EUROPEAN JOURNAL OF PHARMACOLOGY
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2024
·
IF 4.2
Fengjiao Liu,Yaxin Jia,Liwei Zhao,Li-na Xiao,Xizhen Cheng,Yingying Xiao,Ying Zhang,Yuling Zhang,Huimin Yu,Qiao-en Deng,Yuanyuan Zhang,Yimeng Feng,junfang Wang,Yonggang Gao,Xuan Zhang,Yunyun Geng
Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with brain inflammation and neuronal damage. Derived from the Aesculus chinensis Bunge fruit, escin has shown anti-inflammatory and neuroprotective effects. However, its potential as a treatment for MDD is unclear. This study investigates the antidepressant properties of escin using in vivo experimentation. The chronic unpredictable mild stress (CUMS) model was used to analyze the potential antidepressant effects and underlying mechanisms of escin. Wistar rats were exposed to CUMS for 35 consecutive days to induce MDD. The rats were then given either escin (1, 3, and 10 mg/kg) or fluoxetine (2 mg/kg) on a daily basis. Notably, escin significantly alleviated the depressive behaviors induced by CUMS, as evaluated through a series of behavioral assessments. Moreover, escin administration reduced TNF-α, IL-1β, and IL-6 levels in the hippocampus. It also decreased serum adrenal cortical hormone (ACTH) and corticosterone (CORT) levels while increasing 5-HT and Brain-derived neurotrophic factor (BDNF) levels in the CUMS rats, as measured by the enzyme-linked immunosorbent assay (ELISA). Pathological changes in the hippocampal regions were identified through Nissl staining, and Western blotting was used to quantify the protein levels of BDNF, TrkB, CREB, TLR4, MyD88, and NF-κB. Escin mitigated neuronal injury, elevated TrkB, BDNF, and CREB, and reduced TLR4, MyD88, and NF-κB protein levels in CUMS rats. The data from this study suggest that escin holds the potential for alleviating depression-like symptoms induced by CUMS. This effect may be mediated through the modulation of two signaling pathways, BDNF/TrkB/CREB and TLR4/MyD88/NF-κB.
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Journal of Energy Storage
·
2024
·
IF 8.9
Yuting He,Yongjin Zou,Cuili Xiang,Fen Xu,Yongpeng Xia,Yulian Chen,Shunxiang Wang,Zhicong Hu,Sijia Hao,Lixian Sun
Shape-stabilized composite phase change materials (CPCMs) with high photothermal conversion efficiency, high thermal storage capacity, and excellent thermal conductivity hold immense potential for diverse applications and market growth. This study employed a one-step substitution reaction followed by a thermal reduction technique to successfully affix Ni and Cu nanoparticles onto reduced graphene oxide (rGO) nanosheets , which were subsequently integrated into a nickel foam (NF) matrix. This process resulted in the fabrication of an NF/Ni-Cu@rGO porous carrier, facilitating the adsorption of polyethylene glycol (PEG) and the formation of CPCMs. Introducing Ni-Cu@rGO into the NF matrix enhanced the carrier framework, enabling improved PEG loading and leakage prevention. The hybridization of Ni-Cu@rGO effectively bolstered the interaction between the carrier framework and the phase change material (PCM), resulting in enhanced phase change performance. CPCMs prepared from the NF/Ni-Cu@rGO framework exhibited superior shape stability, higher thermal storage density, and enhanced recyclability than pure PCMs. Optimized CPCMs displayed melting and crystallization enthalpies of 121.13 J·g −1 and 113.44 J·g −1 , respectively. The thermal conductivity of NF/Ni-Cu@rGO/PEG CPCMs significantly improved to 0.4780 W·m −1 K −1 , representing a remarkable 315 % increase over that of PEG alone. Furthermore, the NF/Ni-Cu@rGO/PEG composite demonstrated outstanding photothermal conversion efficiency, thermal cycling stability, and exceptional shape stability. These findings offer promising prospects for its application across various fields.
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Food & Function
·
2025
·
IF 5.4
Xiaoran Kong,Li Zhao,He Huang,Qiaozhen Kang,Jike Lu,Jia-Qing Zhu
Hyperuricemia is chronic metabolic disease with a high incidence, and it has become the “fourth highest” health risk in modern times. Isorhamnetin is a natural flavonoid found in a variety of plants, especially fruits such as buckthorn. In vivo hyperuricemia ameliorating effect of isorhamnetin and the specific molecular mechanism were profoundly investigated through a hyperuricemia mice model in the present study. The results demonstrated that isorhamnetin showed a significant uric acid-lowering effect in mice. Isorhamnetin was able to reduce uric acid production by inhibiting XOD activity. On the other hand, it reduced the expression of GLUT9 to inhibit uric acid reabsorption and enhanced the expression of ABCG2, OAT1, and OAT3 to promote uric acid excretion. Metabolomics analysis revealed that isorhamnetin gavage restored the purine metabolism and riboflavin metabolism disorders, and thus significantly alleviated the hyperuricemia in mice. Further, the alleviating effect of isorhamnetin on hyperuricemia-induced renal inflammation and its specific mechanism were explored through network pharmacology and molecular validation experiments. Network pharmacology predicted that seven targets were enriched in the PI3K/AKT pathway (CDK6, SYK, KDR, RELA, PIK3CG, IGF1R, MCL1) and four targets were enriched in the NF-κB pathway (SYK, PARP1, PTGS2, RELA). Western blot validated that isorhamnetin inhibited the phosphorylation of PI3K and AKT and down-regulated the expression of NF-κB p65. It indicated that isorhamnetin could inhibit the PI3K/AKT/NF-κB signaling pathway to reduce the levels of renal inflammatory factors (TNF-α, IL-β and IL-6) and ultimately ameliorate the hyperuricemia-induced renal inflammation in mice. This study will provide comprehensive and penetrating theoretical basis for the application of isorhamnetin in the field of functional foods or dietary supplements to improve hyperuricemia.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Xiaoyu Lu,Congling Li,Li Zhang,Wei Xia,Rui Liu,Aifeng Lv
The rational design of efficient, cost-effective, and durable electrocatalysts is crucial for the realization of hydrogen production through water splitting. The present study describes the synthesis of a novel three-dimensional (3D) volcano-like Fe 3 S 4 /Ni 3 S 2 /WO 3 /NiFe LDH/NF (Layered Double Hydroxides/Nickel Foam) electrocatalyst with a highly wrinkled structure through a two-step hydrothermal method. The as-synthesized electrocatalyst exhibits an exceptionally low overpotential of 77 mV for the hydrogen evolution reaction (HER) and 131 mV for the oxygen evolution reaction (OER) at a current density of 10 mA cm −2 , owing to the unique morphology and strong electronic interactions between Fe 3 S 4 , Ni 3 S 2 and WO 3 heterostructures. The Fe 3 S 4 /Ni 3 S 2 /WO 3 /NiFe LDH/NF electrocatalyst demonstrates exceptional performance in overall water splitting when employed as both anode and cathode, achieving a current density of 10 mA cm −2 at an impressively low cell voltage of 1.5 V as well as exhibiting remarkable durability with little degradation over a period of 12 hours. This study presents a straightforward approach for the synthesis of highly efficient and durable non-noble metal catalysts for overall water splitting under hydrothermal conditions.
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CTS-Clinical and Translational Science
·
2024
·Vol. 17
·期 3
·e13748
·
IF 3.1
Chenyu Song,Kaiyang Wang,Bangping Qian,Jingshun Lu,Mu Qiao,Yong Qiu,Bin Wang,Yang Yu
Ankylosing spondylitis (AS) is an immune chronic inflammatory disease, resulting in back pain, stiffness, and thoracolumbar kyphotic deformity. Based on the reported anti-inflammatory and antioxidant capacities of cynarin (Cyn), this study explored its protective role and molecular mechanisms in mesenchymal stem cells (MSCs) from AS. The target pathways and genes were verified using Western blotting, quantitative real-time polymerase chain reaction, and immunofluorescent staining, while molecular docking analysis was conducted. In AS-MSCs, we found that the expression levels of p-NF-κB, IL-6, IL-1β, and TNF-α were higher and IκB-α, Nrf-2, and HO-1 were lower compared with healthy control (HC)-MSCs. With molecular docking analysis, the biding affinities between Cyn and Keap1-Nrf-2 and p65-IκB-α were predicted. The mRNA and protein expression of p-NF-κB, IL-6, IL-1β, and TNF-α and the reactive oxygen species (ROS) generation were downregulated following Cyn administration. Meanwhile, the expression level of IκB-α, Nrf-2, and HO-1 were significantly increased after Cyn pretreatment. The results suggested that the protective mechanisms of Cyn in AS-MSCs were based on enhancing the antioxidation and suppression of excessive inflammatory responses via Nrf-2/ROS/NF-κB axis. Our findings demonstrate that Cyn is a potential candidate for alleviating inflammation in AS.
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Water
·
2024
·Vol. 17
·期 1
·24
·
IF 3
Yiqiong Yang,Yubin Zhang,Xuyang Gao,Zitong Yang,Haozhou Wang,Xiaodong Zhang
To overcome the disadvantage of difficult recovery of powder catalysts and improve catalyst utilization, the selection of foam metal substrates as supports can reduce the difficulty of material recovery and effectively inhibit the leaching of metal ions. Herein, CoMnNi-layered double hydroxide (LDH) derived from Co-Mn ZIF was immobilized onto nickel foam (NF) through in situ synthesis. The results of XRD and SEM analyses of the samples indicated that the LDH was successfully grown on the nickel foam matrix, and the material could maintain its original morphology to the maximum extent after loading. By comparing the XPS of the material before and after the reaction, it was confirmed that the surface hydroxyl group and C=O of the material were involved in the activation of peroxymonosulfate (PMS). The results of the quenching reaction showed that SO4•−and1O2are the main active substances in the oxidation of enrofloxacin (ENR). When the dosage of NF@CoMnNi-LDH was 0.4 g/L, the pH of the solution was 6.82, and when the dosage of PMS was 2.0 mM, the degradation rate of ENR reached 82.6% within 30 min. This research offers novel insights into the degradation of antibiotics from water using a monolithic catalyst supported by metal foam.
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HISTOLOGY AND HISTOPATHOLOGY
·
2024
·
IF 2.5
Shuang Bai,Shao-Kang Sun,Zhen-Qi Xu,Ying-Bin Yan
Objective: Accumulating evidence has implicated matrix metalloproteinases (MMPs) in the progression of human cancers. Matrix metallopeptidase 25 (MMP25) is a membrane-type MMP whose role in tumorigenesis and cancer development is not well understood. Here, we investigated the functions of MMP25 in tongue squamous cell carcinoma (TSCC). Methods: Gene expression was measured using real-time PCR and western blot. CCK-8 and Transwell assays were used to determine the proliferation, migration, and invasion of TSCC cells. An NK cell co-culture experiment was performed to evaluate the killing of TSCC cells by NK cells. Results: MMP25 had higher expression levels in TSCC tissues than in adjacent non-cancerous tissues. MMP25-overexpressing and MMP25-silenced TSCC cell lines were established by lentiviral transduction. Overexpression of MMP25 promoted proliferation, migration, and invasion of TSCC cells, whereas knockdown of MMP25 had opposite effects. MMP25 modulated the levels of proliferation- and apoptosis-related proteins (PCNA, cyclin D, cyclin B1, p27, and cleaved caspase 3 and 9) and upregulated two invasion-related MMPs (mature MMP2 and MMP9). Additionally, MMP25 promoted tumor growth of TSCC cells in athymic nude mice. Notably, MMP25 upregulated PD-L1 in TSCC cells, attenuated NK cell killing of TSCC cells, and inhibited the secretion of anti-tumor cytokines (TNF-α and IFN-γ). Furthermore, MMP25 promoted the nuclear translocation of NF-κB p65, suggesting that activation of NF-κB signaling may mediate the pro-tumor functions of MMP25 in TSCC. Conclusion: This study revealed a novel role for MMP25 in TSCC, highlighting the potential of MMP25 as a therapeutic target in TSCC.
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DESALINATION
·
2025
·
IF 9.8
Liping Qiu,Shuai Gong,Qi Qiu,Xuewu Zhu,Daliang Xu,Xinwei Kang,Daoji Wu,Feihong Wang,Zhe Yang,Xiaoxiang Cheng
The elimination of natural organic matter (NOM) and organic micropollutants, while effectively preserving essential dietary minerals, constitutes a crucial objective during nanofiltration (NF) of healthy drinking water production. In this study, sodium citrate (SC), distinguished by its unique functional group, was selected as an aqueous phase additive to customize interfacial polymerization for multifunctional NF membranes. The resultant NF membranes exhibited optimal pore sizes, enhanced negative charge density, increased hydrophilicity, and improved separation selectivity. The optimized NF membrane (PIP-SC6) demonstrated a water permeance of 27.8 LMH bar −1 and achieved over 80 % NOM removal while maintaining calcium and magnesium retention below 10 %. Impressively, PIP-SC6 displayed >76.9 % rejection for four selected organic micropollutants while achieving double the permeance compared to commercial NF270. The effluent produced showed low levels of organic matter content while retaining beneficial mineral elements suitable for healthy drinking water consumption. Furthermore, PIP-SC6 exhibited double resistance to both organic fouling and gypsum fouling compared to NF270. This research offers a new approach to customizing highly selective NF membranes aimed at producing healthy drinking water.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2024
·
IF 4.1
Xingnian Duan,Jianmei Cen,Xiaoyu Qiu,Xixiang Liu
The development of high-performance and cost-effective electrocatalysts for oxygen evolution reactions (OER) is key to renewable energy conversion and storage technologies. In this paper, a hierarchical Co(OH) 2 -MoO 3 nanosheets with petal-like architecture was prepared by a simple one-step hydrothermal method using ZIF-67/NF as a precursor, and it was used as a direct electrocatalyst for OER. Notably, this petal-like Co(OH) 2 -MoO 3 /NF layered nanosheets not only prevent the agglomeration of nanostructured material , but also facilitate the complete penetration and diffusion of electrolyte. In addition, due to the strong electronic interaction between Co(OH) 2 and MoO 3 in the Co(OH) 2 -MoO 3 /NF system, Co(OH) 2 -MoO 3 /NF exhibits excellent electrocatalytic OER performance. It has a low overpotential of 273 mV at 10 mA cm −2 and excellent stability. This study provides a simple and effective strategy for the rational design and structural evolution of MOF-derived materials to achieve inexpensive and effective electrocatalysis.
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EUROPEAN JOURNAL OF NUTRITION
·
2024
·Vol. 64
·期 1
·1-13
·
IF 4.1
Han Ning,Li Jie,Li Yangyang,Zhao Feiei,Wang Jun,Ye Peiyu,Zeng Zhenling
Ethnopharmacological relevance Xanthohumol (XN), an isoprenylated flavonoid natural product found only in hops, possesses a variety of biological activities such as anticancer, anti-inflammatory, hepatoprotective, and anti-obesity. Aim of the study The aim of this study was to investigate the effects and mechanisms of XN on the treatment of colitis. Materials and methods First, acute colitis was induced by using distilled water containing 3% DSS for 10 consecutive days. The therapeutic efficacy of XN was assessed by an established DSS-induced mouse colitis model. Subsequently, disease activity index (DAI) and colon length of mice were assessed. The health of the intestines was assessed by histopathological analysis. Inflammatory factors, IL-1β, IL-6, and TNF-α, were detected in colon tissues by ELISA.Finally, mouse intestinal contents were extracted and subjected to 16 S rRNA Sequencing, and the gut microbiota was analysed for Alpha-diversity and Beta-diversity. Results The results showed that XN ameliorated DSS-induced colitis. Furthermore, XN reduced pro-inflammatory cytokine levels such as IL-1β, IL-6, and TNF-α, as well as inhibited the activation of the TLR4/NF-κB pathway, all of which helped to mitigate the inflammatory response. Finally, we also found that XN alleviated intestinal dysbiosis in colitis mice. Conclusion In conclusion, our study demonstrated that XN provides protective effects against colitis, and has the potential to be further explored as a lead compound for the treatment of inflammatory bowel disease (IBD). Graphical
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yue Yan,Wenrui Wu,Yang Yang,Tao Xu,Xianfu Li
Supercapacitors (SCs) have received widespread attention as excellent energy storage devices, and the design of multicomponent electrode materials and the construction of ingenious structures are the keys to enhancing the performance of SCs. In this paper, MoS2 nanorods were used as the carrier structure to induce the anchoring of CoAl-LDH nanosheets and grow on the surface of nickel foam (NF) in situ, thus obtaining a uniformly distributed MoS2 nanorod@CoAl-LDH nanosheet core–shell nanoarray material (MoS2@CoAl-LDH/NF). On the one hand, the nanorod-structured MoS2 as the core provides high conductivity and support, accelerates electron transfer, and avoids agglomeration of CoAl-LDH nanosheets. On the other hand, CoAl-LDH nanosheet arrays have abundant interfacially active sites, which accelerate the electrolyte penetration and enhance the electrochemical activity. The synergistic effect of the two components and the unique core–shell nanostructure give MoS2@CoAl-LDH/NF a high capacity (14,888.8 mF cm–2 at 2 mA cm–2) and long-term cycling performance (104.4% retention after 5000 charge/discharge cycles). The integrated MoS2@CoAl-LDH/NF//AC device boasts a voltage range spanning from 0 to 1.5 V, achieving a peak energy density of 0.19 mW h cm–2 at 1.5 mW cm–2. Impressively, it maintains a capacitance retention rate of 84.6% after enduring 10,000 cycles, demonstrating exceptional durability and stability.
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Pharmaceuticals
·
2025
·Vol. 18
·期 8
·1109
·
IF 4.8
Lingxin Zhuo,Mingxuan Ma,Jiayi Zhang,Jiayu Zhou,Yuqi Zheng,Aiyin Liang,Qingqing Sun,Jia Liu,Wenting Liao
Background/Objectives: Sepsis-induced cardiomyopathy (SIC) is a serious clinical disorder with a high death rate. Qifu decoction (QFD) is a renowned traditional Chinese medicine with documented pharmacological actions, such as anti-inflammatory, anti-oxidant and anti-apoptosis activities, and it has good therapeutic effects on cardiovascular diseases. This study aimed to reveal the cardioprotective effects and underlying mechanisms of QFD against SIC.Methods: Electrocardiography, histopathological examination, and biochemical indicator determination were carried out to investigate the cardioprotective effects of QFD in the treatment of LPS-induced SIC mice. Metabolomics and network pharmacology strategies were employed to preliminarily analyze and predict the mechanisms of QFD against SIC. Molecular docking and Western blot were further applied to validate the core targets and potential pathways for the treatment of SIC in in vitro and in vivo models.Results: It was found that QFD considerably enhanced cardiac function; attenuated myocardial injury; and reduced the serum levels of LDH, CK-MB, IL-1β, and TNF-α by 28.7%, 32.3%, 38.6%, and 36.7%, respectively. Metabolomic analysis showed that QFD could regulate seven metabolic pathways, namely, glutathione metabolism; alanine, aspartate, and glutamate metabolism; arachidonic acid metabolism; glycerophospholipid metabolism; purine metabolism; sphingolipid metabolism; and fatty acid metabolism. Network pharmacology suggested that the anti-SIC effect of QFD may be mediated through the TNF, toll-like receptor, NOD-like receptor, NF-κB, and PPAR signaling pathways. Additionally, 26 core targets were obtained. Molecular docking revealed that active ingredients such as formononetin, kaempferol, quercetin, and (R)-norcoclaurine in QFD had a high affinity for binding to PPARα and TLR4. Further Western blot validation indicated that QFD could regulate the protein levels of NLRP3, TLR4, NF-κB, IL-6, TNF-α, COX2, sPLA2, PPARα, CPT1B, and CPT2.Conclusions: This study demonstrates that QFD can alleviate SIC by suppressing the TLR4/NF-κB/NLRP3 inflammatory pathway and modulating impaired FAO through the activation of the PPARα/CPT pathway, highlighting QFD as a promising candidate drug for SIC treatment.
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