SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9.1
Ruohan Liang,Dongsheng Zhao,Fangming Jin,Jun Xu,Gengmin Jiang,Shiwei Yang,Jing Lu,Nanfu Qiao,Guicai Liu
Conventional polyamide (PA) nanofiltration (NF) membranes suffer from insufficient mono−/divalent anion selectivity and poor chlorine resistance, limiting their water treatment applications. Herein, a polyester–amide (PEA) NF membrane was fabricated via interfacial polymerization using piperazine and hydroxyl-rich D-mannitol as aqueous comonomers. Compared with the traditional PA membrane, the optimal PEA membrane exhibited higher surface roughness, greater thickness, looser structure, stronger hydrophilicity, and higher electronegativity. Specifically, the optimal PEA membrane delivered a water permeability of 21.9 L⋅m −2 ⋅h −1 ⋅bar −1 and an outstanding NaCl/Na 2 SO 4 selectivity of 68.4. This optimal PEA membrane maintained stable performance under chlorination across a wide pH range and showed excellent alkali stability after 20 h in NaOH solution at pH = 12.0. Furthermore, the optimal PEA membrane exhibited better antifouling properties with smaller decline in flux and greater flux recovery. Additionally, stable flux and rejection were observed for the optimal PEA membrane over 28 days of continuous cross-flow filtration. This work offers a facile strategy to develop high-performance PEA NF membranes with increased anion selectivity and chlorine resistance.
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Journal of Nanotechnology
·
2026
·Vol. 2026
·期 1
·7582895
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IF 3.1
Xiaoxia Tang,Jinbao Chen,Shu Zhang,Jiaqi Huang,Hui Liu,Xiao Wang,Liulin Li,Yangcheng Li,Manli Xie
Background Colorectal cancer (CRC) often metastasizes to the liver, which complicates treatment strategies. This study evaluates MSN–TK@SA, a mesoporous silica nanoparticle (MSN) loaded with saikosaponin D (SA) and reactive oxygen species (ROS)–cleaving thioketal (TK), as a targeted approach for CRC metastasis. Methods MSN–TK@SA nanoparticles were formulated by loading SA onto MSN to create MSN@SA, followed by coating with ROS-responsive methoxy polyethylene glycol-thioketal-N-hydroxysuccinimide (mPEG-TK-NHS) to produce MSN–TK@SA. The nanoparticles were characterized using different analytical techniques, and drug release profiles were evaluated. CRC cells and a liver metastasis model of CRC with liver qi stagnation were treated with the nanoparticles, and various techniques were used to assess the effects of MSN–TK@SA on tumorigenicity, immune response, and liver metastasis. Results The MSN, MSN@SA, and MSN–TK@SA nanoparticles were spherical, monodispersed, and colloidally stable, with a progressive decrease in zeta potential, which demonstrated successful loading with SA and thioketal coating. Fourier-transform infrared spectroscopy (FTIR) confirmed the silanol, amine, and PEG-TK functionalization. MSN–TK@SA had high encapsulation (81%) and loading efficiency (29%), which was consistent with pore entrapment stabilized by hydrogen bonding and dipole interactions. Drug release was based on a sustained/controlled profile, and approximately 80% of the drug was released within 72 h without a burst effect. First-order and Weibull models best described the concentration-dependent, diffusion-controlled release with anomalous transport of the nanoparticles. In vitro, MSN–TK@SA exhibited significant anticancer activity, including decreased viability, invasion, and migration, and amplified apoptosis of CRC cells. MSN–TK@SA markedly reduced tumor burden and metastasis, enhanced antitumor immunity, and inhibited inflammation in a CRC liver metastasis model. Conclusion MSN–TK@SA nanoparticles enable effective drug loading, controlled release, and immune activation, significantly inhibiting CRC liver metastasis. They are a promising platform for drug delivery and immunotherapy, deserving further preclinical and translational research.
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Journal of Inorganic and Organometallic Polymers and Materials
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2022
·Vol. 32
·期 2
·572-582
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IF 3.518
Liu Tingting,Zhou Zhiping,Zhang Liming,Zhang Wenwen,Yang Wenming
In this study, we introduced molecular imprinting combined with electrochemical method to determine trace 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide in standard solution and actual samples. For this purpose, we synthesis of vinyl silica coated MWCNTs in alkaline environment with surfactant, molecularly imprinted polymers were prepared on the surface of MWCNTs by free radical polymerization, following the composite materials were dissolved in chitosan solution and dropped on the glassy carbon electrode. The functionalized materials were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, thermogravimetry and nitrogen adsorption desorption. Electrochemical performance of molecularly imprinted membrane was characterized by cyclic voltammetry, electrochemical impedance spectroscopy and differential pulse voltammetry. Selectivity, stability and reproducibility of the sensors were also studied and discussed. A good linear relationship for supervising 2,4-D from 1.0 × 10 −4 to 1.0 × 10 −8 mol L −1 with the correlation coefficient of 0.994 and a low LOD of 4.270 nmol L −1 (S/N = 3). The electrochemical sensor has been successfully applied to detect 2,4-D with a recovery rate ranges from 96.2 to 102.4% and a relative standard deviation of less than 4.74%. This work provides potential ideas for detection of trace 2,4-D in real samples.
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NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 17
·8029-8036
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IF 3.925
Qingju Liu,Saixue Tang,Hui Wang,Ping Han
The current luminescent metal–organic framework (MOF) based fluorescence detection mostly focuses on achiral molecules. The stereospecific recognition and determination of MOF-based detection remain challenging. A novel luminescent terbium-based MOF (Tb-MOF) based biosensing system with excellent performance for stereoselective detection of D-amino acids (D-AAs) was introduced in this paper. D-Amino acid oxidase catalyzes stereospecific oxidative deamination of D-AAs, producing H2O2. The generated H2O2 effectively quenches the fluorescence of Tb-MOF. Under optimum conditions, the D-AAs were detected with excellent efficiency. The linear working range was 0.5–100 μM for D-Alanine (D-Ala) and 0. 5–5 μM for D-Proline (D-Pro), respectively. The limit of detection (Ksv detection) for D-Ala and D-Pro was 0.09 μM and 0.14 μM, respectively. The detection can be performed within 30 min with high selectivity and long-term stability. The fluorescent sensing platform required simple fabrication and operation and was free from complicated reaction processes and expensive reagents. The present sensing system was successfully applied in D-AA detection in human serum with good recovery, indicating its potential application in detection in biological samples.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Dongbo Wang,Ying Wang,Yuan Li,Ting Shi,Dandan Han,Junbo Gong
Impurity sugars produced in upstream process of functional sugars are significantly impacting the product quality. In this work, the effect of congeners ( d -maltose ( d -MAL), d -fructose ( d -FRU), d -glucose ( d -GLU)) on primary and secondary nucleation of d -tagatose ( d -TAG) crystals was investigated. The impurity sugars showed an inhibition on primary nucleation of d -TAG crystals, while a promotion on the secondary nucleation of d -TAG. Interestingly, the impact of impurity sugars on d -TAG crystal growth was similar to that on primary nucleation. The diffusion ability, hydrogen bonding forming ability, interaction energy of d -TAG crystal surfaces and impurity sugars were evaluated by molecular dynamics (MD) simulations to reveal the nucleation and growth behavior. Based on the above findings, we designed the d -TAG crystallization experiments, and obtained d -TAG crystals with uniform particle size distribution and regular morphology. This study helps to understand the influence of impurity sugars on crystallization, guiding the industrial manufacturing of functional sugars.
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PubMed
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Biosensors-Basel
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2021
·Vol. 11
·期 10
·378
·
IF 5.519
Jinfeng Quan,Yihan Wang,Jialei Zhang,Kejing Huang,Xuemei Wang,Hui Jiang
Arch-cruciform DNA are self-assembled on AuNPs/VS2scaffold as a highly sensitive and selective electrochemical biosensor for michigan cancer foundation-7 (MCF-7) breast cancer cells. In the construction, arch DNA is formed using two single-strand DNA sequences embedded with the aptamer for MCF-7 cells. In the absence of MCF-7 cells, a cruciform DNA labeled with three terminal biotin is bound to the top of arch DNA, which further combines with streptavidin-labeled horseradish peroxidase (HRP) to catalyze the hydroquinone-H2O2reaction on the electrode surface. The presence of MCF-7 cells can release the cruciform DNA and reduce the amount of immobilized HRP, thus effectively inhibiting enzyme-mediated electrocatalysis. The electrochemical response of the sensor is negatively correlated with the concentration of MCF-7 cells, with a linear range of 10~1 × 105cells/mL, and a limit of detection as low as 5 cells/mL (S/N = 3). Through two-dimensional materials and enzyme-based dual signal amplification, this biosensor may pave new ways for the highly sensitive detection of tumor cells in real samples.Keywords:MCF-7 cells;electrochemistry;2-D materials;signal amplification;DNA assembly
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
·
IF 3.973
Lifen Wang,Pengpeng Xue,Mengqi Tong,Rui Chen,Waigeng Yang,Deli ZhuGe,Jiandong Yuan,Qing Yao,Yingzheng Zhao,Helin Xu
Inflammatory bowel diseases (IBDs) are chronic relapsing disorders of the gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial injury. Laquinimod (LAQ), a poorly water-soluble compound, was proved to be effective for colitis remission at low dose of 0.5 mg/kg in patients with Crohn’s disease. Due to its extremely low solubility in water, it was difficult to develop an injectable liquid dosage form. Herein, D-α-Tocopheryl polyethylene glycol-1000 succinate (TPGS) polymeric micelles were developed as a delivery vehicle of LAQ for the management of inflammatory bowel disease. Using the LAQ/TPGS ratio of 1:100, LAQ-loaded micelles were successfully prepared by thin-film dispersion method. The solubility of LAQ in water was significantly increased from 10.5 μg/mL in pure water to 500 μg/mL in TPGS micelles. LAQ-loaded micelles of TPGS exhibited the fine particle size of 34.6 nm and Zeta potential of -0.67 mV. Moreover, the good stability of LAQ-loaded micelles in physiology-mimicking medium was confirmed by detecting their particle size, zeta potential and leakage of the loading drug. Therapeutic effect of LAQ-loaded micelles on DSS-induced mice was proved by detecting DAI score, colon length and loss of body weight. Moreover, the morphology and colonic mucosal barrier of the injured colon of DSS-induced mice was largely recovered after treatment with LAQ-loaded micelles. Meanwhile, the inflammation of colitis colon was also obviously alleviated by LAQ-loaded micelles. Conclusively, polymeric micelles of TPGS may be a promising delivery vehicle of LAQ for the management of inflammatory bowel disease.
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ACS Applied Materials & Interfaces
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2023
·
IF 9.5
Xiaohui Niu,Simeng Yan,Rui Zhao,Hongxia Li,Xiaoyu Liu,Kunjie Wang
In the pursuit of chiral materials with significant chiral recognition effects and stability, various strategies have been explored, among which the integration of metal nanoparticles and chiral metal–organic frameworks (CMOFs) is highly promising. However, metal nanoparticles (MNPs)/CMOFs show high chiral properties but inferior stabilities due to the MNPs being easily detached from the outside layer under certain conditions. Sandwich MOFs@MNPs@CMOF chiral materials can overcome this dilemma because the sandwich structure can maximize the regulation of the chiral interface activity, while the controlled outer layer can stop the MNPs from falling off in the procedure of chiral recognition. Here, a novel sandwich chiral material (d-His-ZIF-8@Au@ZIF-8) was synthesized by a ligand-assisted strategy with a well-defined sandwich morphology and chiral recognition capabilities. The electrochemical chiral recognition showed that d-His-ZIF-8@Au@ZIF-8 was the most efficient for the enantiomer of phenylalanine (Phe). This experiment presents a novel perspective for the fabrication of a chiral electrochemical sensing platform based on a solid sandwich chiral nanocomposite.
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ORGANIC ELECTRONICS
·
2023
·
IF 3.2
Di Zhao,Qiuhong Cui,Xingyu Zhang,Hongyu Ji,Xin Liu,Liang Qin,Yuanyuan Hu,Yanbing Hou,Yufeng Hu,Zhidong Lou,Feng Teng
Organic salt doping is an effective method to control the electrical properties of organic semiconductor materials, while its underlying mechanism remains to be studied. In this work, we report the improvement of organic field-effect transistor (OFET) performance by doping the D-A polymer semiconductor PTB7-Th with organic salts. The underlying mechanism of PTB7-Th's organic salt doping in OFETs has been explored to fill the existing research gap. The doping of organic salts can improve the hole mobility of the device and change the threshold voltage . In addition, at low doping ratios, the on-off ratio of the device is not sacrificed but remains unchanged. Finally, we have made a series of characterizations of the properties of doped polymers through absorption, EPR , and UPS , which provide specific guidelines for modifying D-A polymer devices.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2023
·Vol. 47
·期 13
·6378-6384
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IF 3.3
Dongdong Tan,Tianmiao Wang,Jing Hu,Donglian Deng,Tingting Li,Ruijun Li
Considering chiral covalent organic frameworks (COFs) featuring the intriguing properties of porous organic materials, chiral recognition, and separation, the design and synthesis of chiral COFs with high crystallinity has remained a daunting challenge. A brominated functionalized COF (COF-Br) with high crystallinity and stability was synthesized. Using the post-synthetic modification strategy of the Suzuki–Miyaura cross-coupling reaction, a chiral COF (COF-L-Phe) was successfully constructed by combining COF-Br and the chiral functional groups of 4-borono-L-phenylalanine. The chiral recognition ability of COF-L-Phe was verified using an experimental adsorption model. Furthermore, COF-L-Phe-modified capillary columns have been used for the separation of racemic phenylalanine using capillary electrochromatography. This work will provide guidance for constructing chiral COFs for chirality related applications.
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Metals
·
2023
·Vol. 13
·期 4
·649
·
IF 2.9
Xiaoxi Ruan,Linlin Yang,Yan Wang,Yizhe Dong,Dake Xu,Mingxing Zhang
The corrosion of carbon steel causes dramatic economic losses each year. Since conventional corrosion prevention approaches may cause pollution problems to the environment, ecofriendly and effective corrosion approaches are desired. Microbiologically influenced corrosion inhibition (MICI) has been reported as a sustainable corrosion prevention method. This work aims to evaluate the corrosion inhibition effect of two bacterial strains,Tenacibaculum mesophilumD-6 andBacillussp. Y-6 by choosing Q235 carbon steel as a model system. Scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM) and a series of electrochemical techniques were applied to study the corrosion prevention effect. The electrochemical and pitting results indicated thatT. mesophilumD-6 displayed a better corrosion protection effect.T. mesophilumD-6 formed a denser and thicker biofilm on the Q235 surface thanBacillussp. Y-6. The maximum thickness of theT. mesophilumD-6 biofilms was 11.6 ± 0.7 μm, which is about twice as thick than that ofBacillussp. Y-6. The corrosion prevention mechanism was ascribed to the formation of biofilms as a barrier to block corrosive agents such as O2. This study provides a theoretical foundation for the application of biofilms as green and effective corrosion inhibitors for carbon steel.Keywords:Q235 carbon steel;Tenacibaculum mesophilumD-6;Bacillussp. Y-6;corrosion inhibition;biofilm formation ability
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WATER RESEARCH
·
2023
·
IF 12.8
Wei-Ran Han,Wen-Long Wang,Tie-Jun Qiao,Wei Wang,Hang Su,Chen-Xin Xu,Qian-Yuan Wu
Micro-bubble aeration is an efficient way to promote ozonation performance, but the technology is challenged by extensive energy cost. Here, a ceramic ultrafiltration membrane was used to achieve ozone micro-bubble (0–80 µm) aeration in a simple way at gaseous pressures of 0.14–0.19 MPa. Compared with milli-bubble aeration, micro-bubble aeration increased the equilibrium aquatic O 3 concentrations by 1.53–3.25 times and apparent O 3 transfer rates by 3.12–3.35 times at pH 5.0–8.0. Consequently, the • OH yield was 2.67–3.54 times via faster O 3 transfer to the aquatic solution followed by decomposition rather than interfacial reaction. Ozone micro-bubble aeration outperformed milli-bubble aeration, with the degradation kinetics of 2,4-D being 3.08–4.36 times higher. Both O 3 -oxidation and • OH oxidation were important to the promotion with the contributions being 35.8%-45.9% and 54.1%-64.2%, respectively. The operational and water matric conditions influenced the oxidation performance via both O 3 oxidation and • OH oxidation, which is reported for the first time. In general, the ceramic membrane offered a low-energy approach of ozone micro-bubble aeration for efficient pollutant degradation. The O 3 oxidation and • OH oxidation were proportionally promoted by ozone micro-bubble due to O 3 transfer enhancement. Thus, the promotive mechanism can be interpreted as the synchronous enchantment on ozone exposure and • OH exposure for the first time.
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