO 4 ) 3 :Cr 3+ phosphors were developed. This material shows a broadband NIR emission covering 700-1200 nm with emission peak located at 830 nm and a full width at half maximum (FWHM) of 152 nm under 470 nm excitation. Moreover, the photoluminescence quantum yield (PLQY) can be optimized to 79.1%, suggesting a high efficiency among octahedral Al 3+ -containing NIR materials. Finally, a prototype NIR pc-LED device was fabricated via directly coating the InGaN blue LED chip with the optimized Na 2 AlTi(PO 4 ) 3 :Cr 3+ phosphor. The NIR output power of the device was determined to be 17.24 mW at 100 mA driving current, and the corresponding NIR photoelectric conversion efficiency was 7.51%, indicating the excellent output performance, and good potential in practical applications.
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International Journal of Electrochemical Science
·
2026
·
IF 3.9
Qianfei Huang,Junqing Yang,Junkai Hu,Changhong He
Developing highly efficient organic corrosion inhibitors plays a crucial role in enhancing copper's resistance to degradation in aggressive environments. This research evaluates the corrosion inhibition efficacy of 2-aminothiophene-3-carboxamide (2ATCA) at the copper interface in simulated seawater medium (3.5 wt% NaCl). The findings indicate that incorporating 0.60 g/L of 2ATCA into the NaCl solution leads to a significant drop in corrosion current density, from 12.1 μA·cm -2 to 1.7 μA·cm -2 , achieving an inhibition efficiency of 86%. The Langmuir adsorption isotherm model was derived by applying the thermodynamic principles governing the corrosion inhibitor's mechanism. The surface characteristics and composition of copper were characterized through a combination of analytical techniques including scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The adsorption inhibition mechanism and reactivity of 2ATCA on the copper surface were further investigated through theoretical computational analysis. This study not only elucidates the adsorption behavior and mechanism of 2ATCA on copper but also provides a foundation for designing more effective organic inhibitors for copper corrosion in marine environments.
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高影响因子
Food Packaging and Shelf Life
·
2026
·
IF 10.8
Feng Xiao,Yimeng Zhang,Haoran Wang,Ji Wei,Linlin Li,Hualin Wang
Ethylene (C 2 H 4 ), a natural plant hormone, accelerates the ripening and senescence of fruits and vegetables (F&V), posing significant challenges to their post-harvest preservation. Herein, we develop a C 2 H 4 scavenging nanofiber membrane by chemically modifying zein (ZN) with (3-mercaptopropyl) triethoxysilane (MPTES). This modification reduces the hydroxyl content while introducing sulfhydryl groups on zein chain. The typical membrane of ZN-MPTES3 demonstrates excellent hydrophobic property with a water contact angle (WCA) of > 140°, and can maintain structural integrity after 24 h of water immersion. Additionally, the MPTES grafting enhances the membrane's roughness. At 25 °C, the ZN-MPTES3 membrane effectively extends the shelf-life of bananas through a thiol-ene click reaction with C 2 H 4 , which is accelerated under UV exposure (365 nm), further enhancing the preservation efficacy. These results demonstrate the potential of the ZN-MPTES electrospun membrane as a sustainable and effective platform for the preservation of post-harvest F&V.
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