CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2016
·Vol. 94
·期 12
·2276-2281
·
IF 1.066
Dongjing Liu,Weiguo Zhou,Jiang Wu
The high-temperature H 2 S removal at 500–700 °C was conducted over CuO-CeO 2 /ZSM-5 composites prepared with sol-gel method. 7Cu3Ce/ZSM-5 partially reacting at 500 °C yielded Cu 7 S 4 and Cu 2 S. The major sulphidation products at 600 °C were Ce 2 O 2 S, Cu 2 S, CuS, and S. Sulphidation of 7Cu3Ce/ZSM-5 at 700 °C yielded Ce 2 S 3 , Cu 2 S, Cu 2 S, and S. Sulphidation of 7Cu3Ce/ZSM-5 with 20 % H 2 and 20 % CO generated the same products Ce 2 O 2 S, Cu 2 S, Cu 2 S, and S. Increase in the degree of crystallinity of 7Cu3Ce/ZSM-5 resulted in the decrease of sulphur capacity during the sulphidation and regeneration process. Experimental results showed that the activity of CuO improved by adding Ce; 7Cu3Ce/ZSM-5 performed the optimal sulphiation behaviour at 600 °C with sulphur capacity of 1429 μmol/g (micromoles of sulphur per gram) due to the synergy of CuO and CeO 2 . H 2 repressed sulphur removal, causing the reduction of sulphur capacity from 1429 to 1014 μmol/g. CO had little impact on sulphidation reaction; sulphur capacity only reduced from 1429 to 1221 μmol/g due to the presence of 20 % CO.
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2017
·Vol. 36
·期 3
·187-193
·
IF 1.852
Qing-Ning Zhao,Qing-Wen Song,Ping Liu,Qian-Xia Zhang,Jun-Hua Gao,Kan Zhang
The production of fine chemicals using CO 2 as C 1 building block through inexpensive heterogeneous catalysts with high efficiency under low pressure is challenging. Herein we propose for the first time the utilization of a multifunctional heterogeneous zinc-modified HZSM-5 (ZnHZSM-5) catalyst for upgrading CO 2 by incorporation into cyclic carbonates from CO 2 and epoxides. Owing to the nice surface properties such as abundant Lewis acid, Brønsted acid and Lewis base sites, large surface area, and plenty of micropores, CO 2 could be concentrated and well activated in ZnHZSM-5 verified by CO 2 -TPD, TG-MS, etc . Meanwhile, the epoxides were also activated through metal center and hydrogen bond. Therefore, the reaction can easily assemble at the catalyst interface and show exceptional performance, affording the aimed products with high yield of up to 99% in the presence of commercial tetra- n -propylammonium bromide (90% in kilogram scale with 0.004 mol% ZnHZSM-5 and 0.015 mol% n Pr 4 NBr).
✓ 已验证
DOI
高影响因子
ANALYST
·
2021
·Vol. 146
·期 8
·2506-2519
·
IF 4.616
Yue-Ming Yu,Yuan-Yuan Niu,Ling-Yang Wang,Yan-Tuan Li,Zhi-Yong Wu,Cui-Wei Yan
For highlighting the predominance of phenolic acid nutraceutical ferulic acid (FR) in regulating the in vivo/vitro performances of anticancer drug 5-fluorouracil (Flu) and strengthening their cooperativity in antitumor effect, thus achieving a major breakthrough in the development of drug-nutraceutical cocrystal with synergistic antitumor action, a cocrystallization strategy of dual optimization is created, in which both the in vivo and vitro natures of Flu are improved by exploiting the FR's excellent physicochemical property. Moreover, Flu's anticancer effects were promoted by exerting the assistant antitumor peculiarity of FR. Such dual optimization of FR for Flu in physicochemical properties and anticancer activities is beneficial for realizing synergistic augmentation effect by taking the benefit of the cooperativeness of Flu and FR in the anticancer ability. Based on this idea, a novel cocrystal of Flu and FR, namely, Flu-FR-H2O, is successfully assembled as the first 5-fluorouracil-nutraceutical cocrystal with synergistic antitumor effect and its explicit structure is resolved. The single-crystal X-ray diffraction demonstrates that Flu and FR have a ratio of 1 : 1 with one equivalent of solvent water in the cocrystal, where one-dimensional hydrogen-bonding helices and FR-Flu hydrogen-bonding pairs, together construct a three-dimensional supramolecular network. By combining experimental evaluation with theoretical analysis, in vitro/vivo pharmaceutical properties are scientifically investigated. Results show that the permeability and aqueous solubility of Flu are respectively elevated by 5.08 and 1.64 folds, which has brought about ameliorated pharmacokinetics, thus providing prolonged retention time and increased oral bioavailability. More interestingly, the cocrystal shows synergistic inhibition ability of Flu and FR against tested tumor cell strains, hence laying the groundwork for reducing the dosage and even the toxic side effects of Flu. As a result of this, the present research not only provides a new strategy for Flu to optimize its physicochemical properties and antitumor activities simultaneously but also offers some opinions for the development of synergistic antitumor pharmaceutical cocrystals.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BRITISH JOURNAL OF PHARMACOLOGY
·
2026
·
IF 7.5
Wen-yuan Zhang,Qian-qian Wei,Tao Zhang,Chunmei Geng,Hai-yan Wu,Chang-shui Wang,Jing Chen,Lei Feng,Pei Jiang
Background and Purpose Despite breakthroughs in immunotherapy and targeted therapies, chemotherapy remains indispensable in oncology. Experimental Approach This study seeks to pinpoint key pathways in doxorubicin (DOX)-treated mouse hippocampus, utilising comprehensive transcriptomic and metabolomic analyses, and validating the mechanisms in vitro and in vivo. Key Results Our multi-omics investigation revealed that sustained DOX exposure induced significant down-regulation of 5-aminolevulinate synthase 2 (ALAS2) and its catalytic product 5-aminolevulinic acid (5-ALA) in the hippocampal region. ALAS2 deficiency was specific to hippocampal neurons, which were more sensitive to oxidative damage than astrocytes or microglia. In vivo and in vitro studies demonstrated that 5-ALA administration or ALAS2 overexpression protected the brain from DOX-induced neurotoxicity. ALAS2 catalyses the condensation of glycine and succinyl-CoA to form 5-ALA, the key precursor of haem. Beyond its role in erythropoiesis, haem is a metabolite that modulates cellular redox homeostasis through interactions with the BACH1 (BTB and CNC homology 1)/NRF2 (nuclear factor erythroid 2 like 2) pathway. We found that DOX suppressed the ALAS2/5-ALA axis, thereby enhancing BACH1 stability. This stabilised BACH1 competes with NRF2 for binding to antioxidant response elements (AREs) in target gene promoters. Conversely, reinforcing the ALAS2/5-ALA axis elevated intracellular haem levels, promoting BACH1 degradation and enhancing NRF2 activity. Using a zebrafish model, we further highlighted the antioxidant and neuroprotective role of 5-ALA against DOX-induced neurotoxicity. Conclusions and Implications In conclusion, this study elucidates a novel endogenous neuroprotective mechanism wherein the ALAS2/5-ALA axis modulates the BACH1/NRF2 pathway. 5-ALA shows promise for repurposing to mitigate chemotherapy-associated neurotoxicity. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SOLID STATE SCIENCES
·
2018
·
IF 1.861
Chuanling Sun,Yuandong Wu,Dajiang Mei,Thomas Doert
A new bismuth (III) iodate periodate , Bi 2 (IO 3 )(IO 6 ) was obtained from hydrothermal reactions using Bi(NO 3 ) 3 ·5H 2 O, and H 5 IO 6 as starting materials. Bi 2 (IO 3 )(IO 6 ) crystallizes in the monoclinic space group P 2 1 / c (No. 14) with lattice parameters ɑ = 8.1119(6), b = 5.4746(4), c = 16.357(1) Å, β = 99.187(2)°, V = 717.07(9) Å 3 , Z = 4. The structure of Bi 2 (IO 3 )(IO 6 ) features a three-dimensional framework which is a combination of [Bi(1)O 5 ] tetragonal pyramids, [Bi(2)O 8 ] bicapped trigonal prisms and [IO 3 ] − and [IO 6 ] 5− anions. Thermal analysis shows that the compound is thermally stable up to about 350 °C. The solid state UV-vis-NIR diffuse reflectance spectrum indicates that Bi 2 (IO 3 )(IO 6 ) is a semiconductor with a band gap of 2.76 eV.
✓ 已验证
DOI
高影响因子
THERMOCHIMICA ACTA
·
2016
·
IF 1.938
Lipeng Wang,Fucheng Zhang,Yongping Bai,Liping Ding
The kinetic of non-isothermal crystallization of Poly (ethylene terephthalate-co-sodium-5-sulfo- iso -phthalate) (PETI) was investigated using differential scanning calorimetry (DSC). Various macrokinetic models namely the Avrami, Tobin, Ozawa, and Ziabicki were used to describe the non-isothermal crystallization process of PETI. Both of the Avrami crystallization rate constant and the Tobin crystallization rate constant were observed to increase with increasing cooling rate. The Avrami model is better than the Tobin model to describe the non-isothermal crystallization process of PETI. The Ozawa crystallization rate K O was found to decrease with increasing cooling rate, while Ziabicki’s kinetic crystallizability parameter G Z was found to increase with increasing cooling rate. The effective energy barrier △E for non-isothermal crystallization process of PETI, analyzed based on the differential iso-conversional method of Friedman, was found to be an increasing function of the relative crystallinity.
研究领域:
高分子化学
·
材料科学
·
物理化学
·
热分析
·
聚合物结晶
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2012
·Vol. 39
·期 4
·3915-3919
·
IF 1.751
Junxia Wang,Hengchang Nie,Chunfeng Lan,Genshui Wang,Xianlin Dong,Xuefeng Chen,Fei Cao,Hongliang He
Porous Pb (Zr 0.95 Ti 0.05 ) O 3 / x MgO (PZT/MgO, x =0, 0.1, 0.2, 0.5 and 1.0 wt%) ferroelectric ceramics were prepared with MgO nanoparticles as reinforcing phase. The effects of MgO nanoparticles on the phase, microstructure, electrical and mechanical properties of as-prepared ceramics were investigated. The results show that the grain size is reduced obviously when increasing the amount of MgO. Compared with pure porous PZT, T C of MgO-added PZT ceramics shifts to higher temperature. Moreover, dielectric, ferroelectric and piezoelectric properties show no much degradation. Further, PZT/MgO ceramics possess enhanced mechanical properties compared to pure porous PZT ceramics, the largest increment of the fracture toughness and hardness being 31.3% and 19.8%, respectively. The optimal electrical and mechanical properties are obtained with the addition of less than 0.5 wt% MgO nanoparticles.
研究领域:
材料科学
·
无机非金属材料
·
功能陶瓷
·
电子材料
·
固态物理
·
纳米复合材料
✓ 已验证
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2026
·
IF 7.8
Yongning Chen,Yin Wang,Xiaoxuan Guo,Jianan Li,Yijie Jiang,Wenbo Sun,Wenlong Sun,Chong Peng
The electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) is an effective method to produce high-value-added chemicals with low energy consumption. In this work, we prepared a highly efficient electrocatalyst by incorporating Cr-doped NiFe layered double hydroxide nanosheets supported on nickel foam (NiFeCr-LDH/NF). For the HMF oxidation reaction (HMFOR) in 1 M KOH electrolyte, the NiFeCr-LDH/NF catalyst achieves an exceptional current density of 100 mA cm -2 at a low potential of 1.47 V vs . reversible hydrogen electrode (RHE). Critically, it exhibits a high 2,5-furandicarboxylic acid (FDCA) yield of 93.8% and a Faradaic efficiency of 91.5%. Furthermore, in situ Fourier transform infrared spectroscopy (FTIR) studies and transient electrochemical measurements were carried out to investigate the mechanism in the HMFOR. Precisely controlled Cr doping can effectively modulate the synergistic adsorption equilibrium between HMF and hydroxyl intermediates, thereby enhancing electrocatalytic reaction efficiency via optimized interfacial charge transfer dynamics. This work illustrates heteroatom engineering as a powerful strategy for designing efficient electrocatalysts, enabling efficient biomass valorization.
✓ 已验证
DOI
高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2026
·Vol. 95
·期 12
·3886-3902
·
IF 0.8
Lv Yingmei,Shi Lele,Luo Xi,Huang Yuhang,Du Zhenting
Thiazolidine-2,4-dione (TZD), a privileged scaffold, is a versatile pharmacophore and outstanding sulphur-containing heterocyclic compound found in various drugs. In this work, forty-two substituted 5-arylidene-1,3-thiazolidine-2,4-diones derivatives have been designed and synthesized by introducing sulfonyl groups, benzoyl groups, and amide groups into 5-(3/4-hydroxybenzylidene)thiazolidine-2,4-dione through Knoevenagel condensation, and their antibacterial activities were evaluated in vitro. As a result, thirty-five compounds were new compounds, and seven compounds were known compounds. The in vitro assay results disclosed that compared with B/C-series, A-series compounds presented remarkable antimicrobial activity against S. aureus, E. faecalis , and E. faecium . All twenty-one synthesized A-series compounds exhibited excellent antibacterial activity against S. aureus (MIC 80 ≤ 128 µg/mL). Among these, three compounds demonstrated the highest anti- E. faecalis activities (MIC 80 = 8 µg/mL), while E. faecium showed antibacterial susceptibility to A-series compounds except two of the investigated compounds p -cyanophenyl and p -trifluoromethoxyphenyl substituted sulfonate esters. In contrast, the B-series displayed limited activity, with only three compounds showing measurable anti- S. aureus effects, among which substituted phenyl benzoates exhibited the best antibacterial action against E. faecium (MIC 80 = 64 µg/mL). The C-series compounds demonstrated the weakest activity profile, with two N -substituted acetamides ( N -phenyl and N -methylphenyl) displaying moderate anti- S. aureus activity (MIC 80 = 128 µg/mL), which merely compound N - o -nitrophenyl was sensitive to E. faecalis (MIC 80 = 256 µg/mL). SAR analysis revealed that synthetic TZD-derivatives with substituted sulfonyl groups significantly enhanced antibacterial activity against all tested Gram-positive bacterial strains. These molecules may serve as lead compounds for developing more effective and less toxic antibacterial agents.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Liu Nianci,Li Te,Li Shunmei,Feng Xiaofan,Zhang Zhuorui,Jiang Guiquan
To address the low bioavailability of polymeric proanthocyanidins (PPCs) in larch tannin, we developed a bimetallic catalyst, (Pd 1 –Cu 1 ) 5 /ZrO 2 , to convert PPCs into bioactive oligomeric proanthocyanidins (OPCs) via catalytic depolymerization. SEM, XRD, and XPS characterization indicate a high specific surface area and Pd-Cu synergistic active sites; combined with ZrO 2 solid acid sites, these features enhance substrate adsorption and C C bond cleavage. Single-factor optimization showed that under 0.05 g catalyst, 4 MPa H 2 , 140 °C and 3 h, the average degree of polymerization decreased from 9.5 to 2.48, corresponding to a 74 % degradation rate. The degradation products exhibited markedly improved antioxidant activity in DPPH and ABTS + assays.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2015
·Vol. 72
·期 5
·696-703
·
IF 1.106
Liu Yanfang,Zhao Junna,Li Zaixing,Li Guixia,Li Wei,Gao Xiang
Mixed manganese and cerium oxide supported on HZSM-5 were synthesized and used as heterogeneous catalysts for ozonation of bisphenol A (BPA) in aqueous solution. The prepared catalysts of Mn-Ce/HZSM-5 were characterized by X-ray diffraction, scanning electron microscopy and Fourier transform-infrared spectroscopy. The results indicated that Mn-Ce/HZSM-5 exhibits extraordinary catalytic activity for the degradation of BPA. Removal of 89.3% of BPA and 90.4% of total organic carbon (TOC) was achieved in 30 min, compared to non-catalytic ozonation, where only 50.5% BPA and 28.1% TOC removal were reached under the same conditions. Adsorption of BPA on HZSM-5 support and Mn-Ce/HZSM-5 catalysts was negligible. The strong inhibition of BPA removal by tert-butyl alcohol indicated that the attack of hydroxyl radicals was responsible for the improvement of catalytic ozonation. It was observed that at neutral pH, which is near the point of zero charge of the catalyst, the catalytic activity reached its maximum. Increasing the amount of Mn-Ce/HZSM-5 catalyst until it exceeded 3 g/L did not show a strong effect on BPA removal. The catalysts showed high stability and reusability.
✓ 已验证
DOI
高影响因子
ACS Catalysis
·
2026
·Vol. 16
·期 15
·14855-14865
·
IF 13.6
Chen Kun,Wang Zhou,Zhou Xuefei,Ma Tenghao,Zhao Peng,He Yuan,Chen Zhanwei,Zhou Zhihua,Yang Shaowei,Zhang Qiuyu,Zhang Hepeng
ZnIn 2 S 4 -based photocatalysts have attracted considerable attention in biomass valorization owing to their tunable band structures and abundant surface reaction sites. However, the aqueous-phase selective photooxidation of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran (DFF) remains highly challenging due to the insufficient O 2 activation, substrate mineralization, and competitive coupling side reactions. Herein, a single-atom Sn-doped ZnIn 2 S 4 photocatalyst (Sn-ZIS) was constructed. Systematic characterizations confirm that Sn species are atomically dispersed and incorporated into the ZnIn 2 S 4 lattice through Sn-S coordination. Under aqueous-phase reaction conditions, Sn-ZIS achieves 88.7% HMF conversion, 80.5% DFF selectivity, and 93.3% C equilibrium, higher than those of ZnIn 2 S 4 and many reported aqueous-phase photocatalytic systems. The better performance of Sn-ZIS is mainly attributed to the synergistic regulation of the band structure and local electronic structure induced by Sn incorporation. The optimized band structure moderately weakens the oxidative ability of photogenerated holes, thereby reducing HMF mineralization to CO 2 . While the regulation of the local electronic structure promotes O 2 adsorption and activation to generate superoxide radicals, it simultaneously facilitates DFF desorption from the catalyst surface. Synergy between the two functions drives the selective conversion of HMF into DFF. This work demonstrates the potential of single-atom doping for enhancing aqueous-phase biomass photooxidation and provides a rational strategy for designing efficient ZnIn 2 S 4 -based photocatalysts.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）