CARBON
·
2022
·
IF 11.307
Shiyu Yang,Zhiqiong Chen,Ping Zhou,Jiashan Xia,Tao Deng,Chao Yu
Compared with visible fluorescence carbon dots (CDs), the multi-emission (visible and near infrared) fluorescence CDs based platform (V-N Platform) with blood-brain barrier penetration, real-time brain imaging and drug loading capacities, is of great significance. Herein, a novel type of multi-emission fluorescence CDs (GT) was created to penetrate BBB for brain imaging and local drug delivery, which was synthesized by hydrothermal method, using endogenous l -tryptophan and d -glucose. The capability for in vitro imaging was verified through the experiments on cell imaging. Moreover, the ability of in vivo imaging, especially for brain imaging, was confirmed by experiments in mice and zebrafish. In addition, the in vitro and in vivo experiments preliminarily confirmed its potential to act as a drug delivery platform. This V-N Platform (GT) will be expected to have a significant impact on the researches for CDs and the theranostics of brain diseases.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 31
·15064-15070
·
IF 3.925
Zhendong Yan,Yang Wang,Ting Li,Pengwu Xu,Jing Huang,Jie Jiang,Xuhui Zhang,Bihua Xia,Shibo Wang,Weifu Dong
Nanoparticles with ultraviolet/near-infrared (UV/NIR) shielding ability have great potential in the application research of energy-saving materials. In this study, we prepared dual-functional UV/NIR-shielding poly(lactic acid) (PLA) composite films. Firstly, CsxWO3@polydopamine (CWO@PDA) nanoparticles with core–shell structures were formed by dopamine self-polymerization on the surface of CWO, and then CWO@PDA-g-PLLA nanoparticles were successfully prepared by ring-opening polymerization with L-lactide as a raw material. Finally, PDLA/CWO@PDA-g-PLLA composite films containing different proportions of CWO@PDA-g-PLLA nanoparticles were fabricated via a solvent casting method. The results showed that these films have an excellent UV shielding performance and strong absorption in the NIR region (800–2500 nm). When 1.5 wt% of CWO@PDA-g-PLLA nanoparticles was added, the near-infrared transmittance of the composite films decreases significantly from 79.7% to 29.8%. More importantly, the nanoparticles can be used as a heterogenous nucleator to enhance the HC crystallization of PDLA and form stereocomplex crystallites between PDLA and CWO@PDA-g-PLLA nanoparticles which improved the mechanical properties. This study provided a new method for the preparation of PLA nanocomposites with excellent UV/NIR shielding function. These nanocomposites are promising for practical application on energy-saving windows.
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Small
·
2022
·Vol. 18
·期 28
·2202263
·
IF 15.153
Minan Ye,Jie Zhang,Detao Jiang,Qi Tan,Jingyun Li,Cheng Yao,Chenjie Zhu,Yi Zhou
Carbon monoxide (CO) is considered as the second gasotransmitter involved in a series of physiological and pathological processes. Although a number of organic fluorescent probes have been developed for imaging CO, these probes display excitation within the ultraviolet or visible range, which restrict their applications in the complex biosystems. In the present work, a strategy is developed to construct an upconversion nanoparticles-based nanosystem for upconversion luminescent (UCL) sensing CO. This nanosystem exhibits a fast response to CO with high sensitivity and selectivity in aqueous solution by a near-infrared-excited ratiometric UCL detection method. Meanwhile, laser scanning upconversion luminescence microscope experiments demonstrate that this nanosystem can visualize the endogenous CO bio-signaling in living cells, deep tissues, zebrafish, and living mice by ratiometric UCL imaging. In particular, this nanosystem has been successfully employed in visualization of the endogenous CO bio-signaling through up-regulation of heme oxygenase-1 (HO-1) in the progression of hypoxia, acute inflammation, or ischemic injury. This work demonstrates that the outstanding performance of the nanosystem not only can provide an effective tool for further understanding the role of CO in the physiological and pathological environment, but also may have great potential ability for tracking the expression of HO-1 in living systems.
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高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-14
·
IF 17.694
Shen Weicheng,Hu Tingting,Liu Xueyan,Zha Jiajia,Meng Fanqi,Wu Zhikang,Cui Zhuolin,Yang Yu,Li Hai,Zhang Qinghua,Gu Lin,Liang Ruizheng,Tan Chaoliang
Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets. Importantly, the defect-rich CoMo-LDH nanosheets exhibit much higher activity (~97 times) for generation of reactive oxygen species than that of the pristine CoMo-LDH nanosheets under a NIR-III 1567 nm laser irradiation. Therefore, after modification with polyethylene glycol, the defect-rich CoMo-LDH nanosheets can be used as an efficient inorganic PS for PDT to efficiently induce cancer cells apoptosis in vitro and eradicate tumors in vivo under 1567 nm laser irradiation.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 38
·2203964
·
IF 19.924
Xiaojun He,Ji-Ting Hou,Xiaoshuai Sun,Paramesh Jangili,Jusung An,Yuna Qian,Jong Seung Kim,Jianliang Shen
Ultrasound (US)-mediated sonodynamic therapy (SDT) has the advantages of non-invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano-sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining the application of SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich oxygen vacancies are developed and interlayer gaps of molybdenum trioxide nanobelts are expanded. Owing to the increased oxygen vacancy density and wide interlayer gap-induced narrower band gap of SMB NPs, the electrons (e – ) and holes (h + ) generated by US are separated more rapidly, and oxygen vacancies prevent electrons–holes recombination under US irradiation. SMB NPs exhibit a second near-infrared (NIR-II) photothermal effect to promote the generation of ROS by the sonosensitizer. The SMB NPs system is successfully realized to eliminate Staphylococcus aureus ( S. aureus ) and dissipate biofilm. Therefore, multimodal therapy using SMB NPs serves as an effective and promising regimen for deep-seated bacterial infections. The newly developed Mo-based sonosensitizer is presented for the first time to demonstrate excellent antimicrobial activity through hyperthermia-promoting SDT therapeutics. This work proposes a novel strategy in the field of NIR-II photo-amplified SDT with Mo-based materials for bacterial eradication and other important biomedical applications.
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高影响因子
Biomaterials Science
·
2022
·Vol. 10
·期 9
·2370-2383
·
IF 7.59
Lu Tang,Qiaqia Xiao,Yue Yin,Yijun Mei,Jing Li,Lin Xu,Hongbin Gao,Wei Wang
A combination of photothermal therapy (PTT) and chemotherapy is an emerging therapeutic strategy with promising clinical prospects in cancer treatment. Despite the huge progress achieved in the past years, a number of obstacles still hamper the therapeutic efficacy of this synergistic modality such as uneven heat distribution, lack of targetability of anti-cancer agents and dosage-related side effects. Thus, developing a nanoplatform for targeted drug delivery against cancer is of great necessity. Herein, a lipid–polymer hybrid nanosystem (LP/ID) based on polyethyleneimine (PEI)-lecithin-polyethylene glycol (PEG) was fabricated to co-load indocyanine green (ICG) and dichloroacetate (DCA) for combined photothermal/chemotherapy. DCA and ICG were linked to the PEI backbone to form a dense hydrophobic core through amide bonds and electrostatic interactions, which increased the payload of DCA and ICG as well as achieved enzyme-responsive drug release because of the overexpressed amidase in tumor cells. Lecithin and DSPE-PEG2000 self-assembled around the hydrophobic complexes to obtain prolonged blood circulation and attenuated systemic toxicity of the hybrid nanosystem. The prepared LP/ID exhibited favourable stability in a physiological environment, good tumor imaging properties, and satisfactory photothermal/chemotherapeutic performance. Moreover, LP/ID could also enhance the cellular uptake and tumor retention capacity in comparison with free drug administration. Notably, by co-loading two therapeutic agents with different anti-cancer mechanisms, an obvious inhibitory effect on tumor growth was observed with negligible damage to normal tissues and organs because of the synergistic photothermal/chemotherapy effect, indicating the great potential of LP/ID as a robust nanoplatform for cancer treatment.
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高影响因子
CATALYSIS TODAY
·
2022
·
IF 6.562
Yunfei Ma,Wenhui Yue,Zehong Xu,Ziwei Ye,Jinlong Zhang
Composite nanoparticles consisting upconversion nanoparticles (β-NaYF 4 :Yb/Er) and nitrogen doped TiO 2 nanoparticles were constructed via a chemical assembly method. Efficient energy transfer was enabled since the upconverted energy matched up with the band gap of N-TiO 2 . This enables the resulting composite nanoparticles to possess excellent Rhodamine B (RhB) degradation activity under near infrared (NIR) light irradiation.
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高影响因子
Bioactive Materials
·
2021
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IF 14.593
Yuanchi Zhang,Cairong Li,Wei Zhang,Junjie Deng,Yangyi Nie,Xiangfu Du,Ling Qin,Yuxiao Lai
Patients with bone defects suffer from a high rate of disability and deformity. Poor contact of grafts with defective bones and insufficient osteogenic activities lead to increased loose risks and unsatisfied repair efficacy. Although self-expanding scaffolds were developed to enhance bone integration, the limitations on the high transition temperature and the unsatisfied bioactivity hindered greatly their clinical application. Herein, we report a near-infrared-responsive and tight-contacting scaffold that comprises of shape memory polyurethane (SMPU) as the thermal-responsive matrix and magnesium (Mg) as the photothermal and bioactive component, which fabricated by the low temperature rapid prototyping (LT-RP) 3D printing technology. As designed, due to synergistic effects of the components and the fabrication approach, the composite scaffold possesses a homogeneously porous structure, significantly improved mechanical properties and stable photothermal effects. The programmed scaffold can be heated to recover under near infrared irradiation in 60s. With 4 wt% Mg, the scaffold has the balanced shape fixity ratio of 93.6% and shape recovery ratio of 95.4%. The compressed composite scaffold could lift a 100 g weight under NIR light, which was more than 1700 times of its own weight. The results of the push-out tests and the finite element analysis (FEA) confirmed the tight-contacting ability of the SMPU/4 wt%Mg scaffold, which had a signficant enhancement compared to the scaffold without shape memory effects. Furthermore, The osteopromotive function of the scaffold has been demonstrated through a series of in vitro and in vivo studies. We envision this scaffold can be a clinically effective strategy for robust bone regeneration.
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高影响因子
Coatings
·
2023
·Vol. 13
·期 6
·1037
·
IF 3.4
Yixin Xie,Ji Xu,Hui Jin,Yunfeng Yi,Yuqing Shen,Xiuming Zhang,Xinxin Liu,Yanan Sun,Wei Shi,Yuan He,Dongtao Ge
Recently, the near-infrared-II (NIR-II, 1000–1350 nm) region has been extensively applied in deep-tissue photothermal therapy (PTT) on account of it having stronger tissue penetration and a higher maximum permissible exposure (MPE) than the near-infrared-I (NIR-I, 650–950 nm) region. In this study, we developed a rapid and convenient in situ polymerization strategy to fabricate polypyrrole nanosheets (PPy NSs) within a few minutes using manganese dioxide nanosheets (MnO2NSs) as both the oxidant and the self-sacrificed template. The fabricated PPy NSs exhibited excellent NIR-II absorption, which conferred its high photothermal conversion efficiency (66.01%) at 1064 nm and its photoacoustic (PA) imaging capability. Both in vivo and in vitro studies have shown that that PPy NSs possess good biological safety and excellent PTT efficacy and PA imaging performances. Thus, the as-synthesized PPy NSs could effectively achieve PA imaging-guided photothermal tumor ablation under 1064 nm excitation. Our work provides a novel and promising method for the rapid preparation of PPy NSs without the addition of exogenous oxidants and subsequent template removal, which could be regarded as potential photothermal agents (PTAs) to integrate the diagnosis and treatment of cancer.Keywords:polypyrrole nanosheets;in situ polymerization;near-infrared-II region;photoacoustic imaging;photothermal therapy
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Shengfa Deng,Heng Guo,Jianfeng Yan,Dezhi Zhu,Jiaqun Li,Ming Qiao,Jiawang Xie
Photodetectors are widely used in optoelectronic applications such as remote controlling, optical communication, and intelligent manufacturing. Multi-wavelength response capability can expand the application scenarios of a photodetector. However, responding to and recognizing multiple bands is still challenging for a photodetector. Here, we develop a dual-mode photodetector that can respond to and recognize near-infrared (NIR) and ultraviolet (UV) light with the assistance of a machine-learning model. A hybrid laser processing method was proposed to fabricate this photodetector based on the polyimide substrate. This method uses femtosecond laser and continuous wave laser to induce the formation of carbon and zinc oxide composite material in different forms. The femtosecond laser-processed area and the continuous wave laser-processed area realized stable NIR light detection and UV light detection, respectively. Recognition of the type of incident light was realized with the assistance of a machine-learning classification model. The proposed hybrid laser processing method combines the characteristics of two kinds of lasers and provides new insights into fabricating dual-mode photodetector. This photodetector could advance the development of dual-mode photodetection and has application potential in many fields like wearable devices and smart clothing.
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高影响因子
Advanced Optical Materials
·
2023
·Vol. 11
·期 17
·2300378
·
IF 9
Ruiqi Liu,Yihua Qiu,Fengxia Wu,Shuang Duan,Yongkuan Suo,Baisong Chang,Ying Ren,Mei Tian,Hongguang Liu,Zhen Cheng
The second near-infrared biological window two (NIR-II, 1000–1700 nm) imaging has made remarkable achievements in fluorescence imaging of diseases. Here, this work takes advantage of the rich spectral properties of rare-earth doped nanoparticles (RENPs) and their capability to present multiple emission peaks in different luminescence regions simultaneously; novel RENPs are synthesized that have emission peaks in the NIR-II 1000nm (1000–1300 nm) region and enhanced emission in the NIR-IIb (1500–1700 nm) window and are named as NEU-RENPs. These RENPs with new compositions enable a fair comparison to evaluate their imaging performance in NIR-II 1000nm and NIR-IIb regions under the same conditions. The imaging abilities of the resulted nanoparticles in NIR-II 1000 nm and NIR-IIb regions are investigated systematically for local blood vessels, tumor vessels, acute inflammatory vessels, arterial thrombosis, cerebrovascular inflammation, and brain injury models. The results indicate that imaging of NIR-IIb shows higher resolution and sensitivity than that of NIR-II 1000nm , and it has a stronger ability to accurately distinguish normal and pathological tissues. Interestingly, the fuzzy image of NIR-II 1000nm reveals more information about the background structure of the target, which is difficult to be achieved in NIR-IIb imaging. The results prove NEU-RENPs based NIR-IIb imaging is preferable for biomedical applications.
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高影响因子
Acta Biomaterialia
·
2023
·
IF 9.7
Yeneng Dai,Xiangyu Li,Yuwen Xue,Kai Chen,Guanda Jiao,Lipeng Zhu,Meixing Li,Quli Fan,Yunlu Dai,Qi Zhao,Qingming Shen
The effectiveness of phototheranostics induced immunotherapy is still hampered by limited light penetration depth, the complex immunosuppressive tumor microenvironment (TME) and the low efficiency of immunomodulator drug delivery. Herein, self-delivery and TME responsive NIR-II phototheranostic nanoadjuvants (NAs) were fabricated to suppress the growth and metastasis of melanoma through the integration of photothermal-chemodynamic therapy (PTT-CDT) and immune remodeling. The NAs were constructed by the self-assembly of ultrasmall NIR-II semiconducting polymer dots and the toll-like receptor agonist resiquimod (R848) utilizing manganese ions (Mn 2+ ) as coordination nodes. Under acidic TME, the NAs responsively disintegrated and released therapeutic components, which enable NIR-II fluorescence/photoacoustic/magnetic resonance imaging-guided tumor PTT-CDT. Moreover, the synergistic treatment of PTT-CDT could induce significant tumor immunogenic cell death and evoke highly efficacious cancer immunosurveillance . The released R848 stimulated the maturation of dendritic cells, which both amplified the antitumor immune response by modulating and remodeling the TME. The NAs present a promising integration strategy of polymer dot-metal ion coordination and immune adjuvants for precise diagnosis and amplified anti-tumor immunotherapy against deep-seated tumors. Statement of significance The efficiency of phototheranostics induced immunotherapy is still limited by insufficient light penetration depth, low immune response and the complex immunosuppressive tumor microenvironment (TME). In order to improve the efficacy of immunotherapy, self-delivery NIR-II phototheranostic nanoadjuvants (PMR NAs) were successfully fabricated via the facile coordination self-assembly of ultra-small NIR-II semiconducting polymer dots and toll-like receptor agonist resiquimod (R848) utilizing manganese ions (Mn 2+ ) as coordination nodes. PMR NAs not only enable TME responsive cargo release and NIR-II fluorescence/photoacoustic/magnetic resonance imaging mediated precise localization of tumors, but also achieve synergistic photothermal-chemodynamic therapy, evoking an effective anti-tumor immune response by ICD effect. The responsively released R848 could further amplify the efficiency of immunotherapy by reversing and remodeling the immunosuppressive tumor microenvironment, thereby effectively inhibiting tumor growth and lung metastasis.
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