Nature Communications
·
2026
·Vol. 17
·期 1
·5028
·
IF 18.1
Wu Xingjie,Xiong Shasha,Zhang Litao,Zhao Yueyue,Sun Zhilu,Wang Likun,Long Weifeng,Guo Qianqian,Wang Yu-E,Chen Ying,Tao Ling,Li Wei,Shen Xiangchun,Wu Guofeng,Zhao Haitao
Diagnosing intracerebral hemorrhage (ICH) in prehospital settings remains challenging due to unavailability of immediate neuroimaging, clinical overlap with ischemic stroke, and absence of validated circulating biomarkers for time-critical settings. Extracellular vesicles (EVs), subcellular structures capable of transporting biomolecular payloads (e.g., proteins, nucleic acids) across the blood-brain barrier, have emerged as compelling diagnostic candidates for ICH. Nevertheless, their clinical translation has been impeded by inherent biophysical heterogeneity, particularly polydisperse size distributions. To address this limitation, we engineer a s teric h indrance-mediated E V a nalysis and size f ractionation (SHEAF) platform, integrating steric hindrance-based size fractionation with membrane protein profiling to stratify EVs into three size subtypes within a 45-min workflow. Systematic evaluation using the SHEAF platform reveals that the 90 − 180 nm EV subtype exhibits superior discriminative capacity in differentiating ICH from ischemic stroke plasma specimens. This technology not only advances rapid prehospital ICH diagnostics but also establishes a method for elucidating size-dependent EV functionalities across neurological pathologies.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Qiao Xiya,Zhao Mingtao,Gao Lihua,Sun Zhongqi,Hu Ze,He Zhijun
Spinel-type nickel manganate (NiMn 2 O 4 ) has significant application value in areas such as energy storage, sensing, and thermosensitive materials, due to its excellent physical and chemical properties. In this study, during synthesis of Ni x Mn 3-x O 4 (0 < x < 3), the spinel NiMn 2 O 4 with a saturation magnetization (Ms) of 3.52 emu/g was synthesized at 1200 °C for 120 min in an air atmosphere with a Ni/Mn molar ratio of 1:2. Additionally, the synthesized NiMn 2 O 4 samples had a BET surface area of 3.06 m 2 /g, a total pore volume of 0.059 cm 3 /g, a specific surface area (SSA) of 8.87 cm 2 /g, and an average pore size (APS) of 26.44 nm. Compared with traditional methods, the simultaneous presence of normal and inverse spinel NiMn 2 O 4 was prepared by oxidation roasting technology, resulting in slight differences in crystal structure parameters. This work demonstrates that the oxidation roasting process is an effective route for synthesizing spinel nickel manganate (NiMn 2 O 4 ), where normal and inverse spinel structures inevitably coexist and intertransform, with their ratio being controlled by synthesis parameters.
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Nature Communications
·
2026
·
IF 18.1
Gao Guowei,Li Boxin,Huo Xiaomei,Du Zhuzhu,Guan Yuhao,Lin Fangyue,Zhou Zhenkai,Yu Xin,Bi Jingxuan,Ai Wei
Disordered dendrite growth and corrosion reactions of zinc negative electrodes remain critical challenges in aqueous zinc metal batteries. Regulating water states in shear-thickening non-Newtonian fluid electrolytes has emerged as a promising strategy to simultaneously suppress dendrite growth and corrosion for zinc negative electrodes. Herein, we design a multifunctional shear-thickening non-Newtonian fluid electrolyte, based on carboxymethyl cellulose and sulfonate silicon oxide nanoparticles, which addresses both issues through hierarchical regulation of water molecule states. Carboxymethyl cellulose converts free water into weakly bound water, thereby suppressing water-induced parasitic reactions. Concurrently, sulfonated SiO 2 nanoparticles form an integrated shear-thickening network with amylopectin and carboxymethyl cellulose while introducing abundant surface –SO 3 ⁻ groups that disrupt the strongly bound water layer at the zinc interface. This architecture enables localized mechanical stiffening at dendrite tips without compromising ionic conductivity. As a result, Zn | |Zn symmetric cells exhibit stable Zn plating/stripping for 900 h at 50 mA cm⁻ 2 and 25 mAh cm⁻ 2 , and Zn | |I 2 pouch cells with a capacity of 1.5 Ah maintain stability over 200 cycles at 20 mA cm⁻ 2 . These findings offer a alternative pathway toward corrosion-resistant, mechanically adaptive aqueous and practical zinc pouch cells systems.
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高影响因子
IONICS
·
2026
·Vol. 32
·期 6
·6617-6626
·
IF 3.4
Tang Yiming,Zhu Xiangyu,Dong Shiyu,Guo Jing,Shen Chunhui,Gao Shanjun
Sulfonated poly(ether ether ketone) (SPEEK)-based proton exchange membranes have emerged as promising alternatives to Nafion for proton exchange membrane fuel cells; however, their long-term mechanical and chemical stabilities remain key challenges for practical applications. In this work, a series of SPEEK composite membranes were fabricated by incorporating inorganic proton conductors zirconium phosphate (ZrP) and layered double hydroxides (LDHs), a novel functional nanomaterial, into a SPEEK matrix with a degree of sulfonation (DS) of 63%. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) analyses confirmed the uniform dispersion of ZrP and LDHs within the polymer matrix and revealed the formation of continuous proton conduction pathways. The resulting composite membranes demonstrated enhanced mechanical strength and thermal stability. Swelling behavior and water uptake measurements showed that the incorporation of LDHs effectively suppressed dimensional changes in the membranes. Specifically, when the mass ratio of ZrP to LDHs was optimized at 8:2, the SPEEK-2 membrane exhibited a swelling degree of 15.7%, significantly lower than that of the pristine SPEEK membrane. Furthermore, under conditions of 80 °C and 100% relative humidity, the ionic conductivity of the SPEEK-2 membrane reached 217.9 mS cm − 1 , representing a 25.7% improvement over the unmodified membrane. These results demonstrate a viable strategy for enhancing the performance and durability of proton exchange membrane materials.
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JOURNAL OF ELECTRONIC MATERIALS
·
2026
·
IF 2.8
Li Qiu,Zhang Tingting,Wang Yu,Li Xi,Nie Congcong,Lv Changpeng,Song Jingjing,Huang Qihao,Wu Fang
Ni(OH) 2 is considered as one of most promising oxygen evolution reaction (OER) catalysts owing to its low cost and earth abundance. Nevertheless, the low conductivity and poor intrinsic activity of Ni(OH) 2 seriously restricts its industrial application. Meanwhile, the relationship between the structure, OER activity of Ni(OH) 2 -based catalysts, and transition-metal dopants is still unclear. To meet above challenges, a series of Ni(OH) 2 –M (M = Fe, Al, Co, Cr) was prepared by a simple hydrothermal method. The experimental results confirmed that the incorporation of different metal elements into Ni(OH) 2 can not only alter the morphology and modulate electronic structure but also improve the intrinsic catalytic activity. Particularly, the Ni(OH) 2 –Fe exhibits the best OER activity, requiring 252 mV and 288 mV at 10 mA cm −2 and 100 mA cm −2 , with a Tafel slope of 39.1 mV dec −1 and superior stability (50 mA cm −2 for 30 h). This work provides a pathway to understand the relationship between structure, OER activity of Ni(OH) 2 -based catalysts, and incorporation of transition-metal elements, which facilitates the development of advanced OER electrocatalysts.
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高影响因子
CELLULOSE
·
2026
·
IF 4.6
Li Jingzhen,Zhou Jiayi,He Jiatai,Xu Hao,Wang Peng,Lu Ming,Wang Shu,Zhang Tonghua,Xiao Hang
Multifunctional membranes have recently attracted considerable attention as promising separation materials for the purification of complex oily wastewater, owing to their capability of simultaneously removing various contaminants. However, the organic polymer substrates utilized in multifunctional membrane fabrication suffer from low biodegradability and poor environmental compatibility, and their preparation processes are often technically complex. In this study, a multifunctional membrane based on cotton fabric (CF) was fabricated through the grafting of polyethyleneimine (PEI) and the deposition of titanium dioxide nanoparticles (TiO 2 NPs) via a surface micro-dissolution technology. The prepared membrane exhibited excellent oil/water separation, as well as remarkable performance in dye removal, heavy metal ion adsorption, and antibacterial activity. Specifically, it achieved a water flux of 1189 L/(m 2 h) for oil/water mixtures while maintaining separation efficiencies above 98%. The modified CF-based membrane also exhibited removal efficiencies of 96.3% for Congo red and 67.8% for chromium ions, respectively. Furthermore, antibacterial assessment revealed that the membrane generated inhibition zones of 8 mm for Escherichia coli and 5 mm for Staphylococcus aureus after a 6 h contact period, indicating satisfactory antibacterial performance. More than 83% of the membrane’s adsorption was recovered after a facile cleaning step, indicating good regeneration performance. Moreover, the membrane demonstrated satisfactory stability under harsh conditions. This work may provide a facile approach for fabricating multifunctional fabric-based membranes for the effective removal of contaminants in complex oily wastewater. Graphical abstract
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高影响因子
HISTOCHEMISTRY AND CELL BIOLOGY
·
2026
·Vol. 164
·期 1
·19
·
IF 2.9
Tang Yingqi,Wang Siyao,Wang Yu,Zhang Tianyuan,Liu Yu,Di Yunhua
Renal tubular damage and interstitial fibrosis are highly linked to diabetic kidney disease (DKD) progression. Ferroptosis in renal tubular epithelial cells has emerged as one of the key mechanisms of DKD. Spermidine/spermine N1-acetyltransferase 1 (SAT1) knockdown has been found to alleviate repetitive low-dose cisplatin-induced kidney damage and fibrosis, and importantly, SAT1 silencing represses cellular sensitivity to ferroptosis. However, the effect of SAT1 on DKD-associated ferroptosis and its potential mechanism remain understood. In this study, we constructed a high-fat diet/streptozotocin-induced DKD mouse model and a high glucose (HG)-injured HK-2 cell model with the aim of verifying whether SAT1 silencing attenuates DKD tubular damage by regulating ferroptosis. We found that SAT1 was upregulated in DKD mouse kidneys and HG-treated HK-2 cells. Significant tubular damage, fibrosis, ferroptosis, and oxidative stress were observed in DKD mouse kidneys. In an in vitro loss-of-function assay, SAT1 silencing suppressed HG-induced HK-2 cytotoxicity, extracellular matrix (ECM) synthesis, and inflammation. Additionally, SAT1 silencing decreased HG-activated MDA and 4-HNE production, while restoring GSH levels. SAT1 silencing also abrogated HG-activated ferroptosis in HK-2 cells, as evidenced by a reduction in iron overload, inhibition of lipid peroxidation, and upregulation of ferroptosis-related protein (SLC7A11, GPX4, and TFR1) expression. Mechanistically, SAT1 silencing facilitated nuclear translocation and expression of NRF2. Impairment of NRF2 function abrogated the inhibitory effects of SAT1 silencing on HG-stimulated HK-2 cytotoxicity, ferroptosis, and ECM accumulation. Overall, the SAT1/NRF2 axis is a critical regulator of tubular damage in DKD, and suppression of SAT1 may be an underlying target for DKD treatment.
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高影响因子
CELL BIOLOGY AND TOXICOLOGY
·
2026
·
IF 5.7
Na Zhan,Yufeng Wang,Ru Liang,Yousen Wu,Ting Huang,Yuquan Ling,Xinbei Chen,Jiacheng Deng,LiFen Zhou,Kangni Luo,Yilin Cai,Yong-Sheng Tu,Lihui Qu,Jianhua Li
Wood smoke (WS)-derived PM 2.5 is a major environmental risk factor for emphysema, but the role of macrophage-derived exosomes remains unclear. Here, we show that chronic WS exposure in rats induces emphysematous lesions accompanied by markedly increased exosome release, reflected by elevated CD63 expression in alveoli and increased exosome particle number in bronchoalveolar lavage fluid. Pharmacological inhibition of exosome secretion with GW4869 significantly attenuated alveolar destruction. Moreover, intranasal administration of exosomes from PM 2.5 -exposed macrophages was sufficient to recapitulate emphysematous pathology in vivo. Mechanistically, PM 2.5 exposure upregulated the membrane-trafficking protein SNAP23 in macrophages, enhancing exosome secretion and increasing total abundance of ADAM10 within exosomes. Co-localization of CD63 and ADAM10 was observed in alveolar regions of WS-exposed rats and COPD patient lungs. Silencing ADAM10 suppressed caspase-3 activation and reduced epithelial apoptosis, supporting a role for exosomal ADAM10 in driving caspase-3-dependent alveolar epithelial injury. By defining an exosome-mediated macrophage-epithelium pathway that contributes to PM 2.5 -induced emphysema, this study clarifies how combustion-derived PM 2.5 damages lung structure and offers mechanistic insight to reducing the health burden of biomass-related air pollution.
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高影响因子
Emergent Materials
·
2026
·Vol. 9
·期 4
·73
·
IF 4
Li Yi,Li Yuanxia,Han Linjun,Liu Qibin
In this paper, the effect of the sol–gel network structure generated by the reaction of a novel composite hydroxyl-capped polydimethylsiloxane (HPDMS), tetraethoxysilane(TEOS), 3-(isobutyryloxy) propyltrimethoxysilane(KH-570), and poly(methylhydrogen siloxane) (PMHS) on the hydrophobic performance of hemihydrous phosphogypsum (HPG) was investigated. The prepared composite hydrophobic agent (abbreviated as TH hydrophobic agent) was mixed with HPG slurry to explore the effect on the hydrophobic properties of HPG and to analyze the hydrophobic mechanism of its sol–gel network structure. Results showed that the TH hydrophobic agent improved HPG hydrophobicity, with the optimal 9% dosage yielding a maximum contact angle of 126.17°, a water absorption of 1.11%, a softening coefficient of 0.96, dry and water-saturated compressive strengths of 30.35 MPa and 29.25 MPa, an 89.8% reduction in water absorption and an 18.8% increase in softening coefficient compared to the blank sample. Compared with the blank sample, the water absorption decreased by 89.8%, the softening coefficient increased by 18.2%, and the dry compressive strength and water-saturated compressive strength increased by 11% and 215%, respectively. TEOS, KH-570, HPDMS, and PMHS can exert synergistic effects on HPG to further improve the hydrophobic properties of HPG.Compared with the modification efficacy of conventional silane-based hydrophobic modifiers for phosphogypsum, the composite sol–gel hydrophobic system fabricated in this study enables the reduction of phosphogypsum’s water absorption to 1.11% and the elevation of its contact angle to 126.17°. Notably, it achieves the synchronous enhancement of both dry and water-saturated compressive strengths, thus overcoming the technical bottleneck that traditional hydrophobic modifiers tend to impair the mechanical properties of phosphogypsum. Combined with the microscopic morphology analysis of the HPG samples, the appropriate proportion of TH hydrophobes filled the pores of the crystals, reduced the porosity, and changed the structure and morphology of the HPG crystals to some extent. The sol–gel network structure can chemically bond with the silanol groups in HPG from the inside out. Moreover, the sol–gel network structure chemically bonds with HPG’s silanol groups from the inside out and contains abundant methyl groups. These groups fully cover the hydroxyl groups on the HPG surface, block water molecule penetration, and thus turn phosphogypsum-based composites from hydrophilic to hydrophobic.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·246
·
IF 15
Bei Zhongwu,Tong Qi,Yang Yun,Ye Lin,Liang Shiyu,Li Jianan,Liu Jie,Liang Xuyue,Chen Wen,Liu Wenwen,Yu Xiaorui,Chu Bingyang,Shi Bi,Qian Zhiyong
Chronic non-healing wounds represent a severe complication of diabetes mellitus, which frequently progress to infection, limb amputation, and even mortality. The dysregulated wound microenvironment, marked by persistent inflammation and oxidative stress, severely impedes tissue repair, and the presence of MRSA biofilm infection further worsens these impairments and poses major clinical challenges. To address these challenges, we constructed a multifunctional injectable hydrogel (SOT) that integrates antibiofilm, antioxidant, and immunomodulatory properties. This hydrogel is formed through dynamic covalent crosslinking between thiolated hyaluronic acid (HA-SH) and dopamine-modified oxidized dextran (ODex-DA), which enables favorable injectability, self-healing, and in situ gelation. Tannic acid–silver nanoparticles (TA-Ag NPs) incorporated into the system impart antibiofilm and reactive oxygen species (ROS)-scavenging properties. In a diabetic MRSA biofilm infection model, the SOT hydrogel eradicated biofilms, reduced excessive ROS, and promoted wound closure. These findings suggest that this immuno-instructive hydrogel platform may offer a promising therapeutic approach for the treatment of MRSA biofilm-infected chronic diabetic wounds. Graphical
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Zhang Zhenlin,Yan Lang,Li Weiwei,Hu Jinyan,Wang Yang,Dou Hongjing,Pan Dengyu,Shen Longxiang,Shi Sheng,Geng Bijiang
In the development of clinically translatable triplet photosensitizers for hypoxia regulated photodynamic therapy (PDT), there is an unmet need for engineering sensitizers as near-infrared (NIR)-responsive, type I/type Ⅱ dual photosensitizers and mild photothermal agents. Herein, we develop a binary precursor-engineering strategy for precise regulation of the D-π-A configuration of carbon dots (CDs) as ultralong-lived triplet, type I/Ⅱ dual photosensitizers by utilizing phenolic hydroxyl as an electron-rich donor and pyridine N as an electron-withdrawing acceptor. The photodynamic performance of CDs is enhanced by intramolecular charge transfer and mild photothermal conversion. We further design M1-like macrophage-derived cell membrane‑camouflaged CDs to realize preferential tumor accumulation while guaranteeing rapid systemic clearance. D-π-A sensitized CD-mediated PDT induces anti-tumor activity against primary and distant tumors. Our work highlights the crucial roles of D-π-A sensitization of CDs in boosting PDT by triplet state tuning, surface charge transfer, and mild photothermal relief of hypoxia.
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高影响因子
MOLECULAR IMAGING AND BIOLOGY
·
2026
·
IF 2.5
Liao Sisi,Qi Qinli,Jin Lifang,Gong Jiali,Zhao Lingzhou,Zhao Jinhua,Zhu Meilin,Song Ningning
Purpose Sunitinib is an anti-angiogenic drug that can induce drug resistance characterized by hypoxia. We aimed to synthesize two novel radiolabeled LyP-1 peptides, 99m Tc-HYNIC-LyP-1 and 131 I-LyP-1, to detect sunitinib-induced changes in the tumor microenvironment and improve the therapeutic effects in triple-negative breast cancer (TNBC) mice models. Methods We synthesized 99m Tc-HYNIC-LyP-1 using hydrazinonicotinamide (HYNIC) as the chelating agent and labeled the LyP-1 peptide with 131 I using the chloramine-T method to synthesize 131 I-LyP-1. Radiochemical purity and stability of the peptides were assessed in vitro using thin-layer chromatography. Tumor accumulation and biodistribution of 99m Tc-HYNIC-LyP-1 were measured in 4T1 xenografts with or without sunitinib treatment. Immunohistochemical analysis was performed to detect sunitinib-induced changes. The therapeutic potential of 131 I-LyP-1 alone and in combination with sunitinib was evaluated in a TNBC mouse model. Results 99m Tc-HYNIC-LyP-1 and 131 I-LyP-1 could be readily prepared with satisfactory labeling efficiency (95.4% ± 0.6% and 72.5% ± 4.5%, respectively) and stability (both more than 90%) in vitro. Micro-single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging of mice transplanted with 4T1 tumors using 99m Tc-HYNIC-LyP-1 demonstrated that the uptake of this probe was high in 4T1 xenografts treated with sunitinib at 90 min, whereas it was mild in the control group. Semiquantitative analysis of the ratio of radioactivity intensity at tumor site to that of adjacent muscles (T/M value) showed that the average T/M value of the sunitinib treatment group at 90 min was 3.27, while it was 0.91 in the control group ( p = 0.0022). 131 I-LyP-1 could significantly inhibited tumor growth with good organ compatibility and had a synergistic therapeutic effect when combined with sunitinib, with an approximately threefold reduction in the tumor volume in comparison with the control group Conclusion Micro-SPECT/CT imaging using 99m Tc-HYNIC-LyP-1 can be used to monitor sunitinib-induced changes in the TNBC tumor microenvironment. The combination of 131 I-LyP-1 and sunitinib may serve as a novel treatment for TNBC.
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高影响因子
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