BIOMEDICAL CHROMATOGRAPHY
·
2020
·Vol. 34
·期 8
·e4852
·
IF 1.728
Jing Wang,Yong Zhang,Meiqi Zhou,Meizhu Zheng,Jing Cui,Zhiqiang Liu,Chunming Liu,Shu Liu
Superoxide anion radical scavenger and xanthine oxidase inhibitor play an important role in the treatment of several relevant human diseases. In the present study, ultrafiltration liquid chromatography–mass spectrometry coupled to microplate reader was applied to screen and identify superoxide anion radical scavengers and xanthine oxidase inhibitors from total flavonoids of Ginkgo biloba leaves. As a result, four compounds (quercetin, apigenin, kaempferol and isorhamnetin) were screened as xanthine oxidase inhibitors by ultrafiltration LC–MS, and the 50% scavenging concentration values of the screened flavonoids were lower than those for allopurinol. Lineweaver–Burk plot results indicated that kaempferol was a competitive xanthine oxidase inhibitor; the other flavonoids were all anticompetitive inhibitors. Four flavonoids—rutin, quercetin, kaempferol and isorhamnetin—were screened as superoxide anion radical scavengers by LC–MS. The results demonstrate that the method for screening and evaluation of superoxide anion radical scavenger and xanthine oxidase inhibitor from a complex mixture system is feasible and efficient.
研究领域:
药理学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Pei-Pei Luo,Xin-Ke Zhou,Yu Li,Tong-Bu Lu
Solar energy-driven direct CH4 conversion to liquid oxygenates provides a promising avenue toward green and sustainable CH4 industry, yet still confronts issues of low selectivity toward single oxygenate and use of noble-metal cocatalysts. Herein, for the first time, we report a defect-engineering strategy that rationally regulates the defective layer over TiO2 for selective aerobic photocatalytic CH4 conversion to HCHO without using noble-metal cocatalysts. (Photo)electrochemical and in situ EPR/Raman spectroscopic measurements reveal that an optimized oxygen-vacancy-rich surface disorder layer with a thickness of 1.37 nm can simultaneously promote the separation and migration of photogenerated charge carriers and enhance the activation of O2 and CH4, respectively, to •OH and •CH3 radicals, thereby synergistically boosting HCHO production in aerobic photocatalytic CH4 conversion. As a result, a HCHO production rate up to 3.16 mmol g–1 h–1 with 81.2% selectivity is achieved, outperforming those of the reported state-of-the-art photocatalytic systems. This work sheds light on the mechanism of O2-participated photocatalytic CH4 conversion on defective metal oxides and expands the application of defect engineering in designing low-cost and efficient photocatalysts.
研究领域:
材料科学
·
催化
·
光催化
·
环境化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SmartMat
·
2022
·
IF 0
Yajun Ding,Yuanchao Huang,Yuejiao Li,Tao Zhang,Zhong-Shuai Wu
The realization of high-efficiency, reversible, stable, and safe Li-O 2 batteries is severely hindered by the large overpotential and side reactions, especially at high rate conditions. Therefore, rational design of cathode catalysts with high activity and stability is crucial to overcome the terrible issues at high current density. Herein, we report a surface engineering strategy to adjust the surface electron structure of boron (B)-doped PtNi nanoalloy on carbon nanotubes (PtNiB@CNTs) as an efficient bifunctional cathodic catalyst for high-rate and long-life Li-O 2 batteries. Notably, the Li-O 2 batteries assembled with as-prepared PtNiB@CNT catalyst exhibit ultrahigh discharge capacity of 20510 mAh/g and extremely low overpotential of 0.48 V at a high current density of 1000 mA/g, both of which outperform the most reported Pt-based catalysts recently. Meanwhile, our Li-O 2 batteries offer excellent rate capability and ultra-long cycling life of up to 210 cycles at 1000 mA/g under a fixed capacity of 1000 mAh/g, which is two times longer than those of Pt@CNTs and PtNi@CNTs. Furthermore, it is revealed that surface engineering of PtNi nanoalloy via B doping can efficiently tailor the electron structure of nanoalloy and optimize the adsorption of oxygen species, consequently delivering excellent Li-O 2 battery performance. Therefore, this strategy of regulating the nanoalloy by doping nonmetallic elements will pave an avenue for the design of high-performance catalysts for metal-oxygen batteries.
研究领域:
材料科学
·
电化学
·
能源存储与转换
✓ 已验证
产品关联
DOI
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jiayu Xiao,Luo Hai,Ke Yang,Yuze Luo,Zefeng Wang,Junqin Li,Chunlei Ou,Li Wang,Le Deng,Dinggeng He
Reactive oxygen species (ROS) such as hydroxyl radicals ( OH) and singlet oxygen ( 1 O 2 ) have emerged as promising therapeutic agents for combating biofilm-associated bacterial infections. However, the hypoxic microenvironments in the biofilms severely hinder the ROS production. Herein, we have rationally integrated copper peroxide (CP) and indocyanine green (ICG) into a polydopamine (PDA) nanoparticle to construct a versatile hybrid nanoplatform (PDA/CP/ICG), which can enhance ROS generation for highly efficient biofilm elimination by relieving hypoxic microenvironment. When the PDA/CP/ICG accumulates at the infection site or biofilm, the acidic microenvironment triggers the co-release of Cu 2+ and H 2 O 2 , and the former can catalyze the conversion of self-supplied H 2 O 2 into OH via a Fenton-like reaction and consume the overexpressed antioxidant glutathione (GSH) to further promote the oxidative stress. Moreover, with the help of an 808 nm laser, the hyperpyrexia caused by PDA induces the decomposition of CP into O 2 that is immediately converted by ICG into 1 O 2 . The PDA/CP/ICG shows satisfactory antibacterial and antibiofilm effect due to the self-amplified production of OH and 1 O 2 , and outstanding wound healing with good in vivo biosafety. Overall, this study provides a facile paradigm in ROS-based biofilm elimination, and the proposed hypoxia-irrelevant bactericidal nanoplatform has great potential for future biomedical applications.
研究领域:
生物材料
·
纳米医学
·
抗菌治疗
·
生物膜消除
·
伤口愈合
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CATALYSIS
·
2017
·
IF 6.844
Huifang Liu,Min Wang,Hongji Li,Nengchao Luo,Shutao Xu,Feng Wang
Catalytic oxidation of C C bond is a key technology to transform petroleum-based as well as sustainable biomass feedstock into more valuable oxygenates. We herein describe a convenient and useful oxidation strategy of converting ketones into carboxylic acids using homogeneous copper catalyst without additives and with O 2 as the terminal oxidant. A wide range of aryl and aliphatic ketones as well as β–O–4 lignin models were selectively oxidized to acids via C C bond cleavage. Mechanism studies by EPR and in situ NMR elucidate the principles of Cu/O 2 reactivity that involves C H bond and O 2 activation via a peroxide species. This provides an important foundation for expanding the scope of useful aerobic oxidation reactions using copper catalysts.
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Xiaoyu Zhou,Yanqi Zou,Hongjuan Ru,Fei Yan,Jiyang Liu
Herein, we, for the first time, synthesize silver nanoparticles (Ag NPs) within the nanochannels of amino group-functionalized vertically ordered mesoporous silica films (NH2–VMSF) and investigate their coreaction accelerator role in the luminol-dissolved oxygen (O2) electrochemical stripping chemiluminescence (ESCL) system. The synthesized Ag NPs are capable of electrocatalytic reduction of O2 to superoxide radicals, and meanwhile, sliver ions (Ag+) electrochemically stripped from Ag NPs can promote the amount of luminol anion radicals, generating the boosted ECL intensity of the luminol-dissolved O2 system. This proposed Ag NPs@NH2–VMSF on the indium tin oxide electrode was applied to construct the ESCL aptasensor for quantitative determination of prostate-specific antigen (PSA), yielding a low detection limit [0.19 pg/mL (S/N = 3)] and a broad linear dynamic range (1 pg/mL to 100 ng/mL). Furthermore, good analytical performance of PSA in serum with satisfactory recoveries and low relative standard deviation values is achieved by our developed ESCL aptasensor, rendering it a convenient and sensitive method for PSA determination in clinical applications and further broadening the strategy of ESCL techniques.
研究领域:
纳米技术
·
分析化学
·
生物传感器
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 43
·e04409
·
IF 2
Jialong Yang,Guangqun Zhai
The effect of aerobic dioxygen (O 2 ) residues and hydrogen peroxide (H 2 O 2 ) on dithiobenzoate-mediated reversible addition-fragmentation chain transfer (RAFT) polymerization of methyl methacrylate (MMA) was studied. 2-cyano-2-propyl dithiobenzoate (CPDB) displayed excellent thermally oxidative stability against O 2 in O 2 -rarefied dimethylsulfoxide (DMSO) but was readily oxidized by H 2 O 2 . Azo-initiated CPDB-mediated RAFT polymerization of MMA in DMSO under different media led to multi-component products, consisting of PMMA macro-CTAs, MMA-terminated oligomers and low-MW byproducts, while nitrogen deoxygenating and headspace eliminating gave rise to a comparable CTA efficiency, higher than that headspace limiting. H 2 O 2 -initiated CPDB-mediated headspace-free RAFT polymerization of MMA smoothly proceeded in DMSO even at 50 °C, suggesting the co-initiation by CPDB, and also formed predominant PMMA macro-CTAs, negligible oligomers and some low-MW byproducts. H 2 O 2 -initiated CPDB-mediated headspace-free RAFT polymerization of MMA at 70 °C displayed well-controlled behaviors with 2–5 wt.% byproducts, and the high fidelity of the PMMA macro-CTAs was confirmed by the chain extension via azo-initiated RAFT polymerization and Cu I -catalyzed concurrent ATRP/RAFT polymerization. Graphical AIBN-initiated dithiobenzoate-mediated RAFT polymerization of MMA in O 2 -rarefied DMSO under headspace-free media led to well-controlled behaviors comparable to that under N 2 deoxygenating. H 2 O 2 -initiated RAFT polymerization manifested the unprecedented acceleration by dithiobenzoate; ascribed to its oxidation by H 2 O 2 ; and well-controlled polymerization behaviors.
研究领域:
高分子化学
·
自由基聚合
·
可控/活性聚合
·
有机合成
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Guojun Li,Zheng Lian,Zhengwei Wan,Zhinian Liu,Jingwen Qian,Yue Deng,Shule Zhang,Qin Zhong
Photocatalytic oxidation offers a viable method for removing low-concentration NO from the atmosphere. However, poor oxygen adsorption-activation capacity and high re-combination rate of electrons and holes limit the photocatalytic NO oxidation activity. To over-come these problems, Ni(OH) 2 clusters decorated NiTiO 3 Z-scheme heterojunctions are constructed by a precipitation method. The tight interfacial contacts and built-in electric field between the (0 0 2) crystal facet of Ni(OH) 2 and (0 1 2) crystal facet of NiTiO 3 promote a Z-scheme charge transfer mechanism. This Z-scheme mechanism will enhance the charge-transfer driving force and result in high separation efficiency of the charges, thus leading to an enhanced photocatalytic performance. Importantly, introducing Ni(OH) 2 is considered a promising strategy to enhance the adsorption ability of the O 2 , NO and NO 2 . This might help to increase O 2 activation efficiency and speed up NO deep oxidation, leading to high NO removal efficiency and low NO 2 selectivity. Benefiting from the above excellent properties, the photocatalytic NO oxidation efficiency of Ni(OH) 2 /NiTiO 3 composites is enhanced and the formation of more toxic NO 2 is inhibited compared with that of NiTiO 3 . This work offers a promising and effective route to design efficient NiTiO 3 -based photocatalysts in the application of environmental remediation.
研究领域:
环境修复
·
光催化
·
材料科学
·
无机化学
·
空气污染控制
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2026
·
IF 10.6
Xinlei Zhang,Shiying Yang
The removal of hazardous Cr(III) complexes via advanced oxidation processes can generate highly toxic Cr(VI), posing significant environmental risks. Therefore, there is an urgent need to develop alternative methods that completely suppress the generation of Cr(VI). In this study, with no detectable Cr(VI) in the solution (below the detection limit of 0.004 mg/L), the carbon nanotubes-modified micron-sized zero-valent aluminum (CNTs@mAl 0 ) can effectively remove 99.50% of Cr(III)-EDTA and 83.34% of TOC under the typical acidic conditions of industrial chromium wastewater (pH = 3.00) by activating molecular oxygen. Then the following alkaline precipitation can easily remove the decomplexed free chromium, lowering total chromium concentration to 0.11 mg/L, which meets most national and regional standards, whereas direct alkali precipitation fails to meet them. Serving as a strong electron reservoir (E 0 = - 1.662 V), micron-sized zero-valent aluminum (mAl 0 ) synergizes with highly conductive carbon nanotubes (CNTs) to effectively activate O 2 , facilitating the production of reactive oxygen species (primarily 1 O 2 and •OH) that drive the oxidative decomplexation of Cr(III)-EDTA. Furthermore, the organic ligands are efficiently mineralized, thus preventing Cr(III)’s re-complexation. More interestingly, once the Cr(VI) is possibly generated, it would be rapidly absorbed by CNTs and be immediately reduced by mAl 0 with strong reducing power, thereby completely suppressing the generation of any Cr(VI) in bulk solution. In conclusion, this study presents an environmentally friendly and straightforward treatment system for Cr(III)-complexes, offering an effective solution to mitigate the environmental risks posed by chromium, particularly Cr(VI), in wastewater.
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2016
·Vol. 27
·期 4
·1604258
·
IF 11.382
Zhifang Ma,Xiaodan Jia,Jing Bai,Yudi Ruan,Chao Wang,Jianming Li,Mengchao Zhang,Xiue Jiang
Premature leakage of photosensitizer (PS) from nanocarriers significantly reduces the accumulation of PS within a tumor, thereby enhancing nonspecific accumulation in normal tissues, which inevitably leads to a limited efficacy for photodynamic therapy (PDT) and the enhanced systematic phototoxicity. Moreover, local hypoxia of the tumor tissue also seriously hinders the PDT. To overcome these limitations, an acidic H 2 O 2 -responsive and O 2 -evolving core–shell PDT nanoplatform is developed by using MnO 2 shell as a switchable shield to prevent the premature release of loaded PS in core and elevate the O 2 concentration within tumor tissue. The inner core SiO 2 -methylene blue obtained by co-condensation has a high PS payload and the outer MnO 2 shell shields PS from leaking into blood after intravenous injection until reaching tumor tissue. Moreover, the shell MnO 2 simultaneously endows the theranostic nanocomposite with redox activity toward H 2 O 2 in the acidic microenvironment of tumor tissue to generate O 2 and thus overcomes the hypoxia of cancer cells. More importantly, the Mn(ΙΙ) ion reduced from Mn(ΙV) is capable of in vivo magnetic resonance imaging selectively in response to overexpressed acidic H 2 O 2 . The facile incorporation of the switchable MnO 2 shell into one multifunctional diagnostic and therapeutic nanoplatform has great potential for future clinical application.
研究领域:
生物医学工程
·
肿瘤治疗学
·
纳米医学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 23
·10856-10867
·
IF 9.931
Xiangzhong Ren,Moujie Huang,Shan Luo,Yongliang Li,Libo Deng,Hongwei Mi,Lingna Sun,Peixin Zhang
A novel free-standing and binder-free air electrode with excellent electrochemical performance was designed for highly reversible Li–O2 batteries. The 3D hierarchically N, S co-doped macro–mesoporous carbon (NSMmC) was deposited on carbon paper (CP) via a template method, and then uniformly decorated with PdNi nanoparticles. The macropores of the porous carbon can provide enough space to accommodate discharge products, while the interconnected pores and channels efficiently facilitate oxygen and electrolyte diffusion. The introduction of PdNi nanoparticles greatly reduce the charge transfer resistance, resulting in the improvement of electron mobility of the whole cathode. Compared with Pd–NSMmC/CP and NSMmC/CP cathodes, the PdNi–NSMmC/CP cathode shows considerable enhancement of Li–O2 battery performance. The ultrafine and evenly distributed PdNi nanoparticles can not only provide enough catalytic sites, but can also tailor the discharge products into a cage-like morphology, which provides enough channels for electron and lithium ion transport. Moreover, the smaller size of the cage-like Li2O2 makes it decompose more easily, resulting in lower charge overpotential. This study provides a promising strategy to design 3D structured air cathodes for Li–O2 batteries with high electrocatalytic performance.
研究领域:
材料科学
·
电化学
·
能源存储
·
电池技术
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Yufeng Da,Yong Liu,Yong Chen,Rui Han,Jianlong Wang
Recently, the activation of molecular oxygen (O 2 ) by graphite (Gr) supported aluminum (Al) composite for the in-situ generation of H 2 O 2 / OH gains increasing attention. However, the limited O 2 mass transfer and low catalytic activity of decomposition H 2 O 2 at neutral pH restrict its further application in the wastewater treatment. In this work, a novel N-rich graphite supported aluminum (Al-Gr-NPC) composite was fabricated by introducing the nitrogen-rich porous carbon (NPC) obtained from ZIF-8 derivative as precursor, and by a ball-milling and sintering process. The results showed that the NPC introduction not only improved the physiochemical property of Al-Gr, such as specific surface area, pore structure and hydrophobicity, facilitating the mass transfer of O 2 , but also made Al-Gr contain plentiful N species, serving as active sites for the two-electron ORR process and catalytic decomposition of H 2 O 2 . These excellent performances of Al-Gr-NPC favored the production and utilization of H 2 O 2 by the activation of O 2 at neutral pH and air aeration. The carbonization temperature of ZIF-8 determined the type of N species, surface area and the hydrophobicity of NPC. 1 O 2 was the main oxidant for tetracycline hydrochloride (TC) degradation. 100 % TC degradation and 60.57 % of TOC removal were achieved within 60 min at neutral pH, Al-Gr-NPC dosage of 0.5 g/L and initial TC concentration of 20 mg/L. The toxicity of the final products of TC degradation were much lower than TC by ECOSAR software analysis. Al-Gr-NPC could be used for the removal of antibiotic contaminants from wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）