Journal of Materials Chemistry B
·
2024
·
IF 6.1
Xihong Liu,Yan Li,Xiang Gu,Chao Qi,Kaiyong Cai
As a gasotransmitter, endogenous sulfur dioxide (SO2) plays an important role in cardiovascular regulation. In addition, excessive SO2 can react with overexpressed hydrogen peroxide (H2O2) in tumor cells to generate toxic radicals, which can induce severe oxidative damage to tumor cells and result in cell apoptosis. This highlights the potential of SO2 in oncotherapy. However, the limited availability of endogenous H2O2 and uncontrolled release of SO2 gas significantly impede the effectiveness of SO2 gas therapy. To address this challenge, a biodegradable calcium sulfite (CS) nanocarrier loaded with 10-hydroxycamptothecin (HCPT) was developed for tumor pH triggered SO2 gas therapy in combination with chemotherapy. This nanoreactor could be degraded in an acidic tumor microenvironment to release SO2 gas and HCPT drug. The released SO2 gas induced serious oxidative damage to tumor cells by depleting glutathione (GSH) and generating toxic radicals through a reaction with intracellular H2O2. Simultaneously, HCPT drug promoted tumor cell apoptosis through chemotherapy and boosted SO2 gas therapy by elevating the H2O2 level within the tumor cells. Consequently, the combination of SO2 gas therapy and chemotherapy provided a promising approach for effective tumor treatment.
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高影响因子
Nature Nanotechnology
·
2015
·Vol. 10
·期 7
·608-613
·
IF 34.048
Li Likai,Ye Guo Jun,Tran Vy,Fei Ruixiang,Chen Guorui,Wang Huichao,Wang Jian,Watanabe Kenji,Taniguchi Takashi,Yang Li,Chen Xian Hui,Zhang Yuanbo
For decades, two-dimensional electron gases (2DEG) have allowed important experimental discoveries1,2 and conceptual developments in condensed-matter physics3. When combined with the unique electronic properties of two-dimensional crystals, they allow rich physical phenomena to be probed at the quantum level4,5. Here, we create a 2DEG in black phosphorus—a recently added member of the two-dimensional atomic crystal family6,7,8—using a gate electric field. The black phosphorus film hosting the 2DEG is placed on a hexagonal boron nitride substrate. The resulting high carrier mobility in the 2DEG allows the observation of quantum oscillations. The temperature and magnetic field dependence of these oscillations yields crucial information about the system, such as cyclotron mass and lifetime of its charge carriers. Our results, coupled with the fact that black phosphorus possesses anisotropic energy bands with a tunable, direct bandgap6,7,8,9,10,11,12,13,14,15, distinguish black phosphorus 2DEG as a system with unique electronic and optoelectronic properties.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2015
·
IF 1.098
Tong Liu,Tiefeng Wang,Yunlong Huang,Chao Wang,Jinfu Wang
Methylphenyldichlorosilane (MPDS, CH 3 C 6 H 5 SiCl 2 ) is an important silicone monomer for the synthesis of high-performance polymethylphenylsiloxane polymers. In this work, the mechanism of the synthesis of MPDS from methyldichlorosilane and chlorobenzene by gas phase condensation was studied, and a kinetic model with 35 species and 58 elementary reactions was established. Experiments were carried out in a tubular reactor under a wide range of reaction conditions. The calculated mole fractions of the reactants and products were in a good agreement with the experimental results. A mechanism of the insertion of chloromethylsilylene into the C Cl bond of chlorobenzene was proposed, which was proved to be the main pathway of MPDS production. The established kinetic model can be used in design and optimization of the industrial reactor for MPDS synthesis.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xi-Guang Wang,Lu-Yang Qiao,Li-Yuan Xu,Yun-Yun Zeng,Zhi-Shen Huang,Shan-Shan Zong,Jin-Xiang Wang,Zhang-Feng Zhou,Yuan-Gen Yao
The intrinsic nature of irreducible oxides (e.g. Al 2 O 3 ) makes it hard to tune the charge state of supported late-transition metals, then difficult to adjust the selectivity of catalysts in CO 2 hydrogenation. Herein, we find that modifying the Pd/Al 2 O 3 catalyst with alkali metals (especially potassium) is efficient to boost the CO formation in CO 2 hydrogenation. In comparison to Pd/Al 2 O 3 , approximately twenty-fold promotion in reverse water–gas shift (RWGS) rate was achieved on K-modified catalysts with proper K/Pd proportions. Combined structural characterizations demonstrate that the enhanced Pd-O interactions through K mediation stabilize the ca. 2 nm sized Pd particles as well as the electron-deficient state of Pd, which are robust enough during long-termed evaluation with undamped performance. In situ spectroscopy unveils a bi-dentate *HCOO associated reaction mechanism taking effect on alkali-modified catalysts, which contributes to ∼ 100 % of CO selectivity and 3318.1 mmol∙g Pd -1 ∙h −1 of CO formation rate at 340°C.
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RSC Advances
·
2017
·Vol. 7
·期 55
·34609-34617
·
IF 3.108
Xiang Ma,Xinyuan Zhou,Yan Gong,Ning Han,Haidi Liu,Yunfa Chen
ZnO/ZnFe2O4 hollow cube composites with heterogeneous structure are synthesized by a facile strategy through simple and direct pyrolysis of FeIII-modified Zn-based metal–organic frameworks. The as-synthesized ZnO/ZnFe2O4 hollow cubes have well-defined cube morphology with an ∼2 μm and multiple porous shell constructed from interpenetrated ZnO and ZnFe2O4 heterogeneous nanoparticles, providing structurally combined mesoporous channels for facilitating the diffusion and surface reaction of gas molecules. In addition, a comparative sensing performance investigation between ZnO/ZnFe2O4 hollow cubes and singular ZnO demonstrates that, in contrast with ZnO, the ZnO/ZnFe2O4 hollow cubes show significantly enhanced chemical sensing sensitivity towards low-concentration acetone. Furthermore, the ZnO/ZnFe2O4 hollow cubes exhibit good reproducibility and selectivity towards gaseous acetone. The enhanced sensing performance of the MOF-derived ZnO/ZnFe2O4 hollow cubes is ascribed to the unique hierarchical structure with high specific surface area, abundant exposed active sites with surface-adsorbed oxygen species and heterojunctions formed at the interfaces between ZnO and ZnFe2O4.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Lianfeng Zhu,Mengyun Wang,Tsz Kwan Lam,Changyue Zhang,Hongda Du,Baohua Li,Youwei Yao
Tin oxide (SnO 2 ) quantum dots (QDs) have been prepared by microwave-assisted method. Firstly, through microwave-assisted method, organic component-wrapped SnO 2 QDs with size of ca. 2–4 nm can be synthesized in only 0.5 min at 160 °C. Then, SnO 2 of very good crystallinity and ca. 5–10 nm can be obtained by annealing the organic component-wrapped SnO 2 QDs in air at 400 °C for 4 h. The annealed SnO 2 QDs exhibit excellent gas sensitivity towards ethanol vapor. Typically, the relative resistance, i.e., ratio of resistance of sample in air to that in tested gases, of sensors towards 300 ppm of ethanol vapor is 215.
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FOOD CHEMISTRY
·
2016
·
IF 4.052
Xin Wang,Lihui Zhang,Jingli Wu,Weiqi Xu,Xiaoqin Wang,Xin Lü
Although pre-column derivatization with n-propylamine and acetic anhydride combined with the gas chromatograph was a useful method for the analysis of monosaccharide composition, failure often occurs because of lack of detail information on the mechanism as well as the operating key point in derivatization process. In this study, the key points in the derivatization (lactonization time, the amount of n-propylamine and acetic anhydride) were investigated and optimized to improve the method. Under the optimal conditions, the derivatives of seven neutral monosaccharides and two uronic acids were simultaneouly obtained, after which they were well separated and detected by GC. It was also found that all derivatives of monosaccharides were stable even stored for 20 days. The linearity, sensitivity, precision, reproducibility and recovery rate of the improved method were evaluated. Thereafter, five polysaccharide samples from different sources were analyzed to validate the improved method.
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Journal of Chemistry
·
2017
·
IF 1.3
Zhitao Han,Bojun Liu,Shaolong Yang,Xinxiang Pan,Zhijun Yan
The experiments were performed in a lab-scale countercurrent spraying reactor to study the NOx removal from simulated gas stream by cyclic scrubbing using NaClO solution. The effects of NaClO concentration, initial solution pH, coexisting gases (5% CO2 and 13% O2), NOx concentration, SO2 concentration, and absorbent temperature on NOx removal efficiency were investigated in regard to marine exhaust gas. When NaClO concentration was higher than 0.05 M and initial solution pH was below 8, NOx removal efficiency was relatively stable and it was higher than 60%. The coexisting CO2 (5%) had little effect on NOx removal efficiency, but the outlet CO2 concentration decreased slowly with the initial pH increasing from 6 to 8. A complete removal of SO2 and NO could be achieved simultaneously at 293 K, initial pH of 6, and NaClO concentration of 0.05 M, while the outlet NO2 concentration increased slightly with the increase of inlet SO2 concentration. NOx removal efficiency increased slightly with the increase of absorbent temperature. The relevant reaction mechanisms for the oxidation and absorption of NO with NaClO were also discussed. The results indicated that it was of great potential for NOx removal from marine exhaust gas by wet scrubbing using NaClO solution.
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INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
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2017
·
IF 3.458
Chunying Zhu,Yutao Lu,Taotao Fu,Youguang Ma,Huai Z. Li
The gas-liquid two-phase flow and mass transfer with fast chemical reaction in a microchannel were investigated experimentally. Result showed that the bubble volume decreased exponentially with its movement along the channel in a quickly reactable absorbent. The volumetric mass transfer coefficient k L a increased with gas flow rate, while it was insensitive to liquid flow rate under experimental conditions, although the mass transfer coefficient k L increased with liquid flow rate. In slug-bubbly flow regime, the k L decreased when increasing gas flow rate, but inverse tendency was found for slug flow pattern. Both k L and k L a increased with the increase of absorbent concentration. A new correlation for predicting the volumetric mass transfer coefficients k L a was proposed by taking the enhancement factor E of chemical reaction into account.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Xiaogan Li,Yangyang Zhao,Xueyan Wang,Jing Wang,Alexander M. Gaskov,S.A. Akbar
Reduced graphene oxide (rGO) decorated TiO 2 microspheres are prepared by using the hydrothermal method . The as-synthesized sample shows that TiO 2 particles are connected by the rGO nanosheets while some TiO 2 particles are found to be partly covered by rGO sheets. The rGO-decorated TiO 2 based chemoresistive-type sensor shows good sensitivity and excellent selectivity to different concentrations of ammonia from 5 ppm to 50 ppm at room temperature . However, the response and recovery speeds of the sensor to ammonia are sluggish and need further optimization.
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Journal of Chemistry
·
2015
·
IF 0.772
Hao Zhou,Dong-Yao Xu,Hai-Qing Zuo,Wei Liu,Shuang Lin
Urchin-like Cu-W18O49 and flower-like Cu-WO3 structures were successfully synthesized using a hydrothermal process followed by calcination. The synthesized products were characterized using XRD, SEM, and TEM. The results revealed that the as-prepared urchin-like and flower-like samples with monoclinic structures, which were approximately 1 μm and 1-2 μm, respectively, possessed microflower architecture assembled by the nanosheet. In addition, the gas sensing properties of monoclinic-structured Cu-WO3 to acetone were measured using a static state gas sensing test system. The sensor based on the flower-like Cu-WO3 nanostructures, which were calcined at 600°C, exhibited high sensitivity toward 10 ppm acetone at an optimum temperature of 110°C, and the maximum sensitivity reached 40, which was approximately four times higher than that of urchin-like WO3 that was annealed at 300°C. The sensitivity was improved by increasing the acetone concentration. The detection limit was as low as 1 ppm. Using linear fit, the sensor was determined to be sufficiently sensitive to detect acetone in a detection range of 1 to 10 ppm even in the presence of interfering gases, which suggests that this type of sensor has excellent selectivity and has the potential for use in acetone gas sensors in the future.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Yang Li,Huijie Zhao,Huitao Ban,Mujie Yang
Fe 2 O 3 nanosheets were in-situ deposited on the interdigitated gold electrodes by hydrothermal treatment of the electrospun nanofibers containing FeCl 3 and poly(vinyl butyral). As-prepared electrode was further dip-coated with water-dispersible polyaniline (PANI) to fabricate a resistance gas sensor based on Fe 2 O 3 /PANI nanocomposite. The structure and morphology of the nanocomposite were investigated by X-ray diffraction pattern, Fourier transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. It was found that the nanocomposite sensor exhibited much higher response magnitude towards low concentration of NH 3 (0.5–10.7 ppm) than the sensors based on either PANI or Fe 2 O 3 at room temperature (∼20 °C), indicating an obvious synergetic effect. The nanocomposite sensor was featured with ultra high response magnitude (relative resistance change of ∼3070% towards 10.7 ppm of NH 3 ) and excellent selectivity towards NH 3 . A sensing mechanism has been put forward, which takes into account of the conducting network comprising of bulk PANI and composites of PANI and Fe 2 O 3 nanosheets. It was proposed that the p/n heterojunction established between Fe 2 O 3 nanosheets and PANI coating played a major role in the highly desirable sensing performance of the composite.
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