JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-15
·
IF 12.6
Wang Xingyi,Fang Hanyi,Hu Wenzhu,Feng Yuan,Zhou Zhangyongxue,Hu Mengyan,Jiang Dawei,Zhang Yongxue,Lan Xiaoli
Limited treatment response and inadequate monitoring methods stand firmly before successful immunotherapy. Recruiting and activating immune cells in the hypoxic tumor microenvironment is the key to reversing immune suppression and improving immunotherapy efficacy. In this study, biomimetic oxygen-delivering nanoparticles (CmPF) are engineered for homologous targeting and hypoxia alleviation within the tumor environment. CmPF targets the tumor microenvironment and delivers oxygen to reduce hypoxia, thereby promoting immune cell activity at the tumor site. In addition, granzyme B-targeted positron emission tomography (PET) imaging is employed to monitor immune cell activity changes in response to immunotherapy efficacy in vivo. The combination of CmPF with carboplatin and PD-1 inhibitors significantly suppresses tumor growth by 2.4-fold, exhibiting the potential of CmPF to enhance the efficacy of immunotherapy. Immunohistochemistry further confirms increased expression of key immune markers, highlighting the reprogramming of the tumor microenvironment. This study demonstrates that hypoxia alleviation enhances tumor immunotherapy efficacy and introduces a non-invasive PET imaging method for dynamic, real-time assessment of therapeutic response.
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CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Yao Feng,Shuyi Lai,Le Yang,Ralf Riedel,Zhaoju Yu
Polymer-derived porous Bi 2 WO 6 /SiC(O) nanocomposites were prepared by a simple mechanical mixing of Bi 2 WO 6 nanopowders with a polyorganocarbosilane, namely allylhydridopolycarbosilane (AHPCS), followed by pyrolysis of the resulting blend at 700 °C for 2 h. The Bi 2 WO 6 nanopowders were synthesized by the reaction between Bi(NO 3 ) 3 ·5H 2 O and Na 2 WO 4 and characterized by means of X-ray diffraction (XRD) and dynamic light scattering (DLS). The cross-linking and polymer-to-ceramic transformation of the physically blended Bi 2 WO 6 /AHPCS were determined by Fourier transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). TEM studies revealed that the final ceramic composite is comprised of Bi 2 WO 6 nanoparticles homogeneously embedded in a polymer-derived SiC(O) matrix. Nitrogen sorption isothermal analysis showed the meso-macroporous feature of resultant Bi 2 WO 6 /SiC(O) nanocomposites. Finally, the porous Bi 2 WO 6 /SiC(O) composites show a high photodegradation efficiency (ca. 90%) towards a model organic dye Rhodamine B (RhB) under UV irradiation. Therefore, the synthesized ceramic composite has to be considered as a promising candidate material for purification of water contaminated with organic dyes.
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Advanced Sustainable Systems
·
2024
·Vol. 8
·期 12
·2400419
·
IF 6.5
Dongxu Han,Zhi Song,Boxia Liu,Bofei Liu,Xiayan Zhang,Jialu Liu,Yeqiong Huang,Chuhan Xing
Because of its excellent catalytic activity and stability, perovskite materials are widely used in advanced oxidation processes to remove refractory organic pollutants. In this study, a series of catalysts Pr 0.6 Sm 0.4 Co x Mn 1-x O 3 (x = 0, 0.2, 0.4, 0.5, 0.6,0.8 and 1) with limited range effect are prepared by sol–gel method with the regulation strategy of injecting active metal Co at B site in the crystal lattice of perovskite catalyst Pr 0.6 Sm 0.4 MnO 3 . Under the optimal conditions, the Pr 0.6 Sm 0.4 Co 0.8 Mn 0.2 O 3 /PMS/RhB system showed superior catalytic performance, and the removal rate of Rhodamine B (100 mg L −1 ) is close to 100% within 40 min. In addition, the Pr 0.6 Sm 0.4 Co 0.8 Mn 0.2 O 3 catalyst has a wider pH (2-10) tolerance range and still has outstanding catalytic properties after multiple cycle tests. The quenching experiment and EPR test confirmed that a variety of active species are produced in the system, and the singlet oxygen as the leading path of a variety of active substances assisted to promote the efficient degradation of Rhodamine B in wastewater. This study provides a new reaction system and regulatory strategy of active structural sites for the design of Fenton-like catalytic systems based on novel perovskite oxides.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 9
·1-15
·
IF 2.1
Yin Yanbing,Zhang Xueli,Jiang Bei,Wang Zhou,Feng Yongming,Li Xueying
Developing efficient catalysts for visible light reactions is vital in the field of photocatalysis. This study focuses on the synthesis of novel ternary composites (α-DMACoPc/TiO 2 /MIL-101 (Fe)) by leveraging the excellent adsorption properties of MIL-101 (Fe), the photosensitizing capabilities of phthalocyanine, and the photocatalytic potential of TiO 2 . The nanocomposites’ structural and optical attributes were thoroughly analyzed. X-ray powder diffraction (XRD) was utilized to showcase the crystalline nature of the composites. Furthermore, Fourier transform infrared (FT-IR) studies confirmed the formation of ternary nanocomposites. Optical absorption investigations demonstrated the tuning of the optical band gap from the UV to the visible range. The results indicated that nearly 94% of the organic material was decomposed after 150 min of exposure to simulated sunlight from a xenon lamp. This high efficiency can be attributed to the synergistic interaction among the composites, enhancing light absorption. The composite’s robust stability was evidenced through cyclic tests. Valuable information was provided to advance the design and synthesis of photocatalysts consisting of metal–organic frameworks synergized with semiconductors. Exploring the possibility of mesoporous materials was based on MOFs for photodegradation of organic pollutants. The photocatalytic degradation of organic pollutants by MOFs mesoporous materials was also investigated. The potential of composite materials in the field of dye degradation of industrial waste is confirmed. The good recycling photocatalytic reusability indicates the promising application of this photocatalyst. Graphical Abstract
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 236
·期 1
·1-15
·
IF 3.8
Li Xiao-fang,Ding Yue,Wang jing,Feng Xiao-qiang
Based on the excellent adsorption, photosensitization and electron transfer ability of biochar, the combination of photocatalyst and biochar is an effective method to improve the overall photocatalytic activity. Hence, a novel efficient CS-biochar/ZnO/TiO 2 photocatalyst with the different content of N-doped porous CS-biochar were constructed and characterized by a variety of testing methods, such as FT-IR, XRD, UV–vis DRS, SEM–EDS, PL, EIS, TPR, LSV. Photocatalytic experiments indicated that all the CS-biochar/ZnO/TiO 2 composites with different CS-biochar content exhibit excellent photocatalytic activity for Rh B degradation. Among them, 63%-CS/ZnO/TiO 2 composite has the best catalytic activity, which 94.5% of Rh B was degraded within 25 min, and the kinetic constant was 0.0993 min −1 , which is about 1.96 and 1.72 times that ZnO (0.0507 min −1 ) and TiO 2 (0.0576 min −1 ), respectively. Moreover, photoelectrochemical experiment results confirmed that CS-biochar/ZnO/TiO 2 greatly enhanced the charge separation process compare with ZnO and TiO 2 . Meanwhile, CS-biochar/ZnO/TiO 2 has excellent stability, and a possible photocatalytic mechanism was put forward.
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ENVIRONMENTAL TOXICOLOGY
·
2024
·
IF 4.4
Xuening Ma,Qianchao Shao,Shuxian Huang,Weigao Zhang,Hu Liu,Xu Jiayi,Xunan Zhao,Peiqi Li,Da Shao,YuanQing Bu,Dan Weng
The increasing incidence of cancer underscore the necessity of investigating contributors such as endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA). Although BPA's risks are well-documented, comprehensive studies on its substitutes, such as bisphenol B (BPB), are limited. Dysregulated lipid metabolism is a hallmark of cancer progression. Our previous work demonstrated that BPA and bisphenol S (BPS) disrupt lipid metabolism via the peroxisome proliferator-activated receptor γ (PPARγ) pathway. We hence hypothesized that BPB might similarly perturb lipid metabolism and promote tumor growth. BPB's impact on lipid metabolism was investigated in vitro and in vivo using B16 melanoma cancer cells. Our findings indicate BPB exposure significantly increased lipid metabolism in B16 cells, enhancing cell proliferation and migration, and promoting tumor development in mice. Utilizing siRNA transfection or chemical inhibitor, we found that stearoyl-CoA desaturase-1 (SCD1), a key enzyme in lipid synthesis pathway, was required for BPB-induced lipid accumulation and cancer cell migration. Docking analysis revealed BPB may activate gene expression related to lipid metabolism and angiogenesis by interacting with PPARγ and hypoxia-inducible factor-1α (HIF-1α). This study illuminates BPB's potential role in advancing melanoma through lipid metabolism manipulation, highlighting the need for further research into the safety of BPA substitutes and their impact on cancer development.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yifei Ye,Yuanyuan Cui,Li Yang,Jiaxu Zhang,Jianmin Sun
A novel external-skeleton B-containing ionic liquid modified SBA-15 catalyst BBN-Imi-SBA-15-I (BBN denotes borabicyclo[3.3.1]nonane, Imi represents imidazolium ionic liquid) was successfully constructed by a post-modification method for efficiently catalyzing CO 2 -epoxide coupling reaction under both metal- and solvent-free conditions. 5BBN-Imi-SBA-15-I (5 refers to the molar ratio of Si to B), thanks to its synergistic effects of Lewis acid, weak base sites from tertiary amine and quaternary ammonium, hydrogen bond group and nucleophilic group, displayed good catalytic activity with 97 % product yield and 99 % selectivity at 100 °C, 2 MPa in the absence of cocatalyst. The obtained catalyst demonstrated good recyclability during six consecutive catalytic runs, also presented generality for various mono-substitute epoxides. Through in-situ NH 3 diffuse reflectance infrared Fourier transform spectroscopy (NH 3 -DRIFTS) characterization, the Lewis acidity of organo-boron was verified. Besides, kinetics research also proved the positive effect of multiple active components on efficient catalysis under milder conditions over SiO 2 -based metal-free catalysts.
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International Journal of Electrochemical Science
·
2024
·
IF 1.3
Yuanli Zhang,Meilan Sun
A highly responsive and specific electrochemical biosensor utilizing Ag-Au bimetallic nanoparticles was engineered for the measurement of B-type natriuretic peptide (BNP), serving as an indicator for heart failure. The sensor was fabricated by modifying a glassy carbon electrode with Ag-Au bimetallic nanoparticles (average diameter: 20 ± 3 nm) and immobilizing anti-BNP antibodies. The sensor exhibited a wide linear range (0.0001–100 ng/mL), low limit of detection (0.03 pg/mL), and excellent specificity towards BNP, with minimal interference from other proteins (< 5 %). The practicality of the sensor was demonstrated by analyzing spiked serum samples, with recoveries ranging from 96.4 % to 103.5 % and relative standard deviations less than 4.5 %. The superior analytical property of the sensor is due to the synergistic effect of Ag and Au in enhancing electron transfer and antigen-antibody binding. The suggested biosensor holds significant promise for the early detection and monitoring of heart failure in medical environments.
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CHEMICAL ENGINEERING JOURNAL
·
2012
·
IF 3.461
Yan-Ling Luo,Li-Li Zhang,Feng Xu
Brush-like block copolymers with poly( t -butyl methacrylate) (PBMA) and poly(N-ispropylacrylamide) (PNIPAAm) as side arms, PBMA-b-PNIPAAm, were designed and synthesized via a simple free radical polymerization route. The chemical structure and molecular weight of these polymer brushes were characterized and determined by nuclear magnetic resonance ( 1 H NMR), Fourier transform infrared spectrometry (FT-IR) and gel permeation chromatography (GPC). The polymer brushes can spontaneously assembled into regularly spherical core–shell nanostructured micelles with well-dispersed individual nanoparticles in aqueous solutions, and physiochemical properties of the micelles formed were detected by a surface tension technique, nanoparticle analyzer, transmission electron microscope (TEM), dynamic light scattering (DLS) and UV–vis transmittance measurements. Low critical micelle concentration (CMC) and high zeta potentials revealed the micellar stability and the micellar particle size was in the range from 36 to 93 nm by TEM and less than 200 nm by DLS. The resulting block polymer brushes were temperature-sensitive with low critical solution temperature (LCST) about 28.80–29.40 °C. These characteristic parameters were affected by their compositional ratios and the length of hydrophilic or hydrophobic chains. The evaluation for caffeine drug release and release kinetics demonstrated that the drug release and bioavailability may be mediated or improved by the temperature-induced structural changes of the micelles and different diffusion mechanism.
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BULLETIN OF MATERIALS SCIENCE
·
2017
·Vol. 40
·期 1
·187-193
·
IF 0.899
GENG TONG-MOU,WANG XIE,ZHU FENG,JIANG HUI,WANG YU
The water-soluble polymeric chemosensor poly(AM-GRBD) has been synthesized by precipitation copolymerization with the functional monomer, GRBD, which was made of N \(^{\boldsymbol {\prime \prime }}\) -(rhodamine B-yl) diethylenetriamine and glycidyl methacrylate (GMA) and a hydrophilic co-monomer acrylamide (AM). The chemical sensor behaved as a fluorescent and chromogenic sensor towards various heavy metal cations and transition metal cations; particularly, Cr 3+ , Fe 3+ and Hg 2+ ions in completely aqueous media. The fluorescence of poly(AM-GRBD) was enhanced by Cr 3+ , Fe 3+ and Hg 2+ metal ions. Moreover, during titration of Cr 3+ , Hg 2+ or Fe 3+ to the aqueous solution of poly(AM-GRBD), the visual colour changed from colourless to pink or brown yellow under visible light.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Zhixian Du,Yuan Gao,Zhuanzhuan Liang,Yanqing Yang,Weike Zhang
In this work, the Bi 2 WO 6 /KCC-1 photocatalytic composite was prepared by hydrothermal method using Bi 2 WO 6 as photocatalyst and KCC-1 as cocatalyst, for degradation of Rhodamine B (RhB). The result shows that when the mass percentage of KCC-1 in the composite is 7 % (BK-3), the photocatalytic degradation efficiency is the highest, reaching 90.63 %. Furthermore, the BK-3 composite shows a well degradation activity (83.90 %) even after four consecutive cycles of photocatalysis. Characterization of the photocatalyst by various testing techniques show that the BK-3 composite presents high visible light response, narrow energy band, and strong separation of photogenerated carriers. The results of free radical capture experiments indicate that the main active substance in the degradation of RhB under visible light is h + and ·O 2 − also plays a certain auxiliary role. This study offers promising prospects for the preparation of highly efficient photocatalysts through the modification of bismuth-based materials.
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EUROPEAN JOURNAL OF IMMUNOLOGY
·
2024
·
IF 4.5
Caiying Wang,Yue Zhang,Yabin Lu,Xin Huang,Huazheng Jiang,Guohui Chen,Yongheng Shao,Huub F.J. Savelkoul,Christine A. Jansen,Guangliang Liu
Secretory IgA is crucial for preventing the invasion of entero-pathogens via intestinal mucosa. While it is well-established that Transforming growth factor β1 (TGF-β1) regulates IgA production in human and mouse B cells, our previous investigation revealed different functions of TGF-β1 in IgA generation in pigs compared with humans and mice, with the underlying mechanism remaining elusive. In this study, IgM + B cells from porcine Peyer's patches (PPs) were isolated and stimulated with recombinant porcine TGF-β1 to evaluate the effect of TGF-β1 on pigs. The results showed that antibody production from B cells of PPs was impaired by TGF-β1 ex vivo. Furthermore, TGF-β1 treatment led to a decrease in the expression of germ-line transcript αand postswitch transcript α. Moreover, we observed that TGF-β1 predominantly inhibited the phosphorylation of p38-mitogen-activated protein kinases (MAPK), confirming the involvement of the p38-MAPK pathway in porcine IgA generation and IgA class switch recombination. The application of p38-MAPK inhibitor resulted in decreased B-cell differentiation levels. Collectively, this study demonstrates that exogenous TGF-β1 restrains the production and class switch recombination of IgA antibodies by inhibiting p38-MAPK signaling in porcine PPs B cells, which may constitute a component of TGF-β1-mediated inhibition of B-cell activation.
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