Canadian Journal of Chemistry
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2020
·Vol. 99
·期 3
·
IF 1.171
Jianfa Chen,Tianxiang Jin,Hangchun Deng,Jie Huang,Guangyuan Ren,Yong Qian
In this work, MoO2@NPGA nanocomposites were successfully prepared via a simple hydrothermal and calcination route. The as-prepared MoO2@NPGA composites exhibit a synergistic effect between MoO2 and N,P-codoped graphene aerogels, which can significantly improve the electrochemical performance of the MoO2@NPGA electrodes. Moreover, the results also proved that the mass loading of MoO2 has a huge effect on the electrochemical properties of MoO2@NPGA composites. With an appropriate amount of MoO2, the MoO2@NPGA composite shows a high specific capacitance (335 F g−1 at 1 A g−1) and excellent cycle stability (capacitance remains at 88% after 6000 cycles). Furthermore, the assembled symmetric supercapacitor displays a high energy density of 23.75 W h kg−1 at a power density of 300 W kg−1 and can maintain an energy density of 17.1 W h kg−1 when the power density reaches up to 6005 W kg−1.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2020
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IF 3.99
Ruiguang Zhao,Yujiang Li,Jianhua Ji,Quanyong Wang,Gongrang Li,Tao Wu,Bei Zhang
Graphene-based materials with a conjugated π region possess unique advantages for treating wastewater contaminated with phenolic compounds. To investigate the interaction mechanisms and optimize the removal efficiency of phenol and p-nitrophenol, nitrogen-doped reduced graphene oxide (N-RGO) with an enlarged conjugated π region and increased hydrophobicity was prepared by annealing a composite of chitosan exfoliated and anchored in a graphene oxide matrix. Results showed that the equilibrium adsorption capacity of N-RGO for phenol and p-nitrophenol was 155.82 and 80.60 mg/g, respectively, at an initial concentration of 200 mg/L, pH of 6, and contact temperature of 30 °C. The optimized removal efficiency was attributed to robust π-π and hydrophobic interactions. Furthermore, regeneration experiments showed that N-RGO could retain a high removal efficiency (> 80 %) over five cycles of reuse. These findings suggest that N-RGO is a promising technique for the removal of phenolic compounds from wastewater using an efficient and recyclable adsorbent.
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Nanoscale
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2020
·Vol. 12
·期 31
·16451-16461
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IF 6.895
Yuqian Jiang,Zheng Wang,Wei Duan,Lingyan Liu,Mahan Si,Xiaoyuan Chen,Chen-Jie Fang
Multidrug resistance (MDR) remains a huge obstacle during cancer treatment. One of the most studied MDR mechanisms is P-glycoprotein (P-gp) mediated drug efflux. Based on the three-dimensional structural characteristics of P-gp, gold nanoparticles (AuNPs) with average sizes of 4.1 nm and 5.4 nm were designed for the construction of nanodrug delivery systems (NanoDDSs), with the anticancer molecules 2-(9-anthracenylmethylene)-hydrazinecarbothioamide (ANS) and 6-mercaptopurine (6-MP) modified on the AuNP surfaces through the thiol group. In vitro cytotoxicity results suggested that the larger sized AuNPs can effectively decrease the drug resistance index of MCF-7/ADR cells to ∼2. Verapamil and P-gp antibody competitive experiments, combined with the cellular uptake of AuNPs, indicated that larger NanoDDSs were more conducive to intracellular drug accumulation and thus had improved anticancer activities, due to a size mismatch between the nanoparticles and the active site of P-gp, and, therefore, reduced drug efflux was seen. Measurements of ATPase activity and intracellular ATP levels indicated that the larger nanoparticles do not bind well to P-gp, thus avoiding effective recognition by P-gp. This was further evidenced by the observation that 4.1 nm and 5.4 nm NanoDDS-treated MCF-7/ADR cells showed remarkable differences in energy-related metabolic pathways. Therefore, the critical size of AuNPs for overcoming MDR was identified to be between 4.1 nm and 5.4 nm. This provides a more accurate description of the composite dimension requirements for NanoDDSs that are designed to overcome MDR.
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PubMed
高影响因子
Frontiers in Physiology
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2020
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IF 3.367
Song Manyu,Wang Chaoran,Yang Haotian,Chen Yongping,Feng Xiujing,Li Bei,Fan Honggang
Chronic stress leads to immunosuppression and induces splenocyte apoptosis. STAT3 is a transcription factor that regulates immunity and apoptosis; however, it is unclear whether the increased expression of phosphorylated STAT3 (p-STAT3) observed in chronic stress is related to splenocyte apoptosis. To explore the relationship between splenocyte apoptosis and STAT3 in chronic stress, we treated rats undergoing a 21-day chronic restraint stress program with the STAT3 inhibitor S3I-201. This chronic stress model was verified by observing rats’ behavior and measuring their serum corticosterone levels. Chronic stress led to increased expression of anti-inflammatory cytokines, and p-STAT3 inhibition enhanced splenocyte apoptosis in chronic stress. We detected key proteins in three apoptotic pathways to determine which pathway mediated increasing splenocyte apoptosis and found that the death receptor pathway was the main apoptotic pathway that occurred in the spleen during chronic stress. The unfolded protein response (UPR) was also activated, but the Bcl-2 family was not involved in chronic stress. P-STAT3 inhibition had no influence on the Bcl-2 family and the death receptor pathway; however, p-STAT3 inhibition disrupted the pro-survival function of the UPR by decreasing the expression of ATF6α and p-IRE1α. Furthermore, p-STAT3 inhibition activated endoplasmic reticulum stress by promoting the expression of CHOP, p-JNK, and procaspase-12. Collectively, these findings indicate that the increased p-STAT3 expression during chronic stress may promote splenocyte survival by activating the UPR. Consequently, STAT3 and the UPR may be considered as potential therapeutic targets for chronic stress in the future.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2021
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IF 5.279
Di Fan,Xinyi Xie,Canxin Li,Xingwang Liu,Jian Zhong,Xinping Ouyang,Qiyu Liu,Xueqing Qiu
The traditional pretreatment leads to the recalcitration of C–C bonds during lignin fractionation, thus hindering their depolymerization into aromatic monomers. It is essential to develop an applicable approach to extract noncondensed lignin for its high-value applications. In this work, noncondensed lignins were extracted from poplar sawdust using recyclable p-toluenesulfonic acid for cleaving lignin–carbohydrate complex bonds effectively and ethanol as a stabilization reagent to inhibit lignin condensation. Lignin yield of 83.74% was recovered by 3 mol/L acid in ethanol at 85 °C for 5 h, and carbohydrates were well preserved (retaining 98.97% cellulose and 50.01% hemicelluloses). During lignin fractionation, the acid concentration and extraction time were the major drivers of condensation. Ethanol reacted with lignin at the α-position to prevent the formation of the condensed structure. The extracted lignin depolymerized over the Pd/C catalysts gave a yield of 50.35% of aromatic monomers, suggesting that the novel extraction process provided a promising way for noncondensed lignin production.
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JOURNAL OF HAZARDOUS MATERIALS
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2021
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IF 10.588
Yiwei Li,Yaohong Ma,Eric Lichtfouse,Jin Song,Rui Gong,Jinheng Zhang,Shuo Wang,Leilei Xiao
Para-Nitrophenol ( p -nitrophenol) is a common industrial pollutant occurring widely in water bodies, yet actual monitoring methods are limited. Herein we proposed a fully electrochemically in situ synthesized graphene-polyarginine composite functionalized screen printed electrode, as a novel p-nitrophenol sensing platform. The electrode was characterized by morphologic, spectrometric and electrochemical techniques. p -nitrophenol in both pure aqueous solution and real water samples was tested. Results show a detection limit as low as the nanomolar level, and display a linear response and high selectivity in the range of 0.5–1250 μM. Molecular simulation reveals a detailed synergy between graphene and poly-arginine. The preferable orientation of nitrophenol molecules on the graphene interface in the presence of poly-arginine induces H- and ionic binding. This sensor is an ideal prototype for p -nitrophenol quantification in real waters.
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高影响因子
CHEMOSPHERE
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2021
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IF 7.086
Xiaoxia Ye,Huiting Lin,Ruiyang Chi,Zhixuan Guo,Yuancai Lv,Chunxiang Lin,Yifan Liu,Wei Luo
Efficient and rapid removal of p -arsanilic acid ( p -ASA) in water is very important in environmental protection and human health, however it is still a severe challenge in actual engineering. Herein, a novel sorbent (CF-PEI) was successfully fabricated by simply modifying the amphiphilic skin collagen fiber (CF) substrate with Polyethylenimine (PEI). The as-prepared CF-PEI exhibits high-efficiency adsorption for negatively charged p -ASA with aromatic rings due to the introduction of amino groups and the existence of hydrophobic bands, and the maximum adsorption capacity of CF-PEI for p -ASA was high up to 285.71 mg g −1 . In addition, the adsorption mechanism of CF-PEI on p -ASA mainly includes electrostatic interaction, hydrogen bond and amphiphilicity. The multi-level all-fiber structure of CF makes it mainly focus on surface mass transfer with short mass transfer distance, and its capillary drainage effect can realize large flow and rapid separation. CF-PEI based on CF can realize the ability to separate low-concentration p -ASA with high flow rate and high efficiency. The effective processing volume was 12.5 L g −1 when the separation flux reached as high as 9931.27 L m −2 h −1 . Notably, the p -ASA adsorbed on CF-PEI was almost completely eluted by NaOH (0.5 mol L −1 ). The adsorbent is convenient to prepare, recyclable, high in efficiency, and has a great application prospect in removing organic micro-pollutants.
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ANALYTICAL CHEMISTRY
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2019
·
IF 6.35
Juan Li,Xu Zhao,Li-Jian Chen,Hai-Long Qian,Wen-Long Wang,Cheng Yang,Xiu-Ping Yan
Aflatoxin B1 (AFB1) contamination is one of the most critical global issues in food safety. The high carcinogenic nature necessitates rapid and specific methods for the determination of AFB1 in foodstuffs at ultratrace levels. Here, we report an enhanced bienzymatic chemiluminescence competitive immunoassay for ultrasensitive and high-throughput determination of AFB1. In this assay, protein G was first coated on the wells of a microplate for recognizing the Fc fragment of anti-AFB1 mAbs to reduce the antibody dosage and guarantee high immunological reaction efficiency. The target AFB1 competed with glucose oxidase labeled AFB1 for the limited anti-AFB1 mAbs in the wells of the microplate. p-Bromophenol was employed as an enhancer to obtain intense and long-lasting chemiluminescence. The utilization of an enhancer and bienzymatic catalysts effectively improved the detection sensitivity. The developed method offered a good linearity over 5 orders of magnitude, a detection limit of 5 pg L–1, and a relative standard deviation of 1.9% for AFB1. The application of the developed method to the analysis of grain samples gave quantitative recoveries from 94.0% to 97.0%. The developed method provides a universal platform for high-throughput, ultrasensitive, and high specific detection of pollutants or nutrients in foods.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2019
·
IF 2.722
Lingling Ding,Haijun Tao,Chuanxiang Zhang,Jiwei Li,Wenjun Zhang,Jiayue Wang,Jianjun Xue
The hole transport layer (HTL) free carbon based perovskite solar cells (Carbon PSC) are known for low cost, good stability and commercial manufacturing technology . Compared to the structure of traditional cells, the carrier transport performance between the absorber layer and the carbon electrode (CE) is poor. As an excellent P-type material, NiO has been doped in CE for obtaining a better performance of PSCs. However, NiO will inevitably reduce the conductivity of the CE due to the poor conductivity, thus failing to fully exploit the advantages of NiO in hole extraction. In this paper, rGO/NiO composites were successfully prepared by doping rGO with good conductivity, which not only improved the conductivity of the CE, but also ensured good hole extraction of the doped CE. The carrier transport in the cell was significantly improved, resulting in 32% increase in the short circuit current density (J sc ). The performance of perovskite solar cells was optimized by doping the CE, and the power conversion efficiency (PCE) of the cell was increased from 5.48% to 8.50%.
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COMPOSITES COMMUNICATIONS
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2019
·
IF 0
Yunhua Yang,Liang Xiong,Xiaomo Huang,Qingshan Shi,Wei-De Zhang
In this work, we used p-hydroxybenzoic anionic intercalated MgAl-layered double hydroxides (MgAl-(p-BzOH)-LDH) as a filler to modify waterborne polyurethane , and successfully synthesized novel WPU/MgAl-(p-BzOH)-LDH composites. CO 3 2- -type MgAl-LDH was firstly synthesized via hexamethylenetetramine hydrolysis method and then was transferred to p-BzOH-intercalated MgAl-LDH by ion exchange. The nanostructured MgAl-(p-BzOH)-LDH was then grafted by isophorone diisocyanate (IPDI), forming [MgAl-(p-BzOH)-LDH] NCO complex with NCO group on the surface, which promotes its homogeneous dispersion in WPU matrix through chemical bonding. The mechanical properties and water resistance of the composites were improved upon loading the MgAl-(p-BzOH)-LDH in certain levels. Furthermore, the composites can slowly release p-hydroxybenzoic anionic into the surrounding environment, and thus exhibit significant antibacterial activity towards G( _ ) Escherichia coli and G(+) Staphylococcus aureus.
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CHEMICAL ENGINEERING SCIENCE
·
2019
·
IF 3.372
Mingyue Liu,Renliang Huang,Chuanxi Li,Mingda Che,Rongxin Su,Shuzhou Li,Jing Yu,Wei Qi,Zhimin He
Nanoscale zero-valent iron has been widely applied in environmental remediation and toxic waste treatment, especially for the degradation of persistent organic pollutants (POPs). However, the dechlorination activity of Fe nanoparticles (Fe NPs) can be suppressed by the precipitation of iron oxides generated from the corrosion of Fe-Pd NPs under alkaline conditions, leading to a decreased dechlorination efficiency. Faced with this challenge, we report a highly effective dechlorination system that functions over a broad pH range and especially well under alkaline conditions in this work. Procyanidin (PROC), a natural polyphenol, was utilized as a stabilizer to manipulate the size distribution of Fe-Pd NPs and, more importantly, as a scavenger of Fe ions to prevent iron oxide precipitation. Experiments and theoretical calculations reveal that the generated Fe ions was mainly present in the form of bis- and tris-PROC-Fe complexes in the reaction solution. Compared with pristine Fe-Pd NPs, the PROC-modified Fe-Pd NPs had a dechlorination efficiency that was increased 20-fold (pH 9.0). Notably, a normalized rate constant was enhanced by more than 2 orders of magnitude compared to the previously reported dechlorination systems. The PROC-modified Fe-Pd NPs showed excellent dechlorination efficiency over a wide pH range (2.3–13.0).
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CHEMICAL ENGINEERING JOURNAL
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2019
·
IF 8.355
Yan Zhou,Zixin Jia,Lingling Shi,Zhen Wu,Binyong Jie,Siyuan Zhao,Liyuan Wei,Aiguo Zhou,Junwu Zhu,Xin Wang,Yongsheng Fu
Young-Laplace equation and Kelvin equation, as two important and foundational laws in interface physico-chemistry, can reasonably interpret many complicated physico-chemical phenomena at interfaces and have been widely applied to many practical problems arisen from the production and humankind activities. In this work, by means of the large pressure difference generated on a curved surface of nano-sized liquid under the action of surface tension, the transformations from the hollow carbon nanospheres to the carbon nanobowls and the phosphorus-doped carbon nanobowls have been successfully achieved. Compared with the hollow carbon nanospheres, the carbon nanobowls and phosphorus-doped carbon nanobowls possess high packing densities, which are beneficial to form a favorable conductive pathway, leading to enhanced electrochemical performance. In particular, the phosphorus-doped carbon nanobowls, as electrode material for supercapacitors, show a high specific capacitance of 246.22 F cm −3 (273.58 F g −1 ) and can maintain the capacitance at a high current density of 10 A g −1 without noticeable decay over 40,000 cycles. More importantly, the symmetric supercapacitor based on the phosphorus-doped carbon nanobowls exhibits high energy density and power density as well as excellent cycling stability. This work widens the application of Young-Laplace equation in bowl-like materials and offers new insights into the formation mechanism.
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危险品化学品经营许可证（带存储）