Separations
·
2024
·Vol. 11
·期 4
·116
·
IF 2.5
Guijiang Li,Wenze Xu
The escalating demand for cobalt in modern industry necessitates the recycling or extraction of this resource for sustainable development. Despite the abundance of lignin in nature, its utilization remains low, highlighting the need to enhance its value-added potential. This study focuses on the synthesis of quaternary ammonium lignin (QAL) and 2-ethylhexyl phosphoric acid mono-2-ethylhexyl ester (P507) as ionic liquid (QP–IL) compounds for the extraction of metal ions. A comparison of the extraction behavior of Co(II) and Ni(II) from chloride solution between QP–IL and P507 revealed varying extraction ratios under different conditions, with QP–IL demonstrating a higher cobalt extractability than P507. Furthermore, under identical conditions, QP–IL exhibited superior Co/Ni separation performance (βCo/Ni) compared to P507. Ultimately, QP–IL proved to be more effective than P507 in separating cobalt from mixed solutions.
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Bioengineered
·
2021
·
IF 3.269
Shujun Xu,Bingxin Wu,Biying Zhong,Luoqi Lin,Yining Ding,Xiao Jin,Zhiwei Huang,Miaoyang Lin,Huanlin Wu,Danping Xu
Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion injury (MIRI). Naringenin (NAR), as a flavonoid, has a significant advantage in improving MIRI. But the regulatory effect and mechanism of NAR on ferroptosis in MIRI have not been reported. After the rats were given NAR and induced to form myocardial ischemia-reperfusion (MI/R) injury, Tetrazolium chloride (TTC) staining was used to detect the myocardial infarction area of rats, and Hematoxylin-eosin (H&E) staining was used to detect myocardial injury. The markers of tissue inflammation were detected by ELISA. Serum creatine kinase Serum creatin kinase (CPK), Lactate dehydrogenase (LDH), and lipid peroxide (LPO) and oxidative stress related levels were measured. In addition, iron detection kits were used to detect total iron and Fe2+ levels in cardiac tissues, and western blot was used to detect the expression of ferroptosis-related proteins and the expression of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and glutathione peroxidase 4 (GPX4). At the cellular level, H9C2 cardiomyocytes were induced by hypoxia/reoxygenation (H/R), and ferroptosis inducer Erastin was administered to detect cell viability, ferroptosis-related indicators, oxidative stress related indicators, and expressions of Nrf2 and GPX4, to explore the mechanisms involved. NAR alleviated MI/R-induced pathological damage, inflammation and lipid peroxidation in myocardial tissue of rats. NAR adjusted the NRF2 /System xc – /GPX4 axis and improved ferroptosis. At the cellular level, ferroptosis inducer Erastin reversed the protective effect of NAR on H/R-induced H9C2 cardiomyocytes. In conclusion, NAR can alleviate MIRI by regulating the Nrf2/System xc-/GPX4 axis to inhibit ferroptosis.
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高影响因子
ENVIRONMENTAL POLLUTION
·
2018
·
IF 4.358
Zhaocheng Zhang,Dongyang He,Haiyang Liu,Miao Ren,Yanan Zhang,Jiao Qu,Nan Lu,Jiunian Guan,Xing Yuan
Black phosphorus (BP), a superior two-dimensional (2D) semiconductor, has attracted much attention due to its unique properties. The graphene (GR)-BP hybrid was synthesized through one pot chemical vapor transport (CVT) approach. The characterization results indicated that P atom was successfully incorporated into GR by the formation of P-C bond. Remarkably, the newly-synthesized GR-BP represented high photocatalytic activity towards 2-chlorophenol (2-CP) degradation, due to the high efficiency of charge separation and transformation caused by the direct band gap of BP and carrier mobility of GR. The removal efficiency for 2-CP reached up to 87.08% within visible light irradiation for 180 min ( λ > 420 nm). The degradation rate of GR-BP hybrid for 2-CP was approximately 7.29-fold than that of BP within 30 min. In addition, the little increasing of the peak for P-O bond in GR-BP hybrid was observed after being exposed in air for 15 days, meant that the stability of BP was significantly enhanced. It was caused by the decreasing of the oxidation sites in BP due to the formation of P-C bond in hybrid. In brief, our synthetic method for GR-BP not only provides a novel route for the improvement of the stability of BP, but also constitutes an insight into the promising practical application of BP in the photocatalysis field.
研究领域:
材料科学
·
纳米科技
·
光催化
·
半导体材料
·
环境化学
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2024
·
IF 3.1
Fangqi Cao,Shuchen Yu,Xiujuan Chen,Lu Xiao,Tingting Qiu,Xiru Wang,Daiwen Zhang,Xiaoliang Yuan,Ping Shi
Synthetic cannabinoids (SCs) are an evolving class of new psychoactive substances (NPS) with structurally various compounds that are increasing over the past few years. Therefore, they are initially hard to identify because of the lack of analytical information. Moreover, there is little to no information regarding the pharmacology of these compounds despite human abuse. In the present study, gas chromatography-mass spectrometry (GC-MS), ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF MS), and nuclear magnetic resonance (NMR) spectroscopy were used to identify the structure of three compounds obtained from seized materials. The pharmacological properties of these compounds were evaluated by subsequent behavioral testing, including von Frey and cold allodynia tests. The results indicated that these compounds were determined to be 2-(1 H -indazole-3-carboxamido)-3,3-dimethylbutanoate (MDMB-INACA), N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1 H -indazole-3-carboxamide (ADB-INACA), and N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1 H -indazole-3-carboxamide (ADB-HINACA) via GC-MS, UPLC-Q-TOF MS and NMR analysis, and they can attenuate mechanical and cold allodynia induced by paclitaxel in rats with peripheral neuropathy. Compared with MDMB-INACA and ADB-HINACA, ADB-INACA showed better analgesic effects on paclitaxel-induced peripheral neuropathy (PIPN) in rats, and its effect was similar to that of the positive drug N′-(1-hexyl-2-oxoindolin-3-ylidene) benzohydrazide (MDA-19).
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CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
·
2026
·Vol. 53
·期 2
·e70110
·
IF 2.5
Guangwei Yang,Cong Yu,Chao Weng
Objective Abdominal aortic aneurysm (AAA) refers to a disease where the abdominal aorta progressively dilates to 3.0 cm or more, making it prone to rupture. The etiologic and pathophysiological mechanisms underlying the formation and development of AAA are not yet fully understood. A preliminary investigation was conducted into the effects of Kruppel-like factor 5 (KLF5) regulation of the nuclear factor erythroid-2-related factor 2/heme oxygenase 1 (NRF2/HO-1) signalling pathway on ferroptosis in AAA vascular smooth muscle cells (VSMCs). Methods ApoE −/− mice or primary VSMCs were induced with angiotensin II (Ang II). KLF5 overexpression was achieved through adenovirus injection in the mouse model, and ML385 (NFR2 inhibitor) was injected to explore the involvement of the NRF2/HO-1 pathway in KLF5-regulated ferroptosis, inflammation, phenotypic switching and calcium deposition. Ang II-treated VSMCs were transiently transfected to overexpress KLF5 and/or incubated with Erastin (ferroptosis inducer) or ML385. The abdominal aorta was sampled from AAA model mice, and VSMC supernatants were collected to perform functional assays. Results KLF5 expression was downregulated in abdominal aorta tissues from AAA mice. KLF5 overexpression ameliorated inflammatory response by reducing phenotypic switching in VSMCs and inhibited ferroptosis and vascular calcification by reducing oxidative stress. Induction of ferroptosis partially reversed the ameliorative effect of KLF5 on vascular calcification in VSMCs. KLF5 exerted antioxidant effects by increasing NRF2 nuclear translocation and upregulating HO-1. Inhibition of the NRF2/HO-1 pathway partially reversed KLF5 regulation of phenotypic switching and vascular calcification in VSMCs. Conclusion KLF5 may exert a protective effect by inhibiting ferroptosis and calcium deposition in VSMCs in AAA through regulation of the NRF2/HO-1 signalling pathway.
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高影响因子
HYDROMETALLURGY
·
2023
·
IF 4.7
Yimeng Xu,Bicheng Deng,Shengting Kuang,Wuping Liao
An aminophosphonate extractant, di(2-ethylhexyl) (N, N′-di(2-ethylhexyl) amino methyl) phosphonate (abbreviated as L ) was synthesized and applied for the extraction and separation of gallium and indium from chloride solution. The maximum separation factors SF Ga/In reached 995, which is higher than those obtained with its analogues such as Cextrant 230 ( SF Ga/In = 471) and BEADP ( SF Ga/In = 201) at the optimum acidity conditions. The extracted complexes were determined to be HGaCl 4 L 2 and InCl 3 L 2 . The extraction reactions of gallium and indium were both endothermic. The loading capacities of 30 vol% L for Ga and In were 32.9 g/L and 25.2 g/L, respectively. The loaded gallium and indium in organic phase can be effectively stripped by distilled water, H 2 SO 4 and HNO 3 . A process was established for the separation and purification of gallium, by which the purity of Ga 2 O 3 increases from 98.4% to 99.97% with a yield of 92.5%.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Peng-Fei Li,Chun-Li Hu,Bing-Xuan Li,Fang Kong,Jiang-Gao Mao
Two UV inorganic yttrium selenite optical materials, namely, Y(HSeO 3 )(SeO 3 )(H 2 O)·(H 2 O) (1) and Y 2 (SeO 3 ) 2 (SeO 4 )(H 2 O) 2 ·(H 2 O) 0.75 (2), have been synthesized successfully by hydrothermal reactions . Of these, Y 2 (SeO 3 ) 2 (SeO 4 )(H 2 O) 2 ·(H 2 O) 0.75 (2) is a new mixed valent selenium oxide containing Se(IV) and Se(VI) cations simultaneously. Y(HSeO 3 )(SeO 3 )(H 2 O)·(H 2 O) (1) shows a 3D structure composed of 2D yttrium selenite layers linked by O−H···O bonds. Y 2 (SeO 3 ) 2 (SeO 4 )(H 2 O) 2 ·(H 2 O) 0.75 (2) exhibits a 3D structure composed of 2D yttrium selenite layers connected by SeO 4 tetrahedron. Y(HSeO 3 )(SeO 3 )(H 2 O)·(H 2 O) (1) crystallized in a chiral space group P 2 1 2 1 2 1 and could display a moderate SHG intensity about 0.7 times of the commercial KH 2 PO 4 (KDP). Its powder laser damage threshold quantity was estimated to be 120.2 MW/cm 2 , which is about 46.2 times that of AGS (2.6 MW/cm 2 ). UV–vis–NIR spectra reflectance spectra showed that these solids are wide band gap compounds with Eg of 5.5 and 5.1 eV respectively. Theoretical calculations disclosed that Y(HSeO 3 )(SeO 3 )(H 2 O)·(H 2 O) (1) is an indirect band gap structures and its bandgaps is determined by O and Se atoms.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Niu Zhang,Jun-Peng Zeng,Yan-Ping Wu,Meng Wei,Hong Zhang,Liufeng Zheng,Ze-Yuan Deng,Jing Li
The digestion and absorption of different structural lipids in human milk may be different. Hence, by simulating in vitro infant digestion and Caco-2 cells to explore the effects of 1-oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL)/1,3-dilinoleoyl-2-palmitoylglycerol (LPL)/1,3-dioleoyl-2-palmitoylglycerol (OPO) and their mixtures (M) (OPL/LPL/OPO in M1, M2, and M3 were 1.5/0.5/1, 1.2/1.2/1, and 0.5/0.2/1, respectively) on digestion and absorption. The digestibility of the OPO group was higher than those of the OPL and LPL groups, and the M3 group was higher than the M1 and M2 groups. The synthesis and transport of triglycerides in Caco-2 cells in OPL and LPL groups were higher than the OPO group, and the M1 group was significantly higher than that of M3. The expression of FABP1, PPARα, and MTT protein in OPL and M1 groups was significantly higher than OPO and M3, respectively. There are differences in the digestion and absorption of differently structured lipids from this study.
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PubMed
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Ceramics-Switzerland
·
2024
·Vol. 7
·期 1
·426-435
·
IF 2.7
Yuan-Bin Chen,Yu Fan,Shiuan-Ho Chang,Shaobing Shen
In this study, we used solid-state synthesis to prepare Ba[(ZnxCo1−x)1/3(Nb0.5Ta0.5)2/3]O3microwave ceramics for mobile communications. Compared with Ba[Zn1/3(Nb0.5Ta0.5)2/3]O3, in the prepared materials, Co2+substitution with Zn2+improved the Q × f value and enabled densification and sintering at a lower temperature. We used X-ray diffraction (XRD) and scanning electron microscopy (SEM) to analyze the obtained microstructure. Ba[(ZnxCo1−x)1/3(Nb0.5Ta0.5)2/3]O3was found to have a 1:2 ordered hexagonal structure, and its Q × f value increased with the increase in sintering temperature. In this work, excellent microwave dielectric properties—τf= −0.7 ppm/°C, εr= 34.5, and Q × f = 110,000 GHz—were obtained by sintering Ba[(Zn0.3Co0.7)1/3(Nb0.5Ta0.5)2/3]O3at 1400 °C for 5 h.
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Carbon Capture Science & Technology
·
2024
·
IF 10.4
Xiaobin Zhou,Yunqiong Tang,Chao Liu,Shengpeng Mo,Yinming Fan,Dunqiu Wang,Bihong Lv,Yanan Zhang,Yinian Zhu,Zongqiang Zhu,Guohua Jing
To tackle the prevalent challenges encountered with polyamine-based non-aqueous absorbents (NAAs), particularly the formation of viscous products and inferior regeneration performance, this study proposed an innovative synergistic regulation strategy that integrated 2-amino-2-methyl-1-propanol (AMP) and n-propanol (NPA). Accordingly, a novel tertiary tetraethylenepentamine (TEPA)-AMP-NPA (T-A-N) NAA was devised. The optimized T-A-N maintained complete homogeneity throughout the entire CO 2 absorption process and achieved an impressive CO 2 loading of 1.15 mol·mol −1 while maintaining a low viscosity of merely 22.47 mPa·s. Remarkably, its absorption capacity showed little decrement after four consecutive absorption-desorption cycles, underscoring its exceptional recyclability. Within the T-A-N system, AMP underwent a reaction with CO 2 , yielding AMP-carbamate and protonated AMP, while TEPA engaged in CO 2 absorption to form zwitterionic carbamates. During the desorption process, NPA served as a regeneration activator, facilitating the conversion of stable TEPA-carbamates into less stable alkyl carbonate intermediates, thereby enhancing the T-A-N's regeneration performance. Moreover, the T-A-N system addressed the issue of TEPA-carbamate self-aggregation into insoluble gelatinous substances by leveraging the synergistic enhancement effects between AMP derivatives and NPA. Specifically, these components effectively bound TEPA-carbamate species via robust electrostatic affinity and intermolecular hydrogen-bond interactions, inhibiting their self-aggregation and preventing the formation of insoluble products. Furthermore, T-A-N exhibited a significant reduction in both sensible and latent heat requirements, by 67 % and 82 % respectively, compared to 30 wt% MEA, highlighting its advantageous energy-saving potential for CO 2 capture. Overall, harnessing the synergistic enhancement effects of AMP and NPA was conducive to the development of polyamine-based NAAs that offered superior CO 2 capture reversibility, low energy consumption, and resistance to insoluble product formation.
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Human Cell
·
2025
·Vol. 38
·期 3
·1-14
·
IF 3.1
Zhu Xiao-Yu,Li Pi-Song,Qu Hui,Ai Xing,Zhao Zi-Ting,He Jia-Bei
Radiotherapy resistance, is usually caused by enhanced tumor stemness and poses a significant challenge in treating breast cancer (BRCA). In this study, we investigated the molecular regulatory mechanism of radiotherapy sensitivity in BRCA associated with replication factor C4 (RFC4) and insulin-like growth factor 2 mRNA binding protein 2 mRNA Binding Protein 2 (IGF2BP2). RFC4 expression was increased in BRCA cell lines and tissues, and high RFC4 expression in BRCA patients predicted the occurrence of lymphatic metastasis. RFC4-specific short hairpin RNA sequences or RFC4 coding sequences were subsequently cloned and inserted into plasmid vectors to downregulate or upregulate RFC4 expression. Knockdown of RFC4 attenuated stemness, as evidenced by a reduction in sphere formation and the downregulation of CD44 and SOX2. RFC4 silencing inhibited migration and invasion, promoted apoptosis, and improved sensitivity to radiotherapy (4-Gy X-ray). The results were detected by a wound healing assay, a transwell assay, and flow cytometry. The overexpression of RFC4 had the opposite effect on BRCA cells. Like RFC4 expression, IGF2BP2 expression was also increased in the cancer tissues of breast cancer patients. The results of the dual luciferase assay and RIP assay confirmed the binding of IGF2BP2 to the RFC4 mRNA coding sequence. Knockdown of RFC4 eliminated the effects of IGF2BP2 overexpression on increasing cell viability, invasion, the expression of stemness markers and radioresistance, suggesting that the effect of RFC4 on the stemness of BRCA cells was regulated by IGF2BP2. In conclusion, we reported that RFC4, a key regulator of BRCA progression, promoted radioresistance in BRCA and was positively regulated by IGF2BP2.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yichan Huo,Xiong Wang,Yang Yi,Zhirong Yang,Wenchang Wang,Huaijie Yao,Pingping Liu,Wenfen Zhang,Shusheng Zhang
p -Phenylenediamine antioxidants (PPDs) and their quinone derivatives (PPDQs) have emerged as concerning environmental contaminants due to their widespread presence and biological toxicity. Herein, a novel tetraazacalix[2]arene[2]triazine functionalized 2D transition metal carbide (TCT@MXene) with electron-rich and electron-deficient sites, porous structures, abundant adsorption sites was first synthesized and characterized. Combining the advantages of extraordinary adsorption capacities and rates towards PPDs and PPDQs, a dispersive solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) strategy was developed for highly sensitive and selective determination of PPDs and PPDQs in environmental water. The method featured acceptable linearity (R 2 ≥ 0.999), high sensitivity (LOD ranged from 0.10 to 2.96 ng L −1 ), and qualified precision (RSD ≤ 5.90 %). Compared with published works, the LODs of the developed technique were improved 3.8–250 times. Furthermore, its exceptional thermal and chemical stability allows for at least 10 reuse cycles under varying pH conditions. The adsorption mechanism revealed that the complementary charge distribution and robust conjugated system of TCT@MXene enabled the simultaneous and efficient co-adsorption of both PPDs and PPDQs. Besides, the established method was successfully applied to the analysis of trace targets in Yellow River basin in Henan Province. All these results proved the promising application of the developed method for organic pollutants analysis in water samples.
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危险品化学品经营许可证（带存储）