iScience
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2025
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IF 4.1
Hechen Shen,Xu Bao,Bingcai Qi,Xiaoyu Liang,Yun Chang,Xiaomin Hu,Wenqing Gao,Di Sun
Myocardial infarction (MI) poses a severe threat to human life, and timely reperfusion of ischemic myocardium stands as the most effective treatment approach. However, myocardial ischemia-reperfusion (I/R) could lead to the excessive generation of reactive oxygen species (ROS), worsening myocardial injury. In this investigation, a ROS-responsive injectable hydrogel encapsulating melatonin (MLT) was synthesized. This hydrogel could provide a controlled release of MLT, markedly enhancing its antioxidant, anti-inflammatory, anti-apoptotic, and autophagy-modulating effects, thereby significantly mitigating myocardial ischemia-reperfusion injury (MIRI). Moreover, this study proposes an injection method of ultrasound delivery, which offers significant advantages to MI patients without the necessity of thoracotomy In conclusion, This ROS-responsive hydrogel loaded with MLT established the basis for minimally invasive treatment of myocardial I/R injury, which has considerable potential for the treatment of MIRI.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Jitang Chen,Qian Li,Chengbing Ma,Yupeng Yuan,Huiquan Li
The rational design of heterojunction photocatalysts is essential for overcoming the persistent challenge of charge recombination in solar water-splitting systems. Herein, a step-scheme (S-scheme) AgI/Bi₇O₉I₃ heterojunction was fabricated using a facile one-pot hydrothermal method, where deliberate interfacial engineering enables efficient charge separation and transfer. The optimized heterojunction demonstrated remarkable photocatalytic oxygen (O₂) evolution activity, achieving a rate of 2046.22 μmol·g⁻¹·h⁻¹ under visible-light irradiation (λ ≥ 420 nm)—3.1 and 1.97 times higher than those of pristine AgI and Bi₇O₉I₃, respectively. Ultraviolet photoelectron spectroscopy (UPS) and electron spin resonance (ESR) analyses collectively revealed that a built-in electric field formed at the interface drives the directional migration of electrons from AgI to Bi₇O₉I₃, following an S-scheme charge transfer pathway. This mechanism not only enhances the separation of photogenerated carriers but also preserves strong redox capabilities for the water oxidation reaction. This study presents an effective interfacial engineering strategy for developing high-performance heterojunction photocatalysts and provides fundamental insights into charge behavior in S-scheme photocatalytic systems.
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Materials Today Energy
·
2024
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IF 9
Songyu Li,Penghui Ren,Di Zhao,Dan Liu,Jianqiao Wang,Hang Zhou,Wei Liu,Yuheng Zeng,Xuegong Yu,Can Cui,Peng Wang
Recently, p-type inorganic copper-based compounds have attracted increasing interest as hole-selective layers for crystalline silicon (c-Si) heterojunction solar cells. Among them, copper(I) thiocyanate (CuSCN) has a small valence band offset with c-Si and high stability, however, it has not been explored in c-Si solar cell applications. Herein, we successfully demonstrate that solution-processed CuSCN film acts as an effective hole-selective contact layer for p-Si solar cells. Nevertheless, the p-Si/CuSCN heterostructure suffers from an unsatisfactory surface passivation and a relatively high contact resistivity originated from the uncontrollable vacancy defects in the film. The I − doping of CuSCN film (CuSCN:I − ) not only suppresses the generation of SCN vacancies, but also increases the Cu vacancies, significantly improving the hole selectivity . Moreover, a better energy band alignment is formed based on CuSCN:I − /MoO 3 bilayer for hole selective contact of p-Si substrate, achieving a remarkably high photoelectric conversion efficiency (PCE) of 19.42 %. The PCEs of unencapsulated p-Si/CuSCN heterojunction solar cells maintain over 92 % of the initial values under storing in air atmosphere for 1200 h or after annealing at 350 °C. This work highlights that CuSCN is a very promising hole selective layer with superior stability for c-Si solar cell applications.
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NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 44
·期 33
·14103-14107
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IF 3.288
Chanchan Xu,Le Lv,Dawei Luo,Wei Liu
By using pyrazine derivatives, three different types of copper(I) iodide based inorganic–organic hybrid structures, 1D-CuI(2-mo-pz) (1, 2-mo-pz = 2-methoxy-pyrazine), 2D-CuI(2,3-dm-pz)0.5 (2, 2,3-dm-pz = 2,3-dimethyl-pyrazine), and 2D-Cu2I2(2,5-dm-pz)2 (3, 2,5-dm-pz = 2,5-dimethyl-pyrazine), have been obtained by using a slow-diffusion method. Single crystal and powder X-ray diffraction analyses reveal that these hybrid structures are a one-dimensional (1D) staircase chain based structure, two-dimensional (2D) staircase-chain based structure, and 2D rhomboid dimer based structure, respectively. All of the three compounds show photoluminescence, with the internal quantum yield (IQY) as high as 88.2% for 1. This work provides evidence that for this type of hybrid materials, the structure of the inorganic module could be determined by the selection of the organic ligands and that the substituted group on the organic ligands can influence the luminescence efficiency of the hybrid structures.
研究领域:
无机化学
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材料化学
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配位化学
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光物理
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功能材料
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ANALYTICAL CHEMISTRY
·
2026
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IF 6.7
Xiang Chen,Chunxiang Mao,Yuanji Gao,Chaoting Shi,Yu Wang,Zhuolin Jin,Bing Xia,Yan Zhou
Direct quantitative analysis of low-abundance protein biomarkers by electrospray ionization mass spectrometry (ESI-MS) remains challenging due to poor ionization efficiency and matrix interferences. Herein, we report an ultrasensitive analytical platform, termed CRISPR/Cas12a-mediated liposomal amplification coupled with electrospray ionization mass spectrometry (CMLA-MS), that overcomes this limitation by integrating CRISPR/Cas12a-mediated dual-cascade signal amplification with an ESI-MS readout. The strategy converts the detection of poorly ionizable protein molecules into the quantification of numerous, highly ionizable small-molecule reporters: proteins trigger Cas12a trans-cleavage (first amplification), which subsequently cleaves single-stranded DNA (ssDNA) probes anchored to signal-loaded liposomes, causing the burst release of thousands of MS-detectable reporters (second, physical amplification). This dual-amplification strategy enabled an exceptionally low limit of detection (LOD) of 10.8 fg/mL, and the method successfully quantified cardiac troponin I (cTnI) in clinical serum samples with high recoveries (90.3–101.6%).
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.4
Lihong Jia,Zixiang He,Hanchang Huang,Xing Fan,Yuan Sui,Yongping Han
The solubility of meglumine Form I was systematically determined in 12 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, ethyl formate, methyl acetate, ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide (DMF), and acetonitrile) using a gravimetric method over the temperature range of 288.15 to 328.15 K. Solubility increased with temperature in all systems, with DMF exhibiting the highest solubility and acetonitrile the lowest. Three thermodynamic models (the modified Apelblat, λh, and van’t Hoff) were employed to correlate the solubility data, among which the modified Apelblat model provided the best fit. The solubility behavior of meglumine Form I was further analyzed using Hirshfeld surface analysis, the Kamlet–Abboud–Taft linear solvation energy relationship (KAT-LSER) model. The results demonstrate that the solvent’s hydrogen-bond acceptor capability is the key determinant of solubility, as it generates sufficiently strong solute–solvent interactions to overcome the robust hydrogen-bond network within the crystal lattice. These findings provide essential thermodynamic data and mechanistic insights for the optimization of meglumine crystallization and formulation processes.
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LANGMUIR
·
2026
·
IF 4.4
Yan Lu,Qianyun Ye,Can Gao,Xiaoge Li,Pan Gao,Xiaohuan Sun,Jie Han
The development of chiral type-I photosensitizers represents a significant advance, as it can not only overcome the hypoxia limitation inherent to conventional type-II agents but also leverage enantioselectivity to enhance therapeutic precision. However, this promising field remains notably underexplored. Herein, we construct chiral supramolecular self-assemblies via hydrogen-bonding interactions between l/d-arginine (l/d-Arg) and 5,10,15,20-tetrakis(4-sulfophenyl)porphyrin (TPPS). The proximity of the electron-donating porphyrin core to the arginine moiety facilitates efficient photoinduced electron transfer, enabling l/d-Arg-TPPS to operate via simultaneous type-I and type-II pathways. This dual mechanism ensures robust generation of superoxide radicals (O2•–) even under hypoxic conditions, addressing a key limitation of conventional porphyrin photosensitizers. Moreover, the self-assembly process drives effective supramolecular chirality induction, endowing TPPS with substantial dissymmetry factors (gabs) of ∼2.1 × 10–4. This chiral signature translates to significant biological enantioselectivity. d-Arg-TPPS achieves 3.87-fold greater cellular uptake and 1.85-fold higher intracellular reactive oxygen species (ROS) production than l-Arg-TPPS, resulting in markedly enhanced chirality-specific antitumor activity. Importantly, l/d-Arg-TPPS also elicits a chirality-dependent immunogenic cell death (ICD) response, facilitating antitumor immunity. This work establishes a supramolecular chiral-engineering strategy that integrates hypoxia-tolerant photodynamic behavior with stereoselective nanobio interactions, advancing both the fundamental understanding and therapeutic potential of photosensitizer design.
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CANCER LETTERS
·
2026
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IF 11.8
Hui Wang,Yu Zhang,Dinghua Liu,Chang Liu,Shuang Wu,Zhuoyao Wu,Tianming Cui,Gongyao Yu,Yan Xu,Weitao Yang,Bingbo Zhang
The Warburg effect drives cancer cells to rely preferentially on glycolysis, resulting in diminished mitochondrial oxidative phosphorylation (OXPHOS). This metabolic phenotype limits the ability of excess copper (Cu) ions to trigger cuproptosis in dysfunctional mitochondria, leading to suboptimal therapeutic outcomes. Therefore, remodeling tumor energy metabolism to counteract the Warburg effect represents a pivotal strategy to enhance cuproptosis efficacy. Herein, we developed a Cu(I)-stabilized metal-organic framework nanoplatform (CuTz-1) encapsulated by Azurin (CuTz-1@Azurin) as a cuproptosis sensitizer. Mechanistically, Azurin increases p53 protein levels by intercepting MDM2-mediated ubiquitin-proteasome degradation. Elevated p53 subsequently inhibits pyruvate kinase M2 (PKM2) activity, suppressing glycolysis, while simultaneously promoting mitochondrial OXPHOS—collectively shifting cellular metabolism from glycolysis toward mitochondrial respiration and sensitizing tumor cells to Cu-induced proteotoxic stress. In addition, CuTz-1@Azurin triggers oxidative stress via reactive oxygen species (ROS) generation and glutathione (GSH) depletion, which act together with p53-mediated apoptosis to suppress tumor growth. Meanwhile, the oxidation of Cu(I) to paramagnetic Cu(II) enables real-time monitoring of the therapeutic process by magnetic resonance imaging (MRI). Both in vitro and in vivo results demonstrate good antitumor performance of CuTz-1@Azurin. This study highlights the potential of Azurin-mediated metabolic regulation as a promising strategy to potentiate cuproptosis for combined cancer therapy.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Qiao Yang,Chuanhai Xia,Shuai Chen,Xuezhi Cao,Jingcheng Hao
Hypothesis Despite that the development of Cu 2 SnS 3 (CTS) catalyst has attracted increasing interests, few study has reported to investigate its heterogeneous catalytic degradation of organic pollutants in a Fenton-like process. Furthermore, the influence of Sn components towards Cu (II)/Cu (I) redox cycling in CTS catalytic systems remains a fascinating research. Experiments In this work, a series of CTS catalysts with controlled crystalline phases were prepared via a microwave-assisted pathway and applied in the H 2 O 2 activation for phenol degradation. The efficiency of phenol degradation in CTS-1/H 2 O 2 system (CTS-1: the molar ratio of Sn (copper acetate) and Cu (tin dichloride) is determined to be Sn:Cu = 1:1) was systematically investigated by controlling various reaction parameters including H 2 O 2 dosage, initial pH and reaction temperature. We discovered that Cu 2 SnS 3 exhibited superior catalytic activity to the contrast monometallic Cu or Sn sulfides and Cu (I) acted as the dominant active sites. The higher Cu (I) proportions conduce to the higher catalytic activities of CTS catalysts. Quenching experiments and electron paramagnetic resonance (EPR) further proved that the activation of H 2 O 2 by CTS catalyst produces reactive oxygen species (ROS) and subsequently leads to degradation of the contaminants. A reasonable mechanism of enhanced H 2 O 2 activation in Fenton-like reaction of CTS/H 2 O 2 system was proposed for phenol degradation by investigating the roles of copper, tin and sulfur species. Findings The developed CTS acted as a promising catalyst in Fenton-like oxidation progress for phenol degradation. Importantly, the copper and tin species contribute to a synergetic effect for the promotion of Cu (II)/Cu (I) redox cycle, which thus enhanced the activation of H 2 O 2 . Our work may offer new insight on the facilitation of Cu (II)/Cu (I) redox cycle in Cu-based Fenton-like catalytic systems.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Chan Li,Sheng Zhou,Chuncheng Chen,Lijun Zhu,Shijie Li,Zhuoyue Song,Jian Liang,Chunzhi Tang,Nenggui Xu,Tao Liu,Shihui Liu
Disulfiram (DSF), a drug for alcohol withdrawal , has attracted extensive scientific attention due to its potential to treat cancer. The metabolite of DSF, diethyl dithiocarbamate (DDTC), forms a Cu-DDTC complex in vivo with copper ions , which has been shown to be a proteasome inhibitor with high antitumor activity . However, the in vivo stability of Cu-DDTC complexes remains a challenge. In this study, the nanomedicine [email protected] with high antitumor activity was prepared by using the nanoscale metal-organic framework (MOF) Cu-BTC as a carrier and loading diethyldithiocarbamate (DDTC) through coordination interaction. The results showed that [email protected] had high drug loading and adequate stability, and exhibited DDTC-Cu(I) chemical valence characteristics and polycrystalline structure features. In vitro cytocompatibility investigation and animal xenograft tumor model evaluation demonstrated the anti-cancer potential of [email protected] , especially the combination of [email protected] with low-dose cisplatin showed significant antitumor effect and biosafety. This study provides a feasible protocol for developing antitumor drugs based on the drug repurposing strategy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xiaoqi Liu,Yanyun Zhang,Yan Liu,Ting'an Zhang
Chitosan bead grafted by third-generation dendrimers (CB-G3) with a diameter of 1.40 mm was synthesized to investigate their performance in recovering Ag(I), Cu(II), and Pb(II) ions in aqueous media. The prepared adsorbents were characterized by XRD, FT-IR, elemental analysis, TGA , and SEM, and the effects of pH, contact time, concentration, and temperature were examined. The results showed that the adsorbents were successfully fabricated. The optimum pH value was 5, and the increased generation number contributed to adsorption capacity improvement, indicating that electrostatic interactions between amine groups and metal ions are the governing mechanism of adsorption by the CB-G3. The kinetics, isotherms, and thermodynamics of Ag(I), Cu(II), and Pb(II) adsorption onto the CB-G3 were investigated. The adsorption processes can be described using pseudo-second-order kinetic and Langmuir models. The maximum monolayer adsorption capacities were 105.62, 88.82, and 97.87 mg·g −1 for Ag(I), Cu(II), and Pb(II) at 30 °C within 210 min, respectively. Electrostatic interactions and hydrogen bonds are the main mechanisms between metal ions and N atoms. Therefore, the CB-G3 is a promising candidate for Ag(I), Cu(II), and Pb(II) adsorption owing to its splendid ability in easy separation, good adsorptivity, and reusability for efficiently adsorbing Ag(I), Cu(II), and Pb(II) ions.
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JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Shiyu Xiao,Shian Xie,Manbo Zhang,Shengmin Hu,Marc Adape,Jian Wang,Xinhui Zhang,Yongqin Wei,Wei Chen
Here we report two luminescent copper complexes with different structures and luminescent properties, the blue-green [CuI(dmpyHS) (PPh 3 ) 2 ]⸱CH 3 CN (CuPy-PPh 3 ) and the red [Cu 6 (dmpyS) 6 ]⸱H 2 O (CuPy). When the blue-green light (CuPy-PPh 3 ) is heated to above 147 °C, it loses the phosphine-containing ligand, PPh 3 , and turns into CuPy and instead emits red light. Many luminescent complexes show the change of luminescence properties when the temperature is lower than room temperature , while the luminescence change of CuPy-PPh 3 occurs during the heating process above room temperature. Even more interesting, the luminescence wavelength transition span is large, from blue-green light emission at 490 nm to red light at 676 nm. The luminescence of the two copper complexes covers the three primary colors of red, green and blue required for the formation of white light emitting diodes WLEDs, which has potential in the development of non-rare earth phosphor white color displays. The integration of CuPy-PPh 3 and CuPy on a 395 nm near-ultraviolet chip can assemble WLEDs with good white light properties, which provides a new way for the construction of rare earth-free phosphor WLEDs. The synthesis of the two luminescent copper complexes is simple and environmentally friendly. Even though the structures of two copper complexes have been reported, the synthesis methods are different from those in the related literature and the luminescence properties of these complexes have never been described previously. The red emission copper complex CuPy is obtained by the thermal conversion of the blue-green emission copper complex CuPy-PPh 3 , which is a new phenomenon discovered for the first time in this work.
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