Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 5
·123631
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IF 7.5
Tingting Wang,Youfeng Shan,Xinbo Yao,Fuxun Ai,Wenchao Du,Yuanyuan Sun,Jichun Wu,Hongyan Guo
Nitrobenzene (NB) is a highly toxic and persistent groundwater contaminant that poses significant challenges for in situ remediation. Herein, an injectable persulfate (PS) controlled-release gel (CSG) was synthesized from environmentally friendly precursors via a facile room-temperature sol-gel method. CSG exhibited stable PS release under a wide pH range and representative groundwater matrix conditions. In dynamic column experiments, CSG sustained PS release over 42 pore volumes, approximately 17 times longer than free PS injection. The CSG was further coupled with micro zero-valent iron (mZVI) for the remediation of NB-contaminated groundwater. Compared with the conventional mZVI + PS system, controlled PS release in the mZVI + CSG system improved PS utilization and achieved a 2.4-fold higher NB removal efficiency. The mZVI + CSG system maintained high NB removal efficiency under different pH conditions, coexisting ions, and organic matter. Mechanistic analyses suggested that CSG regulated PS flux, while mZVI supplied reactive Fe⁰/Fe²⁺ species for reductive transformation and PS activation. NB removal proceeded through both direct oxidation and reduction-oxidation coupling pathways. SO₄ • − and •OH were identified as the dominant reactive oxygen species responsible for NB degradation. Overall, the mZVI + CSG system offered a feasible strategy for in situ remediation of NB-contaminated groundwater.
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高影响因子
Nanomedicine
·
2023
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IF 5.5
Siying Wang,Feng Han,Lanlan Xie,Yanjie Liu,Qilei Yang,Dongmei Zhao,Xiuhua Zhao
Aim: To formulate and assess the anticancer effect of the poly(lactic-co-glycolic acid) (PLGA) copolymer with the thioether groups (diethyl sulfide [Des]) and disulfide bond (cystamine containing disulfide [Cys]), which encapsulated the anticancer drug paclitaxel (PTX) and triggered PTX release in cancer cell H2O2-rich or glutathione-rich surroundings. Methods: PLGA-b-P (Des@Cys) and PLGA-b-P nanoparticles loaded with PTX were prepared and characterized in vitro. The delivery ability of the PLGA-b-P nanoparticles and PLGA-b-P-PTX nanoparticles was assessed on a CT26 (mouse colon cancer cell line) and mouse lung cancer LLC model. Results: The nanoparticles were successfully prepared. Compared with free PTX, the formulated PLGA-b-P nanoparticles loaded with PTX exhibited greater accumulation at the tumor site in the mouse model. Conclusion: PLGA-b-P nanoparticles promote drug accumulation at tumor sites, providing an effective strategy for an intelligent, responsive drug-delivery system.
研究领域:
药学
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纳米技术
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癌症研究
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药物递送系统
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高影响因子
FIELD CROPS RESEARCH
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2026
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IF 7.9
Wenjing Yin,Yongshan Wan,Guoqing Hu,Guiyang Sun,Yingjie Wu,Fengzhen Liu,Kun Zhang,Yuanjie Dong
Context The peanut ridge mulching system in North China exacerbates the imbalance between water and fertilizer supply and crop demand. Combining water retaining agents (SAPs), nitrogen inhibitors (NIs), and coated urea is a promising strategy to mitigate water fertilizer conflicts. However, conventional coated fertilizers only slightly improve fertilizer use efficiency, making effective water fertilizer synergistic regulation difficult. Thus, further research on integrated application strategies is urgently needed. Objectives This study aimed to develop a novel water-retaining, efficiency-enhancing, controlled-release nitrogen fertilizer (WRSIU) and to elucidate the mechanisms by which coordinated water-nitrogen (N) regulation improves peanut yield, nitrogen use efficiency (NUE), and water use efficiency (WUE). Methods Firstly, hydroquinone (HQ) and dicyandiamide (DCD) were first sprayed onto the surface of urea granules, followed by epoxy resin coating to produce dual controlled-release urea (DCRU). Subsequently, a γ-polyglutamic acid/acrylic acid interpenetrating network copolymer (PGA/PAA-IPN) was synthesized and coated onto the surface of DCRU to obtain WRSIU. The properties of PGA/PAA-IPN and WRSIU were characterized and evaluated via laboratory experiments. Field experiments were then conducted synchronously at two sites. Six treatments were established: CK (no nitrogen fertilizer), U (regular urea), CU (epoxy resin-coated urea), DCRU, WRSBU (DCRU + PGA/PAA-IPN, physical blending), and WRSIU. Results A compact multilayer structure consisting of an inhibitor layer, epoxy resin layer, and water retaining composite layer was formed on the surface of WRSIU granules. At a coating rate of 9%, the controlled-release durations of N, HQ, and DCD were 56, 42, and 34 days, respectively. Compared with CU, ammonia volatilization and N leaching were reduced by 29.53% and 18.78%, respectively. Field results showed that WRSIU significantly increased dry matter accumulation in multiple organs at maturity. Inhibition of soil N transformation enzymes persisted until the pod setting stage, leading to increases in soil NO₃⁻-N and NH₄⁺-N contents of 7.62–29.33% and 14.67–23.27%, respectively. WRSIU significantly enhanced the coupling coordination degree ( D ) of soil water and N, particularly during the pod setting stage, with D values increasing by 44.90–63.48% compared with CU. Consequently, yield, WUE, and N fertilizer apparent utilization efficiency (NFUE) increased by 12.15–15.45%, 31.32–43.58%, and 12.46–33.73%, respectively. Economic analysis indicated that although the fertilization cost of WRSIU was 54.96 $·ha⁻¹ higher than that of CU, but net benefits rose by 584.74 and 556.52 $·ha⁻¹ in Jining and Tai’an, respectively. Conclusions WRSIU integrates three key functions-water retention, controlled N release, and nutrient loss inhibition. It synchronizes soil water and N availability with plant demand, mitigates ammonia volatilization and nitrate leaching, and enhances yield, NUE, and WUE.
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JOURNAL OF POLYMER RESEARCH
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2021
·Vol. 28
·期 8
·1-10
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IF 3.097
Xing Jianyu,Dang Wenwen,Li Jingchang,Huang Jumei,Bai Bo,Zheng Dan,Zhang Xiao
Stimuli-responsive controlled release system is an effective way to increase the efficiency of agrochemicals and reduce environmental pollution. In this work, a novel polypyrrole@gelatin/poly (acrylic acid) (PPy@Gel/PAA x ) hydrogel with a semi-interpenetrating network structure was synthesized by gelatin, polypyrrole (PPy) and acrylic acid (AA). The structure and property of the hydrogel were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, ultraviolet–visible spectroscopy and infrared imaging. The efficiency of the controlled release system was systematically studied by using carbendazim as a template drug. The results indicated that PPy@Gel/PAA x not only has outstanding light-sensitive property, but also has good water retention performance. Therein, PPy used as a light-sensitive component, could convert the absorbed light energy into heat energy. This kind of photothermal conversion could lead to helix-coil structural transition of gelatin which promotes the release of carbendazim by changing the pore diameter of the hydrogel. Consequently, excellent controlled-release capacity and water retention performance enable PPy@Gel/PAA x hydrogel to be a potential candidate in agricultural application.
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Arabian Journal of Chemistry
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2023
·
IF 6
Abid Naeem,Chengqun Yu,Yali Liu,Yali Feng,Jinhui Fan,Yongmei Guan
The development of controlled-release preparations for herbal medicines remains challenging due to their complex compositions and distinct physicochemical properties. Tripterygium Wilfordii (TWHF) is a traditional Chinese medicine used to treat inflammatory diseases like rheumatoid arthritis, neurodegenerative and autoimmune diseases. The main active ingredients include diterpenes, triterpenes and alkaloids. These agents have poor pharmacokinetic and physicochemical characteristics, making it difficult to achieve therapeutic benefits. In the present study, a solid dispersion of TWHF (TWHF-SD) was prepared and loaded into Gelatin-grafted-2-Acrylamido-2-methylpropane sulfonic acid hydrogels (Gelatin-g-AMPS) for controlled drug release. A total of 48 compounds were identified in TWHF-SD using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) analysis. The hydrogel's structure and physicochemical properties were confirmed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Thermogravimetric analysis (TGA), and Differential Scanning Calorimetry (DSC). Studies regarding hydrogel structure–function relationships were conducted, such as average weight between two or mor crosslinks (Mc), polymer volume fraction (V2,s), and diffusion coefficient (D). Hydrogel swelling and drug release from loaded hydrogels were slightly higher at pH 1.2 (swelling ratio of 60.84%, drug release of 85.08) than at pH 7.4 (swelling ratio of 46.46%, drug release of 75.03%) after 48 h. The gel fraction of hydrogel increased with increasing polymer/crosslinker ratios. Additionally, in vitro studies confirmed that the developed hydrogels were effective against bacterial growth and had good antioxidant properties.
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CERAMICS INTERNATIONAL
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2016
·
IF 2.758
An-Nan Chen,Jia-Min Wu,Meng-Yue Liu,Li-Jin Cheng,Jing-Yan Chen,Huan Xiao,Xiao-Yan Zhang,Chen-Hui Li,Yu-Sheng Shi
Rapid in-situ solidification of SiO 2 suspension under the joint action of releasing calcium ions and shifting pH has been proposed. When the suspension was heated up to 60 ℃, decomposition of calcium iodate which released calcium ions , as well as hydrolysis of diacetate (GDA) which shifted the pH toward the isoelectric point, both contributed to the solidification of suspension. The controlled coagulation of SiO 2 suspension could be realized via controlled release of high valence counter ions and pH shift at 60 ℃ within 30 min, which could considerably shorten the coagulation time compared with present reported results (1–3 h). Green body prepared by heating the SiO 2 suspension with 6.5 g L −1 calcium iodate and 2.0 vol% GDA at 60 ℃ for 30 min shows uniform microstructure with compressive strength of close to 0.3 MPa. SiO 2 ceramics sintered at 1275 ℃ for 3 h possess homogeneous microstructure with bulk density of 2.06 g cm −3 and flexural strength of 40.3 MPa.
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BIOMACROMOLECULES
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2015
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IF 5.75
Jianming Pan,Runrun Wu,Xiaohui Dai,Yijie Yin,Guoqing Pan,Minjia Meng,Weidong Shi,Yongsheng Yan
We chemically integrated mesoporous silica nanoparticles (MSNs) and macroporous bowl-like polylactic acid (pBPLA) matrix, for noninvasive electrostatic loading and long-term controlled doxorubicin (DOX) release, to prepare a hierarchical porous bowl-like pBPLA@MSNs-COOH composite with a nonspherical and hierarchical porous structure. Strong electrostatic interaction with DOX rendered excellent encapsulation efficiency (up to 90.14%) to the composite. DOX release showed pH-dominated drug release kinetics; thus, maintaining a weak acidic pH (e.g., 5.0) triggered sustained release, suggesting the composite’s great potential for long-term therapeutic approaches. In-vitro cell viability assays further confirmed that the composite was biocompatible and that the loaded drugs were pharmacologically active, exhibiting dosage-dependent cytotoxicity. Additionally, a wound-healing assay revealed the composite’s intrinsic ability to inhibit cell migration. Moreover, pH- and time-dependent leaching of the integrated MSNs due to pBPLA matrix degradation allow us to infer that the leached (and drug loaded) MSNs may be engulfed by cancer cells contributing to a second wave of DOX-mediated cytotoxicity following pH-triggered DOX release.
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PubMed
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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2024
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IF 3
Yuan Bihe,Wu Shusheng,Zhao Huidong,Niu Yi,Gao Zeyang,Zhu Yu,Kong Yue,Jin Hang,Wang Pengcheng
The combustion of polystyrene (PS) releases enormous amounts of smoke and heat, which seriously affects individuals and property safety. This research employed a porous metal–organic framework (P-Fe-MOF) with excellent adsorption properties to fix 1,1'-bis(diphenylphosphino)ferrocene (BDF) into its porous channels to form a novel flame-retardant system. The peak heat release rate (PHRR) of the neat PS is reduced by 49.3% (from 1128 to 572 kW m −2 ) with the addition of 3 mass% of D-Fe-MOF, while the time to reach the peak is delayed form 170 to 250 s. Additionally, there is an obvious enhancement in thermal stability. The temperature at initial mass losses is significantly delayed from 331 °C for bulk PS to 379 °C for PS/D-Fe-3.0. And the char residue at 700 ℃ is increased from 1.27 to 3.24 mass%. Compared with pure PS, the char residue of PS/D-Fe-MOF is continuous and dense due to the excellent catalytic performance of D-Fe-MOF in the combustion of composites. This research presents a new flame-retardant design strategy and reduces the fire risk of PS, which provides valuable enlightenment for broadening the application field of MOF and improving the comprehensive properties of polymers.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Wenli Yang,Qiurong Liang,Ziqing Zeng,Kewen Yang,Weijing Shao,Xuecai Tan,Shaogang Liu,Rihui Su,Jun Yan
STF 4 stabilizes Tea Tree Oil with 84.2% encapsulation efficiency in emulsion. • STFEF 10 achieves 98% sterilization via photothermal synergy. • STFEF 10 had enhanced mechanical and UV/water vapor/oxygen barrier properties. • STFEF 10 can effectively prolong the shelf life of berries. Natural antimicrobial agents are both environmentally friendly and safe, and exhibit excellent biocompatibility. However, their instability and rapid release characteristics limit their application in food preservation packaging. In this study, a photothermal-responsive packaging film was developed by incorporating a Pickering emulsion of soy protein isolate-tannic acid-Fe 3+ (STF) nanoparticles stabilizing tea tree oil (TTO) into a chitosan (CS)/gelatin (Gel) matrix. The STF nanoparticles, synthesized via coordination-driven self-assembly, stabilized the Pickering emulsion and achieved an encapsulation efficiency of 84% for TTO. Under near-infrared (NIR) irradiation, STF nanoparticles transform light energy into thermal energy. On the one hand, the localized increase in temperature provides the film with a certain sterilizing effect. On the other hand, the film allows for the rapid, controlled release of tea tree oil as needed. Through the synergistic effect of localized thermal therapy and controlled release of essential oils, the film exhibits over 98% antibacterial activity against E. coli and S. aureus . Furthermore, the resultant film has outstanding mechanical strength, barrier properties, and antioxidant effects. Preservation experiments were ultimately carried out using strawberries and grapes as representative berries, and the results showed that the film can extend the shelf life by 3–8 days depending on the fruit type. These results demonstrate the application potential of this photothermal controlled-release film in the field of berry preservation. Download: Download high-res image (136KB) Download: Download full-size image
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Liuzi Du,Xiaodong Zhai,Xinyang Han,Ke Zhang,Junjun Zhang,Xiaobo Zou,Zhihua Li,Zhikun Yang,Quancai Sun,Ye Peng,Xiaowei Huang
A bilayer TPU film integrating volatile-amine-responsive colorimetric sensing and sustained antibacterial release. • Bromocresol purple/fluorescein enabled dual colorimetric and fluorescent responses over a broad pH range. • Carvacrol/tea tree oil-loaded L/HKUST-1 inhibited both Gram-positive and Gram-negative bacteria. • The film showed reversible responses to NH 3 , DMA, and TMA, while ΔE correlated well with beef TVB-N ( R 2 = 0.9417). • The bilayer film delayed refrigerated beef deterioration by about 4 days and enabled freshness monitoring. A bilayer TPU-based intelligent packaging film integrating colorimetric sensing and antibacterial preservation was developed. The film consisted of a dense cast TPU indicator layer containing a bromocresol purple/fluorescein indicator and an electrospun TPU antibacterial layer loaded with lignin-modified HKUST-1 loaded with carvacrol and tea tree oil. The indicator showed reversible responses to ammonia, dimethylamine, and trimethylamine, with detection limits of 0.37, 0.15, and 0.18 μ M, respectively. Lignin modification improved the aqueous structural retention of HKUST-1, and the electrospun layer exhibited sustained, pH-dependent release of the antibacterial components. Water vapor permeability was further evaluated under both 25 and 4 °C conditions. The film showed antibacterial activity against the four tested bacterial strains ( Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , and Bacillus subtilis ), while its extracts caused no detectable cytotoxicity under the tested conditions. In refrigerated beef, the selected TBF3-T-LH@CT formulation delayed quality deterioration by approximately 4 days and provided visible freshness indication from yellow to orange-red. The color variation correlated well with beef spoilage indicators, supporting visual freshness monitoring. These results demonstrate the potential of the bilayer film for intelligent active food packaging. Download: Download high-res image (212KB) Download: Download full-size image
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高影响因子
Food Packaging and Shelf Life
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2021
·
IF 6.429
Lijing Lu,Yingjie Su,Jing Xu,Haoyue Ning,Xueyu cheng,Lixin Lu
In order to inhibit the spoilage of the packaged food , a gas phase controlled-release low-density polyethylene (LDPE) film containing carvacrol loaded with halloysite nanotubes (HNTs) was prepared and studied in this work. HNTs were etched by 4 mol/L hydrochloric acid to obtain HNT-4M, which increased the carvacrol loading capacity. Then, it was characterized before and after loading with carvacrol by transmission electron microscopy , nitrogen adsorption isotherms, and thermogravimetric analysis . A new LDPE film containing carvacrol adsorbed on HNT-4M was prepared by extrusion, and the physical properties were studied. In addition, the release rate of carvacrol in the film was measured, and the antibacterial and antioxidant properties of the film were evaluated. The results showed that the carvacrol load of HNT increased from 6.7% to 24.2% after acid etching. The diffusion coefficient of carvacrol from the active film containing HNT-4 M/carvacrol was 9.546 × 10 -12 cm 2 ·s -1 , which was decreased by 57.3% compared with the films directly adding carvacrol. Moreover, according to the DPPH radical scavenging assay and micro-atmosphere diffusion antibacterial test, it was verified that carvacrol retained its antioxidant activity and antibacterial activity in the new film.
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Environmental Science-Nano
·
2023
·Vol. 10
·期 4
·1016-1029
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IF 7.3
Kunyan Guo,Xile Deng,Yajun Peng,Ni Yang,Kun Qian,Lianyang Bai
Pretilachlor (Pre) is an efficient and broad-spectrum pre-seedling herbicide; however, the excessive use of the Pre traditional formulation causes phytotoxicity to rice seedlings (Oryza sativa), toxicity to soil organisms, and great environmental pollution. 4-(Dichloroacetyl)-1-oxa-4-azospiro[4,5]decane (AD-67) is a herbicide safener and it can reduce the phytotoxicity of herbicides to plants, but it degrades slowly in the aquatic environment, and extensive application leads to a wide range of negative environmental impacts. To reduce the frequency of application and increase the safety of non-target organisms, for the first time, an herbicide-safener nano-double controlled release system AD-67@Pre@ZIF-67 was successfully constructed. Pre was encapsulated in ZIF-67, metal–organic framework (MOF), and the safener AD-67 was adsorbed by self-assembly on the surface of the MOF. The release rates of Pre and AD-67 increased with the decrease in the pH value. With the lowest pH value (5.8), Pre and AD-67 were released 57% and 78% rapidly in the first 2 h, respectively, then were slowly released, and the overall releases were 86% and 96% on the 7th day, respectively. Hence, the safener AD-67 can be released quickly to protect the rice seedlings from injury caused by Pre, while Pre can release slowly from nano-double controlled release for a longer duration and show lower phytotoxicity to rice. Compared to the pre-treatment, the relative root length, relative plant height, and relative fresh weight values of rice seedlings treated with AD-67@Pre@ZIF-67 were increased by 50%, 40%, and 62%, respectively. AD-67@Pre@ZIF-67 also had lower acute toxicity to earthworms (Eisenia foetida), with the 24 h and 48 h LC50 values, which were 6 times and 5 times than that of Pre, respectively. The results showed that AD-67@Pre@ZIF-67 did not only improve the herbicidal activity to target weed barnyard grass (Echinochloa crusgalli) but also met the requirements of minimizing the adverse effects of herbicides on crop plants and environments. This shows the great application prospects in modern agriculture.
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危险品化学品经营许可证（带存储）