JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2026
·
IF 9.2
Shanshan Feng,Ke Liu,Donghui Li,Lixiang Shi,Wenqi Nie,Shiduo Hao,Yunpu Zhai,Yonggang Liu
The photo-Fenton method presents a promising approach for wastewater treatment, yet it faces several significant challenges, including the continuous supply of H 2 O 2 , slow mass transfer rates and a limited operational pH range. In this context, we describe the successful preparation of a novel catalyst: n-p type graphitic carbon nitride nanosheets engineered with nitrogen vacancies and decorated with Cu 2 O-T, which is characterized by controllable crystal planes. This photo-self-Fenton-like catalyst is designed for the in-situ production and activation of H 2 O 2 . The optimized catalyst, CNC-20, demonstrates remarkable efficiency in degrading various organic pollutants, showcasing high cyclic stability and wide applicability. Notably, CNC-20 achieves a degradation rate of 98.8% for tetracycline hydrochloride within 60 min, with a reaction rate constant 4.2 times greater than that of pristine carbon nitride. Characterization studies illustrate that the construction of ultrathin carbon nitride nanosheets featuring nitrogen vacancies, combined with the co-exposure of Cu 2 O-T crystalline planes (111) and (100), significantly enhances carrier separation efficiency, thereby facilitating effective H 2 O 2 generation. Furthermore, Cu 2 O-T plays a crucial role in the direct capture of in-situ generated H 2 O 2 , rapidly activating it to generate abundant ·OH, which effectively mitigates the issue of slow mass transfer associated with H 2 O 2 . This study presents a novel approach integrating in-situ H 2 O 2 generation and activation, effectively overcoming the inherent limitations of traditional photo-Fenton reactions and providing a promising strategy for pollutant degradation in wastewater treatment systems.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2016
·Vol. 33
·期 8
·2460-2468
·
IF 1.408
Wang Jun,Song Hao,Yang Xuzhao,Zou Wenyuan,Chen Yufei,Duan Shaochan,Sun Jun
The density, viscosity, and refractive index of a pure asymmetrical dicationic ionic liquid, 1-(1-methypiperidinium-1-yl) pentane-(1-pyridinium) bis(trifluoromethane)sulfonamide, and its binary mixtures with acetonitrile were investigated at temperatures from 293.15 K to 323.15 K over the entire range of composition at ambient pressure. From the experimental data, the excess molar volumes, dynamic viscosity deviations, and refractive index deviations were, respectively,calculated and correlated with Redlich-Kister-type polynomials. The temperature dependence of viscosity for pure ionic liquid was described by modified Vogel–Tammann-Fulcher (VTF) equation. The enthalpy and entropy of activation for viscous flow were obtained. The values of molar refraction and polarizability indicated that the dominant interactions between ionic liquids and acetonitrile were dipole-dipole molecular interactions. These thermodynamic properties were discussed in terms of nature of molecular interactions between the ionic liquid and acetonitrile.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Yiling Liu,Yaqi Ouyang,Liu Yu,Peng Wang,Zhangwen Peng,Hengdeng Liu,Shixin Zhao,Hanwen Wang,Ziheng Zhou,Yang Deng,Yang Liu,Julin Xie
Skin graft rejection is a significant challenge in skin allografts for skin defects, particularly in extensive burn injury patients when autografts are insufficient. Enhancing the survival duration of allogeneic skin grafts can improve the success rate of subsequent autologous skin grafting, thereby promoting the therapeutic efficacy for wound healing. Rapamycin (Rapa), a potent immunosuppressant with favorable efficacy in organ transplantation, is limited by its systemic administration-associated toxicity and side effects. Therefore, addressing the short survival time of allogeneic skin grafts and minimizing the toxicity related to systemic application of immunosuppressive agents is an urgent requirement. Here, we present a topical formulation based on bioadhesive poly (lactic acid)-hyperbranched polyglycerol nanoparticles (BNPs) with surface-modified encapsulation of Rapamycin (Rapa/BNPs), applied for local immunosuppression in a murine model of allogeneic skin grafts. Our Rapa/BNPs significantly prolong nanoparticle retention, reduce infiltration of T lymphocytes and macrophages, decrease the level of pro-inflammatory cytokines and ultimately extend skin allograft survival with little systemic toxicity compared to free Rapa or Rapamycin-loaded non-bioadhesive nanoparticles (Rapa/NNPs) administration. In conclusion, Rapa/BNPs effectively deliver local immunosuppression and demonstrate potential for enhancing skin allograft survival while minimizing localized inflammation, thus potentially increasing patient survival rates for various types of skin defects.
研究领域:
移植学
·
药学
·
免疫学
·
生物医学工程
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Journal of Asthma and Allergy
·
2022
·
IF 3.027
Yang Sun,Tiancong Liu,Weiliang Bai
Purpose This work aimed to investigate the effects of MAF bZIP transcription factor B (MAFB) on the progression of allergic rhinitis (AR). Patients and Methods Nasal mucosa was isolated from AR patients and healthy individuals from Shengjing Hospital of China Medical University. The experimental procedures were approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University (2019PS341K) in accordance with the Declaration of Helsinki. Informed consents were signed by participants or a parent/legal guardian of the participants under 18 years old of age. Then, an AR mouse model with MAFB overexpression was established with 25 μg ovalbumin (OVA) sensitization on day 0, 7, 14, followed by an injection with 1×10 7 TU/mL lentivirus MAFB on day 19 and a nasal challenge with 500 μg OVA from day 21 to 27. Results The results revealed that MAFB was down-regulated in the nasal mucosa of AR patients. The up-regulation of MAFB protected the AR mice against the OVA-induced allergic symptoms (sneezing and nasal rubbing) by alleviating the OVA-induced epithelial thicknesses, goblet cell hyperplasia, and inflammation including the eosinophil and mast cell infiltration. Moreover, MAFB facilitated the T helper (Th) 1 response and inhibited the Th2 and Th17 responses by the down-regulation of T-box transcription factor 21 and the up-regulation of GATA binding protein-3 as well as retinoid-related orphan receptor-γt in the splenocytes of AR mice. MAFB was found to repress the differentiation of naive CD4 + T cells into Th2 cells. Subsequently, MAFB overexpression reversed the OVA-induced enhancement of epithelial permeability, downregulation of tight junctions, and upregulation of cadherin-26, indicating the protective role of MAFB on epithelial barrier integrity. Conclusion MAFB protected against OVA-induced AR via the alleviation of inflammation by restoring the Th1/Th2/Th17 imbalance and epithelial barrier dysfunction.
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THERMOCHIMICA ACTA
·
2019
·
IF 2.251
Da-Wei Fang,Xiao-Hong Hu,Kun-Hao Liang,Qiang Yan,Jie Wei
The density and surface tension for the binary mixtures of ionic liquid (ILs) [C 2 2O1IM][TfO] with ethanol, 1-propanol and 2-propanol are measured across the entire range of mole fraction at T = (288.15–318.15) K. The excess molar volumes of the binary mixtures are calculated, the relationship between V E and the mole fraction and temperature are explored. Especially, the term, △ V E /△ T is proposed to describe the interaction between the solvent and solute quantificationally. The molar surface Gibbs energy of the binary mixtures are obtained based on the density and surface tension, and the interaction between the components in both liquid and surface phase of the binary mixture is discussed. And its applications are also explored, including the estimation of surface tension for the binary mixtures and the improvement of the traditional Eötvös equation. At the same time, the polarity of the binary mixtures of [C 2 2O1IM][TfO] with alcohols is obtained.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Kun Ge,Yuling Hu,Gongke Li
Herein, Ag nanoparticles decorated MOF-74 (Ni) encapsulated magnetic prickly-like nickel rods (NiRs@MOF-74 (Ni)/Ag) was firstly designed and fabricated for simultaneous surface-enhanced Raman spectroscopy (SERS) analysis of mycotoxins in food samples. The prickly-like NiRs not only provide magnetism with anisotropy structure, but also directly supply Ni 2+ for surface initiated encapsulation of MOF-74 (Ni) on NiRs. The as-fabricated NiRs@MOF-74 (Ni)/Ag exhibits good SERS activity due to the enrichment effect of magnetic NiRs, adsorption of MOF-74 (Ni) and localized surface plasmon resonance properties of AgNPs . The enhancement factor for 5,5′-dithiobis-(2-nitrobenzoic acid) and 4-mercaptobenzoic acid can reach 10 8 level with limits of detection (LOD) of 1.0 ng/L. Subsequently, the magnetic aptamer probes based on NiRs@MOF-74 (Ni)/Ag were fabricated for simultaneous, sensitive and selective SERS analysis of T-2 and deoxynivalenol in food samples. The method exhibited satisfactory linearity in range of 0.5–750.0 μg/L and 0.3–750.0 μg/L with LOD of 0.15 and 0.08 μg/L for T-2 and deoxynivalenol, respectively. The relative errors between the developed method and standard HPLC-MS ranged from −7.7 to 1.4%. Our results open a new venue in design and fabrication of magnetic SERS substrates with unique property for quantification of multiple mycotoxins in complex samples.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2020
·
IF 2.369
Miyangzi Suo,Bokun Chen,Yu Qian,Siyu Yang
The synergistic effect for a solvent mixture of diisopropyl ether and n-Pentanol to extract hydroquinone from aqueous solution was investigated. Liquid–liquid equilibrium data of the quaternary (n-Pentanol + diisopropyl ether + water + hydroquinone) system were measured at T = 298.15 K and P = 101.3 kPa, using various compositions of solvent mixture. It can be seen from the slope of the tie lines that with the increase of distribution coefficients of hydroquinone, the size of the immiscible solution region decreased slightly. The extraction efficiency was evaluated by calculating the separation factor and distribution coefficient. Using the universal quasichemical (UNIQUAC) and nonrandom two-liquid (NRTL) models to correlate with experimental data, the corresponding binary interaction parameters were obtained. The RMSD values of UNIQUAC and NRTL models showed that the calculated results were in good agreement with the liquid–liquid equilibrium data.
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MOLECULAR THERAPY
·
2024
·
IF 12.1
Xiaozhen Kang,Yifeng Han,Mengdi Wu,Yuxin Li,Peng Qian,Chuning Xu,Zhengyun Zou,Jie Dong,Jiwu Wei
Tumor necrosis factor (TNF) has been recognized as an immune activation factor in tumor immunotherapy. Our study demonstrated that TNF blockade markedly enhanced the antitumor efficacy of oncolytic adenovirus (AdV) therapy. To minimize systemic side effects, we engineered a recombinant oncolytic AdV encoding a TNF inhibitor (AdV-TNFi) to confine TNF blockade within the tumor microenvironment (TME). AdV-TNFi significantly improved therapeutic outcomes across various solid tumor models, including four murine and two golden hamster cancers. Immune cell profiling identified CD8 + T cells as the primary mediators of AdV-TNFi-induced antitumor effects, rather than CD4 + T or NK cells. Additionally, AdV-TNFi significantly decreased the infiltration of suppressive myeloid-derived immune cells within the TME and promoted long-term antitumor immune surveillance. Further investigation indicated that TNFR2, more than TNFR1, is pertinent to the immunosuppressive TME, with a recombinant AdV-encoding anti-TNFR2 demonstrating comparable antitumor efficacy to AdV-TNFi. Moreover, AdV-TNFi enhanced the antitumor efficacy of gemcitabine and immune checkpoint blockades (ICBs), such as anti-PD-L1 and anti-TIGIT antibodies, in pancreatic carcinoma and the anti-EGFR antibody in colon carcinoma. In conclusion, intratumoral blockade of the TNF/TNFR2 axis using AdV augments cancer immunotherapy efficacy while mitigating the risks associated with systemic TNF or TNFR2 suppression, warranting further clinical investigation.
研究领域:
肿瘤学
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免疫学
·
分子生物学
·
癌症治疗
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BIOMATERIALS
·
2021
·
IF 12.479
Fengling Feng,Haibin Hao,Jin Zhao,Yanjun Li,Ying Zhang,Ruiting Li,Ziyu Wen,Chunxiu Wu,Minchao Li,Pingchao Li,Ling Chen,Ruikang Tang,Xiaoyu Wang,Caijun Sun
Adenovirus (Ad) has been extensively developed as a gene delivery vector, but the potential side effect caused by systematic immunization remains one major obstacle for its clinical application. Needle-free mucosal immunization with Ad-based vaccine shows advantages but still faces poor mucosal responses. We herein report that the chemical engineering of single live viral-based vaccine effectively modulated the location and pattern of the subsequently elicited immunity. Through precisely assembly of functional materials onto single live Ad particle, the modified virus entered host cell in a phagocytosis-dependent manner, which is completely distinct from the receptor-mediated entry of native Ad. RNA-Seq data further demonstrated that the modified Ad-induced innate immunity was sharply reshaped via phagocytosis-related pathway, therefore promoting the activation and mature of antigen presentation cells (APC). Moreover, the functional shell enabled the modified Ad-based vector with enhanced muco-adhesion to nasal tissues in mice, and then prolonged resident time onto mucosal surface, leading to the robust mucosal IgA production and T cell immunity at local and even remote mucosal-associated lymphoid tissues. This study demonstrated that vaccine-induced immunity can be well modulated by chemistry engineering, and this method provides the rational design for needle-free mucosa-targeting vaccine against a variety of emerging infectious diseases.
研究领域:
病毒学
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免疫学
·
生物医学工程
·
分子生物学
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JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-18
·
IF 10.435
Luo Lihua,Qin Bing,Jiang Mengshi,Xie Lin,Luo Zhenyu,Guo Xuemeng,Zhang Junlei,Li Xiang,Zhu Chunqi,Du Yongzhong,Peng Ling,You Jian
Background Photothermal therapy (PTT) is a highly effective treatment for solid tumors and can induce long-term immune memory worked like an in situ vaccine. Nevertheless, PTT inevitably encounters photothermal resistance of tumor cells, which hinders therapeutic effect or even leads to tumor recurrence. Naïve CD8+ T cells are mainly metabolized by oxidative phosphorylation (OXPHOS), followed by aerobic glycolysis after activation. And the differentiate of effector CD8+ T cell (CD8+ T eff ) into central memory CD8+ T cell (CD8+ TCM) depends on fatty acid oxidation (FAO) to meet their metabolic requirements, which is regulated by adenosine monophosphate activated protein kinase (AMPK). In addition, the tumor microenvironment (TME) is severely immunosuppressive, conferring additional protection against the host immune response mediated by PTT. Methods Metformin (Met) down-regulates NADH/NADPH, promotes the FAO of CD8+ T cells by activating AMPK, increases the number of CD8+ TCM, which boosts the long-term immune memory of tumor-bearing mice treated with PTT. Here, a kind of PLGA microspheres co-encapsulated hollow gold nanoshells and Met (HAuNS-Met@MS) was constructed to inhibit the tumor progress. 2-Deoxyglucose (2DG), a glycolysis inhibitor for cancer starving therapy, can cause energy loss of tumor cells, reduce the heat stress response of tumor cell, and reverse its photothermal resistance. Moreover, 2DG prevents N-glycosylation of proteins that cause endoplasmic reticulum stress (ERS), further synergistically enhance PTT-induced tumor immunogenic cell death (ICD), and improve the effect of immunotherapy. So 2DG was also introduced and optimized here to solve the metabolic competition among tumor cells and immune cells in the TME. Results We utilized mild PTT effect of HAuNS to propose an in situ vaccine strategy based on the tumor itself. By targeting the metabolism of TME with different administration strategy of 2DG and perdurable action of Met, the thermotolerance of tumor cells was reversed, more CD8+ TCMs were produced and more effective anti-tumor was presented in this study. Conclusion The Step-by-Step starving-photothermal therapy could not only reverse the tumor thermotolerance, but also enhance the ICD and produce more CD8+ TCM during the treatment. Graphical Abstract
研究领域:
癌症治疗
·
免疫学
·
纳米技术
·
代谢工程
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2016
·
IF 2.196
Dandan Gao,Dongdong Li,Wu Li
Solubility of RbCl(cr) and CsCl(cr) in pure water were determined at subzero temperatures. The solubility of RbCl(cr) and CsCl(cr) decreased with temperature increment. Specific heat capacity of RbCl(aq) and CsCl(aq) solutions were determined at 298.15 K and concentration to near saturation. The specific heat capacity of RbCl(aq) and CsCl(aq) solutions decreased with concentration increment and for the same molality the specific heat capacity of CsCl(aq) is smaller than that of RbCl(aq). A temperature dependent thermodynamic model based on the Pitzer-Simonson-Clegg activity coefficient equations was used to represent the activity, thermal and solid-liquid equilibria properties of RbCl + H 2 O and CsCl + H 2 O systems. The obtained models can reproduce and predict the thermodynamic properties and phase diagram of the two binary systems well for the temperature range from 200 K to 370 K. The present models have an advantage especially at subzero temperatures due to the utilization of low temperature solubility experimental data in parameterization.
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ECOTOXICOLOGY
·
2010
·Vol. 19
·期 8
·1612-1619
·
IF 3.507
Han Peng,Niu Chang-Ying,Lei Chao-Liang,Cui Jin-Jie,Desneux Nicolas
Transgenic Cry1Ac+CpTI cotton (CCRI41) is a promising cotton cultivar throughout China but side effects and especially sublethal effects of this transgenic cultivar on beneficial insects remain poorly studied. More specifically potential sublethal effects on behavioural traits of the honey bee Apis mellifera L. have not been formally assessed despite the importance of honey bees for pollination. The goal of our study was to assess potential effects of CCRI41 cotton pollen on visual and olfactory learning by honey bees. After a 7-day oral chronic exposure to honey mixed with either CCRI41 pollen, imidacloprid-treated conventional pollen (used as positive sublethal control) or conventional pollen (control), learning performance was evaluated by the classical proboscis extension reflex (PER) procedure as well as a T-tube maze test. The latter assay was designed as a new device to assess potential side effects of pesticides on visual associative learning of honey bees. These two procedures were complementary because the former focused on olfactory learning while the latter was involved in visual learning based on visual orientation ability. Oral exposure to CCRI41 pollen did not affect learning capacities of honey bees in both the T-tube maze and PER tests. However, exposure to imidacloprid resulted in reduced visual learning capacities in T-tube maze evaluation and decreased olfactory learning performances measured with PER. The implications of these results are discussed in terms of risks of transgenic CCRI41 cotton crops for honey bees.
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